An adaptive angle-adjustable biological tissue homogenizer

Abstract

An adaptive angle-adjustable biological tissue homogenizer effectively solves the problem that existing tissue homogenizers cannot change the angle of the stirring blades. It includes a homogenizing cylinder with a detachable sealing cap at its upper end. A stirring column is coaxially rotatably connected to the sealing cap. A receiving groove is coaxially formed inside the stirring column, and a rotatable shaft is coaxially mounted inside the receiving groove. Multiple transmission bevel gears are coaxially arranged along the vertical direction on the rotating shaft. Multiple connecting columns are rotatably connected to the stirring column, with stirring blades detachably connected to the outer ends of the connecting columns. The inner ends of the connecting columns extend into the receiving groove and are equipped with driving bevel gears that can mesh with the corresponding transmission bevel gears. A feed pipe is provided on the sealing cap. This structure is simple, novel in design, easy to use, and highly practical.

Description

Technical Field

[0001] This invention relates to the field of detection technology, and in particular to a biological tissue homogenizer with adaptive angle adjustment. Background Technology

[0002] In biomedical research, drug preparation, and clinical testing, tissue homogenization is a crucial pretreatment step. Its purpose is to disrupt cells and release their contents to obtain a homogeneous liquid phase for subsequent analysis. The adequacy and homogenization of the homogenate directly affect the accuracy and reliability of experimental results. Currently, conventional tissue homogenization devices mostly employ a mechanical stirring structure consisting of a drive motor, a stirring shaft, and fixed-angle impellers.

[0003] However, such devices have the following drawbacks in practical applications: 1. Biological tissue samples are diverse, with significant differences in hardness, toughness, and viscoelasticity (e.g., liver tissue versus muscle tissue), and the rheological properties of the materials change dynamically during homogenization. Fixed-angle blades generate a single flow field and shear force pattern, unable to adapt to different tissue types or different stages of the same homogenization process. This results in insufficient homogenization and dead zones for tough tissues, while for fragile tissues, excessive shearing may lead to the inactivation of active ingredients. 2. To handle different samples, operators frequently need to stop the machine to change blades of different shapes or angles. This process is not only tedious and time-consuming, increasing the operator's burden, but also disrupts experimental continuity and increases the risk of cross-contamination. Furthermore, fixed blades generate high torque at startup, causing strong impact on the motor, and consume more energy when processing high-viscosity samples. Therefore, there is an urgent need in this field for a novel device that can intelligently adapt to the characteristics of biological materials, automatically adjust the stirring force and flow field, achieve efficient and uniform homogenization, and is easy to operate. Utility Model Content

[0004] In view of the above situation and in order to overcome the shortcomings of the existing technology, the purpose of this utility model is to provide a biological tissue homogenizer with adaptive angle adjustment, which effectively solves the problem that the existing tissue homogenizer cannot change the angle of the stirring blade.

[0005] The technical solution is as follows: This utility model includes a homogenizing cylinder, a sealing cover detachably connected to the upper end of the homogenizing cylinder, a stirring column coaxially rotatably connected to the sealing cover, a receiving groove coaxially opened inside the stirring column, a rotatable shaft coaxially provided inside the receiving groove, multiple transmission bevel gears evenly distributed in the vertical direction coaxially provided on the shaft, multiple connecting columns evenly distributed in the circumferential direction rotatably connected to the stirring column, stirring blades detachably connected to the outer end of the connecting columns, and a driving bevel gear that can mesh with the corresponding transmission bevel gears being provided at the inner end of the connecting columns extending out of the receiving groove, and a feed pipe provided on the sealing cover. Preferably, the upper end of the sealing cover is provided with a rotating motor, and the output shaft of the rotating motor is fixedly connected to the stirring column coaxially.

[0006] Preferably, an adjusting motor is coaxially mounted above the rotating shaft within the receiving groove, and the output shaft of the adjusting motor is coaxially and fixedly connected to the rotating shaft.

[0007] Preferably, the outer end of the connecting column is connected to the stirring blade via a fixing pin.

[0008] Preferably, the homogenizing cylinder and the sealing cap are fixed together by multiple bolts.

[0009] Preferably, the homogenizing cylinder is equipped with a discharge pump at its lower end.

[0010] Preferably, the lower end of the homogenizing cylinder is provided with multiple support legs.

[0011] Compared with the prior art, the beneficial effects of this utility model are as follows: By adjusting the motor drive shaft and transmission bevel gear, the active bevel gear and connecting column are driven to rotate, thereby enabling real-time and online changes to the cutting angle of all stirring blades. This solves the problem of poor adaptability of fixed-angle blades. At the same time, by dynamically adjusting the stirring angle, the device can effectively eliminate stirring dead zones and ensure sufficient homogenization of tough tissues. It also avoids excessive shearing of fragile tissues due to a single shearing mode, protecting the activity of bioactive components (such as proteins and nucleic acids), thereby greatly improving the accuracy and reliability of experimental results. Attached Figure Description

[0012] Figure 1 This is the main view axonometric drawing of this utility model.

[0013] Figure 2 This is a full-section main view axonometric drawing of this utility model.

[0014] Figure 3 This is a full-section top-view axonometric drawing of this utility model.

[0015] Figure 4 This is a utility model Figure 2 A magnified view of A in the middle.

[0016] Figure 5 This is a utility model Figure 3 A magnified view of B in the middle.

[0017] Figure label: 1. Homogenizing cylinder; 2. Sealing cap; 3. Stirring column; 4. Receiving tank; 5. Rotating shaft; 6. Transmission bevel gear; 7. Connecting column; 8. Stirring blade; 9. Drive bevel gear; 10. Feed pipe; 11. Rotating motor; 12. Adjusting motor; 13. Fixing pin; 14. Discharge pump. Detailed Implementation

[0018] To make the above-mentioned objectives, features, and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a full understanding of this utility model. However, this utility model can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this utility model. Therefore, this utility model is not limited to the implementations of the base model disclosed below.

[0019] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0020] The specific embodiments of this utility model will be further described in detail below with reference to the accompanying drawings.

[0021] Depend on Figures 1 to 5 The device includes a homogenizing cylinder 1, a sealing cover 2 detachably connected to the upper end of the homogenizing cylinder 1, a stirring column 3 coaxially rotatably connected to the sealing cover 2, a receiving groove 4 coaxially opened inside the stirring column 3, a rotatable shaft 5 coaxially provided inside the receiving groove 4, a plurality of transmission bevel gears 6 evenly distributed in the vertical direction coaxially provided on the shaft 5, a plurality of connecting columns 7 evenly distributed in the circumferential direction rotatably connected to the stirring column 3, a stirring blade 8 detachably connected to the outer end of the connecting column 7, an inner end of the connecting column 7 extending into the receiving groove 4 and provided with a driving bevel gear 9 that can mesh with the corresponding transmission bevel gear 6, and a feed pipe 10 provided on the sealing cover 2.

[0022] In order to make the stirring column 3 rotate, the upper end of the sealing cover 2 is provided with a rotating motor 11, and the output shaft of the rotating motor 11 is fixedly connected to the stirring column 3 on the same axis.

[0023] In order to make the rotating shaft 5 rotate, an adjusting motor 12 is coaxially arranged in the receiving groove 4 above the rotating shaft 5, and the output shaft of the adjusting motor 12 is coaxially and fixedly connected to the rotating shaft 5.

[0024] In order to detach the connecting column 7 from the stirring blade 8, the outer end of the connecting column 7 is connected to the stirring blade 8 via a fixing pin 13.

[0025] To allow the homogenizing cylinder 1 to be detached from the sealing cap 2, the homogenizing cylinder 1 and the sealing cap 2 are fixed together by multiple bolts.

[0026] To facilitate material discharge, a discharge pump 14 is provided at the lower end of the homogenizing cylinder 1.

[0027] To facilitate support of the homogenizing cylinder 1, the lower end of the homogenizing cylinder 1 is provided with multiple support legs.

[0028] When using this utility model, the operator first puts the biological tissue sample to be homogenized into the homogenizing cylinder 1 through the feed tube 10, or directly into the cylinder and then puts the sealing cap 2 back on, and ensures that the two are tightly fixed with bolts to ensure the sealing of the homogenization process. If a specific stirring blade 8 is required, the fixing pin 13 can be pulled out, the old stirring blade 8 can be removed from the outside of the connecting column 7, the required stirring blade 8 can be replaced, and then the fixing pin 13 can be inserted to fix it. Once preparations are complete, the device can be started. Based on the characteristics of the biological sample (such as hardness and toughness), the initial stirring intensity and the operating parameters of the motor 12 are set through the control system. The rotating motor 11 is started, and its output shaft drives the stirring column 3 to rotate coaxially, thereby causing the multiple stirring blades 8 fixed on it to start rotating, performing preliminary cutting and stirring of the sample. At the same time, the regulating motor 12 is started, and its output shaft drives the rotating shaft 5 to rotate in the coaxial receiving groove 4. The multiple transmission bevel gears 6 on the rotating shaft 5 rotate accordingly and mesh with the active bevel gear 9 at the inner end of the connecting column 7. This meshing relationship converts the rotational motion of the rotating shaft 5 into the rotation of the connecting column 7, thereby dynamically changing the cutting angle of each stirring blade 8 relative to the sample. During the homogenization process, the operator can adjust the speed and direction of the motor 12 in real time through the control system according to the changes in the material state (such as the decrease in viscosity). This allows the angle of the stirring blade 8 to change adaptively and continuously, thereby optimizing the flow field, avoiding dead zones, and applying the most suitable shear force to tissues with different toughnesses, ensuring that the homogenization is thorough and efficient, while avoiding the deactivation of fragile components due to excessive shearing. After homogenization is complete, first stop adjusting motor 12, then stop rotating motor 11. After standing for a moment, turn on the discharge pump 14 at the lower end of the homogenizing cylinder 1 to discharge and collect the homogenized slurry for subsequent analysis and experiments. Finally, disconnect the power supply to the equipment, disassemble and clean all parts that come into contact with the sample, such as the homogenizing cylinder 1, sealing cap 2, and stirring blade 8, for future use.

[0029] Compared with existing technologies, the beneficial effects of this invention are as follows: By adjusting the motor drive shaft and transmission bevel gear, the active bevel gear and connecting column are driven to rotate, thereby enabling real-time and online changes to the cutting angle of all stirring blades. This solves the problem of poor adaptability of fixed-angle blades. Furthermore, by dynamically adjusting the stirring angle, the device effectively eliminates stirring dead zones, ensuring sufficient homogenization of tough tissues. It also avoids excessive shearing of fragile tissues due to a single shearing mode, protecting the activity of bioactive components (such as proteins and nucleic acids), thus greatly improving the accuracy and reliability of experimental results. This structure is simple, novel in design, easy to use, and highly practical.

[0030] It should be noted that, depending on the implementation needs, the various components described in the embodiments of this utility model can be split into more components, or two or more components or parts of components can be combined into new components to achieve the purpose of the embodiments of this utility model.

[0031] The above embodiments only illustrate several implementation methods of this utility model, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of this utility model patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these all fall within the protection scope of this utility model. Therefore, the protection scope of this utility model patent should be determined by the appended claims.

Claims

1. An adaptive angle-adjustable biological tissue homogenizer, comprising a homogenizing cylinder (1), characterized in that, A sealing cover (2) is detached and connected to the upper end of the homogenizing cylinder (1). A stirring column (3) is rotatably connected to the sealing cover (2). A receiving groove (4) is coaxially opened inside the stirring column (3). A rotatable rotating shaft (5) is coaxially provided inside the receiving groove (4). Multiple transmission bevel gears (6) are coaxially provided on the rotating shaft (5) in the up-down direction. Multiple connecting columns (7) are rotatably connected to the stirring column (3) in the circumferential direction. A stirring blade (8) is detached and connected to the outer end of the connecting column (7). The inner end of the connecting column (7) extends out of the receiving groove (4) and is provided with an active bevel gear (9) that can mesh with the corresponding transmission bevel gear (6). A feed pipe (10) is provided on the sealing cover (2).

2. The self-adapting angle-adjustable biological tissue homogenizer device according to claim 1, wherein, The sealing cover (2) is equipped with a rotating motor (11) at the upper end, and the output shaft of the rotating motor (11) is coaxially fixedly connected to the stirring column (3).

3. The self-adapting angle-adjustable biological tissue homogenizer device according to claim 1, wherein, An adjusting motor (12) is coaxially mounted in the receiving groove (4) above the rotating shaft (5), and the output shaft of the adjusting motor (12) is coaxially and fixedly connected to the rotating shaft (5).

4. The self-adapting angle-adjustable biological tissue homogenizer device according to claim 1, wherein, The outer end of the connecting column (7) is connected to the stirring blade (8) via a fixing pin (13).

5. The self-adapting angle-adjustable biological tissue homogenizer device according to claim 1, wherein, The homogenizing cylinder (1) and the sealing cap (2) are fixed together by multiple bolts.

6. The self-adapting angle-adjustable biological tissue homogenizing device according to claim 1, wherein, The homogenizing cylinder (1) is equipped with a discharge pump (14) at its lower end.

7. The self-adapting angle-adjustable biological tissue homogenizing device according to claim 1, wherein, The homogenizing cylinder (1) is provided with multiple support legs at its lower end.

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