A polymer resin drug purification device

Abstract

A polymer resin drug purification device includes a resin filling tank and a base. The main body of the resin filling tank is cylindrical, and the height-to-diameter ratio of the main body is 2-1:1. The upper end of the resin filling tank has an upper cap, and the lower end has a lower cap. The upper cap has a first flange, and the lower cap has a second flange. Two fixing blocks are symmetrically arranged on the side wall of the main body of the resin filling tank. The base has two sets of fixing blocks and mounting holes. When the resin filling tank is fixed to the base, the fixing blocks pass through the mounting holes. An upper baffle assembly is located near the upper cap, and a lower baffle is located near the lower cap. The height of the upper baffle assembly is adjustable, while the height of the lower baffle is fixed. The space between the upper baffle assembly and the lower baffle is filled with polymer resin.

Description

Technical Field

[0001] This utility model relates to the field of chemical pharmaceutical purification technology, specifically to a polymer resin drug purification device. Background Technology

[0002] In the production of pharmaceutical intermediates, side reactions often result in the formation of byproducts, i.e., impurities. These impurities can be adsorbed using polymer resins. Existing adsorption tanks use polymer resins with large particle sizes of 16-50 mesh as the impurity adsorbent. While large-particle resins offer low fluid resistance, their adsorption efficiency per unit height is poor. Therefore, the height-to-diameter ratio of the adsorption tanks is relatively large. To ensure processing efficiency and obtain relatively pure drugs, the height of the adsorption tanks is generally quite high, making the equipment installation difficult. Utility Model Content

[0003] The technical problem to be solved by this utility model is: a polymer resin drug purification device, which is filled with 100~150 mesh small particle size polymer resin, has good adsorption effect per unit height, and the height-to-diameter ratio of the attached tank is small.

[0004] The technical solution adopted by this utility model to solve its technical problem is: a polymer resin drug purification device, including a resin filling tank and a base. The main body of the resin filling tank is cylindrical, and the ratio of the height to the diameter of the main body of the resin filling tank is 2~1:1. The upper end of the resin filling tank is provided with an upper end cap, and the lower end is provided with a lower end cap. The upper end cap is provided with a first flange, and the lower end cap is provided with a second flange. There are two fixing blocks on the side wall of the main body of the resin filling tank, which are symmetrically arranged. The base is provided with two sets of fixing blocks and mounting holes. When the resin filling tank is fixed on the base, the fixing blocks pass through the mounting holes. The interior of the resin filling tank is provided with an upper baffle assembly near the upper end cap and a lower baffle near the lower end cap. The height of the upper baffle assembly is adjustable, and the height of the lower baffle is fixed. The space between the upper baffle assembly and the lower baffle is filled with polymer resin.

[0005] Preferably, the upper baffle assembly includes an upper baffle, a bearing ring, and an adjusting block, wherein the upper baffle is fixed to the upper end face of the bearing ring, and the adjusting block is fixed to the lower end face of the bearing ring.

[0006] Preferably, the ratio of the height to the diameter of the main body of the resin filling tank is 1.5:1.

[0007] Preferably, the upper baffle is provided with a first fixing hole, and the bearing ring is provided with a second fixing hole.

[0008] Preferably, the adjusting block is provided with a third fixing hole.

[0009] Preferably, both the upper and lower end caps are semi-circular. The first flange opening has a flange at the end furthest from the upper end cap, and a first flexible connecting pipe is connected to the flange. The other end of the first flexible connecting pipe is connected to a feed pipe, which is connected to a liquid pump, allowing liquid to be delivered into the resin filling tank. The second flange opening has a flange at the end furthest from the lower end cap, and a second flexible connecting pipe is connected to the flange. The other end of the second flexible connecting pipe is connected to a discharge pipe, which is connected to a storage tank.

[0010] Preferably, the resin filling tank has an adjustment hole on its main body side wall, which can be used to adjust the height of the upper baffle assembly inside the resin filling tank.

[0011] Preferably, the adjustment hole is a blind hole with an internal screw. The adjustment hole is arranged in three rows, with two holes in each row. The distance between the adjustment holes in two rows is 1 / 10 to 1 / 8 of the height of the resin filling tank body.

[0012] Preferably, the fixing block is provided with a plurality of first pin holes, and the mounting hole is provided with a second pin hole. The number of second pin holes is the same as the number of first pin holes. One first pin hole and one second pin hole can form a complete pin groove. Each complete pin groove contains a pin block.

[0013] Preferably, a washer is provided between the upper baffle and the bearing ring.

[0014] The beneficial effects of this utility model are as follows: It provides a polymer resin drug purification device, including a resin filling tank and a base. The main body of the resin filling tank is cylindrical, and the ratio of the height to the diameter of the main body of the resin filling tank is 2~1:1. The upper end of the resin filling tank is provided with an upper end cap, and the lower end is provided with a lower end cap. The upper end cap is provided with a first flange, and the lower end cap is provided with a second flange. There are two fixing blocks on the side wall of the main body of the resin filling tank, which are symmetrically arranged. The base is provided with two sets of fixing blocks and mounting holes. When the resin filling tank is fixed on the base, the fixing blocks pass through the mounting holes. The interior of the resin filling tank is provided with an upper baffle assembly near the upper end cap and a lower baffle near the lower end cap. The height of the upper baffle assembly is adjustable, and the height of the lower baffle is fixed. The space between the upper baffle assembly and the lower baffle is filled with polymer resin. Filling the resin filling area with small-particle-size polymer resin can reduce the height of the resin filling area, and the small holes on the baffle can block the passage of small-particle-size polymer resin.

[0015] The position of the upper baffle assembly in the polymer resin drug purification device provided by this utility model is adjustable, and the distance between the upper baffle assembly and the lower baffle can be adjusted according to the different filling amounts of polymer resin. Attached Figure Description

[0016] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0017] In the picture: Figure 1 This is a three-dimensional schematic diagram of the polymer resin drug purification device of this utility model; Figure 2 for Figure 1 Front view of a medium- to high-molecular-weight resin drug purification device; Figure 3 for Figure 1 Top view of a medium- to high-molecular-weight resin drug purification device; Figure 4 for Figure 3 A cross-sectional view of a medium- to high-molecular-weight resin drug purification device along AA. Figure 5 for Figure 2 Enlarged view of point B in the middle; Figure 6 This is a schematic diagram of the upper baffle assembly in the polymer resin drug purification device of this utility model; Figure 7 for Figure 6 Exploded view of the upper and middle baffle assembly.

[0018] 100. Polymer Resin Drug Purification Device; 1. Resin Filling Tank; 11. Upper Head; 12. Lower Head; 13. First Flange; 14. Second Flange; 15. Fixing Block; 151. First Pin Hole; 16. Upper Baffle Assembly; 161. Upper Baffle; 1611. First Fixing Hole; 162. Bearing Ring; 1621. Second Fixing Hole; 163. Adjusting Block; 1631. Third Fixing Hole; 1632. Fixing Component; 17. Lower Baffle; 18. Adjusting Hole; 2. Base; 21. Mounting Hole; 211. Second Pin Hole; 22. Pin Block; 3. First Flexible Connecting Pipe; 4. Feed Pipe; 5. Second Flexible Connecting Pipe; 6. Discharge Pipe. Detailed Implementation

[0019] To make the technical problem to be solved, the technical solution, and the beneficial effects of this utility model clearer, the present utility model will now be described in detail with reference to the accompanying drawings. This drawing is a simplified schematic diagram, illustrating only the basic aspects of the present utility model, and therefore only shows the components relevant to the present utility model. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0020] refer to Figures 1-4As shown, this utility model provides a polymer resin drug purification device 100, including a resin filling tank 1 and a base 2. The main body of the resin filling tank 1 is cylindrical, and the ratio of the height to the diameter of the main body of the resin filling tank 1 is 2~1:1. The upper end of the resin filling tank 1 is provided with an upper end cap 11, and the lower end is provided with a lower end cap 12. The lower end cap 12 is provided with a first flange port 13 and a second flange port 14. There are two fixing blocks 15 on the side wall of the main body of the resin filling tank 1, which are symmetrically arranged. The base 2 is provided with two sets of mounting holes 21. When the resin filling tank 1 is fixed on the base 2, the fixing blocks 15 pass through the mounting holes 21. The interior of the resin filling tank 1 is provided with an upper baffle assembly 16 near the upper end cap 11 and a lower baffle 17 near the lower end cap 12. The height of the upper baffle assembly 16 is adjustable, while the height of the lower baffle 17 is fixed. The space between the upper baffle assembly 16 and the lower baffle 17 is filled with polymer resin.

[0021] In some implementations, specifically: the main body of the resin filling tank 1 is cylindrical, with a height-to-diameter ratio of 1.5 to 1:1, preferably 1.5:1. Both the upper end cap 11 and the lower end cap 12 are semi-circular. The top of the upper end cap 11 has a first flange 13, and the bottom of the lower end cap 12 has a second flange 14. The end of the first flange 13 furthest from the upper end cap 11 has a flange, to which a first flexible connecting pipe 3 is connected. The first flexible connecting pipe 3 is made of a flexible material, such as rubber or a steel wire hose. The other end of the first flexible connecting pipe 3 is connected to a feed pipe 4, which is connected to a liquid pump, allowing liquid to be delivered into the resin filling tank 1. The end of the second flange 14 furthest from the lower end cap 12 has a flange, to which a second flexible connecting pipe 5 is connected. The second flexible connecting pipe 5 is made of a flexible material, such as rubber or a steel wire hose. The other end of the second flexible connecting pipe 5 is connected to a discharge pipe 6, which is connected to a storage tank.

[0022] refer to Figure 4 As shown, the resin filling tank 1 has an adjustment hole 18 on the side wall of its main body. The adjustment hole 18 can be used to adjust the height of the upper baffle assembly 16 inside the main body of the resin filling tank 1.

[0023] In some implementations, specifically, the adjustment hole 18 is a blind hole with an internal screw, and there are three rows of adjustment holes 18, with two holes in each row. The distance between two rows of adjustment holes 18 is 1 / 10 to 1 / 8 of the height of the main body of the resin filling tank 1.

[0024] refer to Figure 5As shown, the fixing block 15 is provided with multiple first pin holes 151, and the mounting hole 21 is provided with second pin holes 211. The number of second pin holes 211 is the same as the number of first pin holes 151. One first pin hole 151 and one second pin hole 211 can form a complete pin groove. Each complete pin groove contains a pin block 22.

[0025] In some implementations, specifically: the fixing block 15 is provided with two sets of first pin holes 151, which are symmetrically arranged, and the mounting hole 21 is provided with two sets of second pin holes 211. One first pin hole 151 and one second pin hole 211 can form a complete pin groove. During installation, the base 2 is first fitted onto the fixing block 15 on the main body of the resin filling tank 1 through the mounting hole 21, and then the pin block 22 is installed to achieve fixation.

[0026] refer to Figure 6 and Figure 7 The upper baffle assembly 16 includes an upper baffle 161, a bearing ring 162, and an adjusting block 163. The upper baffle 161 is disc-shaped with multiple small holes in the center, the diameter of which is 150-200 mesh. The edge of the upper baffle assembly 16 has multiple first fixing holes 1611, which are through holes. The bearing ring 162 is annular, and its outer diameter matches the inner diameter of the resin filling tank 1. The bearing ring 162 has multiple second fixing holes 1621, which are blind holes with internal threads. The position and size of the second fixing holes 1621 on the bearing ring 162 match the position and size of the first fixing holes 1611 on the upper baffle 161, meaning that bolts can be used to fix the upper baffle 161 and the bearing ring 162 through the first fixing holes 1611 and the second fixing holes 1621. The adjusting block 163 is fixed on the bottom surface of the bearing ring 162. The side wall of the adjusting block 163 is provided with a third fixing hole 1631. The adjusting block 163 can be fixed in the adjusting hole 18 by using the fixing member 1632 through the third fixing hole 1631.

[0027] Furthermore, a washer is provided between the upper baffle 161 and the bearing ring 162. The outer diameter of the washer is slightly larger than the outer diameter of 162, which can prevent the polymer resin from passing through the edge gap.

[0028] The lower baffle 17 is disc-shaped with multiple small holes in the middle, the diameter of which is 150~200 mesh. The lower baffle 17 is fixed in the main body of the resin filling tank 1.

[0029] The polymer resin drug purification device 100 provided by this utility model allows the drug liquid to be purified to be input through the feed pipe 4, passing through the first flexible connector 3 and the first flange port 13 into the resin filling tank 1. It then comes into contact with the polymer resin between the upper baffle assembly 16 and the lower baffle 17. Impurities are adsorbed by the polymer resin, and the purified drug liquid flows out through the discharge pipe 6 and is collected in a storage tank. The position of the upper baffle assembly 16 is adjustable, allowing the distance between the upper baffle assembly 16 and the lower baffle 17 to be adjusted according to different amounts of polymer resin.

[0030] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to this application. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0031] It should be noted that the terms "first," "second," etc., used in the specification, claims, and accompanying drawings of this application are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of this application described herein can be implemented in sequences other than those illustrated or described herein.

[0032] Based on the above-described preferred embodiments of this utility model, and through the foregoing description, those skilled in the art can make various changes and modifications without departing from the scope of this utility model. The technical scope of this utility model is not limited to the contents of the specification, but must be determined according to the scope of the claims.

Claims

1. A polymer resin drug purification device, characterized in that: The system includes a resin filling tank (1) and a base (2). The main body of the resin filling tank (1) is cylindrical, and the ratio of the height to the diameter of the main body of the resin filling tank (1) is 2~1:

1. The upper end of the resin filling tank (1) is provided with an upper end cap (11), and the lower end is provided with a lower end cap (12). The upper end cap (11) is provided with a first flange (13), and the lower end cap (12) is provided with a second flange (14). There are two fixing blocks (15) on the side wall of the main body of the resin filling tank (1), which are symmetrically arranged. The base (2) is provided with two sets of mounting holes (21). When the resin filling tank (1) is fixed on the base (2), the fixing block (15) passes through the mounting hole (21). The resin filling tank (1) is provided with an upper baffle assembly (16) near the upper end cap (11) and a lower baffle (17) near the lower end cap (12). The height of the upper baffle assembly (16) is adjustable, and the height of the lower baffle (17) is fixed. The space between the upper baffle assembly (16) and the lower baffle (17) is filled with polymer resin.

2. The polymer resin pharmaceutical purification device of claim 1, wherein: The upper baffle assembly (16) includes an upper baffle (161), a bearing ring (162), and an adjusting block (163). The upper baffle (161) is fixed to the upper end face of the bearing ring (162), and the adjusting block (163) is fixed to the lower end face of the bearing ring (162).

3. The polymer resin pharmaceutical purification device of claim 1, wherein: The ratio of the height to the diameter of the main body of the resin filling tank (1) is 1.5:

1.

4. The polymer resin pharmaceutical purification device of claim 2, wherein: The upper baffle (161) shown is provided with a first fixing hole (1611), and the bearing ring (162) is provided with a second fixing hole (1621).

5. The polymer resin pharmaceutical purification device of claim 2, wherein: The adjusting block (163) is provided with a third fixing hole (1631).

6. The polymer resin pharmaceutical purification device of claim 1, wherein: The upper end cap (11) and the lower end cap (12) are both semi-circular. The first flange (13) is provided with a flange at the end away from the upper end cap (11). A first flexible tube (3) is connected to the flange. The other end of the first flexible tube (3) is connected to a feed pipe (4). The feed pipe (4) is connected to a liquid pump. Liquid can be delivered into the resin filling tank (1) through the feed pipe (4). The second flange (14) is provided with a flange at the end away from the lower end cap (12). A second flexible tube (5) is connected to the flange. The other end of the second flexible tube (5) is connected to a discharge pipe (6). The discharge pipe (6) is connected to a storage tank.

7. The polymer resin pharmaceutical purification device of claim 1, wherein: The resin filling tank (1) has an adjustment hole (18) on its main side wall. The adjustment hole (18) can be used to adjust the height of the upper baffle assembly (16) inside the resin filling tank (1).

8. The polymer resin pharmaceutical purification device of claim 7, wherein: The adjustment hole (18) is a blind hole with an internal screw. The adjustment hole (18) is arranged in three rows, with two holes in each row. The distance between the two rows of adjustment holes (18) is 1 / 10 to 1 / 8 of the height of the main body of the resin filling tank (1).

9. The polymer resin pharmaceutical purification device of claim 1, wherein: The fixing block (15) is provided with a plurality of first pin holes (151), and the mounting hole (21) is provided with a second pin hole (211). The number of second pin holes (211) is the same as the number of first pin holes (151). A first pin hole (151) and a second pin hole (211) can form a complete pin groove. Each complete pin groove is provided with a pin block (22).

10. The polymer resin pharmaceutical purification device of claim 1, wherein: A washer is provided between the upper baffle (161) and the bearing ring (162).

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