Combined respiratory pathogen detection kit

Abstract

This multi-respiratory pathogen combined detection kit belongs to the field of detection kit technology. Addressing the safety risks of traditional kits due to easy deformation during transport and exposed components during disposal, this kit uses a rigid side-opening box and a pull-out box, secured magnetically to resist transport compression. The pull-out box has upper and lower inner lining blocks and grooves to secure components. Disposable sampling swabs are stored in sealed tubes with screw caps on the grip end. Two swabs are also included for backup in case of initial sampling failure. The sample extraction tube opening is sealed with an adhesive film, and the outer wall is connected to a conical dispensing head and a sealing cap. Follow the instructions for use. After testing, seal the components back, reset the pull-out box, and discard it safely, ensuring safety during transport, use, and disposal.

Description

Technical Field

[0001] This invention relates to the field of detection kit technology, and in particular to a combined detection kit for multiple respiratory pathogens. Background Technology

[0002] Multi-respiratory pathogen detection kits are tools used to detect multiple respiratory pathogens simultaneously, helping doctors determine the type of pathogen a patient is infected with. Common examples include triple detection kits for influenza A, influenza B, and mycoplasma pneumoniae.

[0003] Existing multi-respiratory pathogen detection kits mostly use thin cardboard boxes as the main packaging. During transportation and storage, these boxes are prone to deformation under external pressure, which may damage the internal detection components and affect the accuracy of the test. Furthermore, the sampling swabs and extraction tubes in traditional kits are often discarded in an exposed state after testing, lacking effective sealing measures, which poses a risk of pathogen exposure.

[0004] To address the aforementioned issues, this utility model document proposes a combined detection kit for multiple respiratory pathogens. Utility Model Content

[0005] This invention provides a combined detection kit for multiple respiratory pathogens, which solves the shortcomings of existing kits, such as easy deformation during transportation and safety risks associated with discarding exposed components after testing.

[0006] This utility model provides the following technical solution:

[0007] A multi-respiratory pathogen detection kit, including:

[0008] The side-opening box has a sliding pull-out box that is slidably installed in the cavity on one side. The side-opening box and the pull-out box are fixed by magnetic attraction. The pull-out box contains two sealed disposable sampling swabs, a sample extraction tube filled with extraction fluid, a test reagent card sealed in an aluminum foil bag, and an instruction manual.

[0009] In one possible design, a magnetic suction piece I is embedded and fixed at the edge of the inner wall of the side opening box, a magnetic suction piece II that works with the magnetic suction piece I is embedded and fixed at the bottom of the outer wall of the pull-out box, and a pull tab that facilitates its removal is fixedly provided on the upper edge of the outer wall of the pull-out box.

[0010] In one possible design, the pull-out box has an upper inner liner block and a lower inner liner block arranged vertically symmetrically inside, and the contact surfaces of the upper inner liner block and the lower inner liner block are provided with grooves for engaging the top and bottom of corresponding components.

[0011] In one possible design, the top of the upper inner liner block is symmetrically provided with two notches to facilitate its removal from the pull-out box.

[0012] In one possible design, the disposable sampling swab is stored in a corresponding sealed tube, and the gripping end of the disposable sampling swab is fixedly provided with a screw cap, which is threadedly connected to the internal thread at the opening of the corresponding sealed tube through the external thread at the end.

[0013] In one possible design, the opening of the sample extraction tube is sealed with an adhesive sealing film, and a conical liquid outlet head is connected to the outer wall of the sample extraction tube by a rubber ring, with a sealing cap threaded to the output end of the conical liquid outlet head.

[0014] It should be understood that the above general description and the following detailed description are merely exemplary and do not limit the present invention.

[0015] The working principle and usage process of this technical solution are as follows:

[0016] When using the product, the user first tears open the overall transparent film packaging, then pulls the pull-out box out of the side opening box using the pull tab (magnetic tab I and magnetic tab II are separated). Using the notch, the upper inner liner block is removed from the pull-out box, exposing the detection component. Then, following the detailed instructions, the user is guided to complete the test step by step. Take out and unscrew the cap of one of the disposable sampling swabs, and take out the swab from the sealed tube (avoid touching the swab head). If the swab head is contaminated, another spare swab can be used to reduce the risk of operational errors. Then, insert the swab completely into the throat and wipe the throat wall, the reddened area of ​​the palatine tonsils, or the posterior throat wall thoroughly. The cap at the swab grip end makes rotation easy and improves sampling comfort.

[0017] After sampling, remove and tear open the sealing film of the sample extraction tube. Insert the sampled swab into the extraction liquid inside the tube, rotate it about 10 times close to the tube wall, and squeeze the swab head to ensure sufficient liquid retention. After removing the swab, reconnect it to the threaded sealing tube to prevent the swab head from being exposed. Tighten the cap on the conical dispensing head of the sample extraction tube. Then, tear open the aluminum foil bag along the cut, remove the test reagent card, and place it flat on the table. Unscrew the cap on the conical dispensing head and drip the mixed sample solution into the multiple sampling holes of the test reagent card in sequence. Tighten the cap again to prevent liquid leakage. Observe the results on the test reagent card within 15 minutes. After the test is completed, put all parts back on the lower inner liner block. At this time, the swab and sample extraction tube are sealed. Then, put the upper inner liner block back on and return the pull-out box to the side opening box for unified disposal.

[0018] This utility model has the following beneficial effects:

[0019] In this invention, the disposable sampling swab is stored in a corresponding sealed tube, and the grip end is equipped with a screw cap. The external thread is threaded to the internal thread at the opening of the sealed tube, which effectively ensures the sealing of the swab before use, prevents the swab from being contaminated, and also avoids the exposed disposal of the sampling swab after testing, thus reducing safety risks.

[0020] In this invention, the sample extraction tube opening is sealed with an adhesive sealing film to prevent leakage of the extraction liquid; a conical liquid outlet head is connected to the outer wall by a rubber ring, and a sealing cap is threaded to the output end of the conical liquid outlet head. After the sample is dripped in, tightening the sealing cap can prevent the liquid in the sample extraction tube from flowing out, further ensuring the safety of the sample processing.

[0021] This invention uses a rigid outer shell (such as plastic or reinforced cardboard) for side-opening boxes and pull-out boxes to replace traditional thin cardboard boxes, effectively resisting compression and deformation during transportation, protecting the integrity of internal components, and using magnetic fixation and pull-out tabs for convenient opening.

[0022] The grooved structure of the upper and lower inner liner blocks in this invention secures components such as swabs and extraction tubes, ensuring that the components are neatly arranged in the pull-out box for easy storage and management, preventing shaking or confusion, and also providing cushioning and protection. The two notches at the top of the upper inner liner block allow users to easily pry open the upper inner liner block with their fingers and quickly remove the internal components.

[0023] This invention provides two disposable sampling swabs, allowing users to immediately use the backup swab in case of initial sampling failure, reducing anxiety caused by operational errors. Attached Figure Description

[0024] Figure 1 A three-dimensional structural schematic diagram of the combined detection kit for multiple respiratory pathogens provided in this embodiment of the present invention;

[0025] Figure 2 A schematic diagram of the side opening box and pull-out box separation structure of the multi-respiratory pathogen combined detection kit provided in this embodiment of the utility model;

[0026] Figure 3 A top view of the combined detection kit for multiple respiratory pathogens provided in this embodiment of the invention, showing the upper inner liner block separated from the pull-out box.

[0027] Figure 4 A bottom view of the structure of the combined detection kit for multiple respiratory pathogens provided in this embodiment of the present invention, with the upper inner liner block separated from the pull-out box.

[0028] Figure 5 This is a schematic diagram of the lower inner liner structure of the multi-respiratory pathogen combined detection kit provided in this embodiment of the present invention.

[0029] Reference numerals: 1. Side opening box; 2. Pull-out box; 3. Magnetic suction plate I; 4. Magnetic suction plate II; 5. Pull-out plate; 6. Disposable sampling swab; 7. Sealing tube; 8. Sample extraction tube; 9. Sealing film; 10. Conical liquid outlet head; 11. Sealing cap; 12. Test reagent card; 13. Instruction manual; 14. Tightening cap; 15. Upper inner liner block; 16. Notch; 17. Lower inner liner block. Detailed Implementation

[0030] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0031] In the description of this utility model, it should be understood that the terms "opening", "upper", "middle", "length", "inner", etc., which indicate orientation or positional relationship, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0032] To keep the following description of the embodiments of this utility model clear and concise, detailed descriptions of known functions and known components are omitted.

[0033] In one embodiment:

[0034] Please refer to Figure 1-5 The test kit consists of the following components: a side-opening box 1, a pull-out box 2, a disposable sampling swab 6, a sample extraction tube 8, a test reagent card 12, and an instruction manual 13.

[0035] The side box 1 is made of rigid materials, such as plastic or reinforced cardboard, which can effectively resist compression and deformation during transportation and protect the integrity of the internal components. The side box 1 has a cavity on one side, and the pull-out box 2 is slidably placed in the cavity. The two are fixed by magnetic attraction. A magnetic piece I3 is embedded and fixed at the edge of the inner wall of the side box 1, and a magnetic piece II4 that works with the magnetic piece I3 is embedded and fixed at the bottom of the outer wall of the pull-out box 2. When the pull-out box 2 is fully pushed into the side box 1, the magnetic piece I3 and the magnetic piece II4 attract each other, so that the pull-out box 2 is stably fixed in the side box 1. A pull tab 5 is fixedly provided on the upper edge of the outer wall of the pull-out box 2, so that the user can easily pull the pull-out box 2 out of the side box 1. The entire reagent kit is wrapped with a transparent packaging film by thermoplastic to ensure overall airtightness.

[0036] There are two disposable sampling swabs 6, which are stored in corresponding sealed tubes 7. The gripping end of the disposable sampling swab 6 is fixedly equipped with a screw cap 14. The end of the screw cap 14 is provided with an external thread, and the opening of the sealed tube 7 is provided with an internal thread. The screw cap 14 is threadedly connected to the internal thread at the opening of the sealed tube 7 through the external thread, which ensures the sealing of the swab before use, prevents the swab from being contaminated, and also avoids the exposed disposal of the sampling swab after testing, thus reducing safety risks.

[0037] The sample extraction tube 8 is filled with extraction fluid, and its opening is sealed with an adhesive sealing film 9 to prevent leakage of the extraction fluid. A conical liquid outlet head 10 is connected to the outer wall of the sample extraction tube 8 by a rubber ring. The output end of the conical liquid outlet head 10 is threadedly connected to a sealing cap 11. After the sample is dripped in, tightening the sealing cap 11 can prevent the liquid in the sample extraction tube 8 from flowing out, further ensuring the safety of the sample processing. The extraction fluid filled in the sample extraction tube 8 is used to lyse pathogens (such as viruses or bacteria) in the sample, releasing their genetic material or characteristic proteins. By rotating and squeezing, the swab head is thoroughly mixed with the extraction fluid. The chemical components in the extraction fluid (such as surfactants) can destroy the cell membrane of pathogens, releasing nucleic acids or antigen proteins. In influenza virus detection, the extraction fluid lyses the viral envelope, exposing the internal nucleoprotein (NP) or matrix protein (M1), which facilitates subsequent binding with the specific antibodies in the test reagent card 12.

[0038] The test kit 12 is sealed with an aluminum foil bag to prevent external contamination. Based on lateral immunochromatography, the test kit 12 detects pathogens through specific antigen-antibody binding. Taking the colloidal gold method as an example, the internal structure of the kit includes a sample well, a conjugate pad, a test line (T line), a control line (C line), and an absorbent pad. When the sample solution is added to the sample well, it flows along the nitrocellulose membrane under capillary action. The conjugate pad is pre-coated with colloidal gold-labeled specific antibodies (such as anti-influenza virus nucleoprotein antibodies). Pathogen antigens (such as influenza virus NP) bind to colloidal gold antibodies to form antigen-antibody complexes. The detection line (T line) is immobilized with another specific antibody (such as anti-influenza virus M1 antibody), which can capture the above complexes, forming an "antibody-antigen-colloidal gold antibody" sandwich structure. The T line shows color (red band), indicating the presence of the target pathogen in the sample. The control line (C line) is coated with anti-mouse IgG antibody, which can capture free colloidal gold-labeled antibodies to ensure the normal operation of the chromatography process. If the C line does not show color, it indicates that the reagent card is invalid or the operation is incorrect.

[0039] The instruction manual 13 is placed inside the pull-out box 2, providing users with detailed guidance on the testing procedures.

[0040] The pull-out box 2 has vertically symmetrical upper inner liner block 15 and lower inner liner block 17 made of EVA material. The contact surfaces of the upper inner liner block 15 and lower inner liner block 17 are provided with grooves for locking the top and bottom of the corresponding components, so as to prevent the detection components from shaking and play a role in buffering and protection.

[0041] In actual use, the user first tears open the overall transparent film packaging, and then pulls the pull box 2 out of the side box 1 through the pull tab 5. At this time, the magnetic suction tab I 3 and the magnetic suction tab II 4 are separated. The upper inner liner block 15 is taken out from the pull box 2 using the notch 16, exposing the detection component. Then, according to the detailed explanation in the operation manual 13, the user is guided to complete the test step by step. Take out and rotate to unscrew the screw cap 14 of one of the disposable sampling swabs 6, and take out the swab from the sealing tube 7. Be careful to avoid touching the swab head. If the swab head is contaminated, another spare swab 6 can be used to reduce the risk of operational errors. Then, insert the swab completely into the throat and wipe the throat wall, the red area of ​​the palatine tonsils, or the posterior throat wall thoroughly. The screw cap 14 at the swab holding end is easy to rotate and improves sampling comfort.

[0042] After sampling, remove and tear open the sealing film 9 of the sample extraction tube 8, insert the sampled swab into the extraction liquid inside the tube, rotate it 10 times close to the tube wall, and squeeze the swab head to ensure sufficient liquid retention. After removing the swab, reconnect it to the threaded connection of the sealing tube 7 to prevent the swab head from being exposed, and tighten the conical liquid outlet head 10 of the sample extraction tube 8. Then, tear along the cut of the aluminum foil bag, take out the test reagent card 12 and place it flat on the table. Unscrew the sealing cap 11 of the conical liquid outlet head 10, and drip the mixed sample liquid into the multiple sampling holes of the test reagent card 12 in sequence. Tighten the sealing cap 11 again to prevent liquid leakage. Observe the results on the test reagent card 12 within 15 minutes. After the test is completed, put all parts back on the lower inner liner block 17. At this time, the swab and sample extraction tube are sealed. Then, cover it with the upper inner liner block 15, and then reset the pull-out box 2 into the side opening box 1 for unified disposal.

[0043] This application can be used for the combined detection of multiple respiratory pathogens, and can also be used in other fields applicable to this application.

[0044] In another embodiment:

[0045] A multi-respiratory pathogen combined detection kit is used in the field of detection kits;

[0046] Please refer to Figure 2 The top of the upper inner liner block 15 has two symmetrical notches 16. Users can use their fingers to pry open these two notches 16 to easily remove the upper inner liner block 15 from the pull-out box 2, so as to expose and access the internal detection components.

[0047] The accompanying drawings in this application are for illustrative purposes only. The dimensions and shapes of the components shown are not actual limitations but are merely schematic representations. In actual implementation, the components can be reasonably configured and adjusted according to specific needs and actual conditions.

[0048] The above are merely specific embodiments of this utility model, but the protection scope of this utility model is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model. In the absence of conflict, the embodiments and features in the embodiments of this utility model can be combined with each other. Therefore, the protection scope of this utility model should be determined by the scope of the claims.

Claims

1. A multi-respiratory pathogen combined detection kit, characterized in that, include: A side-opening box (1) is provided with a sliding pull-out box (2) that is slidably disposed in the cavity on one side of the side-opening box (1). The side-opening box (1) and the pull-out box (2) are fixed by magnetic attraction. The pull-out box (2) is fitted with two sealed disposable sampling swabs (6), a sample extraction tube filled with extraction liquid (8), a test reagent card (12) sealed with an aluminum foil bag, and an instruction manual (13).

2. The combined detection kit for multiple respiratory pathogens according to claim 1, characterized in that, A magnetic suction piece I (3) is embedded and fixed at the edge of the inner wall of the side opening box (1), a magnetic suction piece II (4) that works with the magnetic suction piece I (3) is embedded and fixed at the bottom of the outer wall of the pull-out box (2), and a pull-out piece (5) that is convenient to pull out is fixedly provided on the upper edge of the outer wall of the pull-out box (2).

3. The combined detection kit for multiple respiratory pathogens according to claim 1, characterized in that, The pull-out box (2) is vertically symmetrically provided with an upper inner liner block (15) and a lower inner liner block (17). The contact surfaces of the upper inner liner block (15) and the lower inner liner block (17) are provided with grooves for engaging the top and bottom of the corresponding components.

4. The combined detection kit for multiple respiratory pathogens according to claim 3, characterized in that, The top of the upper inner liner block (15) is symmetrically provided with two notches (16) to facilitate its removal from the pull-out box (2).

5. The combined detection kit for multiple respiratory pathogens according to claim 1, characterized in that, The disposable sampling swab (6) is stored in the corresponding sealing tube (7). The gripping end of the disposable sampling swab (6) is fixedly provided with a screw cap (14). The screw cap (14) is threadedly connected to the internal thread at the opening of the corresponding sealing tube (7) through the external thread at the end.

6. The combined detection kit for multiple respiratory pathogens according to claim 1, characterized in that, The opening of the sample extraction tube (8) is sealed by an adhesive sealing film (9). A conical liquid outlet head (10) is connected to the outer wall of the sample extraction tube (8) by a rubber ring. A sealing cap (11) is threaded to the output end of the conical liquid outlet head (10).

Images