A negative pressure filling system for pharmaceutical liquids

Abstract

This utility model discloses a negative pressure filling system for pharmaceutical solutions, relating to the field of pharmaceutical filling technology. It includes a filling machine connected to a liquid filling pipe and a first negative pressure pipe, which is connected to a foam tank. The top of the foam tank is connected to a second negative pressure pipe, which is connected to a vacuum tank. The liquid filling pipe is connected to a balance tank, which is connected to a liquid filling pipe and a return pipe, which is connected to the bottom of the foam tank. This utility model incorporates a foam tank to collect and temporarily store pharmaceutical foam. After the foam dissipates, it can be added to the balance tank for continued filling, avoiding the problem of pharmaceutical foam being drawn into the vacuum tank. Furthermore, the system can be processed without interrupting production, ensuring smooth operation.

Description

Technical Field

[0001] This utility model relates to the field of liquid medicine filling technology, specifically a liquid medicine negative pressure filling system. Background Technology

[0002] Pharmaceutical liquid filling machines are automated equipment used for liquid filling in industries such as pharmaceuticals. They achieve precise liquid filling through vacuum negative pressure and self-priming liquid filling technology.

[0003] Generally, when using a liquid medicine filling machine for liquid medicine filling operations, simply connect the filling machine's pipeline to a vacuum tank and a liquid medicine tank. The vacuum tank provides negative pressure to the filling machine, which then draws the liquid medicine from the tank for filling. (See reference...) Figure 1 However, in actual production, due to the large amount of foam generated during the filling process of a certain medicine, the vacuum tank will suck the medicine foam from the filling machine into the tank when providing negative pressure. In severe cases, the medicine foam accumulated in the vacuum tank will also be sucked into the upper pipe section or even into the vacuum pump.

[0004] To address the aforementioned issues, the company organized a technical team to conduct targeted technical modifications to the negative pressure filling system for pharmaceutical liquids using a pharmaceutical liquid filling machine, resulting in a new type of negative pressure filling system technology for pharmaceutical liquids.

[0005] A search revealed that publication number CN 223001747 U discloses an anti-backflow device in a negative pressure filling system for pharmaceutical solutions. This technology encountered a similar technical problem: "For certain special agents, foam is generated when the solution flows back from the buffer tank to the storage tank, and this foam affects the quality and filling volume of the agent." The proposed solution involves installing a monitoring component on a third pipeline to monitor the flow rate of the pharmaceutical solution in real time. This allows operators to control the start and stop of the self-priming pump in a timely manner to prevent backflow, thereby reducing or eliminating foam generation and improving the quality control of the pharmaceutical solution. Analysis shows that this solution differs from the technical approach of this invention. The proposed solution prevents backflow by monitoring the flow rate and allowing operators to start and stop the pump in a timely manner; while this invention collects the foam from the pharmaceutical solution and allows it to dissipate before continuing to use the solution, without stopping the production process. Utility Model Content

[0006] This invention provides a negative pressure filling system for pharmaceutical liquids, which aims to solve the technical problem mentioned in the background art caused by excessive foaming during the filling process of pharmaceutical liquids.

[0007] This utility model provides the following technical solution to achieve the above objectives: A negative pressure filling system for pharmaceutical liquid includes a pharmaceutical liquid filling machine, which is connected to a liquid filling pipe and a negative pressure pipe one. The negative pressure pipe one is connected to a foam tank, and the top of the foam tank is connected to a negative pressure pipe two, which is connected to a vacuum tank. The liquid filling pipe is connected to a balance tank, and the balance tank is connected to a pharmaceutical liquid pipe and a return liquid pipe, which is connected to the bottom of the foam tank.

[0008] In the aforementioned negative pressure filling system for medicine, the medicine pipe is connected to the cleaning water return pipe; the return pipe is connected to the vacuum tank via a flexible hose.

[0009] In the aforementioned negative pressure filling system for medicine, valves are installed on the liquid addition pipe, medicine pipe, negative pressure pipe, vacuum pipe, and hose.

[0010] In the aforementioned negative pressure filling system for medicine, a cleaning water drain valve is provided at the bottom of the medicine filling machine, on the liquid addition pipe, below the balance tank, and at the bottom of the vacuum tank.

[0011] In the aforementioned negative pressure filling system for medicine, transparent tubes are installed on the liquid addition pipe, negative pressure pipe one, medicine pipe, cleaning water return pipe, and return pipe.

[0012] In the aforementioned negative pressure filling system for medicine, the balance tank is equipped with an observation port.

[0013] In the aforementioned negative pressure filling system for medicine, the cleaning water return pipe is connected to the system return pipe.

[0014] Compared with the prior art, the negative pressure filling system for medicine provided by this utility model is equipped with a foam tank for collecting and temporarily storing medicine foam. After the medicine foam dissipates, it can be added to the balance tank for continued filling, avoiding the problem of medicine foam being drawn into the vacuum tank. Moreover, the system does not need to be stopped during the process of handling medicine foam, and the production is smooth. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of a filling system using a conventional liquid medicine filling machine; Figure 2 This is a schematic diagram of the structure of this utility model; Attached reference numerals: 1-Medicine filling machine; 2-Balance tank; 3-Vacuum tank; 4-Liquid filling pipe; 5-Negative pressure pipe one; 6-Foam tank; 7-Medicine pipe; 8-System return water pipe; 9-Cleaning water return water pipe; 10-Negative pressure pipe two; 11-Vacuum extraction pipe; 12-Return pipe; 13-Transparent pipe; 14-Valve; 15-Observation port; 16-Hose; 17-Cleaning water drain valve. Detailed Implementation

[0016] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention.

[0017] Example: A negative pressure filling system for pharmaceutical solutions, referenced Figure 2 As shown, the system includes a purchased liquid filling machine 1, which is connected to a liquid filling pipe 4 and a negative pressure pipe 5. The negative pressure pipe 5 is connected to a foam tank 6, and the top of the foam tank 6 is connected to a negative pressure pipe 10, which is connected to a vacuum tank 3. The liquid filling pipe 4 is connected to a balance tank 2, which is connected to a liquid filling pipe 7 and a return pipe 12. The return pipe 12 is connected to the bottom of the foam tank 6.

[0018] The liquid pipe 7 is connected to the cleaning water return pipe 9; the return pipe 12 is connected to the vacuum tank 3 via a hose 16. The cleaning water return pipe 9 is used for cleaning water return; the hose 16 is used to introduce cleaning water into the vacuum tank 3.

[0019] Valves 14 are installed on the liquid addition pipe 4, the medicine liquid pipe 7, the negative pressure pipe 10, the vacuum pipe 11, and the hose 16. The valves 14 are manual valves, which are opened and closed manually as needed for filling or stopping operations.

[0020] The cleaning water return pipe 9 is connected to the system return pipe 8, and the system return pipe 8 is also equipped with a valve 14. The valves on each pipe are independently set.

[0021] The bottom of the liquid filling machine 1, the liquid filling pipe 4 and below the balance tank 2, and the bottom of the vacuum tank 3 are all equipped with cleaning water drain valves 17. The cleaning water drain valves 17 are used to drain the cleaning water in each tank.

[0022] Transparent tubes 13 are installed on the liquid addition tube 4, negative pressure tube 5, medicine tube 7, cleaning water return tube 9, and return tube 12. The transparent tubes 13 at each location are used to observe the liquid flow inside the tube.

[0023] The balance tank 2 is provided with an observation port 15. The observation port 15 is used to observe the condition of the liquid medicine inside the balance tank 2.

[0024] The preferred layout of this utility model in actual production is as follows: the entire system is arranged on the first floor of the factory building, while the liquid medicine pipe 7, the system return water pipe 8, and the cleaning water return water 9 extend upwards into the second floor of the factory building; the liquid medicine pipe 7 is connected to the liquid medicine tank arranged on the second floor, and the liquid medicine pipe 7 is also connected to the cleaning water pipe through a pipeline. The cleaning water pipe is equipped with a valve. When the valve is opened, cleaning water can be introduced into the system on the first floor through the liquid medicine pipe 7; the vacuum pipe 11 is connected to the vacuum pump.

[0025] The working process and principle of this utility model for filling medicine liquid: The vacuum pump provides negative pressure to the vacuum tank 3. The vacuum tank 3 provides negative pressure to the medicine filling machine 1 through the negative pressure pipe 2 10, the foam tank 6, and the negative pressure pipe 1 5. The medicine filling machine 1 obtains medicine liquid from the balance tank 2 through the liquid filling pipe 4 for filling. The medicine liquid in the balance tank 2 is obtained from the medicine tank by the medicine liquid pipe 7. When a large amount of medicine liquid foam appears during the filling process and is drawn out with the negative pressure pipe 1 5, it will be collected in the foam tank 6. The connection end of the negative pressure pipe 2 10 is at the top of the foam tank 6 and will not suck up the medicine liquid foam, thereby preventing the medicine liquid foam from entering the vacuum tank 3 through the negative pressure pipe 2 10. After the medicine liquid foam collected in the foam tank 6 dissipates in the foam tank 6 and re-gathers into medicine liquid, the valve 14 on the return pipe 12 is opened, and this part of the medicine liquid can flow into the balance tank 2 from the return pipe 12.

[0026] The working process and principle of cleaning the entire system of this utility model (the system needs to be cleaned after the filling work is completed to prepare for the next filling): Clean water is introduced into the system from the liquid pipe 7 into the balance tank 2. The clean water in the balance tank 2 can enter the liquid filling machine 1 through the liquid filling pipe 4. The clean water in the balance tank 2 can enter the liquid filling machine 1 through the hose 16 in sequence through the vacuum tank 3, the second negative pressure pipe 10, the foam tank 6, and the first negative pressure pipe 5. After the cleaning water enters the system, it can be returned to the system through the cleaning water return pipe 9 and discharged after treatment. In addition, the water in the liquid filling machine 1, the balance tank 2, and the vacuum tank 3 that cannot be discharged through the loop after cleaning can be discharged through the cleaning water drain valve 17 at the bottom or below of each tank. In addition to the cleaning of this system, since there are more than one system on the first floor of the factory, the system return water pipe can be connected to the system return water pipe 8, and then discharged through the cleaning water return water pipe 9.

[0027] Additionally, it should be noted that the normal manual control of the opening and closing process of valve 14, depending on the path of the filling solution or cleaning water, is a technique known to technicians.

[0028] Implementation results: After the system of the above embodiment was applied in practice, the problem of liquid foam was overcome and the production effect was good.

[0029] The above description is merely a preferred embodiment of this application, but the scope of protection of this application is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in this application, based on the technical solution and concept of this application, should be included within the scope of protection of this application.

Claims

1. A liquid medicine negative pressure filling system, comprising a liquid medicine filling machine (1); characterized in that: The liquid filling machine (1) is connected to the liquid filling pipe (4) and the negative pressure pipe one (5). The negative pressure pipe one (5) is connected to the foam tank (6). The top of the foam tank (6) is connected to the negative pressure pipe two (10). The negative pressure pipe two (10) is connected to the vacuum tank (3). The liquid filling pipe (4) is connected to the balance tank (2). The balance tank (2) is connected to the liquid pipe (7) and the return pipe (12). The return pipe (12) is connected to the bottom of the foam tank (6).

2. The liquid medicine negative pressure filling system according to claim 1, characterized in that: The liquid pipe (7) is connected to the cleaning water return pipe (9); the return pipe (12) is connected to the vacuum tank (3) through the hose (16).

3. The negative pressure filling system for pharmaceutical liquid according to claim 2, characterized in that: Valves (14) are provided on the liquid addition pipe (4), medicine pipe (7), negative pressure pipe II (10), vacuum pipe (11) and hose (16).

4. The liquid under pressure filling system of claim 3, wherein: The bottom of the liquid filling machine (1), the liquid adding pipe (4) and below the balance tank (2) and the bottom of the vacuum tank (3) are all equipped with cleaning water drain valves (17).

5. The liquid under pressure filling system of claim 2, wherein: A transparent tube (13) is provided on each of the liquid addition tube (4), negative pressure tube (5), medicine tube (7), cleaning water return tube (9), and return tube (12).

6. The system according to claim 1, wherein: The balance tank (2) is provided with an observation port (15).

7. The system according to claim 3, wherein: The cleaning water return pipe (9) is connected to the system return pipe (8), and a valve (14) is provided on the system return pipe (8).

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