A reaction kettle for compound miconazole nitrate

Abstract

The utility model discloses a reaction kettle for compound miconazole nitrate, relates to reaction kettle technical field, including the reaction kettle body, inner shaft and outer shaft, the top of reaction kettle body is provided with independent drive mechanism, the upper end of outer shaft is symmetrically installed with the fairing, the lower extreme of outer shaft is installed with spiral blade, the upper end and the lower extreme of outer shaft are symmetrically installed with the scraper, the lower extreme of inner shaft is equipped with the sleeve that is in line with outer shaft, the outside of sleeve is symmetrically installed with the stirring vane. In the utility model, set up fairing, spiral blade, scraper and stirring vane, make the ointment more delicate and even, set up independent drive mechanism and drive inner shaft and outer shaft respectively, in the emulsification stage, drive inner shaft and outer shaft rotate, drive fairing, spiral blade, scraper and stirring vane to rotate, realize high -intensity shearing dispersion, overall circulation and defoaming, in the cooling stage, drive outer shaft alone, drive fairing, spiral blade and scraper to rotate, and gently promote the paste to go up and down circulation.

Description

Technical Field

[0001] This utility model relates to the field of reaction vessel technology, and in particular to a reaction vessel for compound miconazole nitrate. Background Technology

[0002] Miconazole nitrate compound is a commonly used topical antifungal drug, usually formulated as an ointment. Ointments are semi-solid preparations, typically made by emulsifying an oil phase and an aqueous phase. They are characterized by high viscosity, heat sensitivity, and extremely high requirements for mixing uniformity. During processing, a reaction vessel (often called an emulsification tank or preparation tank) is required to synthesize miconazole nitrate compound and to mix and emulsify it.

[0003] Traditional reactors often employ single-shaft stirring, which has significant drawbacks when producing high-viscosity pastes. It has low mixing efficiency, is prone to creating dead zones, and results in uneven material mixing. Material tends to adhere to the reactor wall, forming an insulating layer that severely affects heat transfer efficiency, leading to localized overheating or uneven cooling, which may cause degradation of drug components. Furthermore, the stirring flow pattern is singular and cannot simultaneously achieve the functions of high-shear dispersion and main body circulation and material turning. Utility Model Content

[0004] The purpose of this invention is to provide a reaction vessel for compound miconazole nitrate in order to solve the above-mentioned problems.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a reaction vessel for compound miconazole nitrate, comprising a reaction vessel body, an inner shaft rotatably connected inside the reaction vessel body, an outer shaft sleeved at the upper end of the inner shaft, an independent drive mechanism provided at the top of the reaction vessel body for independently driving the inner shaft and the outer shaft to rotate, a guide shroud symmetrically installed at the upper end of the outer shaft, a spiral blade installed at the lower end of the outer shaft, scrapers symmetrically installed at the upper and lower ends of the outer shaft, a sleeve fitted to the outer shaft at the lower end of the inner shaft, and stirring blades symmetrically installed on the outer side of the sleeve.

[0006] Preferably, the flow guide is semi-circular in shape and tilted upwards, and multiple flow guide vanes are installed equidistantly inside the flow guide.

[0007] Preferably, the reactor body includes a lower tank and an upper tank. The top of the upper tank is provided with an installation cylinder for detachably installing an independent drive mechanism. The independent drive mechanism includes a motor one and a motor two. The output end of the motor one is connected to the top end of the inner shaft, and the output end of the motor two is connected to a driving bevel gear. The upper end of the outer shaft is equipped with a driven bevel gear that meshes with the driving bevel gear.

[0008] Preferably, the inner side of the sleeve is provided with a plurality of protrusions arranged in an array, the lower end of the inner shaft is provided with a groove that matches the size of the protrusions, and the bottom of the lower tank is provided with a base that is inserted into and rotates with the sleeve.

[0009] Preferably, the upper tank has symmetrically arranged inlet ports at the top, and the lower tank has symmetrically arranged outlet ports at the bottom.

[0010] Preferably, the lower tank is provided with a jacket on its outer side, and a connecting pipe connected to the external circulating water is symmetrically installed on the outer side of the jacket. The connecting pipe is in communication with the cavity between the jacket and the lower tank.

[0011] Preferably, both ends of the upper tank are also connected to water spray pipes that are connected to external water pipes, and one end of the water spray pipe that extends into the upper tank is inclined to the flow guide shroud.

[0012] In summary, due to the adoption of the above technical solution, the beneficial effects of this utility model are:

[0013] 1. In this application, a flow guide is set to eliminate air bubbles during the stirring process, thereby improving the appearance and stability of the compound miconazole nitrate product. A spiral blade is set to stir the mixture, ensuring uniform mixing of the upper and lower layers of the ointment and preventing stratification. A scraper is set to prevent the ointment from coagulating. The stirring blade is used to break up clumps and droplets (which is crucial in the emulsification process) and to evenly disperse solid powders (such as drug particles) in the matrix, making the ointment more delicate and uniform.

[0014] 2. In this application, an independent drive mechanism is set to drive the inner shaft and the outer shaft respectively. During the emulsification stage, the inner shaft and the outer shaft are driven to rotate, which drives the guide shroud, spiral blade, scraper and stirring blade to rotate, so as to achieve high-intensity shear dispersion, overall circulation and defoaming. During the cooling stage, the outer shaft is driven separately, which drives the guide shroud, spiral blade and scraper to rotate, and gently pushes the paste to circulate up and down. Attached Figure Description

[0015] Figure 1 A schematic diagram of the overall structure according to an embodiment of the present utility model is shown;

[0016] Figure 2 A schematic diagram of an independent drive mechanism according to an embodiment of the present invention is shown;

[0017] Figure 3 A schematic diagram of the flow guide structure provided according to an embodiment of the present utility model is shown;

[0018] Figure 4 A schematic diagram of the inner shaft and sleeve connection structure provided according to an embodiment of the present utility model is shown;

[0019] Figure 5A cross-sectional view of the overall structure provided according to an embodiment of the present invention is shown.

[0020] Legend:

[0021] 1. Reactor body; 101. Lower tank; 102. Upper tank; 103. Mounting cylinder; 104. Base; 105. Inlet; 106. Outlet; 107. Jacket; 108. Connecting pipe; 109. Water spray pipe; 2. Independent drive mechanism; 201. Motor 1; 202. Motor 2; 203. Driving bevel gear; 204. Driven bevel gear; 3. Inner shaft; 4. Outer shaft; 5. Flow guide shroud; 6. Spiral blade; 7. Scraper; 8. Sleeve; 9. Stirring blade; 10. Flow guide blade; 11. Protrusion; 12. Groove. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0023] Please see Figure 1 and Figure 2 This utility model provides a technical solution: a reaction vessel for compound miconazole nitrate, including a reaction vessel body 1, an inner shaft 3 rotatably connected inside the reaction vessel body 1, an outer shaft 4 sleeved on the upper end of the inner shaft 3, an independent drive mechanism 2 set on the top of the reaction vessel body 1 for independently driving the inner shaft 3 and the outer shaft 4 to rotate, a guide shroud 5 symmetrically installed on the upper end of the outer shaft 4, a spiral blade 6 installed on the lower end of the outer shaft 4, a scraper 7 symmetrically installed on the upper and lower ends of the outer shaft 4, a sleeve 8 fitted to the outer shaft 4 on the lower end of the inner shaft 3, and stirring blades 9 symmetrically installed on the outer side of the sleeve 8;

[0024] The function of the spiral blade 6 is to act as an axial flow pump, generating a strong axial thrust when rotating, forcibly pushing the material in the vessel to circulate from top to bottom or bottom to top, ensuring full exchange of materials between the upper and lower layers, completely eliminating mixing dead zones, and avoiding stratification;

[0025] The scraper 7 maintains a small gap or elastic fit with the inner wall and bottom curved surface of the lower tank 101. Its core function is to continuously scrape off the high-viscosity paste adhering to the metal wall surface, eliminate the static insulation layer, and enable the heat or cold in the jacket 107 to be efficiently transferred to the main material, ensuring the temperature uniformity of the entire reaction process and preventing local overheating from causing drug failure or local cooling from causing paste to solidify.

[0026] Specifically, such as Figure 3As shown, the guide shroud 5 is semi-circular in shape and tilted upward. Multiple guide vanes 10 are installed equidistantly inside the guide shroud 5. The semi-circular shape of the guide shroud 5 is used to smoothly guide the material lifted by the spiral vane 6 to the surrounding area, forming a stable circulation path. At the same time, it can effectively break up liquid vortices, prevent the generation of vortices and entrain air into the material, thereby significantly reducing bubbles and improving the appearance and stability of the finished cream.

[0027] Specifically, such as Figure 4 As shown, multiple protrusions 11 are arranged in an array on the inner side of the sleeve 8. The lower end of the inner shaft 3 has a groove 12 that matches the size of the protrusions 11. A base 104 is installed at the bottom of the lower tank 101, which is inserted into and rotates with the sleeve 8. The protrusions 11 and groove 12 are set to increase the frictional resistance, so that the inner shaft 3 rotates and drives the sleeve 8 to rotate. The sleeve 8 can be slidably removed from the lower end of the inner shaft 3. The base 104 is a bottom bearing with a mechanical seal. The bottom bearing is installed in the bottom of the lower tank 101. The mechanical seal is responsible for axial sealing to prevent material leakage along the shaft. The bottom bearing is responsible for radial support to ensure stable rotation of the shaft. When the bottom bearing or mechanical seal is worn, the inner shaft 3 can be removed and the bottom bearing or mechanical seal can be disassembled and replaced.

[0028] Specifically, such as Figure 5 As shown, the reactor body 1 includes a lower tank 101 and an upper tank 102. The top of the upper tank 102 is provided with a mounting cylinder 103 for detachably installing an independent drive mechanism 2. The independent drive mechanism 2 includes a first motor 201 and a second motor 202. The output end of the first motor 201 is connected to the top end of the inner shaft 3. The output end of the second motor 202 is connected to a driving bevel gear 203. The upper end of the outer shaft 4 is equipped with a driven bevel gear 204 that meshes with the driving bevel gear 203.

[0029] The upper tank 102 has symmetrically arranged inlet ports 105 at the top, and the lower tank 101 has symmetrically arranged outlet ports 106 at the bottom for feeding and discharging.

[0030] The lower tank 101 is provided with a jacket 107 on the outside. A connecting pipe 108 connected to the external circulating water is symmetrically installed on the outside of the jacket 107. The connecting pipe 108 is connected to the cavity between the jacket 107 and the lower tank 101. The connecting pipe 108 is used to connect to the external circulation system and introduce steam (heating), cooling water or heat transfer oil (cooling) to precisely control the reaction temperature of the material in the reactor.

[0031] The upper tank 102 is also connected to two ends of a water spray pipe 109 that is connected to an external water pipe. One end of the water spray pipe 109 extends into the upper tank 102 and is tilted towards the flow guide 5. When cleaning is required, the high-pressure cleaning fluid is sprayed through the water spray pipe 109 onto the rotating flow guide 5. The splashing droplets can cover the entire inner wall of the tank, achieving online cleaning without dead angles.

[0032] The lower tank 101 and the upper tank 102 are detachably connected by flanges. This split design greatly facilitates the cleaning and maintenance of the equipment. The independent drive mechanism 2 is installed on the mounting cylinder 103 by means of bolt fastening. The lateral rotation of the motor 202 is converted into the longitudinal rotation of the outer shaft 4 by the driving bevel gear 203 and the driven bevel gear 204. Thus, the inner shaft 3 and the outer shaft 4 achieve completely independent drive and control. Both motors can be variable frequency motors, and their start, stop, speed and direction can be independently controlled by the central control system (such as PLC), thereby providing the optimal stirring power combination for different process stages.

[0033] In summary, the reaction vessel for compound miconazole nitrate provided in this embodiment is used as follows:

[0034] Emulsification stage: Start motor 1 201 and motor 2 202, inner shaft 3 rotates at high speed, driving stirring blade 9 to perform high shear dispersion and emulsification of materials; outer shaft 4 rotates at medium speed, driving spiral blade 6 to perform overall circulation, scraper 7 scrapes the wall to promote heat transfer, guide shroud 5 optimizes the flow field and defoams, all components work together to quickly achieve uniform mixing;

[0035] Cooling stage: Stop motor 1 201, only start motor 2 202 at low speed to drive the outer shaft 4, drive the spiral blade 6 and scraper 7 to continue working, carry out a gentle and efficient heat exchange cycle, avoid excessive shearing, and at the same time the guide shroud 5 continues to play a defoaming role.

[0036] The above description of the embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A reaction vessel for compound miconazole nitrate, comprising a reaction vessel body (1), characterized in that, The reactor body (1) is internally connected to an inner shaft (3), and an outer shaft (4) is fitted on the upper end of the inner shaft (3). An independent drive mechanism (2) is provided on the top of the reactor body (1) for independently driving the inner shaft (3) and the outer shaft (4) to rotate. A guide shroud (5) is symmetrically installed on the upper end of the outer shaft (4), and a spiral blade (6) is installed on the lower end of the outer shaft (4). Scrapers (7) are symmetrically installed on the upper and lower ends of the outer shaft (4). A sleeve (8) that fits against the outer shaft (4) is fitted on the lower end of the inner shaft (3), and stirring blades (9) are symmetrically installed on the outer side of the sleeve (8).

2. The reaction vessel for compound miconazole nitrate according to claim 1, characterized in that, The flow guide (5) is semi-circular in shape and tilted upwards. Multiple flow guide vanes (10) are installed equidistantly inside the flow guide (5).

3. The reaction vessel for compound miconazole nitrate according to claim 1, characterized in that, The reactor body (1) includes a lower tank (101) and an upper tank (102). The top of the upper tank (102) is provided with an installation cylinder (103) for detachably installing an independent drive mechanism (2). The independent drive mechanism (2) includes a motor one (201) and a motor two (202). The output end of the motor one (201) is connected to the top end of the inner shaft (3). The output end of the motor two (202) is connected to a driving bevel gear (203). The upper end of the outer shaft (4) is equipped with a driven bevel gear (204) that meshes with the driving bevel gear (203).

4. A reaction vessel for compound miconazole nitrate according to claim 3, characterized in that, The inner side of the sleeve (8) is provided with a plurality of protrusions (11) arranged in an array. The lower end of the inner shaft (3) is provided with a groove (12) that matches the size of the protrusions (11). The bottom of the lower tank (101) is provided with a base (104) that is inserted into and rotates with the sleeve (8).

5. A reaction vessel for compound miconazole nitrate according to claim 3, characterized in that, The upper tank (102) has a symmetrically arranged inlet (105) at the top, and the lower tank (101) has a symmetrically arranged outlet (106) at the bottom.

6. A reaction vessel for compound miconazole nitrate according to claim 5, characterized in that, The lower tank (101) is provided with a jacket (107) on the outside. A connecting pipe (108) connected to the external circulating water is symmetrically installed on the outside of the jacket (107). The connecting pipe (108) is connected to the cavity between the jacket (107) and the lower tank (101).

7. A reaction vessel for compound miconazole nitrate according to claim 6, characterized in that, The upper tank (102) is also connected to two ends of a water spray pipe (109) that is connected to an external water pipe. The end of the water spray pipe (109) that extends into the upper tank (102) is inclined to the guide shroud (5).

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