Magnetic separation device

Abstract

The utility model relates to the field of medical apparatus and instruments, and specifically discloses a magnetic separation device, which comprises a main shell, which is a square cylindrical box body; a magnetic core assembly, which is slidably connected to the inner side wall of the main shell and is used for generating a magnetic field to adsorb magnetic substances in a sample; and a sliding assembly, which is detachably connected to the magnetic core assembly and is used for driving the magnetic core assembly to slide up and down inside the main shell to adjust the magnetic force. The utility model can control the relative distance between the magnetic core and the magnetic beads by adjusting the sliding of the sliding block in the device, accurately adsorbs or releases the magnetic beads, separates the magnetic beads and the target components combined with the magnetic beads from the mixed system in the bottle, and avoids cross contamination by using the disposable gun head of the device once. The stability of the device during operation is ensured by the main body shell and other structures, the magnetic force is efficient and controllable, and the directional separation and extraction of the magnetic beads and the target components in the bottle are finally realized.

Description

Technical Field

[0001] This utility model relates to the field of medical devices, and more specifically, to a magnetic separation device. Background Technology

[0002] Magnetic bead enrichment technology is a highly efficient separation and enrichment method based on magnetic microspheres (magnetic beads). Through functional modification of the magnetic bead surface, it specifically binds to the target substance, achieving rapid separation under an external magnetic field, thereby enriching the target analyte. Due to its advantages such as ease of operation, high efficiency, and automation, this technology is widely used in various fields including life sciences, medical diagnostics, and environmental monitoring.

[0003] After enrichment with magnetic beads, the beads need to be separated. Existing separation devices are divided into automatic and manual separation. Automatic separation mainly uses multiple magnetic racks to separate the magnetic beads, but its process is precise and expensive, requiring professional laboratories and only compatible with specific reagent kits, resulting in poor applicability. For manual separation, CN213803827U discloses a manual magnetic nucleic acid separation device that uses springs and pressing to adjust the magnetic force to achieve the adsorption and separation of magnetic beads. However, its pressing adjustment method has poor precision, and the control of the magnetic rod stroke is also relatively rough, resulting in low separation efficiency.

[0004] Therefore, a magnetic separation device is needed to solve the problems of poor magnetic adjustment accuracy and rough stroke control in existing manual separation devices. Summary of the Invention

[0005] In view of this, the present invention proposes a magnetic separation device, which aims to solve the problems of poor magnetic force adjustment accuracy and rough stroke control in existing manual separation devices.

[0006] This utility model provides a magnetic separation device, comprising: The main shell is a square cylindrical box; The magnetic core assembly is slidably connected to the inner wall of the main housing and is used to generate a magnetic field to adsorb magnetic materials in the sample. A sliding component, detachably connected to the magnetic core assembly, is used to drive the magnetic core assembly to slide up and down inside the main housing to adjust the magnetic force.

[0007] Furthermore, the main housing includes: The main outer shell is a square cylindrical box used to house the magnetic core assembly; The slider groove is a long, vertically formed groove on one outer side wall of the main body shell. A limiting groove is formed at one end of the slider groove near the bottom of the main body shell. Sliding grooves are laid vertically on the three inner surfaces of the main body shell that do not have the sliding grooves; The gun body is a cylindrical tube, with one end of the gun body fixedly connected to the bottom surface of the main body shell, and the gun body and the main body shell are in communication with each other.

[0008] Furthermore, the magnetic core assembly includes: A magnetic core mounting block is disposed inside the main body shell. A first groove is provided on one side of the magnetic core mounting block near the slider groove, and protrusions that fit into the slider groove are provided on the other three sides. The magnetic core mounting block is slidably connected to the slider groove through the three protrusions. The mounting post is a cylinder, with one end fixedly connected to the bottom surface of the magnetic core mounting block, and the other end having a cylindrical second groove on its bottom surface; The magnetic core is a cylindrical magnetic rod, which is inserted and fixed into the second groove.

[0009] Furthermore, the sliding component includes: A sliding block spring is disposed inside the first groove; A press-fit connector is disposed inside the main body shell. One end of the press-fit connector engages with the first groove, and the other end is trapezoidal and abuts against the inner wall of the main body shell. The sliding block is located on the outside of the main body shell and is fixedly connected to the pressing connector through the slider groove.

[0010] Furthermore, a first threaded hole is provided on one end face of the pressing connector near the slider groove in the horizontal direction.

[0011] Furthermore, a threaded post is fixedly provided on the side of the sliding block near the slider groove, and the threaded post passes through the slider groove and is detachably connected to the first threaded hole by threads.

[0012] Furthermore, the mounting post is fitted with a compression spring, which is used to buffer the magnetic core during sliding.

[0013] Furthermore, it also includes a rear cap, the bottom of which is fitted and connected to the top opening of the main body shell, and the rear cap is used to close and protect the internal structure of the main body shell.

[0014] Furthermore, a limit handle is provided on the top of one side of the main body shell adjacent to the side where the slider groove is provided, and the limit handle is used to prevent the slider from slipping off the hand when sliding the slider block.

[0015] Furthermore, it also includes a disposable gun head, which is a cylindrical tube with one open end. The open end of the disposable gun head is inserted into the end of the gun body away from the main body shell. The disposable gun head is used to wrap the magnetic core.

[0016] Compared with the prior art, the beneficial effects of this utility model are as follows: by adjusting the sliding block in the device, the relative distance between the magnetic core and the magnetic bead can be controlled, so as to achieve precise adsorption or release of the magnetic bead, thereby separating the magnetic bead and its bound target components from the mixing system inside the bottle.

[0017] Meanwhile, the disposable nozzle of the device can directly contact the magnetic bead sample. With the magnetic force of the magnetic core, the target component can be easily transferred after the magnetic bead is adsorbed. The single use can avoid cross-contamination. The main body shell and other structures ensure the stability of the device during operation, ensuring that the magnetic force is efficient and controllable, and ultimately achieving the directional separation and extraction of magnetic beads and target components in the bottle. Attached Figure Description

[0018] Various other advantages and benefits will become apparent to those skilled in the art upon reading the following detailed description of preferred embodiments. The accompanying drawings are for illustrative purposes only and are not intended to limit the scope of the invention. Furthermore, the same reference numerals denote the same parts throughout the drawings. In the drawings: Figure 1 An exploded perspective view of a magnetic separation device provided in one embodiment of this utility model; Figure 2 A perspective structural view of the main housing provided in one embodiment of this utility model; Figure 3 This is a perspective structural view of a magnetic core assembly provided in one embodiment of the present invention; Figure 4 An exploded perspective view of a sliding component provided in one embodiment of this utility model; Figure 5 This is a front view of a magnetic separation device provided in one embodiment of the present invention; Figure 6 A cross-sectional view of a magnetic separation device provided in one embodiment of this utility model; Figure 7 Provided as one embodiment of this utility model Figure 6 A magnified view of part A in the image.

[0019] In the diagram: 100 - Main housing; 110 - Main body shell; 120 - Slider groove; 121 - Limiting groove; 130 - Sliding groove; 140 - Gun body; 150 - Limiting handle; 200 - Magnetic core assembly; 210 - Magnetic core mounting block; 211 - First groove; 220 - Mounting post; 221 - Compression spring; 230 - Magnetic core; 300 - Sliding assembly; 310 - Sliding block spring; 320 - Pressing connector; 321 - First threaded hole; 330 - Sliding block; 331 - Threaded post; 400 - Shell rear cap; 500 - Disposable gun head. Detailed Implementation

[0020] The specific embodiments of this utility model will be described in further detail below with reference to the accompanying drawings and examples. The following examples are used to illustrate this utility model, but are not intended to limit its scope.

[0021] In the description of this application, it should be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation; or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0022] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, unless otherwise stated, "a plurality of" means two or more.

[0023] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0024] See Figure 1 , Figure 5 as well as Figure 6 As shown, this embodiment provides a magnetic separation device, including: The main shell 100 is a square cylindrical box; The magnetic core 230 assembly 200 is slidably connected to the inner wall of the main housing 100 and is used to generate a magnetic field to adsorb magnetic materials in the sample. The sliding component 300 is detachably connected to the magnetic core 230 component 200 and is used to drive the magnetic core 230 component 200 to slide up and down inside the main housing 100 to adjust the magnetic force.

[0025] It is understood that this utility model can control the relative distance between the magnetic core 230 and the magnetic bead by adjusting the sliding block 340 in the device, thereby achieving precise adsorption or release of the magnetic bead and separating the magnetic bead and its bound target components from the mixing system inside the bottle.

[0026] Meanwhile, the disposable nozzle 500 of the device can directly contact the magnetic bead sample. With the magnetic force of the magnetic core 230, the target component can be easily transferred after the magnetic bead is adsorbed. The single use can avoid cross-contamination. The main body shell 110 and other structures ensure the stability of the device during operation, ensuring that the magnetic force is efficient and controllable, and ultimately achieving the directional separation and extraction of magnetic beads and target components in the bottle.

[0027] See Figure 2 As shown, in some embodiments provided by this utility model, the main housing 100 includes: The main outer shell 110 is a square cylindrical box used to house the magnetic core 230 assembly 200; The slider groove 120 is a long, strip-shaped groove that is vertically opened on one outer side wall of the main body shell 110. A limiting groove 121 is opened at one end of the slider groove 120 near the bottom of the main body shell 110. Sliding grooves 130 are laid vertically on the three inner sides of the main body shell 110 that do not have sliding grooves 120. The gun body 140 is a cylindrical tube. One end of the gun body 140 is fixedly connected to the bottom surface of the main body shell 110, and the gun body 140 and the main body shell 110 are interconnected.

[0028] See Figure 3 As shown, in some embodiments provided by this utility model, the magnetic core 230 assembly 200 includes: The magnetic core mounting block 210 is disposed inside the main body shell 110. A first groove 211 is provided on one side of the magnetic core mounting block 210 near the slider groove 120, and protrusions 212 that fit into the slider groove 130 are provided on the other three sides. The magnetic core mounting block 210 is slidably connected to the slider groove 130 through the three protrusions 212. The mounting post 220 is a cylinder, one end of which is fixedly connected to the bottom surface of the magnetic core mounting block 210, and the bottom surface of the other end is provided with a cylindrical second groove. The magnetic core 230 is a cylindrical magnetic rod, which is inserted and fixed into the second groove.

[0029] Specifically, the magnetic core mounting block 210 is slidably connected to the sliding groove 130 via three protrusions 212, and the mounting post 220 is fixedly connected to the bottom surface of the magnetic core mounting block 210; the magnetic core 230 is fixedly inserted into the mounting post 220 via a second groove. When the magnetic core mounting block 210 slides up and down along the sliding groove 130, it drives the mounting post 220 and the magnetic core 230 to slide up and down, thereby controlling the relative distance between the magnetic core 230 and the magnetic bead.

[0030] See Figure 4 As shown, in some embodiments provided by this utility model, the sliding component 300 includes: The sliding block spring 310 is disposed inside the first groove 211; The press-fit connector 320 is disposed inside the main body shell 110. One end of the press-fit connector 320 is fitted into the first groove 211, and the other end is trapezoidal and abuts against the inner wall of the main body shell 110. The sliding block 330 is located on the outside of the main body shell 110, and is fixedly connected to the pressing connector 320 through the slider groove 120.

[0031] Specifically, one end of the sliding block spring 310 abuts against the inner wall of the first groove 211, and the other end abuts against the end of the pressing connector 320 embedded in the first groove 211. The other end of the pressing connector 320 is a trapezoidal block, the top of which is the narrower end of the trapezoidal block and abuts against the inner wall of the main body shell 110. The width of the narrower top of the trapezoidal block is greater than the width of the slider groove 120 but less than the width of the limiting groove 121, while the wider tail is greater than the limiting groove. The width of 121 allows the sliding block 330 to slide onto the limiting groove 121, causing the sliding block spring 310 to extend so that the top of the trapezoidal block in the pressing connector 320 extends into the limiting groove 121, while the tail cannot extend into the limiting groove 121 due to its larger width. At this time, the pressing connector 320 is stuck and fixed, unable to move up and down. When the sliding block 330 is pressed, the sliding block spring 310 retracts, causing the top of the pressing connector 320 to retract back into the main body shell 110, at which point it can move up and down again.

[0032] See Figure 7 As shown, in some embodiments of this utility model, the pressing connector 320 has a first threaded hole 321 on one end face near the slider groove 120 along the horizontal direction.

[0033] See Figure 7 As shown, in some embodiments provided by this utility model, a threaded post 331 is fixedly provided on one side of the sliding block 330 near the slider groove 120. The threaded post 331 passes through the slider groove 120 and is detachably connected to the first threaded hole 321 by threads.

[0034] Specifically, the threaded post 331 in the sliding block 330 passes through the slider groove 120 and is fixedly connected to the pressing connector 320 through the first threaded hole 321.

[0035] See Figure 3 , Figure 6 As shown, in some embodiments provided by this utility model, the mounting post 220 is fitted with a compression spring 221, which is used to buffer and reset the magnetic core 230 when sliding.

[0036] See Figure 1 , Figure 6 As shown, in some embodiments provided by this utility model, a rear cap 400 is also included. The bottom of the rear cap 400 is fitted and connected to the top opening of the main body shell 110. The rear cap 400 is used to close and protect the internal structure of the main body shell 110.

[0037] See Figures 1-2 As shown, in some embodiments of the present invention, a limit handle 150 is provided on the top of one side of the main body shell 110 adjacent to the side where the slider groove 120 is provided. The limit handle 150 is used to prevent the slider block 340 from slipping out of the hand.

[0038] See Figure 1 , Figure 6 As shown, in some embodiments provided by this utility model, a disposable gun head 500 is also included. The disposable gun head 500 is a cylindrical body with one end open. The open end of the disposable gun head 500 is inserted into the end of the gun body 140 away from the main body shell 110. The disposable gun head 500 is used to wrap the magnetic core 230.

[0039] Specifically, the sliding block 330 slides downward, causing the magnetic core 230 to also move downward, so that the magnetic core 230 extends into the disposable gun head 500. At this time, the diameter of the compression spring 221 is larger than the inner diameter of the gun body 140. The compression spring 221 cannot enter the gun body 140 and is gradually compressed, and the sliding resistance gradually increases, effectively avoiding the impact of the magnetic core 230 on the disposable gun head 500 caused by sliding too fast. At the same time, the sliding block 330 slides into the limiting groove 121 and is stuck. The magnetic core 230 reaches the maximum displacement distance. When the slider is pressed again, the fixation is released, the compression spring 221 is released, and the magnetic core 230 quickly returns to its original position.

[0040] Specifically, the working principle of this utility model is as follows: The disposable gun tip 500 is installed into the gun body 140, and then inserted into the culture bottle rich in magnetic beads. The sliding block 330 is slid down. When the sliding block 330 slides to the limiting groove 121, the sliding block spring 310 extends. At this time, the sliding block 330 is stuck by the limiting groove 121, and the magnetic core 230 reaches the maximum displacement distance. At this time, the magnetic force of the magnetic core 230 is at its maximum, which can accurately attract magnetic beads. After the attraction is completed, the device is removed from the culture bottle and inserted into the required container. The sliding block 330 is pressed. At this time, the sliding block 330 is released from its fixed position, and the compression spring 221 releases its elastic potential energy, causing the magnetic core 230 to reset. The magnetic force at the disposable gun tip 500 is greatly weakened, and the attracted magnetic beads fall off, thereby realizing the transfer and release of magnetic beads.

[0041] It will be understood by those skilled in the art that the above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A magnetic separation device, characterized in that, include: The main shell is a square cylindrical box; The magnetic core assembly is slidably connected to the inner wall of the main housing and is used to generate a magnetic field to adsorb magnetic materials in the sample. A sliding component, detachably connected to the magnetic core assembly, is used to drive the magnetic core assembly to slide up and down inside the main housing to adjust the magnetic force.

2. The magnetic separation device according to claim 1, characterized in that, The main housing includes: The main outer shell is a square cylindrical box used to house the magnetic core assembly; The slider groove is a long, vertically formed groove on one outer side wall of the main body shell. A limiting groove is formed at one end of the slider groove near the bottom of the main body shell. Sliding grooves are laid vertically on the three inner surfaces of the main body shell that do not have the sliding grooves; The gun body is a cylindrical tube, with one end of the gun body fixedly connected to the bottom surface of the main body shell, and the gun body and the main body shell are in communication with each other.

3. The magnetic separation device according to claim 2, characterized in that, The magnetic core assembly includes: A magnetic core mounting block is disposed inside the main body shell. A first groove is provided on one side of the magnetic core mounting block near the slider groove, and protrusions that fit into the slider groove are provided on the other three sides. The magnetic core mounting block is slidably connected to the slider groove through the three protrusions. The mounting post is a cylinder, with one end fixedly connected to the bottom surface of the magnetic core mounting block, and the other end having a cylindrical second groove on its bottom surface; The magnetic core is a cylindrical magnetic rod, which is inserted and fixed into the second groove.

4. The magnetic separation device according to claim 3, characterized in that, The sliding component includes: A sliding block spring is disposed inside the first groove; A press-fit connector is disposed inside the main body shell. One end of the press-fit connector engages with the first groove, and the other end is trapezoidal and abuts against the inner wall of the main body shell. The sliding block is located on the outside of the main body shell and is fixedly connected to the pressing connector through the slider groove.

5. The magnetic separation device according to claim 4, characterized in that, The pressing connector has a first threaded hole in the horizontal direction on one end face near the slider groove.

6. The magnetic separation device according to claim 5, characterized in that, A threaded post is fixedly provided on the side of the sliding block near the slider groove. The threaded post passes through the slider groove and is detachably connected to the first threaded hole by threads.

7. The magnetic separation device according to claim 6, characterized in that, The mounting post is fitted with a compression spring, which is used to buffer the magnetic core during sliding.

8. The magnetic separation device according to claim 7, characterized in that, It also includes a rear cap, the bottom of which is fitted into the top opening of the main body shell, and the rear cap is used to close and protect the internal structure of the main body shell.

9. The magnetic separation device according to claim 8, characterized in that, A limit handle is provided on the top of one side of the main body shell adjacent to the side where the slider groove is provided. The limit handle is used to prevent the slider from slipping out of the hand when sliding the slider block.

10. The magnetic separation device according to claim 9, characterized in that, It also includes a disposable gun head, which is a cylindrical tube with one end open. The open end of the disposable gun head is inserted into the end of the gun body away from the main body shell. The disposable gun head is used to wrap the magnetic core.

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