A detection device for diabetic nephropathy
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-10
- Publication Date
- 2026-08-14
AI Technical Summary
[0003]分散式的胶体金分析仪、尿微量白蛋白检测试纸、滴管和尿杯通常是分开存放，尿微量白蛋白检测试纸需避光、低温保存，而滴管需单独常温保存，但在外出或紧急情况下，患者可能因遗漏某一项而无法及时完成尿微量白蛋白检测，可能延误糖尿病肾病的干预时机
本实用新型通过壳体内两个相互独立的腔室分别对若干个试纸和滴管进行存放，通过半导体制冷片对第一腔室内的试纸进行低温保存，确保其检测准确性，当需要进行糖尿病肾病的检测时，通过推送组件推动最上侧试纸，使其伸出固定槽后将其取出，利用滴管将尿液吸附后滴落在试纸上，利用胶体金分析仪本体对试纸进行分析，外出时方便胶体金分析仪本体、试纸和滴管的组合携带，避免遗失，随取随用，患者能够快速完成糖尿病肾病的检测。
Smart Images
Figure CN224636529U_ABST
Abstract
Description
Technical Field
[0001] This utility model belongs to the technical field of diabetic nephropathy detection devices, and in particular relates to a detection device for diabetic nephropathy. Background Technology
[0002] Diabetic nephropathy is one of the most serious microvascular complications of diabetes and has become a major cause of end-stage renal disease. The colloidal gold analyzer for the detection of diabetic nephropathy is mainly based on colloidal gold immunochromatography technology. This colloidal gold analyzer utilizes the high electron density of colloidal gold particles to form complexes with target proteins in urine, generating visual signals. Only a small amount of urine sample is needed to detect early markers of diabetic nephropathy such as urinary microalbumin, enabling early detection of the disease. It can also regularly monitor changes in renal function indicators, evaluate treatment effectiveness, and help diabetic patients monitor their kidney disease risk over the long term.
[0003] Dispersed colloidal gold analyzers, urine microalbumin test strips, droppers, and urine cups are usually stored separately. Urine microalbumin test strips need to be protected from light and stored at low temperatures, while droppers need to be stored separately at room temperature. However, when out or in an emergency, patients may miss one item and fail to complete the urine microalbumin test in time, which may delay the intervention of diabetic nephropathy. Utility Model Content
[0004] The purpose of this invention is to provide a detection device for diabetic nephropathy that is convenient to carry in combination with a colloidal gold analyzer, test strips, and droppers, thus avoiding loss.
[0005] The aforementioned detection device for diabetic nephropathy includes a colloidal gold analyzer body and a housing fixed to the bottom of the colloidal gold analyzer body. The housing has two independent chambers, each containing a test strip and a dropper, respectively. Each chamber has a through-slot at its bottom, and a sealing plate is hinged to each through-slot. The inner wall of the first chamber containing the test strip has several semiconductor cooling chips embedded in it. A squeezing plate is provided in the first chamber to push the test strip into contact with the top of the chamber. Several first springs are provided between the squeezing plate and the sealing plate. A fixing groove for the test strip to extend is provided on the side wall of the first chamber. A pushing component is provided in the first chamber to push the test strip out of the fixing groove.
[0006] Furthermore, the pushing component includes a groove formed on the rear side wall of the first chamber, a push plate with an "L" shape structure is provided in the groove, a second spring is provided between the push plate and the inner wall of the groove, two sliders are provided on the top of the push plate, a sliding groove is provided in the top of the first chamber to slide with the sliders, a moving groove is provided on the side wall of the housing corresponding to the push plate, and a moving block that extends out of the housing through the moving groove is fixed on the push plate.
[0007] Furthermore, folding curtains are provided on both the front and rear sides of the movable block at the movable groove. One end of each folding curtain is fixed to the inner wall of the movable groove, and the other end is fixed to the side wall of the movable block. Several sliding blocks are provided on the upper and lower sides of each folding curtain, and a sliding groove is provided on the inner wall of the movable groove to slide with the corresponding sliding block.
[0008] Furthermore, a protective cover for protecting the moving block is hinged at the moving slot.
[0009] Furthermore, the inner wall of the first cavity is provided with a heat insulation layer.
[0010] Furthermore, a sliding cover is slidably connected to the fixing groove to seal it.
[0011] Furthermore, an anti-slip pad is provided at the bottom of the housing.
[0012] Compared with the prior art, the present invention has the following beneficial effects: This invention uses two independent chambers within the housing to store multiple test strips and droppers respectively. A semiconductor cooling chip is used to preserve the test strips in the first chamber at low temperatures, ensuring their accuracy. When diabetic nephropathy testing is required, the top test strip is pushed out of the fixing groove by the push component and then removed. Urine is absorbed by the dropper and dripped onto the test strip. The colloidal gold analyzer analyzes the test strip. When traveling, the combination of the colloidal gold analyzer, test strips, and droppers is convenient to carry, avoiding loss. It is readily available and allows patients to quickly complete the testing for diabetic nephropathy. Attached Figure Description
[0013] Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 for Figure 1 Schematic diagram of the cross-sectional structure of AA; Figure 3 This is a perspective view of the present utility model; Figure 4 This is a schematic diagram of the internal structure of the housing of this utility model; Figure 5 This is an exploded view of the present invention; The components in the diagram are as follows: 1. Colloidal gold analyzer body; 2. Housing; 3. Second spring; 4. Squeezing plate; 5. Push plate; 6. First spring; 7. Sealing plate; 8. Test paper; 9. Sliding cover; 10. Semiconductor cooling chip; 11. Dropper; 12. Moving block; 13. Sliding block; 14. Folding curtain; 15. Protective cover; 16. Moving slot. Detailed Implementation
[0014] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, but this is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.
[0015] Example This embodiment describes a detection device for diabetic nephropathy, such as... Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 As shown, the analyzer includes a colloidal gold analyzer body 1 and a housing 2 fixed to the bottom of the colloidal gold analyzer body 1. The housing 2 has two independent chambers, in which test strips 8 and droppers 11 are stored respectively. Both chambers have through slots at the bottom, and sealing plates 7 are hinged to the through slots. Several semiconductor cooling chips 10 are embedded in the inner wall of the first chamber where the test strips 8 are stored. A squeezing plate 4 is provided in the first chamber to push the test strips 8 to contact the top of the first chamber. Several first springs 6 are provided between the squeezing plate 4 and the sealing plate 7. A fixing slot for the test strips 8 to extend is provided on the side wall of the first chamber. A pushing component is provided in the first chamber to push the test strips 8 out of the fixing slot. In this embodiment, the colloidal gold analyzer body 1 is a handheld colloidal gold analyzer in the prior art. The handheld colloidal gold analyzer includes a photoelectric detection module for reading the colorimetric reaction signal of the test strip; a scanning module for identifying the barcode or chip information (such as batch number and expiration date) of the test strip; a control motherboard for processing test data and outputting results; a display screen for displaying test results and operation instructions (in this embodiment, the colloidal gold analyzer body 1 is a touch screen); a power supply for supporting instrument operation, and some models are rechargeable; and an information acquisition module, such as a two-dimensional barcode scanner or IC chip reader, for inputting sample information. In use, the test strip is removed, a fresh urine sample is collected using a urine cup, and 1-2 drops of urine are vertically added to the sample application area of the test strip using a dropper. Wait for the colloidal gold-labeled antibody to bind with the urinary microalbumin and develop color. Then, insert the test strip into the slot of the handheld colloidal gold analyzer. The main unit automatically scans the color band and quantifies the result, which is displayed on the screen. It can detect microalbuminuria of 30-300 mg / 24h, which can detect glomerular filtration membrane damage earlier than conventional urine protein testing. Abnormalities can be detected in stage II of diabetic nephropathy (compensated renal function). The portable handheld colloidal gold analyzer supports frequent testing, which is convenient for tracking the trend of microalbuminuria and distinguishing between transient elevation and persistent renal disease progression. This embodiment does not improve the structure and principle of the colloidal gold analyzer itself, but only adds a shell at the bottom to store the test strip 8 and the dropper 11, which facilitates the carrying of the test strip 8 and the dropper 11. The colloidal gold analyzer body 1 has a housing 2 attached to its bottom. The housing 2 contains two independent chambers, each with a through-slot at its bottom. The length and width of the test strip 8 are smaller than the through-slot dimensions of the first chamber, allowing the test strip 8 to pass smoothly into the first chamber for storage. The length and width of the dropper 11 are smaller than the second chamber, allowing the dropper 11 to be easily inserted into the second chamber. Each chamber contains a number of test strips 8 and droppers 11, with the number of test strips 8 and droppers 11 being equal to facilitate repeated testing for diabetic nephropathy. A sealing plate 7 is hinged to each through-slot. A locking block is located at the top of the sealing plate 7, and a corresponding locking groove is located at the bottom of the housing 2 at the through-slot. The locking block and the locking groove engage to fix the sealing plate 7 at the through-slot, sealing the through-slot and ensuring the airtightness of the chamber. A mounting slot is provided on the inner wall of the first chamber, into which several thermoelectric coolers 10 are embedded. The mounting slot is then sealed by a sealing plate. Several ventilation holes, connecting the inside and outside, are provided on the inner wall of the mounting slot. The cold end of the thermoelectric cooler 10 faces the sealing plate, and its cooling action transfers cold air to the sealing plate, ensuring that cold air enters the first chamber and keeps the test paper 8 in the first chamber at a low temperature. The hot end faces the ventilation holes, which are provided to dissipate heat. The thermoelectric cooler 10 is electrically connected to an integrated temperature sensor and a PID controller. The positive and negative terminals of the thermoelectric cooler 10 must be clearly marked; typically, the red wire is positive and the black wire is negative. It is connected to the analog input port of the PID controller via a voltage divider circuit. The resistance-temperature curve needs to be calibrated before directly connecting to the controller's digital I / O port. The single-bus protocol simplifies wiring. The controller output drives the cooler via an H-bridge or solid-state relay to achieve current direction control (switching between heating and cooling by reversing the connection). A DRV8834 driver chip is used, configured... PWM signal controls cooling power; high-precision temperature control requires a bidirectional current drive module (such as discrete MOSFET or dedicated H-bridge) to avoid mechanical relay delay; the PID controller uses an integrated 24-bit ADC to improve temperature sampling resolution; the semiconductor cooling chip 10 is electrically connected to the integrated temperature sensor and PID controller, which is existing technology, to achieve automatic adjustment of cooling power and better low-temperature preservation of the test strip in the first chamber; the low temperature environment can slow down the oxidation rate of the antibody-colloidal gold complex in the test strip 8, avoiding label failure, and the constant low temperature (usually 4-8℃) can extend the shelf life of the test strip 8, avoiding repeated testing or missed diagnosis due to test strip 8 failure; it avoids the destruction of the protein (such as antibody) structure of the test strip 8 due to high temperature, maintaining its specific binding ability with urinary microalbumin; the test strip 8 can be used for regular monitoring to assess the progression of diabetic nephropathy and treatment effect; the semiconductor cooling chip 10 can cool down quickly, suitable for immediate access to the test strip 8, and adapted to the outdoor use scenarios of the portable colloidal gold analyzer body 1; Furthermore, the inner wall of the first chamber is equipped with a heat insulation layer made of aerogel composite material. The nanoporous structure of the aerogel makes its thermal conductivity low, which can effectively block the transfer of external heat and ensure the stability of the internal temperature of the first chamber. The hydrophobic aerogel can avoid the influence of humidity and prevent the test paper 8 from getting damp and deteriorating. A squeezing plate 4 is installed on the upper side of the sealing plate 7 in the first chamber. Several first springs 6 are installed between the squeezing plate 4 and the sealing plate 7. One end of the first spring 6 is welded to the top of the sealing plate 7, and the other end of the first spring 6 is welded to the bottom of the squeezing plate 4. When the first spring 6 is in its natural state, it pushes the top of the squeezing plate 4 to contact the top of the first chamber. After several test strips 8 are placed into the first chamber, the sealing plate 7 closes the through slot. Under the elastic force of the first spring 6, the squeezing plate 4 is pushed to squeeze the test strips 8, so that the test strips 8 contact the top of the first chamber. Then, the pushing component pushes the test strips 8 out of the fixing slot, making it easy for the patient to take the test strips 8 for testing. In addition, a telescopic rod is installed inside the first spring 6. The telescopic rod makes the extension or compression movement trajectory of the first spring 6 more stable, and better drives the squeezing plate 4 to squeeze the test strips 8. The push assembly includes an electric push rod installed on the rear wall of the first chamber. The push rod end is equipped with a push plate, which slides against the inner wall of the first chamber. Activating the electric push rod causes it to extend or retract within the base, moving the push plate towards the fixing slot, which in turn moves a test strip 8 towards the fixing slot until it extends out of the slot, allowing the patient to easily grasp the test strip 8 and remove it from the first chamber. Then, the dropper 11 in the second chamber is removed, and urine is collected using a separately carried urine cup. After the dropper 11 draws up the urine, it is dripped into the test strip 8. The test strip 8 is then inserted into the slot of the colloidal gold analyzer body 1 to detect urinary microalbumin and diabetic nephropathy. The operation is convenient, eliminating the need to search for separately stored test strips 8 and droppers 11, making it easy to carry and use when traveling. The pushing assembly also includes a groove formed in the rear side wall of the first chamber, with an "L"-shaped push plate 5 positioned therein. A second spring 3 is positioned between the push plate 5 and the inner wall of the groove. Two sliders 13 are positioned on the top of the push plate 5. A sliding groove is formed in the top of the first chamber to slide with the sliders 13. A moving groove 16 is formed on the side wall of the housing 2 corresponding to the push plate 5. A moving block 12 is fixed on the push plate 5, extending outward through the moving groove 16. The groove in the rear side wall of the first chamber contains the push plate 5, which is connected to the inner wall of the groove by several second springs 3. One end of each second spring 3 is welded to the side wall of the push plate 5, and the other end is welded to the rear side wall of the groove. Two sliders 13 are welded or attached to the top of the push plate 5. A sliding groove is formed in the top of the first chamber to slide with the sliders 13. The sliding engagement between the sliding groove and the sliders 13 allows the push plate 5 to move more smoothly within the first chamber, thus improving its performance. The test strip 8 is pushed forward; a moving block 12 is provided in the moving groove 16 opened on the side wall of the housing 2, and the moving block 12 is connected to the push plate 5; when in use, push the moving block 12 that extends out of the outer side of the housing 2, so that it drives the push plate 5 to approach the fixed groove. Under the sliding cooperation of the slider 13 and the groove, the test strip 8 is pushed to move towards the fixed groove until it partially extends out of the fixed groove. The second spring 3 is stretched. The patient pinches the test strip 8 that extends out of the fixed groove and takes it out of the first chamber. Release the moving block 12. Under the elastic force of the second spring 3, the push plate 5 moves towards the groove. The push plate 5 drives the moving block 12 to move in the moving groove 16 until the push plate 5 is located in the groove; when it is necessary to take the test strip 8 again, the above operation can be repeated; the test strip 8 and the dropper 11 are safely stored in the closed and dry housing 2, and can be used as needed. This ensures that the test strip 8 and the dropper 11 will not be damaged or contaminated during the carrying process, and the patient can quickly complete the test for diabetic nephropathy; Furthermore, the height of the push plate 5 is lower than the height of the test strip 8. When the top of the test strip 8 contacts the top of the first chamber, the push plate 5 can only push one test strip 8 to move, avoiding multiple test strips 8 from moving with it and ensuring that the test strip 8 moves smoothly. The height of the fixing slot is also limited to the extension of one test strip 8. Therefore, when other test strips 8 move to the fixing slot, they will not follow the push of the push plate 5 to move out of the fixing slot, ensuring that the test strip 8 can be picked up more easily. like Figure 3 , Figure 4 and Figure 5As shown, folding curtains 14 are provided on both the front and rear sides of the movable block 12 at the movable groove 16. One end of each folding curtain 14 is fixed to the inner wall of the movable groove 16, and the other end is fixed to the side wall of the movable block 12. Several sliding blocks are provided on the upper and lower sides of each folding curtain 14, and a sliding groove is provided on the inner wall of the movable groove 16 to slide with the corresponding sliding block. Folding curtains 14 are attached to both the front and rear sides of the movable block 12, wherein the front end of the folding curtain 14 on the front side of the movable block 12 is attached to the front inner side wall of the movable groove 16, and the rear end of the folding curtain 14 on the rear side of the movable block 12 is attached to the rear inner side wall of the movable groove 16. Sliding blocks are welded to the top and bottom of each folding curtain 14, and the sliding blocks slide at the top and bottom of the movable groove 16. The sliding groove has a sliding fit. In use, the moving block 12 moves the push plate 5, which pushes the test strip 8 out of the fixed groove. When the moving block 12 moves, one side of the folding curtain 14 is stretched and the other side of the folding curtain 14 is compressed. The sliding fit between the sliding block and the sliding groove makes the stretching and compression of the folding curtain 14 more stable. The two folding curtains 14 seal the moving groove 16. The top and bottom of the folding curtain 14 can extend into the corresponding sliding grooves respectively. The folding curtain 14 will deform when stretched or compressed. The sliding groove can adapt to the deformation size of the folding curtain 14, so that the folding curtain 14 can better seal the moving groove 16. When pushing the test strip 8 out of the housing 2, it does not affect other test strips 8 stored in the first chamber. like Figure 3 , Figure 4 and Figure 5 As shown, a protective cover 15 for protecting the moving block 12 is hinged at the moving slot 16; a hinge seat is fixed on the outer wall of the housing 2 corresponding to the rear side wall of the moving slot 16, and the protective cover 15 is hinged to the hinge seat through a damping pivot. When the push plate 5 is pulled to the groove by the elastic force of the second spring 3, the rear side wall of the moving block 12 contacts the rear inner side wall of the moving slot 16. At this time, the protective cover 15 is rotated to rotate around the hinge, which can cover the moving block 12 and prevent the test strip 8 from being pushed out of the housing 2 by accidentally touching the moving block 12 when carrying the colloidal gold analyzer body 1. When it is necessary to take out the test strip 8, the protective cover 15 is rotated to rotate around the hinge, exposing the moving block 12. Moving the moving block 12 causes the push plate 5 to push the test strip 8 to move, thereby pushing the test strip 8 out of the fixed slot, making it more convenient for the patient to take out the test strip 8. picture Figure 1 , Figure 3 , Figure 4 and Figure 5As shown, a sliding cover 9 for sealing is slidably connected to the fixed groove; two symmetrically distributed chutes are provided on the front side wall of the housing 2, and sliders fixed to the rear side wall of the sliding cover 9 are arranged in the chutes. The sliding cover 9 is moved at the fixed groove through the sliding fit between the chutes and the sliders to close or expose the fixed groove, facilitating the extension of the test strip 8. A sealing layer is pasted on the rear side wall of the sliding cover 9 to further ensure the sealing performance of the first chamber and the cleanliness and hygiene of the test strip 8; As Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 As shown, an anti-slip pad is provided at the bottom of the housing 2; an anti-slip pad in the shape of a "mouth" is pasted at the bottom of the housing 2. The anti-slip pad increases the anti-slip effect and also raises the bottom of the housing 2. The bottom height of the anti-slip pad is lower than the bottom height of the sealing plate 7, which does not affect the use of the sealing plate 7; During actual use, a number of test strips 8 and droppers 11 need to be stored in the two chambers inside the housing 2 in advance. When carrying the colloidal gold analyzer body 1, the test strips 8 and droppers 11 can be carried to avoid omission. The semiconductor refrigeration sheet 10 stores the test strips 8 in the first chamber at a low temperature to ensure the accuracy of the detection. Under the elastic force of the first spring 6, the pressing plate 4 is driven to push the test strip 8 to contact the top inside the first chamber. When diabetes nephropathy needs to be detected, the uppermost test strip 8 is pushed through the pushing component to extend it from the fixed groove and then taken out. The urine is sucked by the dropper 11 and dripped onto the test strip 8. The colloidal gold analyzer body 1 analyzes the test strip 8 to detect diabetes nephropathy in patients. When going out, the test strips 8 and droppers 11 can be used at any time, and patients can quickly complete the detection of diabetes nephropathy.
Claims
1. A detection device for diabetic nephropathy, comprising a colloidal gold analyzer body (1) and a housing (2) fixed to the bottom of the colloidal gold analyzer body (1), characterized in that: The housing (2) has two independent chambers, each containing a test strip (8) and a dropper (11). Both chambers have through slots at their bottoms and are hinged with sealing plates (7). The inner wall of the first chamber containing the test strip (8) is embedded with several semiconductor cooling chips (10). The first chamber has a pressing plate (4) that pushes the test strip (8) to contact the top of the chamber. Several first springs (6) are arranged between the pressing plate (4) and the sealing plate (7). The side wall of the first chamber has a fixing slot for the test strip (8) to extend out. The first chamber has a pushing component that pushes the test strip (8) out of the fixing slot.
2. The detection device for diabetic nephropathy according to claim 1, characterized by: The pushing component includes a groove on the rear side wall of the first chamber, a push plate (5) with an "L" shape is provided in the groove, a second spring (3) is provided between the push plate (5) and the inner wall of the groove, two sliders (13) are provided on the top of the push plate (5), a sliding groove is provided on the top of the first chamber to slide with the sliders (13), a moving groove (16) is provided on the side wall of the housing (2) corresponding to the push plate (5), and a moving block (12) is fixed on the push plate (5) to extend out of the outer side of the housing (2) through the moving groove (16).
3. The device for detection of diabetic nephropathy according to claim 2, characterized in that: The front and rear sides of the movable block (12) are provided with folding curtains (14) located in the movable groove (16). One end of each folding curtain (14) is fixed to the inner wall of the movable groove (16), and the other end is fixed to the side wall of the movable block (12). Several sliding blocks are provided on the upper and lower sides of each folding curtain (14). A sliding groove is provided on the inner wall of the movable groove (16) corresponding to the sliding block to slide with it.
4. The detection device for diabetic nephropathy according to claim 2, characterized by: A protective cover (15) for protecting the moving block (12) is hinged at the moving slot (16).
5. The detection device for diabetic nephropathy according to claim 1, characterized by: The inner wall of the first chamber is provided with a heat insulation layer.
6. The detection device for diabetic nephropathy according to claim 1, characterized by: A sliding cover (9) is slidably connected to the fixing groove to seal it.
7. The detection device for diabetic nephropathy according to claim 1, characterized in that: The bottom of the housing (2) is provided with an anti-slip pad.