A novel QuEChERS purification device

Abstract

This utility model discloses a novel QuEChERS purification device, comprising an outer cylinder, an inner cylinder, a piston rod, and several filter connectors. During operation, the adsorbent and sample solution are placed in the inner cylinder, which is slidably positioned inside the outer cylinder. When it is necessary to agitate the inner cylinder, simply hold the handle and slide it along the slide rail; there is no need to remove the inner cylinder, thus reducing the risk of infection of the contents for personnel. The piston rod accelerates the filtration process after agitation. Multiple filter connectors are located between the first and second sections, facilitating the replacement of filter layers or the use of multiple filter layers to meet different filtration needs, thus solving the problem of the cumbersome handling of existing QuEChERS purification tubes.

Description

Technical Field

[0001] This utility model belongs to the field of pesticide residue detection technology and relates to a novel QuEChERS purification device. Background Technology

[0002] Currently, food safety is a major issue concerning national health and a significant bottleneck in international trade. With my country's economic development and rising living standards, public attention has shifted from ensuring food supply to ensuring food safety and nutrition, thus placing higher demands on testing methods, the technical skills of testing personnel, and testing equipment. How to perform trace analysis on increasingly complex sample matrices and improve sample pretreatment techniques has become a major challenge for the industry. Traditional sample pretreatment techniques have gone through several stages: liquid-solid extraction, liquid-liquid extraction, solid-phase extraction, solid-phase microextraction, and matrix solid-phase dispersion extraction. Drawing on the experience of these pretreatment methods, in 2003, Professor Anastassiades and others from the U.S. Department of Agriculture jointly developed a rapid, simple, inexpensive pretreatment method that can provide high-quality pesticide residue analysis—the QuEChERS method. Since its inception, this method has been widely adopted for veterinary drug residue and additive analysis due to its simplicity and practicality. Currently, the commonly used pretreatment methods for pesticide and veterinary drug residues according to national standards include liquid-solid extraction, liquid-liquid extraction, solid-phase extraction, solid-phase microextraction, and matrix solid-phase dispersion extraction. The above methods use a lot of organic reagents and are time-consuming, resulting in large losses, poor repeatability, and poor recovery rate in the processing process; and some solid phase extraction purification columns are expensive. In contrast, the QuEChERS method is more convenient, faster, more efficient, and more economical than traditional liquid-liquid extraction and solid phase extraction methods. The QuEChERS method has the following advantages: (1) High recovery rate, with a recovery rate of more than 85% for a large number of polar and volatile pesticides; (2) High precision and accuracy, which can be corrected by internal standard method; (3) Wide range of pesticides that can be analyzed, including polar and non-polar pesticides, all of which can be recovered well by this technology; (4) Fast analysis speed, which can complete the processing of 6 samples within 30 minutes; (5) Low solvent consumption, low pollution, low price and no use of chloride-containing solvents; (6) Simple operation, which can be completed well without good training and high skills; (7) Acetonitrile is sealed immediately after being added to the container to reduce the chance of contact with the staff; (8) Very few glasswares are used in the sample preparation process and the device is simple. To reduce testing costs while improving food testing efficiency and accuracy, it is crucial to widely apply the QuEChERS method in food testing.

[0003] The main steps in QuEChERS detection are: (1) sample crushing; (2) extraction and separation with acetonitrile as a single solvent; (3) adding salts such as MgSO4 to remove water; (4) adding adsorbents such as ethylenediamine-N-propylsilane (PSA) and shaking by hand to remove impurities; (5) centrifugation, filtering the supernatant, and then performing GC-MS and LC-MS detection. QuEChERS purification tubes are a common type of test tube based on QuEChERS. During sample processing, it is often necessary to shake the sample up and down to achieve thorough purification. Currently, QuEChERS purification tubes are usually fixed on a device, which can be a test tube rack or iron stand, etc. After fixing, various treatment agents are added according to the purification process of different samples. When shaking up and down is required, the QuEChERS purification tube needs to be removed and manually shaken up and down, which is quite cumbersome. Utility Model Content

[0004] The purpose of this invention is to provide a new type of QuEChERS purification device, which solves the problem of the cumbersome processing of existing QuEChERS purification tubes.

[0005] The technical solution adopted in this utility model is as follows:

[0006] A novel QuEChERS purification device includes an outer cylinder, an inner cylinder, a piston rod, and several filter connectors. The outer cylinder has a slide rail along its length on its outer wall. The inner cylinder includes a first section and a second section, and the inner cylinder slides inside the outer cylinder. A handle is provided on the side wall of the inner cylinder, and the handle passes through the slide rail and can move along the slide rail. One end of the piston rod slides on the inner wall of the inner cylinder, and the other end extends out of the first section. The second section has an outlet. The filter connectors have built-in filter layers. The several filter connectors are disposed between the first section and the second section, and the filter connectors are detachably connected to each other, to the first section, and to the second section.

[0007] Furthermore, the upper part of the first section is provided with a feed inlet and a plug that matches the feed inlet.

[0008] Furthermore, the inner walls of the slides are all covered with cushioning pads.

[0009] Furthermore, the top of the slide rail abuts against the edge of the outer cylinder.

[0010] Furthermore, the outer cylinder is a transparent outer cylinder.

[0011] Furthermore, the ratio of the first segment to the second segment is 1.2-1.5:1.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0013] This utility model of the QuEChERS purification device includes an outer cylinder, an inner cylinder, a piston rod, and several filter connectors. During operation, the adsorbent and sample solution are placed in the inner cylinder, which is slidably positioned inside the outer cylinder. When it is necessary to agitate the inner cylinder, simply hold the handle and slide it along the slide rail; there is no need to remove the inner cylinder, thus reducing the risk of infection of the contents for personnel. The piston rod accelerates the filtration process after agitation. Multiple filter connectors are located between the first and second sections, facilitating the replacement of filter layers or the use of multiple filter layers to meet different filtration needs. This solves the problem of the cumbersome handling of existing QuEChERS purification tubes. Attached Figure Description

[0014] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the embodiments will be briefly described below. It should be understood that the following drawings only show some embodiments of this utility model and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort, wherein:

[0015] Figure 1 This is a schematic diagram of the structure of a novel QuEChERS purification device according to an embodiment of the present invention.

[0016] Marked in the image:

[0017] 10-Outer cylinder; 11-Slide track;

[0018] 20-Inner cylinder; 21-First section; 22-Second section; 23-Handle; 24-Feed inlet; 25-Plug;

[0019] 30 - Piston rod;

[0020] 40 - Filter connector. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only for explaining the present utility model and are not intended to limit the present utility model; that is, the described embodiments are only some embodiments of the present utility model, and not all embodiments. The components of the embodiments of the present utility model described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0022] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0023] It should be noted that relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0024] As described in the background section, the main steps in QuEChERS detection are: (1) sample pulverization; (2) extraction and separation using acetonitrile as a single solvent; (3) addition of salts such as MgSO4 to remove water; (4) addition of adsorbents such as ethylenediamine-N-propylsilane (PSA) and manual shaking to remove impurities; (5) centrifugation, filtration of the supernatant, and detection by GC-MS and LC-MS. QuEChERS purification tubes are a common type of test tube based on QuEChERS. During sample processing, up-and-down shaking is often required to achieve thorough purification of the sample. Currently, QuEChERS purification tubes are usually fixed on a device, which can be a test tube rack or iron stand, etc. After fixing, various treatment agents are added according to the purification process of different samples. When up-and-down shaking is required, the QuEChERS purification tube needs to be removed and manually shaken, which is quite cumbersome.

[0025] Based on this, the inventors created a novel QuEChERS purification device as described in this application to solve the aforementioned technical problems.

[0026] The features and performance of this utility model will be further described in detail below with reference to the embodiments.

[0027] Example

[0028] Please see Figure 1A novel QuEChERS purification device includes an outer cylinder 10, an inner cylinder 20, a piston rod 30, and several filter connectors 40. It should be noted that the outer cylinder 10 is through-hole at both ends, while the inner cylinder 20 is open at both ends, and a corresponding cover can be installed at the input end. A slide rail 11 is provided along the length of the outer wall of the outer cylinder 10. The inner cylinder 20 includes a first section 21 and a second section 22, and is slidably disposed within the outer cylinder 10. In other words, the inner cylinder 20 is assembled from the first section 21 and the second section 22, and the two are connected by several filter connectors 40, the number of which can be set according to actual needs.

[0029] A handle 23 is provided on the side wall of the inner cylinder 20. The handle 23 passes through the slide rail 11 and can move along the slide rail 11. One end of the piston rod 30 slides on the inner wall of the inner cylinder 20, and the other end extends out of the first section 21. The second section 22 is provided with an outlet. In other words, the piston rod 30 extends into the inner cylinder 20 from the first section 21, and moves along the slide rail 11 via the handle 23, thereby causing the inner cylinder 20 to oscillate, preventing the inner cylinder 20 from being removed and increasing the risk of infection for workers. The filter connector 40 has a built-in filter layer. Several filter connectors 40 are disposed between the first section 21 and the second section 22, and the filter connectors 40 are detachably connected to each other, to the first section 21, and to the second section 22. For example, the connection to the filter connector 40 can be a threaded connection.

[0030] The QuEChERS purification device of this invention includes an outer cylinder 10, an inner cylinder 20, a piston rod 30, and several filter connectors 40. During operation, the adsorbent and sample solution are placed in the inner cylinder 20, which is slidably disposed inside the outer cylinder 10. When it is necessary to vibrate the inner cylinder 20, the handle 23 can be held and slid along the slide 11 without removing the inner cylinder 20, thus reducing the risk of infection of the contents for the staff. The piston rod 30 can accelerate the filtration process after vibration. Multiple filter connectors 40 are disposed between the first section 21 and the second section 22, which facilitates the replacement of filter layers or the use of multiple filter layers for filtration to meet different filtration needs, thus solving the problem of the cumbersome handling of existing QuEChERS purification tubes.

[0031] In another embodiment, the upper part of the first segment is provided with a feed inlet 24 and a plug 25 that matches the feed inlet 24. This arrangement makes it more convenient to add the required adsorbent or other materials through the feed inlet 24.

[0032] In another embodiment, the inner wall of the slide 11 is covered with a cushioning pad. This arrangement prevents damage to the outer cylinder 10 from impact when vibrating with the handle 23. Furthermore, the top of the slide 11 abuts against the edge of the outer cylinder 10 to facilitate the removal of the inner cylinder 20 when needed. Furthermore, the outer cylinder 10 is a transparent outer cylinder 10 to allow personnel to observe the internal condition of the inner cylinder 20.

[0033] In another embodiment, the ratio of the first segment 21 to the second segment 22 is 1.2-1.5:1.

[0034] The above description is only a preferred embodiment of the present utility model and is not intended to limit the scope of protection of the present utility model. Any modifications, equivalent substitutions and improvements made by those skilled in the art within the spirit and principles of the present utility model should be included within the scope of protection of the present utility model.

Claims

1. A novel QuEChERS purification device, characterized in that, The device includes an outer cylinder, an inner cylinder, a piston rod, and several filter connectors. The outer cylinder has a slide rail along its length on its outer wall. The inner cylinder includes a first section and a second section, and the inner cylinder slides inside the outer cylinder. A handle is provided on the side wall of the inner cylinder, and the handle passes through the slide rail and can move along the slide rail. One end of the piston rod slides on the inner wall of the inner cylinder, and the other end extends out of the first section. The second section has an outlet. The filter connectors have built-in filter layers. The several filter connectors are disposed between the first section and the second section, and the filter connectors are detachably connected to each other, to the first section, and to the second section.

2. A novel QuEChERS purification device according to claim 1, characterized in that, The upper part of the first section is provided with a feed inlet and a plug that matches the feed inlet.

3. A novel QuEChERS purification device according to claim 1, characterized in that, The inner walls of the slides are all covered with cushioning pads.

4. A novel QuEChERS purification device according to claim 1, characterized in that, The top of the slide rail abuts against the edge of the outer cylinder.

5. The novel QuEChERS purification device according to claim 1, characterized in that, The outer cylinder is a transparent type.

6. A novel QuEChERS purification device according to any one of claims 1 to 5, characterized in that, The ratio of the first segment to the second segment is 1.2-1.5:1.

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