A mouse tail vein injection aid

Abstract

The utility model discloses a mouse tail intravenous injection auxiliary device relates to animal experiment instrument technical field, including mouse bucket, mouse tail clamp, lamp box and guide rail, mouse bucket, mouse tail clamp and lamp box can be connected with guide rail in order from front to back, mouse bucket includes bucket body, mouse head clamp and bucket door, the bucket body can accommodate mouse, and the bucket body extends along the front -back direction, and the front part of bucket body is provided with mouse head export, and the rear part of bucket body is provided with mouse tail export, and the middle part of bucket body is provided with observation port, mouse head clamp sets up at mouse head export place to hold the mouse head that stretches out the bucket body, bucket door sets up at observation port, lamp box is light -proof box, and is provided with illuminating lamp in lamp box, is provided with the light transmission groove on lamp box, mouse tail clamp can hold the mouse tail that stretches out the bucket body to make it place in light transmission groove and carry out intravenous blood vessel development, the utility model discloses can assist mouse tail intravenous injection, and, it is convenient to carry out real -time imaging monitoring to the mouse of tail intravenous injection after.

Description

Technical Field

[0001] This utility model relates to the field of animal experimental equipment technology, and in particular to a mouse tail vein injection aid. Background Technology

[0002] In drug screening and biomedical research, tail vein injection in mice is a common method of drug administration for experiments such as drug research and blood sampling. However, due to the small size of mice and the thinness of their tail blood vessels, problems such as failed bloodletting and tissue damage can easily occur during the procedure.

[0003] Existing mouse tail vein injection instruments, such as the Chinese patent document with announcement number CN221691457U, disclose a mouse tail vein blood collection device, including an operating platform, a container with an open end is mounted on the operating platform, a through hole is opened at the bottom of the container, a support platform is provided on the operating platform, a clamping groove is provided on the support platform that is close to and connected to the through hole, and a lifting clamping arm that can be engaged with the clamping groove is also provided on the operating platform.

[0004] Although the above-mentioned technical solution can effectively help the operator quickly locate the relatively thick tail vein by pulling the mouse's tail out of the through hole and placing it in the clamping groove on the support platform, and then lowering the lifting clamp arm to engage with the clamping groove to clamp the base of the mouse's tail, after using this instrument to assist in tail vein injection, the mouse needs to be removed from the container first and then fixed on the stage of the animal in vivo imaging instrument for observation. It is not possible to observe the mouse immediately after tail vein injection, resulting in poor experimental timeliness and affecting the accuracy of the observation data. Utility Model Content

[0005] The purpose of this invention is to provide a mouse tail vein injection aid to solve the problems existing in the above-mentioned related technologies. It can assist in tail vein injection in mice and facilitate real-time imaging monitoring of mice after tail vein injection.

[0006] To achieve the above objectives, this utility model provides the following solution:

[0007] This utility model provides a mouse tail vein injection aid, including a mouse bucket, a mouse tail clamp, a light box, and a guide rail. The mouse bucket, the mouse tail clamp, and the light box can be connected to the guide rail in sequence from front to back.

[0008] The mouse cage includes a cage body, a mouse head clamp, and a cage door. The cage body is capable of accommodating a small mouse and extends in a front-to-back direction. The front of the cage body has a mouse head outlet, the rear of the cage body has a mouse tail outlet, and the middle of the cage body has an observation port. The mouse head clamp is located at the mouse head outlet to hold the head of a small mouse protruding from the cage body. The cage door is located at the observation port.

[0009] The light box is a light-shielding box, and a light lamp is installed inside the light box. A light-transmitting groove is provided on the light box. The mouse tail clamp can hold the mouse tail that extends out of the barrel so that it can be placed in the light-transmitting groove for venous vascular imaging.

[0010] Preferably, the bucket door includes a left door panel and a right door panel, which are respectively hinged to the left and right sides of the observation port on the bucket body, and a door lock assembly is provided between the left door panel and the right door panel.

[0011] Preferably, the door lock assembly includes a first buckle, a first connecting post, and a first latching post. The first buckle is a strip-shaped plate structure and extends in the left-right direction. The left end of the first buckle is provided with a first connecting hole, and the right end of the first buckle is provided with a first latching interface.

[0012] The first connecting post is fixed to the middle of the right side of the left door panel; the first snap-fit ​​post is fixed to the middle of the left side of the right door panel; the left end of the first buckle is hinged to the first connecting post through the first connecting hole, and the right end of the first buckle can be snapped to the first snap-fit ​​post through the first snap-fit ​​interface.

[0013] Preferably, the mouse head clamp includes a left clamp plate and a right clamp plate, the left clamp plate and the right clamp plate are respectively hinged to the left and right sides of the mouse head outlet of the barrel body, and a locking assembly is provided between the left clamp plate and the right clamp plate.

[0014] Preferably, the locking assembly includes a second buckle, a second connecting post, and a second locking post. The second buckle is a strip-shaped plate structure and extends in the left-right direction. The left end of the second buckle is provided with a second connecting hole, and the right end of the second buckle is provided with a second locking interface.

[0015] The second connecting post is fixed to the upper part of the left clamping plate, and the lower part of the left clamping plate is hinged to the lower left side of the rat head outlet of the barrel body; the second snap-fit ​​post is fixed to the upper part of the right clamping plate, and the lower part of the right clamping plate is hinged to the lower right side of the rat head outlet of the barrel body; the left end of the second buckle is hinged to the second connecting post through the second connecting hole, and the right end of the second buckle can be snapped to the second snap-fit ​​post through the second snap-fit ​​interface.

[0016] Preferably, the rat tail clamp includes a pressure rod base and a rat tail pressure rod. The pressure rod base is slidably connected to the guide rail at the position of the rat head outlet near the barrel body, and the pressure rod base is provided with a rat tail groove, which extends in the front-to-back direction. The rat tail pressure rod extends in the left-to-right direction, and one end of the rat tail pressure rod is hinged to the pressure rod base at the position near the rat tail groove, while the other end can press down on the rat tail of the small rat in the rat tail groove.

[0017] Preferably, the side of the guide rail is provided with a dovetail groove along its extension direction; the barrel body, the pressure rod base, and the side of the lamp box near the guide rail are all provided with a dovetail block, and the dovetail block matches the dovetail groove.

[0018] Preferably, a battery box is provided on the side of the lamp box away from the guide rail, and a battery is provided in the battery box. The battery is electrically connected to the lighting lamp inside the lamp box.

[0019] Preferably, the lighting lamp is an LED lamp; the battery is a button battery.

[0020] Preferably, the lamp box is further provided with a hemostatic component, which includes a left locking block, a right locking block, and a hemostatic rod. The left locking block and the right locking block are respectively fixed to the left and right sides of the light-transmitting groove of the lamp box. The hemostatic rod extends in the left-right direction, and the left end of the hemostatic rod can engage with the left locking block, and the right end of the hemostatic rod can engage with the right locking block. An annular protrusion is provided on the hemostatic rod near the light-transmitting groove to press down on the mouse tail in the light-transmitting groove to stop bleeding.

[0021] This utility model achieves the following technical advantages compared to related technologies:

[0022] This invention provides a mouse tail vein injection aid, comprising a mouse bucket, a tail clamp, a light box, and a guide rail. The mouse bucket includes a bucket body, a head clamp, and a bucket door. In use, the mouse is placed in the bucket body, with its head protruding from the head outlet and its tail from the tail outlet. The head clamp holds the mouse's head in place. The mouse can then be placed on the stage of an animal in vivo imaging instrument, and the bucket door at the observation port can be opened to simultaneously observe the mouse's body and head. Real-time imaging is performed. Then, the mouse bucket, tail clamp, and light box are connected to the guide rail from front to back. The relative positions of the mouse bucket, tail clamp, and light box are adjusted. The mouse tail is held by the tail clamp and placed in the light-transmitting groove on the light box. The light inside the light box is turned on, and the vascular structure inside the mouse tail can be clearly observed. If necessary, the tail vein vessels can be visualized on the stage of the animal in vivo imaging instrument, and then the mouse can be injected with drugs through the tail vein, thereby realizing real-time imaging monitoring of mice after tail vein injection. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of this utility model or related technologies, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 A perspective view of the mouse tail vein injection aid provided in an embodiment of this utility model;

[0025] Figure 2 A front view of the mouse tail vein injection aid provided in an embodiment of this utility model;

[0026] Figure 3 Left view of the mouse tail vein injection aid provided in an embodiment of this utility model;

[0027] Figure 4 A bottom view of the mouse tail vein injection aid provided in an embodiment of this utility model;

[0028] Figure 5 A perspective view of the rat cage provided for an embodiment of this utility model;

[0029] Figure 6 A front view of the rat cage provided in an embodiment of this utility model;

[0030] Figure 7 Left view of the mouse bucket provided in an embodiment of this utility model;

[0031] Figure 8A bottom view of the rat cage provided in an embodiment of this utility model;

[0032] Figure 9 A front view of the first buckle provided in an embodiment of this utility model;

[0033] Figure 10 Left view of the first buckle provided in an embodiment of this utility model;

[0034] Figure 11 A bottom view of the first buckle provided in an embodiment of this utility model;

[0035] Figure 12 A front view of the left clamping plate provided in an embodiment of this utility model;

[0036] Figure 13 Right view of the left clamping plate provided in an embodiment of this utility model;

[0037] Figure 14 A bottom view of the left clamping plate provided in an embodiment of this utility model;

[0038] Figure 15 This is a front view of the right clamping plate provided in an embodiment of the present utility model;

[0039] Figure 16 A left view of the right clamp provided in an embodiment of this utility model;

[0040] Figure 17 A bottom view of the right clamping plate provided in an embodiment of this utility model;

[0041] Figure 18 A front view of the second buckle provided in an embodiment of this utility model;

[0042] Figure 19 Left view of the second buckle provided in an embodiment of this utility model;

[0043] Figure 20 A bottom view of the second buckle provided in an embodiment of this utility model;

[0044] Figure 21 This is a front view of the pressure rod base provided in an embodiment of the present utility model;

[0045] Figure 22 Left view of the pressure rod base provided in an embodiment of this utility model;

[0046] Figure 23 A top view of the pressure rod base provided in an embodiment of this utility model;

[0047] Figure 24 A front view of the rat-tail pressure bar provided in an embodiment of this utility model;

[0048] Figure 25 Right view of the rat tail pressure bar provided in an embodiment of this utility model;

[0049] Figure 26 A bottom view of the rat-tail pressure bar provided in an embodiment of this utility model;

[0050] Figure 27 This is a front view of the rat-tail pressure rod connecting shaft provided in an embodiment of the present utility model;

[0051] Figure 28 Left view of the rat tail pressure rod connecting shaft provided in an embodiment of this utility model;

[0052] Figure 29 A top view of the lamp box and battery box provided in an embodiment of this utility model;

[0053] Figure 30 This is a front view of the battery box cover provided in an embodiment of the present utility model;

[0054] Figure 31 A left view of the battery box cover provided in an embodiment of this utility model;

[0055] Figure 32 A top view of the battery box cover provided in an embodiment of this utility model;

[0056] Figure 33 A front view of the blood pressure control rod provided in an embodiment of this utility model;

[0057] Figure 34 Left view of the blood pressure control rod provided in an embodiment of this utility model;

[0058] Figure 35 A front view of the guide rail provided in an embodiment of this utility model;

[0059] Figure 36 Left view of the guide rail provided in an embodiment of this utility model;

[0060] Figure 37 This is a top view of the guide rail provided in an embodiment of the present utility model.

[0061] In the diagram: 1-Rat bucket, 101-Bucket body, 1011-Rat head outlet, 1012-Rat tail outlet, 102-Rat head clamp, 1021-Left clamp plate, 1022-Right clamp plate, 1023-Second buckle, 1024-Second connecting post, 1025-Second locking post, 1026-Third connecting post, 1027-Fourth connecting post, 1028-Limiting hole, 103-Bucket door, 1031-Left door panel, 1032-Right door panel, 1033-First buckle, 1034-Second... 1. Connecting post, 1035-First locking post, 2-Rat tail clamp, 201-Pressure rod base, 202-Rat tail groove, 203-Rat tail pressure rod, 204-Rat tail pressure rod connecting seat, 205-Rat tail pressure rod connecting shaft, 3-Lamp box, 301-Light transmission groove, 302-Lamp box sliding cover, 303-Battery box, 304-Battery box cover, 305-Left locking block, 306-Right locking block, 307-Blood pressure stop bar, 4-Guide rail, 401-Dovetail groove, 402-Dovetail block, 403-Side locking block. Detailed Implementation

[0062] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0063] The purpose of this invention is to provide a mouse tail vein injection aid to solve the problems existing in related technologies. It can assist in tail vein injection in mice and facilitate real-time imaging monitoring of mice after tail vein injection.

[0064] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the utility model will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0065] like Figures 1-4 As shown, this embodiment provides a mouse tail vein injection aid, including a mouse barrel 1, a mouse tail clamp 2, a light box 3, and a guide rail 4. The mouse barrel 1, the mouse tail clamp 2, and the light box 3 can be connected to the guide rail 4 in sequence from front to back.

[0066] In this embodiment, as Figures 5-8As shown, the mouse cage 1 includes a cage body 101, a mouse head clamp 102, and a cage door 103. The cage body 101 is preferably a cylindrical structure that can accommodate mice. The cage body 101 extends in the front-to-back direction. A mouse head outlet 1011 is provided at the front of the cage body 101, a mouse tail outlet 1012 is provided at the rear of the cage body 101, and an observation port is provided in the middle of the cage body 101. The mouse head clamp 102 is provided at the mouse head outlet 1011 to clamp the head of the mouse that extends out of the cage body 101. The cage door 103 is provided at the observation port.

[0067] It should be noted that "front" refers to the direction in which the rat head outlet 1011 of the barrel 101 faces, "rear" refers to the direction in which the rat tail outlet 1012 of the barrel 101 faces, "left" refers to the left side when facing the rat head outlet 1011 of the barrel 101, and "right" refers to the right side when facing the rat head outlet 1011 of the barrel 101.

[0068] In this embodiment, the bucket door 103 includes a left door panel 1031 and a right door panel 1032. The left door panel 1031 and the right door panel 1032 are respectively hinged to the left and right sides of the observation port of the bucket body 101, and a door lock assembly is provided between the left door panel 1031 and the right door panel 1032.

[0069] Furthermore, the door lock assembly includes a first latch 1033, a first connecting post 1034, and a first engaging post 1035, such as... Figures 9-11 As shown, the first buckle 1033 is a strip-shaped plate structure that extends in the left-right direction. The left end of the first buckle 1033 is provided with a first connecting hole, and the right end of the first buckle 1033 is provided with a first locking interface. The first connecting post 1034 is fixed to the middle of the right side of the left door panel 1031. The first locking post 1035 is fixed to the middle of the left side of the right door panel 1032. The left end of the first buckle 1033 is hinged to the first connecting post 1034 through the first connecting hole, and the right end of the first buckle 1033 can be locked to the first locking post 1035 through the first locking interface. The left door panel 1031 and the right door panel 1032 can be opened or closed by rotating the first buckle 1033.

[0070] In this embodiment, the mouse head clamp 102 includes a left clamping plate 1021 and a right clamping plate 1022, as shown below. Figures 12-17 As shown, the left clamping plate 1021 and the right clamping plate 1022 are respectively hinged to the left and right sides of the rat head outlet 1011 of the barrel body 101, and a locking assembly is provided between the left clamping plate 1021 and the right clamping plate 1022.

[0071] Furthermore, the locking assembly includes a second latch 1023, a second connecting post 1024, and a second engaging post 1025, such as... Figures 18-20As shown, the second buckle 1023 is a strip-shaped plate structure, extending in the left-right direction. A second connecting hole is provided at the left end of the second buckle 1023, and a second locking interface is provided at the right end. The second connecting post 1024 is fixed to the upper part of the left clamping plate 1021, and the lower part of the left clamping plate 1021 is hinged to the lower left side of the rat head outlet 1011 of the barrel body 101. The second locking post 1025 is fixed to... The upper part and lower part of the right clamping plate 1022 are hinged to the lower right side of the rat head outlet 1011 of the barrel body 101; the left end of the second buckle 1023 is hinged to the second connecting post 1024 through the second connecting hole, and the right end of the second buckle 1023 can be engaged with the second connecting post 1025 through the second locking interface. The left clamping plate 1021 and the right clamping plate 1022 can be separated or closed by rotating the second buckle 1023.

[0072] It should be noted that, in this embodiment, a third connecting hole is provided at the lower part of the left clamping plate 1021, and a third connecting post 1026 is provided at the lower left side of the rat head outlet 1011 of the barrel body 101. The left clamping plate 1021 is hinged to the third connecting post 1026 through the third connecting hole. A fourth connecting hole is provided at the lower part of the right clamping plate 1022, and a fourth connecting post 1027 is provided at the lower right side of the rat head outlet 1011 of the barrel body 101. The right clamping plate 1022 is hinged to the fourth connecting post 1027 through the fourth connecting hole. In order to restrict the forward and backward movement of the left clamping plate 1021, a third connecting post 1027 is also provided at the lower part of the left clamping plate 1021 near the third connecting hole. A limiting hole 1028 is provided, and the side of the third connecting post 1026 is also provided with a limiting hole 1028. By inserting a plug into the two corresponding limiting holes 1028, the forward and backward movement of the left clamp 1021 can be restricted. The same applies to the right clamp 1022. A limiting hole 1028 is provided at the lower part of the right clamp 1022 near the fourth connecting hole, and the side of the fourth connecting post 1027 is also provided with a limiting hole 1028. By inserting a plug into the two corresponding limiting holes 1028, the forward and backward movement of the right clamp 1022 can be restricted, which serves to prevent the mouse head from pushing the mouse head clamp 102 out.

[0073] In this embodiment, the rat tail clamp 2 includes a pressure rod base 201, such as Figures 21-23 As shown, the pressure rod base 201 is slidably connected to the guide rail 4 at the position of the rat's head outlet 1011 near the barrel body 101, and the pressure rod base 201 is provided with a rat's tail groove 202, which extends in the front-to-back direction; the rat's tail clamp 2 also includes a rat's tail pressure rod 203, as shown. Figures 24-28As shown, the rat tail pressure rod 203 extends in the left and right direction, and one end of the rat tail pressure rod 203 is hinged to the pressure rod base 201 near the rat tail groove 202, while the other end can press down on the rat tail of the mouse in the rat tail groove 202. Specifically, in this embodiment, the pressure rod base 201 is provided with a rat tail pressure rod connecting seat 204, which is located on the right side of the rat tail groove 202. The rat tail pressure rod 203 is hinged to the rat tail pressure rod connecting seat 204 through the rat tail pressure rod connecting shaft 205.

[0074] In this embodiment, as Figure 29 As shown, the light box 3 is a light-shielding box, and a light is provided inside the light box 3. The light is preferably an LED light. A light-transmitting groove 301 is provided on the light box 3. A light box sliding cover 302 is also provided at the rear of the light box 3. A suction cup base is also provided at the bottom of the light box 3. The mouse tail clamp 2 can clamp the mouse tail that extends out of the barrel 101 so that it can be placed in the light-transmitting groove 301 for venous vascular imaging.

[0075] Furthermore, a battery box 303 is provided on the side of the light box 3 away from the guide rail 4. A battery, preferably a button battery, is housed inside the battery box 303 and is electrically connected to the LED light inside the light box 3. Specifically, in this embodiment, a battery box cover 304 is also provided on the side of the battery box 303 away from the light box 3. Figures 30-32 As shown, the battery compartment cover 304 has an opening in the middle for mounting a switch.

[0076] In this embodiment, the lamp box 3 is also provided with a hemostatic component, which includes a left locking block 305, a right locking block 306, and a hemostatic rod 307. The left locking block 305 and the right locking block 306 are respectively fixed to the left and right sides of the light-transmitting groove 301 of the lamp box 3; the hemostatic rod 307 extends in the left and right direction, and the left end of the hemostatic rod 307 can be engaged with the left locking block 305, and the right end of the hemostatic rod 307 can be engaged with the right locking block 306; for example Figures 33-34 As shown, an annular protrusion is provided on the blood pressure control rod 307 near the light-transmitting groove 301, and the mouse tail inside the light-transmitting groove 301 is pressed down to stop bleeding.

[0077] In this embodiment, as Figures 35-37 As shown, a dovetail groove 401 is provided on the side of the guide rail 4 along its extension direction; a dovetail block 402 is provided on the side of the barrel body 101, the pressure rod base 201, and the lamp box 3 near the guide rail 4. The dovetail block 402 matches the dovetail groove 401 to realize the sliding connection between the barrel body 101, the pressure rod base 201, and the lamp box 3 and the guide rail 4. In addition, two side locking blocks 403 are provided on the side of the guide rail 4 away from the dovetail groove 401 in this embodiment. When the hemostatic rod is not in use, it is placed between the two side locking blocks 403 to avoid loss.

[0078] The usage process of the mouse tail vein injection aid provided in this embodiment is as follows:

[0079] Step 1, Equipment Assembly: Place the mouse in the mouse bucket 1 and lock the mouse's head with the mouse head clamp 102; the mouse bucket 1 can be placed on the stage of an animal live imaging instrument (such as an ultrasound imaging instrument) as needed, and the bucket door 103 at the top of the mouse bucket 1 can be opened to perform real-time imaging of the mouse's body parts and head.

[0080] Step 2, Adjust position: After the dovetail block 402 of the mouse barrel 1 is embedded into the dovetail groove 401 of the guide rail 4, the mouse barrel 1 can move along the guide rail 4 to facilitate the adjustment of the mouse position. After the position of the mouse barrel 1 is determined, move the mouse tail clamp 2 and place the mouse tail in the mouse tail groove 202.

[0081] Step 3, fix the mouse tail: press down the mouse tail pressure rod 203 to compress and fix the mouse tail in the mouse tail groove 202, thereby improving the stability of observation.

[0082] Step 4, vascular imaging: Place the fixed mouse tail in the light-transmitting slot 301 of the light box 3, turn on the LED light in the light box 3, and the vascular structure inside the mouse tail can be clearly observed; the tail vein vessels can be visualized on the stage of the animal in vivo imaging instrument as needed.

[0083] Step 5, Injection and Drug Administration: After observing the vascular structure inside the mouse tail, determine the needle insertion point, push the needle into the mouse's body, lift the tail lever 203, and inject the drug into the mouse's body.

[0084] Step 6, Hemostasis: After withdrawing the needle, press the blood pressure control rod 307 down onto the injection site. After 5-10 seconds, remove the blood pressure control rod 307, open the barrel door 103, and take out the mouse. If imaging monitoring is required, the animal in vivo imaging instrument can be operated at the same time as hemostasis.

[0085] Step 7, LED replacement: If you need to replace the LED, first open the sliding cover 302 of the lamp box, take the LED chip out of the lamp box 3, then pull out the old LED chip, and insert the new LED chip according to the positive and negative markings.

[0086] Compared to existing devices, the optimization directions of the mouse tail vein injection aid provided in this embodiment are as follows:

[0087] First, the rationality of the design: The design of the rat barrel 1 and the combination of the guide rail 4 with the dovetail joint reflects the mechanical principles in mechanical design, which can effectively disperse stress, improve the stability of the structure, and simplify the loading, unloading and replacement process, which is crucial to the efficiency of experimental operation.

[0088] Second, biomedical applications: This device is specifically designed for intravenous injection in the tail vein of mice, has good scientific application, can be adapted to various animal in vivo imaging instruments, can accurately present the tail blood vessels of mice and prevent drug leakage, thus providing reliable experimental data, which is of great significance in small animal imaging observation and drug injection-real-time monitoring.

[0089] Third, modular design: The LED lights inside the light box 3 adopt a replaceable LED chip design, which is a significant improvement over existing technologies. Many traditional devices often require complicated disassembly steps when changing the light source, causing inconvenience. This design achieves a simple and quick replacement process, making it convenient for experimental personnel to maintain the device during use. The modular design of the device makes it easy to upgrade and modify the device based on the first version during subsequent use. Compared with the fixed functions of existing devices, the modular design can adapt to new experimental needs more quickly.

[0090] Fourth, optimization of the focusing function: The opaque design of the lamp box 3 enhances the focusing effect of the light source and the visible blood vessel length. Compared with ordinary light sources, this design can effectively improve the visibility of rat tail blood vessels and optimize observation conditions. Compared with the existing device, the visible distance of the lamp column is only 15mm, while the visible blood vessel length of this device reaches 30mm, which is of great significance for improving the accuracy of blood vessel imaging in scientific research.

[0091] Fifth, ease of use: The application of the rat tail pressure rod 203 makes it easier to install and fix the rat tail. Compared with the complicated operating steps in traditional equipment, this device significantly improves the convenience and efficiency of operation and reduces human error.

[0092] Sixth, all detachable parts are replaceable: the rat cage 1, rat tail clamp 2, and light box 3 can all be separated from the guide rail 4, allowing for disassembly and replacement. This design's flexibility is distinctly different from the integrated structure of traditional products, providing greater convenience. The detachable design not only significantly reduces maintenance costs but also effectively extends the overall service life of the equipment, ensuring stability and reliability during long-term use. By simplifying the maintenance process, users can quickly replace damaged or aging components, thereby reducing equipment downtime and improving work efficiency. This design concept reflects the significant progress of modern equipment in terms of maintenance convenience and economic efficiency.

[0093] Seventh, material saving and design optimization: Referring to the mortise and tenon structure's interlocking connection method, not only is material saved, but the joint strength between components is also enhanced. This design concept is receiving increasing attention in modern mechanical engineering. Relevant literature points out that mortise and tenon structures can effectively reduce stress concentration at the connection points and improve the durability and reliability of the overall structure.

[0094] Eighth, the advantages of LED lighting technology: Modern LED technology is not only more environmentally friendly in terms of energy consumption, but also has an absolute advantage over traditional light sources in terms of brightness and lifespan; the use of replaceable LED beads allows for adjustment of brightness and LED bead color to adapt to tail vein injection in different strains of mice (C57 black mice have excellent tail vein imaging effect, the LED bead color is green, and the power is 5 watts). This design can also further extend the service life of the equipment and has economic benefits.

[0095] Ninth, detachable and real-time imaging monitoring mouse tank design: The mouse tank 1 is designed to be compatible with various small animal imaging instruments. According to the operation method of the imaging instrument, the mouse tank 1 can expose the mouse's head and back as needed, providing more accurate observation data for time-sensitive experiments and reducing errors.

[0096] The mouse tail vein injection aid provided in this embodiment has the following advantages:

[0097] First, this device uses mortise and tenon joints (dovetail joints) in many places, which makes almost all parts detachable, adjustable and replaceable.

[0098] Secondly, compared with existing mouse tail vein auxiliary injectors on the market, this device is designed with a mouse tail clamp 2 and a light box 3, which can effectively visualize the veins at the base of the mouse tail.

[0099] Third, this device is designed with a battery box 303 and a suction cup base, which does not require external power and can better fix the auxiliary device, making the whole device more convenient.

[0100] Fourth, the LED lamp holder inside the lamp box 3 can accommodate multiple LED beads, and the brightness and color of the LED beads can be adjusted to adapt to tail vein injection in mice of different strains.

[0101] Fifth, the main body of this device is made of resin material, which is more environmentally friendly and the cost is far lower than that of existing mouse tail vein auxiliary injectors on the market.

[0102] Sixth, the iteration of this device is more compatible with various animal in vivo imaging instruments, enabling integrated drug injection and real-time imaging.

[0103] In summary, the mouse tail vein injection aid provided in this embodiment is compatible with various mouse strains (such as BABL-C, C57, Kunming rat, field mouse, etc.), and solves problems such as integrated drug injection-in vivo drug delivery imaging, drug leakage, short and unclear tail vein imaging length in existing devices, cumbersome operation procedures, difficulty in cleaning and disinfecting non-removable structures, and high cost of high-precision automatic devices. It improves the efficiency and accuracy of tail vein injection in mouse experiments, is compatible with various imaging instruments, and can smoothly assist various animal imaging instruments to achieve integrated drug intravenous injection-in vivo imaging.

[0104] This utility model uses specific examples to illustrate its principles and implementation methods. The above description of the embodiments is only for the purpose of helping to understand the method and core idea of ​​this utility model. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the idea of ​​this utility model. In summary, the content of this specification should not be construed as a limitation of this utility model.

Claims

1. A mouse tail vein injection aid, characterized in that: It includes a mouse bucket, a mouse tail clamp, a light box, and a guide rail. The mouse bucket, the mouse tail clamp, and the light box can be connected to the guide rail in sequence from front to back. The mouse cage includes a cage body, a mouse head clamp, and a cage door. The cage body is capable of accommodating a small mouse and extends in a front-to-back direction. The front of the cage body has a mouse head outlet, the rear of the cage body has a mouse tail outlet, and the middle of the cage body has an observation port. The mouse head clamp is located at the mouse head outlet to hold the head of a small mouse protruding from the cage body. The cage door is located at the observation port. The light box is a light-shielding box, and a light lamp is installed inside the light box. A light-transmitting groove is provided on the light box. The mouse tail clamp can hold the mouse tail that extends out of the barrel so that it can be placed in the light-transmitting groove for venous vascular imaging.

2. The mouse tail vein injection aid according to claim 1, characterized in that: The bucket door includes a left door panel and a right door panel, which are respectively hinged to the left and right sides of the observation port on the bucket body, and a door lock assembly is provided between the left door panel and the right door panel.

3. The mouse tail vein injection aid according to claim 2, characterized in that: The door lock assembly includes a first buckle, a first connecting post, and a first latching post. The first buckle is a strip-shaped plate structure and extends in the left-right direction. The left end of the first buckle is provided with a first connecting hole, and the right end of the first buckle is provided with a first latching interface. The first connecting post is fixed to the middle of the right side of the left door panel; the first snap-fit ​​post is fixed to the middle of the left side of the right door panel; the left end of the first buckle is hinged to the first connecting post through the first connecting hole, and the right end of the first buckle can be snapped to the first snap-fit ​​post through the first snap-fit ​​interface.

4. The mouse tail vein injection aid according to claim 1, characterized in that: The mouse head clamp includes a left clamp plate and a right clamp plate, which are respectively hinged to the left and right sides of the mouse head outlet of the barrel body, and a locking assembly is provided between the left clamp plate and the right clamp plate.

5. The mouse tail vein injection aid according to claim 4, characterized in that: The locking assembly includes a second buckle, a second connecting post, and a second locking post. The second buckle is a strip-shaped plate structure and extends in the left-right direction. The left end of the second buckle is provided with a second connecting hole, and the right end of the second buckle is provided with a second locking interface. The second connecting post is fixed to the upper part of the left clamping plate, and the lower part of the left clamping plate is hinged to the lower left side of the rat head outlet of the barrel body; the second snap-fit ​​post is fixed to the upper part of the right clamping plate, and the lower part of the right clamping plate is hinged to the lower right side of the rat head outlet of the barrel body; the left end of the second buckle is hinged to the second connecting post through the second connecting hole, and the right end of the second buckle can be snapped to the second snap-fit ​​post through the second snap-fit ​​interface.

6. The mouse tail vein injection aid according to claim 1, characterized in that: The rat tail clamp includes a pressure rod base and a rat tail pressure rod. The pressure rod base is slidably connected to the guide rail at the position of the rat head outlet near the barrel body, and the pressure rod base is provided with a rat tail groove, which extends in the front-back direction. The rat tail pressure rod extends in the left-right direction, and one end of the rat tail pressure rod is hinged to the pressure rod base at the position near the rat tail groove, while the other end can press down on the rat tail of the small rat in the rat tail groove.

7. The mouse tail vein injection aid according to claim 6, characterized in that: The side of the guide rail is provided with a dovetail groove along its extension direction; the barrel body, the pressure rod base and the side of the lamp box near the guide rail are each provided with a dovetail block, and the dovetail block matches the dovetail groove.

8. The mouse tail vein injection aid according to claim 1, characterized in that: A battery compartment is provided on the side of the light box away from the guide rail, and a battery is provided inside the battery compartment. The battery is electrically connected to the lighting lamp inside the light box.

9. The mouse tail vein injection aid according to claim 8, characterized in that: The lighting is an LED light; the battery is a button battery.

10. The mouse tail vein injection aid according to claim 1, characterized in that: The lamp box is also equipped with a hemostatic assembly, which includes a left locking block, a right locking block, and a hemostatic rod. The left locking block and the right locking block are respectively fixed to the left and right sides of the light-transmitting groove of the lamp box. The hemostatic rod extends in the left and right direction, and the left end of the hemostatic rod can engage with the left locking block, and the right end of the hemostatic rod can engage with the right locking block. An annular protrusion is provided on the hemostatic rod near the light-transmitting groove to press down on the mouse tail in the light-transmitting groove to stop bleeding.

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