A sample introduction device for a time-of-flight mass spectrometer

Abstract

This utility model relates to the field of molecular diagnostic instruments, and more particularly to a sample introduction device for a time-of-flight mass spectrometer, comprising a base; a time-of-flight mass spectrometer body fixedly connected to the top of the base, with a sample inlet fixedly connected to one side of the time-of-flight mass spectrometer body; a connecting frame fixedly connected to the top of the base on one side of the time-of-flight mass spectrometer body, a lead screw rotatably connected inside the connecting frame, a drive motor fixedly connected to one end of the lead screw extending out of the connecting frame, guide rods fixedly connected to both sides of the lead screw inside the connecting frame, a movable seat threadedly connected to the surface of the lead screw, and a sliding connection between the movable seat and the guide rod. This utility model has the following beneficial effects: the protective sleeve can prevent solid samples coated on the surface of the sample delivery rod from being contaminated by the outside; after the protective sleeve contacts the outside of the sample inlet, it will slide along the surface of the slide rod and compress the return spring, thereby ensuring that the sample delivery rod can smoothly enter the time-of-flight mass spectrometer body.

Description

Technical Field

[0001] This utility model relates to the field of molecular diagnostic instruments, and in particular to a sample introduction device for a time-of-flight mass spectrometer. Background Technology

[0002] Time-of-flight mass spectrometry (TOF-MS) is an instrument used in molecular diagnostics. Its workflow mainly includes two core steps: ionization and mass detection. During the detection process, the sample to be analyzed is introduced into the instrument through the sample introduction device and undergoes an ionization process to generate charged ions. Subsequently, the instrument analyzes these ions using "time-of-flight detection," which determines their mass-to-charge ratio based on the time difference of the ions' flight in an electric field, thereby achieving qualitative or quantitative analysis of the sample components.

[0003] In existing technologies, some time-of-flight mass spectrometers require the sample introduction device to first coat the solid sample onto the surface of the sample delivery rod fixed to one side of the sample delivery plate. Then, the sample delivery plate is moved along the surface of the lead screw by a motor, lead screw, and guide rod to deliver the sample delivery rod into the main body of the time-of-flight mass spectrometer. However, the air contains particles such as dust, fibers, or microorganisms. Since the sample delivery rod is exposed, these particles will fall directly onto the sample surface, thus affecting the accuracy of the detection results. Utility Model Content

[0004] In view of the shortcomings of the existing technology, the purpose of this utility model is to provide a sample introduction device for a time-of-flight mass spectrometer, so as to solve the problem mentioned in the background art that in some common time-of-flight mass spectrometer sample introduction devices, the sample delivery rod is exposed, which causes these particles to fall directly onto the sample surface, thereby affecting the accuracy of the detection results.

[0005] To achieve the above objectives, this utility model is implemented through the following technical solution: a sample introduction device for a time-of-flight mass spectrometer, including a base;

[0006] The main body of the time-of-flight mass spectrometer is fixedly connected to the top of the base, and an inlet is fixedly connected to one side of the main body of the time-of-flight mass spectrometer;

[0007] A connecting frame is fixedly connected to the top of the base on one side of the time-of-flight mass spectrometer body. A lead screw is rotatably connected inside the connecting frame. A drive motor is fixedly connected to one end of the lead screw extending out of the connecting frame. Guide rods are fixedly connected to both sides of the lead screw inside the connecting frame. A movable seat is threadedly connected to the surface of the lead screw. The movable seat and the guide rod are slidably connected.

[0008] A sliding rod is disposed on one side of the movable seat. A protective sleeve is slidably connected to the surface of the sliding rod. A return spring is sleeved on the surface of the sliding rod on one side of the protective sleeve. A sample feeding rod is fixedly connected to one end of the sliding rod, and a baffle is fixedly connected to one end of the sample feeding rod.

[0009] Optionally, the slide bar surface is provided with scale markings, and an adjustment seat is threadedly connected to the slide bar surface on one side of the scale markings.

[0010] Optionally, the vertical cross-section of the slide rod is T-shaped, and the maximum diameter of the slide rod is smaller than the inner diameter of the protective sleeve.

[0011] Optionally, the inner wall of the protective sleeve is stepped, a sealing gasket is fixedly connected to one side of the protective sleeve, and a sealing ring is fixedly connected to the inner wall of the protective sleeve.

[0012] Optionally, a rotating seat is rotatably connected inside the movable seat, and a locking bolt is threadedly connected to one side of the movable seat.

[0013] Optionally, a mounting screw is fixedly connected to one side of the movable seat, and the slide rod and the mounting screw are threaded together.

[0014] Optionally, the axis of the mounting screw is on the same horizontal line as the axis of the injection port, and the diameter of the injection port is slightly larger than the diameter of the baffle.

[0015] Optionally, an anti-slip sleeve is fixedly connected to the surface of the rotating base, and the surface of the anti-slip sleeve is provided with a textured surface.

[0016] The beneficial effects of this utility model are: the protective sleeve can prevent the solid sample coated on the sample delivery rod from being contaminated by the outside. After the protective sleeve comes into contact with the outside of the sample inlet, it will slide along the surface of the slide rod and compress the return spring, thereby ensuring that the sample delivery rod can smoothly enter the main body of the time-of-flight mass spectrometer.

[0017] The preload of the reset spring can be accurately adjusted by adjusting the seat and scale markings, thereby optimizing the buffering effect of the reset spring and ensuring that the sample delivery rod can smoothly enter the main body of the time-of-flight mass spectrometer.

[0018] Rotating the slide bar allows it to be removed from the mounting screw surface, making it easier to maintain components such as the protective sleeve on the slide bar surface. Attached Figure Description

[0019] Other features, objects, and advantages of this invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0020] Figure 1 This is a schematic diagram of the overall structure of the sample introduction device for a time-of-flight mass spectrometer according to the present invention.

[0021] Figure 2 For the present utility model Figure 1 Enlarged structural diagram at point A in the middle;

[0022] Figure 3 This is a schematic diagram of the disassembly and assembly structure of the protective sleeve of the sample introduction device of a time-of-flight mass spectrometer according to the present invention.

[0023] Figure 4 This is a cross-sectional schematic diagram of the protective sleeve structure of the sample introduction device of a time-of-flight mass spectrometer according to the present invention;

[0024] Figure label:

[0025] 1. Base;

[0026] 1. Time-of-flight mass spectrometer main body; 201. Sample inlet;

[0027] 2. Connecting frame; 301. Lead screw; 302. Drive motor; 303. Guide rod; 304. Moving seat; 305. Rotary seat; 306. Locking bolt; 307. Mounting screw; 308. Anti-slip sleeve;

[0028] 3. Slide rod; 401. Protective sleeve; 402. Return spring; 403. Sample feeding rod; 404. Baffle; 405. Scale markings; 406. Adjustment seat; 407. Sealing gasket; 408. Sealing ring. Detailed Implementation

[0029] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.

[0030] Please see Figures 1 to 4 This utility model provides a technical solution: a sample introduction device for a time-of-flight mass spectrometer, comprising: a base 1, a time-of-flight mass spectrometer body 2 fixedly connected to the top of the base 1, a sample inlet 201 fixedly connected to one side of the time-of-flight mass spectrometer body 2, a connecting frame 3 fixedly connected to the top of the base 1 on one side of the time-of-flight mass spectrometer body 2, a lead screw 301 rotatably connected inside the connecting frame 3, a drive motor 302 fixedly connected to one end of the lead screw 301 extending out of the connecting frame 3, guide rods 303 fixedly connected to both sides of the lead screw 301 inside the connecting frame 3, a movable seat 304 threadedly connected to the surface of the lead screw 301, a sliding connection between the movable seat 304 and the guide rods 303, a slide rod 4 provided on one side of the movable seat 304, a protective sleeve 401 slidably connected to the surface of the slide rod 4, a return spring 402 sleeved on one side of the protective sleeve 401 on the surface of the slide rod 4, a sample delivery rod 403 fixedly connected to one end of the slide rod 4, and a baffle 404 fixedly connected to one end of the sample delivery rod 403.

[0031] The drive motor 302 is started, causing the lead screw 301 to rotate within the connecting frame 3. Due to the restriction of the guide rod 303, the moving seat 304 will move along the surface of the lead screw 301. During this process, the protective sleeve 401 can prevent the solid sample coated on the surface of the sample delivery rod 403 from being contaminated by the outside. After the protective sleeve 401 comes into contact with the outside of the inlet 201, it will slide along the surface of the slide rod 4 and compress the return spring 402 due to the pressure of the inlet 201, thereby exposing the sample delivery rod 403 fixed at one end of the slide rod 4. The sample delivery rod 403 can then be sent into the main body 2 of the time-of-flight mass spectrometer through the inlet 201.

[0032] Furthermore, the vertical cross-section of the slide bar 4 is T-shaped, and the maximum diameter of the slide bar 4 is smaller than the inner diameter of the protective sleeve 401.

[0033] The vertical cross-section of the slide bar 4 is T-shaped, which can limit the movement trajectory of the protective sleeve 401. The maximum diameter of the slide bar 4 is smaller than the inner diameter of the protective sleeve 401, ensuring that the slide bar 4 can move smoothly in the protective sleeve 401.

[0034] Furthermore, the inner wall of the protective sleeve 401 is stepped, a sealing gasket 407 is fixedly connected to one side of the protective sleeve 401, and a sealing ring 408 is fixedly connected to the inner wall of the protective sleeve 401.

[0035] The stepped inner wall of the protective sleeve 401 can improve the sealing between the baffle 404 and the protective sleeve 401. The sealing gasket 407 can improve the sealing between the protective sleeve 401 and the injection port 201 after they come into contact. The sealing ring 408 can improve the sealing between the protective sleeve 401 and the slide rod 4.

[0036] Please see Figures 2 to 4 The present invention provides a technical solution: the surface of the slide rod 4 is provided with a scale mark 405, and an adjustment seat 406 is threadedly connected to the side of the slide rod 4 located on the scale mark 405.

[0037] Rotate the adjustment seat 406 to move it along the surface of the slide bar 4. Observe the positional relationship between the side of the adjustment seat 406 and the scale mark 405 to accurately adjust the preload of the reset spring 402, thereby optimizing the buffering effect of the reset spring 402 and ensuring that the sample delivery rod 403 can smoothly enter the main body 2 of the time-of-flight mass spectrometer.

[0038] Please see Figures 1 to 3 This utility model provides a technical solution: a rotating seat 305 is rotatably connected inside the movable seat 304; a locking bolt 306 is threadedly connected to one side of the movable seat 304; a mounting screw 307 is fixedly connected to one side of the movable seat 304; and the sliding rod 4 is threadedly connected to the mounting screw 307.

[0039] After the sample feeding rod 403 enters the container containing the sample, the rotating seat 305 is rotated. The rotating seat 305 will drive the sample feeding rod 403 to rotate inside the container, so that the sample can be coated on the surface of the sample feeding rod 403. Tightening the locking bolt 306 makes it move along the moving seat 304 until one end of it is pressed against the rotating seat 305, which limits the rotating seat 305. Rotating the slide rod 4 can remove it from the surface of the mounting screw 307, so as to facilitate the maintenance of components such as the protective sleeve 401 set on the surface of the slide rod 4.

[0040] Furthermore, the axis of the mounting screw 307 is on the same horizontal line as the axis of the injection port 201, and the diameter of the injection port 201 is slightly larger than the diameter of the baffle 404.

[0041] The axis of the mounting screw 307 is on the same horizontal line as the axis of the injection port 201, and the diameter of the injection port 201 is slightly larger than the diameter of the baffle 404 to ensure that the sample delivery rod 403 can smoothly enter the injection port 201.

[0042] Preferably, an anti-slip sleeve 308 is fixedly connected to the surface of the rotator 305, and the surface of the anti-slip sleeve 308 is provided with a textured surface.

[0043] The anti-slip sleeve 308 increases the friction between the hand and the rotating base 305, thereby preventing the hand from slipping when rotating the rotating base 305.

[0044] Although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A sample introduction device for a time-of-flight mass spectrometer, characterized in that, include: Base (1); The main body (2) of the time-of-flight mass spectrometer is fixedly connected to the top of the base (1), and an inlet (201) is fixedly connected to one side of the main body (2). A connecting frame (3) is fixedly connected to the top of the base (1) on one side of the time-of-flight mass spectrometer body (2). A lead screw (301) is rotatably connected inside the connecting frame (3). A drive motor (302) is fixedly connected to one end of the lead screw (301) extending out of the connecting frame (3). Guide rods (303) are fixedly connected to both sides of the lead screw (301) inside the connecting frame (3). A movable seat (304) is threadedly connected to the surface of the lead screw (301). The movable seat (304) and the guide rod (303) are slidably connected. A slide rod (4) is provided on one side of the movable seat (304). A protective sleeve (401) is slidably connected to the surface of the slide rod (4). A return spring (402) is sleeved on the surface of the slide rod (4) on one side of the protective sleeve (401). A sample feeding rod (403) is fixedly connected to one end of the slide rod (4). A baffle (404) is fixedly connected to one end of the sample feeding rod (403).

2. The sample introduction device for a time-of-flight mass spectrometer according to claim 1, characterized in that, The slide bar (4) has a scale mark (405) on its surface, and an adjustment seat (406) is threadedly connected to the side of the scale mark (405) on the slide bar (4).

3. The sample introduction device for a time-of-flight mass spectrometer according to claim 1, characterized in that, The vertical cross section of the slide rod (4) is T-shaped, and the maximum diameter of the slide rod (4) is smaller than the inner diameter of the protective sleeve (401).

4. The sample introduction device for a time-of-flight mass spectrometer according to claim 1, characterized in that, The inner wall of the protective sleeve (401) is stepped, and a sealing gasket (407) is fixedly connected to one side of the protective sleeve (401), and a sealing ring (408) is fixedly connected to the inner wall of the protective sleeve (401).

5. The sample introduction device for a time-of-flight mass spectrometer according to claim 1, characterized in that, The movable seat (304) is rotatably connected to a rotating seat (305), and a locking bolt (306) is threadedly connected to one side of the movable seat (304).

6. The sample introduction device for a time-of-flight mass spectrometer according to claim 1, characterized in that, The movable seat (304) is fixedly connected to one side of the mounting screw (307), and the slide rod (4) is threadedly connected to the mounting screw (307).

7. The sample introduction device for a time-of-flight mass spectrometer according to claim 6, characterized in that, The axis of the mounting screw (307) is on the same horizontal line as the axis of the injection port (201), and the diameter of the injection port (201) is slightly larger than the diameter of the baffle (404).

8. The sample introduction device for a time-of-flight mass spectrometer according to claim 5, characterized in that, The surface of the rotating base (305) is fixedly connected to an anti-slip sleeve (308), and the surface of the anti-slip sleeve (308) is provided with a textured surface.

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