An animal brain stimulation experiment auxiliary device

Abstract

The utility model provides a kind of animal brain stimulation experiment auxiliary device, it is accommodated experimental animal by pipe body, so that experimental animal cannot move along the radial direction of pipe body, by the cooperation of clamping head component and limiting groove, so that the neck of experimental animal is limited, by the setting of adjusting assembly, so that experimental animal cannot move along the length direction of pipe body, under the restriction of above three dimensions, the experimental animal in brain stimulation experiment is better fixed in clear state;Fixed band on pipe body is equipped with brain stimulation part, and pipe body side wall is equipped with the opening of experimental animal experimental site exposure, when the other end of fixed band and the other side wall of pipe body or with fixed band itself connection, opening corresponds with brain stimulation part, so that brain stimulation part enters opening and contacts with experimental animal head experimental site, to realize brain stimulation experiment to clear experimental animal;Breathing hole on pipe body is used to provide air for clear experimental animal.

Description

Technical Field

[0001] This utility model relates to the field of animal brain experiment technology, specifically to an auxiliary device for animal brain stimulation experiments. Background Technology

[0002] The purpose of animal brain stimulation experiments is usually to study the effects of specific physical stimuli on the brain's nervous system or behavior. Commonly used forms of stimulation include physical stimuli such as light, electricity, magnetism, sound, and temperature. These stimuli act on the nervous system (organs, tissues, cells, body fluids, etc.) of organisms and elicit responses. Taking transcranial direct current stimulation (tDCS) in mice as an example, its main purpose includes evaluating the potential therapeutic effects of tDCS on neurodegenerative diseases (such as Alzheimer's disease) or other neurological diseases. These experimental results will have guiding significance for the treatment of human neurodegenerative diseases with transcranial direct current stimulation.

[0003] However, when a human receives transcranial direct current stimulation therapy, he is generally in a conscious state. In order to prevent the animal from struggling, the existing experimental techniques for animal brain stimulation experiments often use animals in a coma, which reduces the guiding significance of the experimental results. How to enable animals to complete brain stimulation experiments in a conscious state is a problem that animal experimental technicians are committed to solving. Utility Model Content

[0004] The problem this invention aims to solve is to provide an auxiliary device for animal brain stimulation experiments, in order to address the issue that conscious experimental animals may struggle, preventing the stimulation experiment from proceeding normally.

[0005] The technical solution adopted by this utility model to solve the above problems is as follows: an auxiliary device for animal brain stimulation experiments, including a tube for accommodating experimental animals, a breathing hole at one end of the tube, a fixing strap on the tube, one end of the fixing strap being fixedly connected to one side wall of the tube, the other end of the fixing strap being detachably connected to the other side wall of the tube or to the fixing strap itself, a brain stimulation part being fixedly connected to the fixing strap, an opening on the side wall of the tube, and when the other end of the fixing strap is connected to the other side wall of the tube or to the fixing strap itself, the opening corresponds to the brain stimulation part, and a limiting groove is provided on the side wall of the tube; It also includes a locking head component and an adjustment component; the locking head component is detachably disposed in the limiting groove for fixing the neck of the experimental animal; the adjustment component is disposed at the bottom of the tube for restricting the movement of the experimental animal along the length of the tube.

[0006] Compared with existing technologies, this invention uses a tube to accommodate experimental animals, preventing them from moving radially within the tube due to the confinement of the inner wall. The combination of a head-locking component and a limiting groove restricts the animal's neck, effectively securing the head closest to the experimental position. Adjustable components prevent movement along the length of the tube. Under these three constraints, conscious experimental animals are well-secured during brain stimulation experiments. The tube has a fixation strap with a brain stimulation unit, and an opening on the side wall exposes the experimental site of the animal. When the other end of the fixation strap connects to the other side wall of the tube or to the strap itself, the opening aligns with the brain stimulation unit, allowing it to enter and contact the experimental site on the animal's head, thus enabling brain stimulation experiments on conscious animals. A breathing hole on the tube provides air to the conscious animal to maintain its vital signs during the experiment.

[0007] According to one embodiment of the present invention, the adjusting component includes a cover, a rotating rod rotatably connected inside the cover, a stop piece fixedly connected to one end of the rotating rod, a soft pad fixedly connected to the top of the stop piece, the soft pad being made of rubber, and a rotating cap fixedly connected to the end of the rotating rod away from the stop piece.

[0008] According to one embodiment of the present invention, a hook and loop fastener is fixedly connected to the inner side of one end of the fixing strap, and a hook and loop fastener is fixedly connected to the outer side of the other end of the fixing strap. The hook and loop fasteners adhere to each other when they come into contact.

[0009] According to one embodiment of the present invention, the card head component includes a card, the width of which is consistent with the limiting groove, and an arc-shaped opening is provided at one end of the card.

[0010] According to one embodiment of the present invention, the card has symmetrical through holes at one end near the arc-shaped opening, and an elastic pad is fixedly connected inside the through hole.

[0011] According to one embodiment of the present invention, an arc-shaped card block is detachably connected inside the arc-shaped opening; the arc-shaped card block has symmetrical card posts at one end near the card, and the size of the card posts corresponds to the through hole; the arc-shaped card block includes various sizes.

[0012] According to one embodiment of the present invention, a handle is fixedly connected to the end of the card away from the arc-shaped opening, and an anti-slip strip is fixedly connected to the outside of the handle.

[0013] According to one embodiment of the present invention, the handle is provided with symmetrical arc-shaped hooks on both sides, and a limiting block is detachably provided at the end of the arc-shaped hook away from the handle; the side wall of the tube is provided with symmetrical slots; when the card is placed in the limiting slot, the limiting block engages the slot.

[0014] According to one embodiment of the present invention, a magnetic block is fixedly connected to the outside of the tube body, and a magnetic strip is fixedly connected to one end of the side wall of the fixing band, with the magnetic block and the magnetic strip corresponding to each other. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0016] Figure 2 This is a partial structural diagram of the present invention.

[0017] Figure 3 This is a schematic diagram of the card head component of this utility model.

[0018] Figure 4 This is a top view of the overall structure of this utility model.

[0019] Figure 5 This is a schematic diagram showing the unfolded structure of this utility model.

[0020] Figure 6 This is a cross-sectional view of the overall structure of this utility model.

[0021] Figure 7 This is a schematic diagram of the fixing strap structure of this utility model.

[0022] The components represented by each number in the attached diagram are listed below: 1. Tube body; 2. Breathing hole; 3. Fixing strap; 4. Brain stimulation part; 5. Opening; 6. Limiting groove; 7. Locking head component; 8. Adjustment component; 9. Cover; 10. Rotating rod; 11. Abutment; 12. Soft pad; 13. Rotating cap; 14. Card; 15. Arc-shaped opening; 16. Through hole; 17. Elastic pad; 18. Arc-shaped locking block; 19. Locking post; 20. Handle; 21. Anti-slip strip; 22. Magnetic block; 23. Magnetic strip; 24. Velcro surface; 25. Velcro hook surface; 26. Arc-shaped hook; 27. Limiting block; 28. Locking groove. Detailed Implementation

[0023] Before describing any embodiment of this invention in detail, it should be understood that the invention is not limited in its application to the details of the construction and arrangement of the components set forth in the following description or illustrated in the following figures. The invention is capable of other embodiments and can be practiced or carried out in various ways. Furthermore, it should be understood that the wording and terminology used herein are for descriptive purposes and should not be considered limiting. The use of “comprising” or “having” and variations thereof herein is intended to cover the items set forth below and their equivalents, as well as any additional items. Unless otherwise specified or limited, the terms “installation,” “connection,” “support,” and “linkage,” and variations thereof are used broadly and cover both direct and indirect installation, connection, support, and linking. Moreover, “connection” and “linkage” are not limited to physical or mechanical connections or links.

[0024] Furthermore, firstly, in the disclosure of this utility model, the terms "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, the above terms should not be construed as a limitation on this utility model. Secondly, the term "a" should be understood as "at least one" or "one or more," that is, in one embodiment, the number of an element can be one, while in another embodiment, the number of the element can be multiple. The term "a" should not be construed as a limitation on the quantity.

[0025] Those skilled in the art should understand that the embodiments of the present invention described above and shown in the accompanying drawings are merely examples and do not limit the present invention. The purpose of the present invention has been fully and effectively achieved. The functions and structural principles of the present invention have been shown and explained in the embodiments. Without departing from the stated principles, the implementation of the present invention may have any variations or modifications.

[0026] The embodiments of this utility model will be further described below with reference to the accompanying drawings.

[0027] Please see Figure 1-7The device shown is an auxiliary device for animal brain stimulation experiments, including a tube 1 for accommodating experimental animals. One end of the tube 1 has a breathing hole 2. A fixing strap 3 is provided on the tube 1. One end of the fixing strap 3 is fixedly connected to one side wall of the tube 1, and the other end of the fixing strap 3 is detachably connected to the other side wall of the tube 1 or to the fixing strap 3 itself. A brain stimulation unit 4 is fixedly connected to the fixing strap 3. An opening 5 is provided on the side wall of the tube 1. When the other end of the fixing strap 3 is connected to the other side wall of the tube 1 or to the fixing strap 3 itself, the opening 5 corresponds to the brain stimulation unit 4. A limiting groove 6 is provided on the side wall of the tube 1. The device also includes a locking head component 7 and an adjustment component 8. The locking head component 7 is detachably mounted in the limiting groove 6 for fixing the neck of the experimental animal. The adjustment component 8 is located at the bottom of the tube 1 for restricting the movement of the experimental animal along the length of the tube 1.

[0028] Please continue reading. Figure 5 , Figure 6 The adjusting component 8 includes a cover 9, a rotating rod 10 is rotatably connected inside the cover 9, a stop plate 11 is fixedly connected to one end of the rotating rod 10, a soft pad 12 is fixedly connected to the top of the stop plate 11, the soft pad 12 is made of rubber, and a rotating cap 13 is fixedly connected to the end of the rotating rod 10 away from the stop plate 11.

[0029] Please continue reading. Figure 4 , Figure 5 , Figure 7 The inner side of one end of the fixing strap 3 is fixedly connected with a hook and loop fastener 24, and the outer side of the other end of the fixing strap 3 is fixedly connected with a hook and loop fastener 25. When the hook and loop fastener 24 and the hook and loop fastener 25 come into contact with each other, they adhere to each other.

[0030] Please continue reading. Figure 2 , Figure 3 , Figure 5 The card head component 7 includes a card 14, the width of which is the same as that of the limiting groove 6, and an arc-shaped opening 15 is provided at one end of the card 14.

[0031] Please continue reading. Figure 3 In this case, the card 14 has symmetrical through holes 16 at one end near the arc-shaped opening 15, and an elastic pad 17 is fixedly connected inside the through hole 16.

[0032] Please refer to further information. Figure 3 The arc-shaped opening 15 has an arc-shaped locking block 18 detachably connected inside; the arc-shaped locking block 18 has symmetrical locking posts 19 at one end near the card 14, and the size of the locking posts 19 corresponds to the through hole 16; the arc-shaped locking block 18 includes various sizes.

[0033] Please refer to further information. Figure 3 In this case, a handle 20 is fixedly connected to the end of the card 14 away from the arc-shaped opening 15, and an anti-slip strip 21 is fixedly connected to the outside of the handle 20.

[0034] Please refer to further information. Figure 2 , Figure 3 Among them, the handle 20 is symmetrically provided with arc-shaped hooks 26 on both sides, and the end of the arc-shaped hook 26 away from the handle 20 is detachably provided with a limiting block 27; the side wall of the tube body 1 is symmetrically provided with a slot 28; when the card 14 is placed in the limiting slot 6, the limiting block 27 locks the slot 28.

[0035] Please continue reading. Figure 4 , Figure 5 The tube body 1 is fixedly connected to a magnetic block 22, and a magnetic strip 23 is fixedly connected to one side wall of the fixing band 3. The magnetic block 22 and the magnetic strip 23 correspond to each other.

[0036] Example 1: Please continue reading Figure 1 - Figure 7 The diagram shows an auxiliary device for animal brain stimulation experiments, including a tube 1 with a circular top. The tube 1 is made of transparent plastic for easy observation of the experimental animal. It also includes at least one breathing hole 2 at one end of the tube 1, providing necessary airflow to ensure smooth breathing during the experiment and preventing interference with experimental results due to hypoxia. A fixing strap 3 is provided on the tube 1, with one end fixedly connected to one side wall of the tube 1 and the other end detachably connected to the tube 1. A magnetic block 22 is fixedly connected to the other side wall of the tube 1, and a magnetic strip 23 is fixedly connected to one side wall of the fixing strap 3. The magnetic block 22 and magnetic strip 23 correspond to each other, allowing for flexible adjustment of the tightness of the fixing strap 3. A brain stimulation part 4 is fixedly connected to the fixing strap 3. An opening 5 is provided on the outside of the tube 1, corresponding to the brain stimulation part 4. A Velcro surface 24 is fixedly connected to the inner side of one end of the fixing strap 3. The other end of the strap 3 is fixedly connected to a hook and loop fastener 25. When the hook and loop fastener 24 and the hook and loop fastener 25 come into contact with each other, they will adhere to each other, so that the strap 3 is fixed to itself after wrapping around the tube body 1 at least once. By the cooperation of at least one of the hook and loop fastener 24 and the hook and loop fastener 25, as well as the magnetic block 22 and the magnetic strip 23, it can be ensured that the brain stimulation part 4 on the strap 3 is fixed at a designated position on the animal's head. When the experimental animal is properly fixed in the device, the brain stimulation part 4 can accurately perform brain stimulation operation on the experimental animal. A limiting groove 6 is provided on the outside of the tube body 1 and at the bottom of the opening 5. A locking member 7 is detachably set inside the limiting groove 6. The locking member 7 is used to fix the neck of the experimental animal to prevent the animal from rotating or twisting its body, and can also prevent the animal's head from struggling at the experimental position. An adjustment component 8 is threadedly connected to the bottom of the tube body 1. The adjustment component 8 is used to limit the experimental animal and prevent the animal from moving along the length of the tube body 1.

[0037] For further details, please refer to Figure 5 The adjustment component 8 includes a cover 9. Locking the cover 9 can restrict the forward and backward movement of the experimental animal. A rotating rod 10 is rotatably connected inside the cover 9. One end of the rotating rod 10 is fixedly connected to a stop plate 11, and the other end of the rotating rod 10 away from the stop plate 11 is fixedly connected to a rotating cap 13. A soft pad 12 is fixedly connected to the top of the stop plate 11. The soft pad 12 is made of rubber and can effectively protect the animal from injury when in contact with the experimental animal's body, while also playing a good limiting role. The adjustment component 8 can then be adapted to experimental animals of different sizes, thus facilitating experiments on the experimental animals. By rotating the rotating cap 13, the rotating rod 10 can be easily rotated, thereby achieving precise control of the position of the stop plate 11 to adapt to experimental animals of different sizes. This ensures that the head of the experimental animal can be stably kept below the opening 5, creating ideal conditions for the smooth conduct of brain stimulation experiments and greatly improving the convenience of experimental operation and the accuracy of experimental results.

[0038] Example 2: This embodiment is a further explanation of Example 1, based on... Figure 3 and Figure 5 As shown, it is worth noting that the clamping head component 7 includes a card 14. The width of the card 14 is consistent with the limiting groove 6, ensuring that there will be no shaking or displacement after installation, which would affect the fixation effect on the neck of the experimental animal. One end of the card 14 has an arc-shaped opening 15, and the end of the card 14 near the arc-shaped opening 15 has symmetrical through holes 16. An elastic pad 17 is fixedly connected inside the through hole 16. An arc-shaped clamping block 18 is clamped inside the card 14. The arc-shaped clamping block 18 is designed according to the physiological curve of the experimental animal's neck, which can gently and effectively clamp the animal's neck and avoid causing unnecessary injury. The curved locking block 18 has symmetrical locking posts 19 near the end of the card 14. The size of the locking posts 19 corresponds to the through hole 16. The locking posts 19 and the through hole 16 are locked together. The elastic pad 17 can prevent the locking posts 19 and the through hole 16 from loosening after repeated disassembly and reassembly, which can further increase the tightness of the connection between the locking posts 19 and the through hole 16. There are multiple sets of curved locking blocks 18 with different inner diameters. Multiple sets of curved locking blocks 18 with different inner diameters provide more choices for the experimenters. The appropriate curved locking block 18 can be flexibly replaced according to the actual size of the experimental animal's neck to achieve the best fixation effect.

[0039] Further reference Figure 3As shown, a handle 20 is fixedly connected to the end of the card 14 away from the arc-shaped opening 15. An anti-slip strip 21 is fixedly connected to the outside of the handle 20. The anti-slip strip 21 facilitates the operation of the experimenter when installing and disassembling the card head component 7. An arc-shaped hook 26 is symmetrically fixedly connected to the outside of the handle 20. The arc-shaped hook 26 is made of plastic. A limiting block 27 is detachably provided at the end of the arc-shaped hook 26 away from the handle 20. The limiting blocks 27 are symmetrically fixedly installed on the tube body 1. The two limiting blocks 27 have slots 28 inside. When the card 14 is inserted into the limiting slot 6, the arc-shaped hook 26 is inserted into the corresponding slot 28 to limit the card 14 and improve the limiting effect.

[0040] Example 3: Taking transcranial direct current stimulation of animals as an example, the experimental procedure includes the following steps: Step 1: Implant and fix conductive electrodes at the experimental site in the head of the experimental animal; Step 2: The experimental animal is herded into tube 1. After the animal reaches the experimental position, i.e., the head of the animal is positioned below opening 5, Step 3: Lock the cover 9, and at the same time rotate the rotating cap 13, which in turn drives the rotating rod 10 to rotate, thereby driving the abutment 11 to restrict the experimental animal; Step 4: Insert the appropriately sized arc-shaped card block 18 into the through hole 16 through the card post 19, then insert the card 14 into the limiting groove 6 through the handle 20, and insert the arc-shaped card hook 26 into the card groove 28 to limit the card 14 so that the experimental part of the experimental animal's head is aligned with the opening 5. Step 5: Fix the brain stimulation unit 4 above the opening 5 using the fixing strap 3, and electrically connect it to the conductive electrode on the head of the experimental animal; In this embodiment, the brain stimulation unit 4 is a miniature DC transmitter, and the brain stimulation unit 4 is externally connected to a DC control host via wires. Step 6: Start the DC control host to perform transcranial DC stimulation on an awake experimental animal.

[0041] The above description only illustrates the preferred embodiment of this utility model and should not be construed as limiting the scope of the claims. This utility model is not limited to the above embodiments, and variations in its specific structure are permitted. All changes made within the scope of the independent claims of this utility model are also within the scope of protection of this utility model.

Claims

1. An auxiliary device for animal brain stimulation experiments, characterized in that: The tube (1) is used to accommodate experimental animals. One end of the tube (1) is provided with a breathing hole (2). The tube (1) is provided with a fixing strap (3). One end of the fixing strap (3) is fixedly connected to one side wall of the tube (1). The other end of the fixing strap (3) is detachably connected to the other side wall of the tube (1) or to the fixing strap (3) itself. A brain stimulation part (4) is fixedly connected to the fixing strap (3). An opening (5) is provided on the side wall of the tube (1). When the other end of the fixing strap (3) is connected to the other side wall of the tube (1) or to the fixing strap (3) itself, the opening (5) corresponds to the brain stimulation part (4). A limiting groove (6) is provided on the side wall of the tube (1). It also includes a locking head component (7) and an adjustment component (8); the locking head component (7) is detachably disposed in the limiting groove (6) for fixing the neck of the experimental animal; the adjustment component (8) is disposed at the bottom of the tube (1) for restricting the movement of the experimental animal along the length direction of the tube (1).

2. The animal brain stimulation experimental auxiliary device according to claim 1, characterized in that: The adjustment component (8) includes a cover (9), a rotating rod (10) is rotatably connected inside the cover (9), a stop plate (11) is fixedly connected to one end of the rotating rod (10), a soft pad (12) is fixedly connected to the top of the stop plate (11), the soft pad (12) is made of rubber, and a rotating cap (13) is fixedly connected to the end of the rotating rod (10) away from the stop plate (11).

3. The animal brain stimulation experimental auxiliary device according to claim 1, characterized in that: The inner side of one end of the fixing strap (3) is fixedly connected with a hook and loop fastener (24), and the outer side of the other end of the fixing strap (3) is fixedly connected with a hook and loop fastener (25). When the hook and loop fastener (24) and the hook and loop fastener (25) come into contact with each other, they adhere to each other.

4. The animal brain stimulation experimental auxiliary device according to claim 1, characterized in that: The card head component (7) includes a card (14), the width of which is consistent with the limiting groove (6), and an arc-shaped opening (15) is provided at one end of the card (14).

5. The animal brain stimulation experimental auxiliary device according to claim 4, characterized in that: The card (14) has symmetrical through holes (16) at one end near the arc-shaped opening (15), and an elastic pad (17) is fixedly connected inside the through hole (16).

6. The animal brain stimulation experimental auxiliary device according to claim 5, characterized in that: The arc-shaped opening (15) is detachably connected to an arc-shaped locking block (18); the arc-shaped locking block (18) has a locking post (19) symmetrically arranged at one end near the card (14), and the size of the locking post (19) corresponds to the through hole (16); the arc-shaped locking block (18) includes various sizes.

7. The animal brain stimulation experimental auxiliary device according to claim 6, characterized in that: A handle (20) is fixedly connected to one end of the card (14) away from the arc-shaped opening (15), and an anti-slip strip (21) is fixedly connected to the outside of the handle (20).

8. The animal brain stimulation experimental auxiliary device according to claim 7, characterized in that: The handle (20) is symmetrically provided with arc-shaped hooks (26) on both sides, and the end of the arc-shaped hook (26) away from the handle (20) is detachably provided with a limiting block (27); the side wall of the tube body (1) is symmetrically provided with slots (28); when the card (14) is placed in the limiting slot (6), the limiting block (27) locks the slot (28).

9. The animal brain stimulation experimental auxiliary device according to claim 1 or 3, characterized in that: A magnetic block (22) is fixedly connected to the outside of the tube body (1), and a magnetic strip (23) is fixedly connected to one side wall of the fixing band (3). The magnetic block (22) and the magnetic strip (23) correspond to each other.

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