A device for cross-linked collagen repair materials

Abstract

This invention provides a device for crosslinking collagen repair materials, comprising: a crosslinking tank with a first connection port, a second connection port, an inlet, and a outlet, wherein collagen repair materials can be placed inside the crosslinking tank; a circulation pump with a first connecting pipe and a second connecting pipe, the end of the first connecting pipe being connected to the first connection port, and the end of the second connecting pipe being connected to the second connection port; and a controller communicatively connected to the circulation pump to control the start, stop, and constant flow of the circulation pump. Through the closed-loop circulation system formed by the circulation pump and the crosslinking tank, the crosslinking agent continuously flows within the tank, maintaining a large circulation of the crosslinking reagent without damaging the product, ensuring the uniformity of crosslinking of the collagen repair material, and guaranteeing the product's quality properties.

Description

Technical Field

[0001] This invention belongs to the field of biomedical material preparation technology, specifically relating to a device for cross-linked collagen repair material. Background Technology

[0002] Bone collagen repair materials are mainly composed of porous bone particles and collagen through freeze-drying and cross-linking. Due to the properties of the two raw materials, the freeze-dried sample is prone to delamination and brittleness. If the product is not cross-linked, it is easily damaged and degraded during use, and the material has low mechanical properties, which is not conducive to filling damaged areas in the oral cavity and failing to provide support.

[0003] In related technologies, cross-linking of products is mainly achieved through stirring. During the cross-linking process, the stirring paddle of the equipment can damage the product, such as causing bone particles to fall off, product displacement, and the introduction of foreign impurities. Utility Model Content

[0004] In view of this, the present invention provides a device for cross-linking collagen repair materials to solve the problems existing in the prior art.

[0005] This utility model provides a device for crosslinking collagen repair material, comprising: a crosslinking tank having a first connection port, a second connection port, a liquid inlet, and a liquid outlet, wherein collagen repair material can be placed inside the crosslinking tank; a circulation pump having a first connecting pipe and a second connecting pipe, wherein the end of the first connecting pipe is connected to the first connection port, and the end of the second connecting pipe is connected to the second connection port; and a controller communicatively connected to the circulation pump to control the start, stop, and constant flow of the circulation pump.

[0006] In one optional embodiment, the liquid inlet is provided with a sealing cap, which is sealed to the liquid inlet.

[0007] In one alternative embodiment, the sealing cover has at least one viewing window.

[0008] In one optional embodiment, the inner wall of the liquid inlet is provided with a protrusion away from the inner wall, the sealing cap overlaps with the protrusion, and a sealing buckle is provided between the sealing cap and the inner wall.

[0009] In one alternative embodiment, the first connection port is connected to a first valve, and the second connection port is connected to a second valve.

[0010] In one optional embodiment, the device for cross-linked collagen repair material further includes a filter frame with multiple filtration spaces therein, and the collagen repair material is placed in the filtration spaces.

[0011] In one alternative embodiment, the filter frame is provided with multiple layers of grilles in the height direction, and each layer of grilles is provided with a plurality of filter spaces in the transverse direction.

[0012] In one optional embodiment, the circulating pump includes: a constant flow pump; and a servo motor electrically connected to the constant flow pump; wherein the servo motor is communicatively connected to the controller.

[0013] In one optional embodiment, the device for cross-linked collagen repair material further includes a flow sensor, which is communicatively connected to the controller, so that the controller controls the operating state of the constant flow pump based on the flow data from the flow sensor.

[0014] In one alternative embodiment, the apparatus for cross-linked collagen repair material further includes a frame, with the cross-linking tank and the circulation pump respectively connected to the frame.

[0015] The beneficial effects of this invention are as follows: through the closed-loop circulation system formed by the circulation pump and the crosslinking tank, the crosslinking agent flows continuously in the tank, maintaining the large circulation of the crosslinking reagent without damaging the product, ensuring the uniformity of crosslinking of the collagen repair material, and guaranteeing the product quality attributes. Attached Figure Description

[0016] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without any creative effort.

[0017] Figure 1 This is a schematic diagram of the device structure of a cross-linked collagen repair material according to an embodiment of the present invention; Figure 2 This is a partially enlarged structural diagram of the filter frame of a device for cross-linked collagen repair material according to an embodiment of the present invention.

[0018] Explanation of reference numerals in the attached figures: 10. Crosslinking tank; 101. First connection port; 102. Second connection port; 103. Drain port; 104. Sealing cap; 105. Viewing window; 106. Protrusion; 107. Sealing buckle; 20. Circulation pump; 201. First connecting pipe; 202. Second connecting pipe; 21. Constant flow pump; 22. Servo motor; 30. Controller; 40. Filter frame; 401. Filtration space; 50. Flow sensor; 61. First valve; 62. Second valve; 63. Third valve; 70. Frame. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0020] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0021] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0022] Furthermore, the technical features involved in the different embodiments of this utility model described below can be combined with each other as long as they do not conflict with each other.

[0023] The cross-linking process of collagen repair materials involves prolonged soaking. It relies on precise fluid output of cross-linking reagents from the equipment to immerse the product, ensuring cross-linking stability and color consistency. This device can securely stack the products, maintain a large-scale circulation of the cross-linking reagents (with controllable flow), and prevent damage to the products. This ensures uniform cross-linking and consistent color of the collagen repair materials, maintaining their quality attributes.

[0024] The following is combined Figures 1 to 2 The following describes embodiments of the present invention.

[0025] like Figure 1As shown in the embodiment of the utility model, a device for crosslinking collagen repair material is provided, comprising: a crosslinking tank 10, having a first connection port 101, a second connection port 102, a liquid inlet and a liquid outlet 103, wherein collagen repair material can be disposed in the crosslinking tank 10; a circulation pump 20, having a first connecting pipe 201 and a second connecting pipe 202, wherein the end of the first connecting pipe 201 is connected to the first connection port 101 and the end of the second connecting pipe 202 is connected to the second connection port 102; and a controller 30, which is communicatively connected to the circulation pump 20 to control the start, stop and constant flow of the circulation pump 20.

[0026] The device mainly consists of three parts: a cross-linking tank 10, a circulation pump 20, and a controller 30. The components work together to achieve efficient cross-linking treatment of collagen repair materials.

[0027] The cross-linking tank 10, as the core container for the material cross-linking reaction, has an inner wall made of biocompatible materials, such as medical-grade stainless steel or polytetrafluoroethylene, to avoid contamination of the bone collagen raw materials. The first connection port 101 and the second connection port 102 of the cross-linking tank 10 are used to connect the inlet and outlet pipes of the circulation pump 20, i.e., the first connecting pipe 201 and the second connecting pipe 202, to form a closed-loop circulation path. The inlet is used to inject the cross-linking agent (such as genipin, glutaraldehyde, etc.) and buffer solution into the tank, while the outlet 103 is used to discharge waste liquid or recover unreacted cross-linking agent after the reaction. Furthermore, a detachable fixing frame can be installed inside the cross-linking tank 10 to stably place the bone collagen repair materials (such as collagen sponges, membranes, etc.), ensuring that the materials are in uniform contact with the cross-linking agent during the reaction.

[0028] The circulating pump 20 draws the mixture (containing crosslinking agent and material exudate) from the first connection port 101 of the crosslinking tank 10 through the first connecting pipe 201, and then pumps it back into the tank through the second connection port 102 through the second connecting pipe 202, forming a forced circulation flow field. The circulating pump 20 can control the circulation flow rate by adjusting the speed to adapt to the requirements of crosslinking agents and materials with different viscosities.

[0029] The first connection port 101 is connected to the first valve 61, the second connection port 102 is connected to the second valve 62, the first connecting pipe 201 is connected to the first valve 61, and the second connecting pipe 202 is connected to the second valve 62. Both the first connecting pipe 201 and the second connecting pipe 202 are flexible hoses.

[0030] The controller 30 can be a microprocessor-based control system, connected to the circulating pump 20 via wired or wireless communication. It can preset and adjust the pump's start-up and stop times, operating speed, and constant flow parameters in real time. The controller 30 is equipped with a touch screen and a data storage module, allowing operators to easily set reaction cycles (e.g., 0.5-24 hours) and record circulation flow curves. It also features over-temperature and over-current protection functions to ensure the stability of the device operation.

[0031] Through the closed-loop circulation system formed by the circulation pump 20, the crosslinking agent flows continuously in the tank, which can avoid local concentrations that are too high or too low, and ensure that all parts of the bone collagen raw material are in full contact with the crosslinking agent. This solves the problem of large differences in the degree of crosslinking between the surface and the interior of the material in the static reaction, and improves the consistency of the product's mechanical properties (such as tensile strength) and degradation stability. It maintains the large circulation of the crosslinking agent without damaging the product, and can ensure the uniformity of crosslinking of the bone collagen repair material, the consistency of product color, and guarantee the product quality attributes.

[0032] The controller 30 can precisely control the constant flow parameters and running time of the circulating pump 20. Operators can adjust the flow rate and reaction cycle of the crosslinking agent according to the material type (such as collagen molecular weight and porosity) to achieve quantitative control of the degree of crosslinking (such as controlling the penetration depth of the crosslinking agent by adjusting the circulation flow). Compared with the traditional method of manually adding crosslinking agents, it can improve the reaction efficiency, for example, by more than 30%, and reduce human operation errors.

[0033] The integrated design of the device reduces manual intervention steps, and the automated control and protection functions of the controller 30 reduce the difficulty of operation, while avoiding direct contact between operators and toxic crosslinking agents (such as glutaraldehyde), thus improving the safety of the production process.

[0034] This device achieves high efficiency, uniformity, and controllability in the cross-linking process of collagen repair materials through closed-loop circulation, precise flow control, and automated control, providing reliable equipment support for the large-scale production of high-quality collagen medical materials (such as wound repair membranes and bone defect filling materials).

[0035] Furthermore, the liquid inlet is provided with a sealing cap 104, which is sealed to the liquid inlet.

[0036] The inlet is a key interface for injecting crosslinking agents, buffer solutions, and other fluids into the crosslinking tank 10. It is also the entrance for taking out and putting in collagen repair materials. The sealing cap 104 needs to form a sealed connection with the inlet to prevent liquid leakage or contaminants from entering the crosslinking tank 10 during the crosslinking process.

[0037] The sealing cap 104 is provided with at least one viewing window 105. This invention has two viewing windows 105, facilitating observation of the stable cross-linking process of the product and achieving full-process visibility. The viewing windows 105 can be made of glass.

[0038] Furthermore, the inner wall of the liquid inlet is provided with a protrusion 106 away from the inner wall, the sealing cap 104 overlaps with the protrusion 106, and a sealing buckle 107 is provided between the sealing cap 104 and the inner wall.

[0039] An annular protrusion 106 (such as an inwardly protruding step or annular flange) extends radially from the inner wall of the inlet. Its end face is precision-polished and serves as the supporting reference surface for the sealing cap 104. The sealing buckle 107 between the sealing cap 104 and the inner wall of the inlet adopts a snap-fit ​​quick-release structure. When the sealing cap 104 is pressed down to overlap the protrusion 106, the claws of the sealing buckle 107 are compressed and contracted by the inner wall. After fully engaging, the claws spring into the slot, forming a circumferential fixation. For disassembly, simply press the claw unlocking piece to remove the sealing cap 104 upwards. Furthermore, a thin nitrile rubber sealing gasket can be added between the overlapping surfaces of the sealing cap 104 and the protrusion 106 to further enhance the sealing effect.

[0040] Setting two sealing buckles 107 can ensure the sealing of the cross-linking process, prevent the introduction of foreign objects, and prevent the escape of cross-linking reagent gas.

[0041] The snap-on sealing buckle 107 can achieve quick sealing by "pressing and snapping". Compared with traditional threaded connections, it reduces the time cost of tightening operations (the efficiency of opening and closing is increased by about 50%). In addition, the mechanical locking of the claw and the slot, combined with the elastic fit of the sealing gasket, can maintain a stable seal when the circulating pressure in the tank fluctuates, avoiding the loosening and leakage problems caused by vibration of the threaded connection.

[0042] Furthermore, combined Figure 1 and Figure 2 As shown, the device for cross-linking collagen repair materials also includes a filter frame 40, which has multiple filtration spaces 401, and the collagen repair materials are placed in the filtration spaces 401.

[0043] The filter frame 40 separates the collagen repair material into multiple independent filter spaces 401, avoiding localized adhesion caused by material stacking. This allows the cross-linking agent to penetrate evenly into the surface and internal pores of each material through the gaps in the filter, solving the problem of "insufficient cross-linking in the central area" when materials aggregate and improving the overall cross-linking reaction efficiency.

[0044] The structured design of the filter frame 40 can stably support different forms of bone glue raw materials (such as granules, sponges, membranes, etc.), preventing the materials from shifting or breaking under the impact of the fluid driven by the circulating pump 20. At the same time, the filter frame 40 can be removed from the crosslinking tank 10 as a whole, simplifying the material filling and unloading process and reducing the contamination of the materials by human contact.

[0045] The mesh structure of the filter holder 40 (such as a 100-300 mesh medical filter) allows the crosslinking agent to flow freely while intercepting material debris or detached particles, preventing them from entering the circulation pump 20 and causing pipeline blockage. This ensures the long-term stable operation of the circulation system and reduces equipment maintenance costs. The filter holder 40 is also equipped with clips that allow for a detachable connection with the crosslinking tank 10. This ensures the stability of the filter holder 40 within the crosslinking tank 10, and that the samples are arranged in the filtration space 401 without displacement or sample breakage, thus guaranteeing crosslinking stability.

[0046] Multiple filtration spaces 401 can simultaneously accommodate multiple materials, supporting large-scale production. If cross-linking of materials of different specifications (such as collagen membranes of different thicknesses) is required, they can be placed in different filtration spaces 401 and processed synchronously in the same reaction system, reducing batch differences and improving product consistency.

[0047] The filter frame 40 has multiple layers of grilles in the height direction, and each layer of grilles has multiple filtration spaces 401 arranged in the horizontal direction.

[0048] The filter frame 40 adopts a multi-layer three-dimensional design, with multiple layers of grids spaced at intervals along the height direction, such as 3 to 5 layers. The layer spacing can be adjusted according to the material thickness, such as 2-5cm. Each grid layer is a hollow frame structure (mesh aperture 0.5-2mm, material is medical-grade titanium alloy or polymer filter mesh). The frame is divided into multiple independent filtration spaces 401 horizontally by longitudinal partitions (the size of a single space is adapted to the material specifications, such as 10cm×10cm×5cm). Each filtration space 401 can be equipped with a movable pressure plate at the top to prevent the bone glue raw materials (such as collagen sponge blocks) from shifting under fluid impact, while ensuring that a 1-2mm gap is reserved between the material and the grid for the free flow of cross-linking agent.

[0049] The multi-layer grid design expands the material placement area within the limited tank height. Compared with single-layer flat placement, it can increase the amount of bone glue raw materials processed in a single batch by N times. Moreover, each layer and each space is independently separated, avoiding material stacking and compression, which is suitable for the needs of large-scale production.

[0050] The reasonable setting of the interlayer spacing, combined with the forced convection of the circulating pump 20, enables the crosslinking agent to form a vertical circulation between each layer of grid. At the same time, the separation of the transverse filtration space 401 prevents materials from blocking each other, ensuring that the materials in each layer and each space can be evenly contacted by the crosslinking agent. This solves the problem of "sufficient crosslinking of the upper layer material and insufficient reaction of the lower layer material" when multiple layers are stacked, and improves the consistency of product performance between different batches and within the same batch.

[0051] The layered and spaced design can process bone glue raw materials of different forms (such as film, block, granules) or different specifications at the same time. Each layer of grid can be removed separately, which facilitates loading, unloading and cleaning, reduces the equipment adjustment time caused by differences in material types and improves process adaptability.

[0052] The openwork structure and spatial partitioning design of the grid can not only fix the material to prevent it from breaking in the circulating flow, but also intercept material debris through the grid to prevent it from being lost with the waste liquid, thereby improving the utilization rate of raw materials. At the same time, the multi-layer structure allows the cross-linking agent to fully penetrate in the vertical direction, reducing the waste of cross-linking agent caused by material accumulation, and indirectly reducing reagent costs.

[0053] Furthermore, the circulating pump 20 includes: a constant flow pump 21; and a servo motor 22 electrically connected to the constant flow pump 21; wherein the servo motor 22 is communicatively connected to the controller 30.

[0054] The servo motor 22 has high control precision, which is beneficial for achieving precise control of the constant flow pump 21, especially when high-precision adjustment of the pump speed is required.

[0055] By controlling the constant flow pump 21 with the servo motor 22, precise fluid output can be achieved without damaging the product or introducing foreign impurities, ensuring the uniformity of cross-linking of the collagen repair material and the consistency of product color.

[0056] The servo motor 22 of the constant flow pump 21 is connected to the controller 30. The circuit is controlled by an external power supply to realize the power input to the motor.

[0057] The device for cross-linked collagen repair materials also includes a flow sensor 50, which is communicatively connected to a controller 30, enabling the controller 30 to control the working state of the constant flow pump 21 based on the flow data from the flow sensor 50.

[0058] The constant flow pump 21 is connected to the controller 30, and the controller 30 is connected to the flow sensor 50. The controller 30 adjusts the working state of the constant flow pump 21 according to the feedback provided by the flow sensor 50 to ensure that the actual flow rate matches the set value.

[0059] Furthermore, the device for cross-linking collagen repair materials also includes a rack 70, with the cross-linking tank 10 and the circulation pump 20 respectively connected to the rack 70. The rack 70 is connected to the cross-linking tank 10 and the constant flow pump 21, and the two devices are neatly arranged in one rack 70, which can greatly improve space utilization and simplify wiring and maintenance.

[0060] The working principle of this utility model is as follows: First, the collagen repair material is loaded into the filter frame 40 grid. The multi-layer filter frame 40 is stacked in the crosslinking tank 10 through the liquid inlet. The drain port 103 is connected to the third valve 63. The third valve 63 is closed. Next, the first valve 61 and the second valve 62 are locked. The crosslinking reagent is poured in through the liquid inlet. The liquid level should be greater than the sample height. The crosslinking tank 10 is locked with the sealing buckle 107 to form a recyclable sealed state. The constant flow pump 21 is turned on, and the crosslinking agent circulation rate and time are set to complete the crosslinking of the product and achieve the crosslinking uniformity of the product.

[0061] After crosslinking is completed, first close the second valve 62 to drain the crosslinking reagent from the tubing, then close the first valve 61 to prevent reagent backflow, open the third valve 63 to drain the waste liquid, and finally open the sealing cover 104 of the crosslinking tank 10 to remove the filter frame 40 and the sample.

[0062] Obviously, the above embodiments are merely examples for clear illustration and are not intended to limit the implementation.

[0063] For those skilled in the art, various variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations. However, obvious variations or modifications derived therefrom remain within the protection scope of this invention.

Claims

1. An apparatus for cross-linking a bone collagen repair material, characterized by, include: The crosslinking tank is provided with a first connection port, a second connection port, a liquid inlet, and a liquid outlet. Collagen repair material can be placed inside the crosslinking tank. A filter frame, wherein the filter frame is provided with multiple filtration spaces, and the collagen repair material is placed in the filtration spaces; A circulating pump is provided with a first connecting pipe and a second connecting pipe, the end of the first connecting pipe being connected to the first connecting port, and the end of the second connecting pipe being connected to the second connecting port; The controller is communicatively connected to the circulating pump to control the pump's start, stop, and constant flow.

2. The device of cross-linked bone collagen repair material according to claim 1, characterized in that, The liquid inlet is equipped with a sealing cap, which is sealed to the liquid inlet.

3. The device of cross-linked bone collagen repair material according to claim 2, characterized in that, The sealing cover has at least one viewing window.

4. The apparatus for cross-linked collagen repair material according to claim 2, characterized in that, The inner wall of the liquid inlet is provided with a protrusion away from the inner wall, the sealing cap overlaps with the protrusion, and a sealing buckle is provided between the sealing cap and the inner wall.

5. The apparatus for cross-linked collagen repair material according to any one of claims 1 to 4, characterized in that, The first connection port is connected to a first valve, and the second connection port is connected to a second valve.

6. The apparatus for cross-linked collagen repair material according to claim 1, characterized in that, The filter frame has multiple layers of grilles in the height direction, and each layer of grilles has multiple filtration spaces arranged in a horizontal sequence.

7. The apparatus for cross-linked collagen repair material according to any one of claims 1 to 4, characterized in that, The circulating pump includes: Constant flow pump; A servo motor is electrically connected to the constant flow pump; The servo motor is communicatively connected to the controller.

8. The apparatus for cross-linked collagen repair material according to claim 7, characterized in that, It also includes a flow sensor, which is communicatively connected to the controller, so that the controller controls the operating state of the constant flow pump based on the flow data from the flow sensor.

9. The apparatus for cross-linked collagen repair material according to any one of claims 1 to 4, characterized in that, It also includes a frame, with the crosslinking tank and the circulation pump respectively connected to the frame.

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