A sterile sampling mechanism for biopharmaceuticals

Abstract

This utility model discloses a sterile sampling mechanism for biopharmaceuticals, belonging to the field of biopharmaceutical technology. It includes a collection tube with a groove A and a slot on its outer surface. A support plate is fixedly connected to the inner wall of the slot, and a memory spring is fixedly connected to the upper surface of the support plate. A guide plate is fixedly connected to the other end of the memory spring, and a scraper is fixedly connected to the guide plate away from the support plate. Both the scraper and the guide plate have guide grooves on their outer surfaces. By inserting the collection tube into the inner wall of a container, the scraper rotates due to the elasticity of the spring, causing it to abut against the inner wall of the container. Then, the spool is released, and the pull rope is in a released state. The spool is then rotated to collect the pull rope, causing it to pull the scraper to continue rotating. During rotation, the scraper scrapes solid medicine from the inner wall of the container, and the scraped medicine enters the collection tube along the guide grooves.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceutical technology, specifically a sterile sampling device for biopharmaceutical applications. Background Technology

[0002] In the biopharmaceutical field, aseptic sampling is a crucial step in ensuring drug quality and safety; however, existing sampling methods have many problems. Traditional manual sampling relies on human operation, which is prone to contamination due to differences in personnel skills, and its representativeness and efficiency are insufficient when handling high-viscosity, large-volume materials. Conventional sampling tools, such as syringes, can easily introduce external microorganisms when used repeatedly or improperly, making it difficult to meet strict aseptic requirements.

[0003] Currently, the sampling method is commonly used in drug extraction. However, this method is only suitable for extracting liquid drugs, while solid drugs inside the container cannot be extracted, which can easily lead to insufficient extraction and inaccurate sampling.

[0004] Therefore, this invention provides a sterile sampling mechanism for biopharmaceutical applications to solve the above-mentioned problems. Utility Model Content

[0005] (a) Technical problems to be solved

[0006] This invention provides a sterile sampling mechanism for biopharmaceutical applications, aiming to solve the problems mentioned in the background art.

[0007] (II) Technical Solution

[0008] To achieve the above objectives, this utility model provides the following technical solution: a sterile sampling mechanism for biopharmaceuticals, comprising a collection tube, wherein a groove A and a slot are respectively formed on the outer surface of the collection tube, a support plate is fixedly connected to the inner wall of the slot, a memory spring is fixedly connected to the upper surface of the support plate, a guide plate is fixedly connected to the other end of the memory spring, a scraper is fixedly connected to the guide plate away from the support plate, and guide grooves are provided on the outer surfaces of both the scraper and the guide plate, a pull rope is fixedly connected to the scraper near the guide groove, and a spool is wound around the other end of the pull rope.

[0009] As a preferred technical solution of this utility model, the inner wall of the groove A is provided with through holes A, and the through holes A are arranged in a straight line array on the inner wall of the groove A. Both the slot and the groove A are provided with two lines, which are opened opposite to each other.

[0010] As a preferred technical solution of this utility model, the collecting tube is tapered from one end to the other, and a connecting tube is connected to the collecting tube away from the tapered end. A sealing tube is threaded to the outer surface of the connecting tube, and a shell is fixedly connected to the outer surface of the sealing tube, which is tapered. An injection tube is connected to the other end of the connecting tube.

[0011] As a preferred technical solution of this utility model, a push rod is slidably connected to the inner wall of the injection tube, and scale lines are provided on the outer surface of the injection tube.

[0012] As a preferred technical solution of this utility model, a limiting groove is provided on the outer surface of the injection tube, the spool is rotatably connected to the inner wall of the limiting groove, and the pull rope abuts against the inner wall of the limiting groove and passes through the injection tube and the collection tube and is fixedly connected to the scraper.

[0013] As a preferred technical solution of this application, the scraper is semi-circular and is inclined to the guide plate and hinged to the support plate.

[0014] As a preferred technical solution of this application, a collar is fixedly connected to the inner wall of the outer shell, a partition is fixedly connected to the inner wall of the collar, a sealing plate is fixedly connected to the inner wall of the partition, a plurality of through holes B are provided on the outer surface of the sealing plate, and a baffle is fixedly connected to the inner wall of the collar near the partition surface.

[0015] As a preferred technical solution of this application, the baffle and the sealing plate are inclined, and the baffle and the sealing plate are inclined from the outer surface of the outer shell to the center. An extension plate is fixedly connected to the sealing plate near the center.

[0016] As a preferred technical solution of this application, a movable plate is fixedly connected to the extension plate near the sealing plate surface, the movable plate and the extension plate are bent to form an angle, and a frame is fixedly connected to the inner wall of the outer shell, the frame being L-shaped.

[0017] As a preferred technical solution of this application, a groove B is provided on the upper surface of the inner wall of the outer shell, a spring ring is abutted against the inner wall of the groove B, a protective sleeve is provided on the upper surface of the groove B, a sealing lip is fixedly connected to the outer shell near the center, the sealing lip is V-shaped and shrinks towards the center, and a dustproof lip is also fixedly connected to the outer shell near the center, the dustproof lip is inclined and its lower surface is at the same horizontal position as the sealing lip.

[0018] (III) Beneficial Effects

[0019] 1. In the process of extracting solid medicine, the collection tube is first inserted into the inner wall of the container. Due to the elasticity of the spring, the scraper is squeezed and rotated, so that the scraper comes into contact with the inner wall of the container. Then the spool is released, and the pull rope is in the released state. Then the spool is rotated to collect the pull rope, which pulls the scraper to continue rotating. During the rotation, the scraper can scrape the solid medicine on the inner wall of the container. The scraped medicine enters the collection tube along the guide groove.

[0020] 2. During the sealing process, the medicine enters the sealing plate along the sealing lip. Because the sealing plate is inclined, the medicine is resisted when it flows to the inclined part and is difficult to flow. Then the medicine enters the through hole in the sealing plate and enters the interior of the partition. The interior of the partition is a closed space, and the medicine that enters the partition cannot flow to the baffle, thereby achieving the sealing effect and forming a sterile environment. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0022] Figure 2 This is a schematic diagram of the sampling component structure of this utility model;

[0023] Figure 3 This is a schematic diagram of the solid extraction component of this utility model;

[0024] Figure 4 This is a three-dimensional structural diagram of the scraper of this utility model;

[0025] Figure 5 This is a schematic diagram of the sealing component of this utility model;

[0026] Figure 6 This is a three-dimensional structural diagram of the outer shell of this utility model;

[0027] Figure 7 This is a schematic diagram of the three-dimensional structure of the collar of this utility model;

[0028] Figure 8 This is a three-dimensional structural diagram of the partition of this utility model;

[0029] Figure 9 This is a three-dimensional schematic diagram of the baffle of this utility model;

[0030] Figure 10 This is a partial cross-sectional view of the outer shell of this utility model.

[0031] In the picture:

[0032] 101. Collection tube; 102. Groove A; 103. Slot; 104. Support plate; 105. Memory spring; 106. Guide plate; 107. Scraper; 108. Guide groove; 109. Pull rope; 110. Spool; 201. Through hole A; 301. Injection tube; 401. Push rod; 402. Scale line; 501. Limiting groove; 701. Connecting tube; 702. Sealing tube; 703. Outer shell; 704. Collar; 705. Partition; 706. Sealing plate; 707. Through hole B; 708. Baffle; 801. Extension plate; 802. Movable plate; 803. Frame; 804. Groove B; 805. Spring ring; 806. Protective sleeve; 807. Sealing lip; 808. Dustproof lip. Detailed Implementation

[0033] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0034] Please see Figures 1-10 As shown, the purpose of this embodiment is to provide a sterile sampling mechanism for biopharmaceuticals, including a collection tube 101. The outer surface of the collection tube 101 is respectively provided with a groove A102 and a slot 103. A support plate 104 is fixedly connected to the inner wall of the slot 103. A memory spring 105 is fixedly connected to the upper surface of the support plate 104. A guide plate 106 is fixedly connected to the other end of the memory spring 105. A scraper 107 is fixedly connected to the side of the guide plate 106 away from the support plate 104. Both the scraper 107 and the guide plate 106 are provided with guide grooves 108 on their outer surfaces. A pull rope 109 is fixedly connected to the side of the scraper 107 near the guide groove 108. A spool 110 is wound around the other end of the pull rope 109.

[0035] In this embodiment, during the extraction of solid medicine, the collection tube 101 is first inserted into the inner wall of the container. Due to the elasticity of the memory spring 105, the scraper 107 is squeezed and rotates, causing the scraper 107 to come into contact with the inner wall of the container. Then, the spool 110 is released, and the pull rope 109 is in the released state. Then, the spool 110 is rotated to collect the pull rope 109, causing it to pull the scraper 107 to continue rotating. During the rotation, the scraper 107 can scrape the solid medicine on the inner wall of the container. The scraped medicine enters the collection tube 101 along the guide groove 108.

[0036] In this embodiment, as Figure 3As shown, the inner wall of the groove A102 is provided with through holes A201, which are arranged in a straight line array on the inner wall of the groove A102. Both the slot 103 and the groove A102 are provided with two slots, which are opened opposite to each other.

[0037] In this embodiment, the through hole A201 provided on the inner wall of the groove A102 is used to collect liquid medicine. During collection, the medicine flows along the through hole A201 into the collection tube 101.

[0038] In this embodiment, as Figure 1 , Figure 2 and Figure 3 As shown, the collecting tube 101 narrows from one end to the other, forming a variable diameter shape. The collecting tube 101 is connected to a connecting tube 701 away from the narrowing end. A sealing tube 702 is threaded onto the outer surface of the connecting tube 701. The outer surface of the sealing tube 702, which has a variable diameter shape, is fixedly connected to a shell 703. The other end of the connecting tube 701 is connected to an injection tube 301.

[0039] In this embodiment, the collection tube 101 is configured to taper from one end to the other to a variable diameter shape so that the collection tube 101 can be inserted into the container and prevent the scraper 107 on the surface of the collection tube 101 from damaging the container.

[0040] In this embodiment, as Figure 2 As shown, a push rod 401 is slidably connected to the inner wall of the injection tube 301, and a scale line 402 is provided on the outer surface of the injection tube 301.

[0041] In this embodiment, the push rod 401, which is slidably connected to the inner wall of the injection tube 301, is used to apply negative pressure to the inside of the injection tube 301 by sampling, so as to collect the medicine. The scale line 402 set on the outer surface of the injection tube 301 can be used to observe the amount of medicine collected.

[0042] In this embodiment, as Figure 2 and Figure 3 As shown, a limiting groove 501 is provided on the outer surface of the injection tube 301, the spool 110 is rotatably connected to the inner wall of the limiting groove 501, and the pull rope 109 abuts against the inner wall of the limiting groove 501 and passes through the injection tube 301 and the collection tube 101 and scraper 107 for fixed connection.

[0043] In this embodiment, the limiting groove 501 provided on the outer surface of the injection tube 301 can prevent the pull rope 109 from detaching from the injection tube 301 during the pulling process, and the spool 110 rotating on the inner wall of the limiting groove 501 is used to collect the pull rope 109.

[0044] In this embodiment, as Figure 4 As shown, the scraper 107 is semi-circular and is inclined to the guide plate 106 and hinged to the support plate 104.

[0045] In this embodiment, the scraper 107 is set in a semi-circular shape and is hinged to the support plate 104 at an angle to the guide plate 106 so that the scraper 107 can scrape the medicine by rotating.

[0046] In this embodiment, as Figure 5 , Figure 6 , Figure 7 , Figure 8 and Figure 9 As shown, a collar 704 is fixedly connected to the inner wall of the outer shell 703, a partition 705 is fixedly connected to the inner wall of the collar 704, a sealing plate 706 is fixedly connected to the inner wall of the partition 705, a plurality of through holes B707 are provided on the outer surface of the sealing plate 706, and a baffle 708 is fixedly connected to the inner wall of the collar 704 near the partition 705.

[0047] The baffle 708 and the sealing plate 706 are inclined. The baffle 708 and the sealing plate 706 are inclined from the outer surface of the outer shell 703 toward the center. An extension plate 801 is fixedly connected to the sealing plate 706 near the center.

[0048] An extension plate 801 is fixedly connected to a movable plate 802 near the sealing plate 706. The movable plate 802 and the extension plate 801 are bent to form an angle. A frame 803 is fixedly connected to the inner wall of the outer shell 703. The frame 803 is L-shaped.

[0049] In this embodiment, during the sealing process, the medicine enters the sealing plate 706 along the sealing lip 807. Since the sealing plate 706 is inclined, the flowing medicine is resisted when it reaches the inclined part and is difficult to flow. Then the medicine enters the through hole B707 on the sealing plate 706 and enters the interior of the partition 705. The interior of the partition 705 is a closed space, and the medicine entering the partition 705 cannot flow to the baffle 708, thereby achieving the effect of sealing and forming a sterile environment.

[0050] The extension plate 801, which is fixedly connected to the sealing plate 706 near the center, can block the medicine that permeates through the sealing lip 807 by fixing it with the movable plate 802, thus preventing the medicine from seeping out. In addition, the movable plate 802 and the extension plate 801 form an angle to prevent the flowing medicine from overflowing along the surfaces of the extension plate 801 and the movable plate 802.

[0051] The skeleton 803 is made of materials such as metal or high-strength plastic, and has high strength and rigidity. It provides a stable support frame for other components of the sampling mechanism, such as the sealing lip 807 and the spring ring 805, ensuring that the sampling mechanism can maintain its specific shape and size during installation and use, and will not be excessively deformed or twisted due to external forces or working pressure, thereby ensuring the sealing performance of the sampling mechanism.

[0052] In this embodiment, as Figure 5 , Figure 6 and Figure 10 As shown, a groove B804 is provided on the upper surface of the inner wall of the outer casing 703. A spring ring 805 abuts against the inner wall of the groove B804. A protective sleeve 806 is provided on the upper surface of the groove B804. A sealing lip 807 is fixedly connected to the outer casing 703 near the center. The sealing lip 807 shrinks towards the center in a V shape. A dustproof lip 808 is also fixedly connected to the outer casing 703 near the center. The dustproof lip 808 is inclined, and its lower surface is at the same horizontal position as the sealing lip 807.

[0053] In this embodiment, the spring ring 805 is in a pre-tightened state in the sampling mechanism, which can apply a uniform radial force to the sealing lip 807, so that the sealing lip 807 fits tightly against the surface of the shaft or component being sealed, thereby forming a good sealing effect during initial installation and effectively preventing leakage of media such as oil. During equipment operation, the spring ring 805 continues to play a role, ensuring that the sealing lip 807 always maintains appropriate pressure with the shaft. The spring ring 805 can automatically adjust the pressure on the sealing lip 807 through its own elastic deformation, so that the sealing force between the sealing lip 807 and the shaft is kept within a suitable range, maintaining good sealing performance.

[0054] The sealing lip 807 is in direct contact with the surface of the shaft or component being sealed. Through its own elastic deformation and appropriate pre-tightening force, it forms a very tight sealing interface between the two, thereby effectively preventing the medicine from leaking out from the sealing part.

[0055] Furthermore, during equipment operation, the dust lip 808 maintains contact with the rotating shaft surface. As the shaft rotates, the dust lip 808 scrapes off dust, moisture, and other foreign matter adhering to the shaft surface, preventing them from entering the equipment. The inclined dust lip 808 can better conform to the surface of the sealed component. When the shaft rotates, the inclined dust lip 808 can adaptively adjust its contact state with the shaft surface according to the shaft's rotation direction and motion characteristics, resulting in a tighter and more uniform contact, reducing sealing gaps, and thus more effectively preventing external contaminants such as dust, impurities, and moisture from entering the container.

[0056] In summary, the working principle of this utility model is as follows:

[0057] In the extraction process of solid medicine, the collection tube 101 is first inserted into the inner wall of the container. Due to the elasticity of the memory spring 105, the scraper 107 is squeezed and rotates, causing the scraper 107 to come into contact with the inner wall of the container. Then, the spool 110 is released, at which point the pull rope 109 is in the released state. Next, the spool 110 is rotated to collect the pull rope 109, causing it to pull the scraper 107 to continue rotating. During the rotation, the scraper 107 can scrape the solid medicine from the inner wall of the container. The medicine enters the collection tube 101 along the guide channel 108; during the sealing process, the medicine enters the sealing plate 706 along the sealing lip 807. Since the sealing plate 706 is inclined, the flowing medicine is resisted when it reaches the inclined part and is difficult to flow. Then the medicine enters the through hole B707 on the sealing plate 706 and enters the partition 705. The partition 705 is a closed space. The medicine entering the partition 705 cannot flow to the baffle 708, thereby achieving the effect of sealing and forming a sterile environment.

[0058] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A sterile sampling device for biopharmaceutical applications, comprising a collection tube (101), characterized in that: The outer surface of the collection tube (101) is provided with a groove A (102) and a slot (103). A support plate (104) is fixedly connected to the inner wall of the slot (103). A memory spring (105) is fixedly connected to the upper surface of the support plate (104). A guide plate (106) is fixedly connected to the other end of the memory spring (105). A scraper (107) is fixedly connected to the side of the guide plate (106) away from the support plate (104). A guide groove (108) is provided on the outer surface of both the scraper (107) and the guide plate (106). A pull rope (109) is fixedly connected to the side of the scraper (107) near the guide groove (108). A spool (110) is wound around the other end of the pull rope (109).

2. The aseptic sampling device for biopharmaceutical use according to claim 1, characterized in that: The inner wall of the groove A (102) is provided with through holes A (201), which are arranged in a straight line array on the inner wall of the groove A (102). The slot (103) and the groove A (102) are both provided with two slots, which are opened opposite to each other.

3. The aseptic sampling device for biopharmaceutical use according to claim 1, characterized in that: The collecting tube (101) is tapered from one end to the other, and a connecting tube (701) is connected to the collecting tube (101) away from the tapered end. A sealing tube (702) is threaded onto the outer surface of the connecting tube (701). A shell (703) is fixedly connected to the outer surface of the sealing tube (702), which is tapered. An injection tube (301) is connected to the other end of the connecting tube (701).

4. The aseptic sampling device for biopharmaceutical use according to claim 3, characterized in that: A push rod (401) is slidably connected to the inner wall of the injection tube (301), and a scale line (402) is provided on the outer surface of the injection tube (301).

5. The aseptic sampling device for biopharmaceutical use according to claim 3, characterized in that: The outer surface of the injection tube (301) is provided with a limiting groove (501), the spool (110) is rotatably connected to the inner wall of the limiting groove (501), and the pull rope (109) abuts against the inner wall of the limiting groove (501) and passes through the injection tube (301) and is fixedly connected to the collection tube (101) and the scraper (107).

6. The aseptic sampling device for biopharmaceutical use according to claim 1, characterized in that: The scraper (107) is semi-circular and is inclined to the guide plate (106) and hinged to the support plate (104).

7. The aseptic sampling device for biopharmaceutical use according to claim 3, characterized in that: A collar (704) is fixedly connected to the inner wall of the outer shell (703). A partition (705) is fixedly connected to the inner wall of the collar (704). A sealing plate (706) is fixedly connected to the inner wall of the partition (705). A plurality of through holes B (707) are provided on the outer surface of the sealing plate (706). A baffle (708) is fixedly connected to the inner wall of the collar (704) near the partition (705).

8. The aseptic sampling device for biopharmaceutical use according to claim 7, characterized in that: The baffle (708) and the sealing plate (706) are inclined. The baffle (708) and the sealing plate (706) are inclined from the outer surface of the outer shell (703) towards the center. An extension plate (801) is fixedly connected to the sealing plate (706) near the center.

9. A sterile sampling device for biopharmaceutical use according to claim 8, characterized in that: The extension plate (801) is fixedly connected to a movable plate (802) near the sealing plate (706). The movable plate (802) and the extension plate (801) are bent to form an angle. The inner wall of the outer shell (703) is fixedly connected to a frame (803), which is L-shaped.

10. A sterile sampling device for biopharmaceutical use according to claim 3, characterized in that: The inner wall of the outer shell (703) is provided with a groove B (804) on the upper surface. A spring ring (805) abuts against the inner wall of the groove B (804). A protective sleeve (806) is provided on the upper surface of the groove B (804). A sealing lip (807) is fixedly connected to the outer shell (703) near the center. The sealing lip (807) shrinks towards the center in a V shape. A dustproof lip (808) is also fixedly connected to the outer shell (703) near the center. The dustproof lip (808) is inclined and its lower surface is at the same horizontal position as the sealing lip (807).

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