A freeze-drying device for naphthostat mesylate for injection

Abstract

This utility model discloses a freeze-drying device for naphthostat mesylate for injection, including a freeze chamber with a fully open top surface. A connecting seat is fixedly mounted on the top surface, and a vacuum chamber is movably fitted onto the connecting seat. A door is rotatably mounted on the outer wall of the freeze chamber opening. A heat dissipation chamber is fixedly mounted on the lower side of one side of the freeze chamber. A lifting device is fixedly mounted on the bottom surface of the inner wall of the freeze chamber. A placement rack is magnetically attached to the upper end of the lifting device. The lifting device drives the placement rack to switch between the freeze chamber and the vacuum chamber, eliminating the need for defrosting and waiting in the same chamber as in traditional devices, significantly shortening the sublimation cycle and improving continuous processing efficiency. A locking plate and a second electric push rod inside the connecting seat stably lock the placement rack, and a sealing ring on the base ensures the airtightness and vacuum level of the vacuum sublimation. The placement rack can be removed and placed as a whole after sublimation, facilitating continuous operation.

Description

Technical Field

[0001] This utility model relates to the field of medical freeze-drying equipment technology, and in particular to a freeze-drying device for injectable naphthostat mesylate. Background Technology

[0002] Naphamostat mesylate is a commonly used anti-inflammatory and anticoagulant drug in clinical practice. Its formulation is sensitive to moisture and temperature. To ensure drug stability and facilitate storage and transportation, naphamostat mesylate for injection is usually processed using freeze-drying.

[0003] Existing freeze-drying equipment generally completes the two steps of pre-freezing and vacuum sublimation drying sequentially in the same chamber. That is, after freezing, a vacuum is directly drawn in the freezing chamber to sublimate the icy solvent and remove moisture. The structure and heat conduction conditions of the freezing chamber are not optimized for the sublimation process, resulting in a long vacuum drying time. Vacuuming in a large-volume freezing chamber requires more energy, and the insulation and refrigeration systems are still working during the sublimation process, resulting in poor water vapor discharge. The residual low temperature environment in the freezing zone is prone to water vapor condensation or frost formation, affecting the stability of the vacuum. Utility Model Content

[0004] The main objective of this invention is to provide a freeze-drying device for naphthostat mesylate for injection, which aims to solve the problems mentioned in the background art.

[0005] To address the aforementioned issues, this invention proposes a freeze-drying device for injectable naphthostat mesylate, comprising a freeze chamber: the top surface of the freeze chamber is a fully open structure, a connecting seat is fixedly provided on the top surface, a vacuum chamber is movably fitted on the connecting seat, a door is rotatably provided on the outer wall of the freeze chamber opening, and a heat dissipation chamber is fixedly provided on the lower end of one side of the freeze chamber.

[0006] The bottom surface of the inner wall of the freezer compartment is fixedly equipped with a lifting device, and the upper end of the lifting device is equipped with a placement rack by magnetic attraction.

[0007] In one embodiment, a partition plate is fixedly provided on one side of the bottom of the inner wall of the freezer, and fixing strips are fixedly provided on both sides of the upper part of the inner wall of the freezer. A second electric push rod is vertically installed in the mounting groove at the upper end of the fixing strip, and a push plate is fixedly provided at the top of the output end of the second electric push rod.

[0008] A locking plate is horizontally installed at the lower end of the mounting groove. Springs are fixed at both ends of one side of the locking plate, and the other end of the springs is fixed to the inner wall of the vertical mounting groove.

[0009] The mounting slot where the second electric push rod is located is a fully enclosed structure, while the mounting slot where the locking plate is located is an open structure.

[0010] In one embodiment, a vacuum pump is fixedly installed on the bottom surface of the inner wall of the heat dissipation cavity, the output end of the vacuum pump is fixedly connected to a vacuum tube, and the other end of the vacuum tube passes through the connecting seat and communicates with its inner wall.

[0011] In one embodiment, the lifting device includes a first electric push rod, a lifting plate is fixedly provided at the top of the first electric push rod, and guide rods are fixedly provided around the bottom of the lifting plate;

[0012] The top surface of the lifting plate is fixed with upward-protruding magnetic bases around all four sides.

[0013] In one embodiment, the placement rack includes a housing, two placement plates are slidably disposed on the inner wall of the housing, sealing rings are fixedly disposed in the slots on the longer two sides of the base of the housing, and locking grooves that cooperate with locking plates are opened in the middle of the shorter two sides of the base of the housing.

[0014] The bottom surface of the outer casing is provided with magnetic connection ports around its perimeter, which cooperate with the magnetic base on the top of the lifting plate.

[0015] In one embodiment, a sealing strip is fixedly arranged around the bottom of the vacuum chamber, and the bottom of the vacuum chamber matches the top mounting port of the connector to achieve a sealed connection.

[0016] Beneficial effects:

[0017] 1. This utility model, by setting a lifting device between the freezing chamber and the vacuum chamber, allows the placement rack to directly enter the vacuum chamber for vacuum sublimation after low-temperature freezing. This avoids the problems of long vacuuming time and repeated heating and cooling of the freezing chamber wall and refrigeration components that are caused by the need to perform vacuum extraction in the same freezing chamber in the traditional technology, thereby significantly shortening the sublimation cycle and improving the overall processing efficiency.

[0018] 2. By using a locking plate and a second electric push rod installed on the inner wall of the connecting seat, both sides can be locked synchronously after the placement rack rises to the correct position, ensuring the placement rack remains stable during vacuum sublimation and preventing vibration or displacement from affecting the freeze-drying effect. The base of the placement rack is equipped with a sealing ring, which can effectively isolate the connection with the lower freezing chamber when it rises to the vacuum chamber position, ensuring the airtightness and vacuum stability of the vacuum sublimation process. After sublimation is completed, the placement rack can be removed as a whole by releasing the second electric push rod limiter on the inner wall of the connecting seat and removing the vacuum chamber cover, simplifying material handling and facilitating continuous operation. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the main axial structure of this utility model;

[0021] Figure 2 This is a schematic diagram of the main exploded structure of this utility model;

[0022] Figure 3 This is a schematic diagram of the internal structure of the main cavity of this utility model;

[0023] Figure 4 This is a schematic diagram of the lifting device structure of this utility model;

[0024] Figure 5 This is a schematic diagram of the placement rack structure of this utility model;

[0025] Figure 6 This is a schematic diagram of the locking plate and the second electric push rod of this utility model;

[0026] Figure 7 This is the utility model Figure 6 Enlarged structural diagram at point A.

[0027] The annotations in the attached figures are explained as follows:

[0028] 1. Freezer compartment; 101. Divider plate; 2. Connecting seat; 3. Vacuum chamber; 31. Sealing strip; 4. Heat dissipation chamber; 5. Placement rack; 51. Outer shell; 52. Placement plate; 53. Sealing ring; 54. Locking groove; 55. Connection port; 6. Lifting device; 61. First electric push rod; 62. Guide rod; 63. Lifting plate; 7. Fixing strip; 8. Locking plate; 81. Spring; 9. Vacuum tube; 10. Door; 11. Vacuum pump; 12. Second electric push rod; 121. Push plate. Detailed Implementation

[0029] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0030] To achieve the above-mentioned utility model objectives, such as Figure 1-7 As shown, this utility model provides a freeze-drying device for injectable naphthostat mesylate, including a freeze chamber (1), characterized in that: the top surface of the freeze chamber (1) is a fully open structure, a connecting seat (2) is fixedly provided on the top surface, a vacuum chamber (3) is movably sleeved on the connecting seat (2), a door (10) is rotatably provided on the outer wall of the cavity opening of the freeze chamber (1), a heat dissipation chamber (4) is fixedly provided on the lower end of one side of the freeze chamber (1); a lifting device (6) is fixedly provided on the bottom surface of the inner wall of the freeze chamber (1), a placement rack (5) is provided on the upper end of the lifting device (6) by magnetic attraction; a partition plate (101) is fixedly provided on one side of the bottom of the inner wall of the freeze chamber (1), and fixing strips (7) are fixedly provided on both sides of the upper position of the inner wall of the freeze chamber (1), a second electric push rod (12) is vertically installed in the mounting groove at the upper end of the fixing strip (7), and a push plate (121) is fixedly provided on the top of the output end of the second electric push rod (12);

[0031] A locking plate (8) is horizontally installed at the lower end of the mounting groove. A spring (81) is fixed at both ends of one side of the locking plate (8), and the other end of the spring (81) is fixed to the inner wall of the vertical mounting groove.

[0032] The mounting slot where the second electric push rod (12) is located is a fully enclosed structure, and the mounting slot where the locking plate (8) is located is an open structure; a vacuum pump (11) is fixedly installed on the bottom surface of the inner wall of the heat dissipation cavity (4), and the output end of the vacuum pump (11) is fixedly connected to the vacuum tube (9), and the other end of the vacuum tube (9) passes through the connecting seat (2) and communicates with its inner wall.

[0033] Specifically, the top surface of the freezer chamber 1 is a fully open structure, which facilitates the loading and unloading of materials. A connecting seat 2 is fixedly installed on the top surface of the freezer chamber 1, and a vacuum chamber 3 is movably fitted on the connecting seat 2 to provide a vacuum environment. A door 10 is rotatably installed on the outer wall of the cavity opening of the freezer chamber 1 to seal and open the freezer chamber 1. A heat dissipation chamber 4 is fixedly installed on one side of the lower end for heat dissipation of the condensation and vacuum system.

[0034] A lifting device 6 is fixedly installed on the bottom surface of the inner wall of the freezer compartment 1, and a placement rack 5 is installed on its upper end by magnetic attraction to support the material containers to be freeze-dried.

[0035] A partition plate 101 is fixedly installed on one side of the bottom of the inner wall of the freezer compartment 1 to isolate the lifting device 6 from the low-temperature area of ​​the freezer cavity, so as to prevent the low temperature from adversely affecting the performance of the lifting device 6 and other mechanical moving parts. Fixing strips 7 are fixedly installed on both sides of the upper part of the inner wall of the freezer compartment 1 to provide support and guidance for the placement rack 5 during replacement or lifting. A second electric push rod 12 is vertically installed in the mounting groove on both sides of the inner wall of the freezer compartment 1, and a push plate 121 is fixed on its top to drive the locking plate 8 below to lock the placement rack 5.

[0036] A locking plate 8 is horizontally installed at the lower end of the mounting slot. Both ends of the locking plate 8 are fixedly connected to the inner wall of the vertical mounting slot by springs 81 to form an elastic locking structure. When the second electric push rod 12 is started, the push plate 121 moves downward along the vertical slide, and pushes the locking plate 8 along the horizontal slide through the top force to enter the locking slot 54 of the placement rack 5, thereby achieving reliable locking of the placement rack 5. When unlocking, it is only necessary to control the second electric push rod 12 to reset, and the locking plate 8 will automatically return to its original position under the pulling force of the spring 81.

[0037] A vacuum pump 11 is fixedly installed on the bottom surface of the inner wall of the heat dissipation cavity 4. The output end of the vacuum pump 11 is fixedly connected to the vacuum tube 9. The other end of the vacuum tube 9 passes through the connecting seat 2 and communicates with the inner wall of the vacuum cavity 3 to provide a stable vacuum environment for the vacuum cavity 3.

[0038] To achieve the above-mentioned utility model objectives, such as Figure 1-5 As shown, this utility model provides a freeze-drying device for injectable naphthostat mesylate. The lifting device 6 includes a first electric push rod 61, a lifting plate 63 is fixedly provided at the top of the first electric push rod 61, and guide rods 62 are fixedly provided around the bottom of the lifting plate 63.

[0039] The lifting plate 63 has upwardly protruding magnetic seats fixed around its top surface; the placement rack 5 includes a shell 51, and two placement plates 52 are slidably provided on the inner wall of the shell 51. Sealing rings 53 are fixedly provided in the slots on the longer two sides of the base of the shell 51, and locking grooves 54 that cooperate with locking plates 8 are opened in the middle of the shorter two sides of the base of the shell 51.

[0040] The bottom surface of the outer shell 51 is provided with magnetic connection ports 55 that cooperate with the magnetic base on the top of the lifting plate 63; a sealing strip 31 is fixedly surrounded around the bottom of the vacuum chamber 3, and the bottom of the vacuum chamber 3 matches the top mounting port of the connecting seat 2 to achieve a sealed connection.

[0041] Specifically, the top surface of the lifting plate 63 is fixedly equipped with upward-protruding magnetic seats around its perimeter for magnetic connection with the placement rack 5, thereby achieving reliable support and detachable installation of the placement rack 5. The placement rack 5 includes a housing 51, with two placement plates 52 slidably mounted on the inner wall of the housing 51 for carrying material containers. Sealing rings 53 are fixedly mounted in the grooves on the longer sides of the base of the housing 51 for sealing when the placement rack 5 rises to the position of the vacuum chamber 3 to prevent vacuum leakage, and for sealing when the placement rack 5 is located in the freezer chamber 1 to prevent cold air from affecting the lifting device 6. Locking grooves 54 are opened in the middle of the shorter sides of the base of the housing 51 for cooperating with the locking plate 8 to lock and position the placement rack during the lifting process.

[0042] The bottom surface of the outer shell 51 is provided with magnetic connection ports 55 around the perimeter, which precisely match the magnetic seat on the top of the lifting plate 63, ensuring a stable connection of the placement rack 5 during the lifting process. When the placement rack 5 is lifted to the combination structure of the second electric push rod 12 and the locking plate 8 on both sides of the inner wall of the connecting seat 2, the lifting plate 63 can quickly return to its original position and disengage after the two are locked together. The bottom of the lifting plate 63 is provided with four guide rods 62 at the four corners for support and fixation. The guide rods 62 adopt a double-section telescopic structure, which can effectively ensure the smooth operation of the lifting plate 63. In addition, a sealing strip 31 is fixedly arranged around the bottom of the vacuum chamber 3. Its bottom matches the top mounting port of the connecting seat 2, which can achieve a tight sealing connection, thereby ensuring the vacuum tightness during the freeze-drying process.

[0043] Working principle of this utility model;

[0044] The material container is first placed on the placement plate 52 of the placement rack 5. The placement rack 5 is connected to the lifting device 6 through the magnetic seat at the top of the lifting plate 63, so as to achieve stable support and detachable installation. After the freeze-drying operation is started, the low temperature zone of the freezing chamber 1 freezes the material. The partition plate 101 effectively isolates the lifting device 6 from the freezing part of the freezing chamber, so as to avoid the low temperature from affecting the lifting mechanism and the second electric push rod 12, and ensure its stable operation in the low temperature environment. After the material is frozen, the lifting device 6 lifts the placement rack 5 to the position of the vacuum chamber 3. The sealing ring 53 of the base of the placement rack 5 is tightly fitted with the sealing strip 31 at the bottom of the vacuum chamber 3 to form a sealed connection, isolating the outside air to maintain the negative pressure environment in the vacuum chamber. At this time, the second electric push rod 12 on the inner wall of the connecting seat 2 runs along the vertical mounting groove, and its top push plate 121 drives the lower locking plate 8 to move along the horizontal sliding groove, and engages in the locking groove 54 of the placement rack 5, thus completing the locking and positioning of the placement rack 5; then the vacuum pump 11 starts, and the air and water vapor in the vacuum chamber 3 are extracted through the vacuum tube 9. At the same time, the heat dissipation chamber 4 dissipates heat from the vacuum pump 11 and the pipeline, ensuring the stability and vacuum efficiency of the equipment during long-term operation. Under the combined effect of negative pressure and low temperature, the moisture in the material directly sublimates to complete the freeze-drying process. After drying, the second electric push rod 12 is unlocked, making it easy for the operator to take out the material, and at the same time preparing for the lifting and lowering cycle of the next batch of material, realizing continuous operation.

[0045] The above description is only a preferred embodiment of the present utility model and does not limit the patent scope of the present utility model. All equivalent structural transformations made under the inventive concept of the present utility model using the contents of the present utility model specification and drawings, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present utility model.

Claims

1. A freeze-drying apparatus for naphthostat mesylate for injection, comprising a freezer chamber (1), characterized in that: The top surface of the freezer (1) is a fully open structure, and a connecting seat (2) is fixedly provided on the top surface. A vacuum chamber (3) is movably fitted on the connecting seat (2). A door (10) is rotatably provided on the outer wall of the cavity opening of the freezer (1). A heat dissipation chamber (4) is fixedly provided on the lower side of the freezer (1). The bottom surface of the inner wall of the freezer compartment (1) is fixedly provided with a lifting device (6), and the upper end of the lifting device (6) is provided with a placement rack (5) by magnetic attraction.

2. The freeze-drying apparatus for naphthol mesylate for injection as described in claim 1, characterized in that, A partition plate (101) is fixedly provided on one side of the bottom of the inner wall of the freezer (1). Fixing strips (7) are fixedly provided on both sides of the upper part of the inner wall of the freezer (1). A second electric push rod (12) is vertically installed in the mounting groove at the upper end of the fixing strip (7). A push plate (121) is fixedly provided at the top of the output end of the second electric push rod (12). A locking plate (8) is horizontally installed at the lower end of the mounting groove. A spring (81) is fixed at both ends of one side of the locking plate (8), and the other end of the spring (81) is fixed to the inner wall of the vertical mounting groove. The mounting slot where the second electric push rod (12) is located is a fully enclosed structure, while the mounting slot where the locking plate (8) is located is an open structure.

3. The freeze-drying apparatus for naphthol mesylate for injection as described in claim 2, characterized in that, A vacuum pump (11) is fixedly installed on the bottom surface of the inner wall of the heat dissipation cavity (4). The output end of the vacuum pump (11) is fixedly connected to a vacuum tube (9). The other end of the vacuum tube (9) passes through the connecting seat (2) and communicates with its inner wall.

4. The freeze-drying apparatus for naphthol mesylate for injection as described in claim 3, characterized in that, The lifting device (6) includes a first electric push rod (61), a lifting plate (63) is fixedly provided at the top of the first electric push rod (61), and guide rods (62) are fixedly provided around the bottom of the lifting plate (63). The top surface of the lifting plate (63) is fixed with upward-protruding magnetic seats around its perimeter.

5. The freeze-drying apparatus for naphthol mesylate for injection as described in claim 4, characterized in that, The placement rack (5) includes a shell (51), and two placement plates (52) are slidably provided on the inner wall of the shell (51). Sealing rings (53) are fixedly provided in the slots on the longer two sides of the base of the shell (51), and locking grooves (54) that cooperate with locking plates (8) are opened in the middle of the shorter two sides of the base of the shell (51). The bottom surface of the outer shell (51) is provided with magnetic connection ports (55) that cooperate with the magnetic base on the top of the lifting plate (63).

6. The freeze-drying apparatus for naphthol mesylate for injection as described in claim 5, characterized in that, A sealing strip (31) is fixedly arranged around the bottom of the vacuum chamber (3), and the bottom of the vacuum chamber (3) matches the top mounting port of the connecting seat (2) to achieve a sealed connection.

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