Chemical liquid protection device

Abstract

The utility model discloses a kind of chemical liquid protection devices, including chemical liquid storage tank, the top of chemical liquid storage tank is equipped with air inlet, liquid inlet and pressure release port, bottom is equipped with liquid outlet, air inlet connects the output end of air inlet pipe, air inlet pipe is equipped with air inlet valve, liquid inlet connects the output end of liquid inlet pipe, liquid inlet pipe is equipped with liquid inlet valve, liquid outlet connects the output end of liquid outlet pipe, liquid outlet pipe is equipped with liquid outlet valve, pressure release port is connected buffer bag by two-way flow pipe, buffer bag is connected with air outlet pipe, air outlet pipe is equipped with air outlet valve, buffer bag has telescopic gas containing cavity.The utility model reduces inert gas consumption, saves production cost, prevents air backfilling, and guarantees chemical liquid quality.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical equipment technology, specifically to a liquid medicine protection device. Background Technology

[0002] In the field of pharmaceutical liquid production, some pharmaceutical liquid components are highly sensitive to oxygen. When these liquids come into contact with oxygen, they are prone to oxidation, leading to degradation of the active ingredients, alteration of their properties, or the generation of impurities, severely impacting the quality stability and safety of the pharmaceutical liquid. Therefore, effective anti-oxidation protection measures must be taken during the production, storage, and transfer of these sensitive pharmaceutical liquids to prevent contact between the liquid and oxygen.

[0003] Currently, the industry primarily employs a technical solution of continuously introducing an inert gas (such as nitrogen) into the storage or reaction vessel to protect the aforementioned sensitive pharmaceutical solutions from oxidation. By continuously introducing nitrogen, air (including oxygen) inside the container is expelled, creating an inert gas atmosphere and thus protecting the pharmaceutical solution from oxidation. Furthermore, considering the operational scenarios during pharmaceutical production where solutions are replenished (e.g., added to the container) or reduced (e.g., extracted from the container), existing technologies typically incorporate gas release ports on the container to prevent excessively high back pressure (during replenishment) or excessively low negative pressure (during reduction) caused by changes in solution volume, which could compromise operational safety or container sealing.

[0004] However, the above-mentioned existing technical solutions have obvious defects in practical applications: On the one hand, in order to maintain a stable inert gas protective atmosphere, nitrogen needs to be continuously and uninterruptedly input, and some nitrogen will be directly discharged through the release port, resulting in a huge consumption of inert gas, causing serious waste of inert gas and increasing production costs; on the other hand, during the process of the reduction of liquid medicine leading to a decrease in pressure inside the container, negative pressure is easily formed at the release port, and outside air (including oxygen) may flow back into the container through the release port, destroying the inert gas protective atmosphere inside the container, causing the liquid medicine to come into contact with oxygen and undergo an oxidation reaction, affecting the quality of the liquid medicine. Utility Model Content

[0005] This invention provides a liquid medicine protection device that reduces inert gas consumption, saves production costs, prevents air backflow, and ensures the quality of the liquid medicine.

[0006] To achieve the above-mentioned technical objectives, the technical solution adopted by this utility model is as follows: A liquid medicine protection device includes a liquid medicine storage tank. The top of the liquid medicine storage tank is provided with an air inlet, a liquid inlet and a pressure relief port, and the bottom is provided with a liquid outlet. The air inlet is connected to the output end of an air inlet pipe and an air inlet valve is provided on the air inlet pipe. The liquid inlet is connected to the output end of a liquid inlet pipe and an liquid inlet valve is provided on the liquid inlet pipe. The liquid outlet is connected to the output end of a liquid outlet pipe and an liquid outlet valve is provided on the liquid outlet pipe. The pressure relief port is connected to a buffer bag through a bidirectional flow pipe. The buffer bag is connected to an air outlet pipe and an air outlet valve is provided on the air outlet pipe. The buffer bag has a retractable gas containing cavity.

[0007] Furthermore, a filter is connected between the pressure relief port and the bidirectional flow tube.

[0008] Furthermore, the cushioning bag is made of an elastic material.

[0009] Furthermore, the exhaust valve is a one-way valve.

[0010] Furthermore, the medicine storage tank is equipped with an oxygen detector.

[0011] Furthermore, the buffer bag is equipped with a pressure detector.

[0012] Furthermore, the inert gas supplied by the intake pipe is nitrogen.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows: This invention achieves dynamic compensation of inert gas by setting up a buffer bag that can temporarily store inert gas. On the one hand, it can balance the pressure fluctuations inside the container caused by changes in the volume of the liquid medicine in real time, avoid negative pressure and air backflow, and ensure the quality of the liquid medicine. On the other hand, it can maintain the inert protective atmosphere inside the container without maintaining a continuous gas input, reduce the ineffective discharge of excess inert gas through the pressure relief port, reduce the total consumption of inert gas, and save production costs. Attached Figure Description

[0014] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0015] Figure 1 This is a schematic diagram of the structure of this utility model; In the diagram: 1-Medicine storage tank, 2-Air inlet pipe, 3-Air inlet valve, 4-Liquid inlet pipe, 5-Liquid inlet valve, 6-Liquid outlet pipe, 7-Liquid outlet valve, 8-Two-way flow pipe, 9-Buffer bag, 10-Air outlet pipe, 11-Air outlet valve, 12-Filter. Detailed Implementation

[0016] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0017] In the description of the embodiments of this application, it should be noted that the indicated orientation or positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship that the product of this application is usually placed in when in use, or the orientation or positional relationship that is commonly understood by those skilled in the art. It is only for the convenience of describing this application and simplifying the description, and is not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation of this application.

[0018] In the description of the embodiments of this application, it should also be noted that, unless otherwise expressly specified and limited, the terms "set," "install," and "connect" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0019] like Figure 1 As shown, a liquid medicine protection device includes a liquid medicine storage tank 1. The top of the storage tank 1 has an air inlet, a liquid inlet, and a pressure relief port, while the bottom has a liquid outlet. The air inlet is connected to the output end of an air inlet pipe 2, which is equipped with an air inlet valve 3. The liquid inlet is connected to the output end of a liquid inlet pipe 4, which is equipped with a liquid inlet valve 5. The liquid outlet is connected to the output end of an outlet pipe 6, which is equipped with an outlet valve 7. The pressure relief port is sequentially connected to a filter 12, a bidirectional flow pipe 8, and a buffer bag 9. The buffer bag 9 is connected to an air outlet pipe 10, which is equipped with an air outlet valve 11. The buffer bag 9 is made of an elastic material (such as PE) and has a retractable gas-containing cavity. The storage tank 1 is equipped with an oxygen detector, the main body of which is fixed to the outer wall of the storage tank 1, and its detection probe is sealed to the sampling interface at the top of the storage tank 1. The buffer bag 9 is equipped with a pressure detector. The main body of the pressure detector is fixed to the outer wall of the buffer bag 9, and its detection probe is sealed to the sampling interface at the top of the buffer bag 9.

[0020] The method of using this device is as follows: S1: Initial inert gas replacement of the system Open the inlet valve 3 and outlet valve 11, and close the liquid inlet valve 5 and outlet valve 7. Inert gas (such as nitrogen or argon) is introduced into the liquid storage tank 1 through the inlet pipe 2. The inert gas flows sequentially through the liquid storage tank 1, filter 12, and bidirectional flow pipe 8 into the buffer bag 9. At the same time, the air in the connected system consisting of the liquid storage tank 1, bidirectional flow pipe 8, and buffer bag 9 is discharged through the outlet pipe 10. After the air in the system is completely replaced (the oxygen concentration in the system is detected to be ≤0.1%), close the outlet valve 11 and continue to introduce inert gas to expand the buffer bag 9. The pressure inside the bag gradually increases, forming a pressure difference of "high inside and low outside" with the outside. Then close the inlet valve 3 and slowly open the outlet valve 11 to discharge most of the inert gas in the buffer bag 9. Then close the outlet valve 11. At this time, the liquid storage tank 1, bidirectional flow pipe 8, and buffer bag 9 form a closed connected body, which is filled with inert gas.

[0021] S2: Pressure balance during drug infusion phase Open the inlet valve 5, and the external medicine is injected into the medicine storage tank 1 through the inlet pipe 4; as the liquid level in the storage tank rises, the inert gas in the storage tank is squeezed by the medicine and flows into the buffer bag 9 through the filter 12 and the bidirectional flow pipe 8 in sequence. The buffer bag 9 expands due to the gas injection and temporarily stores redundant inert gas to avoid excessive back pressure in the storage tank; after the amount of medicine injected reaches the preset value, close the inlet valve 5 to complete the medicine input. S3: Pressure balance during the drug delivery phase Open the outlet valve 7, and the liquid medicine in the medicine storage tank 1 is transported to the external equipment through the outlet pipe 6, and the liquid level in the storage tank dynamically decreases. As the gas space in the storage tank increases, the pressure of the inert gas in the tank decreases, forming a slight negative pressure. At this time, the redundant inert gas temporarily stored in the buffer bag 9 flows back to the medicine storage tank 1 through the bidirectional flow pipe 8 and the filter 12 under the action of pressure difference, balancing the gas pressure in the storage tank, maintaining the stability of the inert gas atmosphere in the storage tank, and avoiding the generation of negative pressure in the tank that would cause air backflow. After the liquid medicine is output to the preset amount, close the outlet valve 7 to complete the liquid medicine output.

[0022] S4: Loop Operation Repeat steps S2-S3 to achieve multiple liquid inlet and outlet operations of the liquid medicine; throughout the entire cycle, there is no need to supplement inert gas through the air inlet pipe 2. The system pressure balance and inert gas protective atmosphere can be maintained by relying solely on the bidirectional flow of inert gas between the "liquid medicine storage tank and buffer bag" in the sealed connecting body.

[0023] Preferably, the vent valve 11 is a one-way valve to prevent external air from entering the buffer bag 9.

[0024] Preferably, the filter 12 of this application is a bidirectional filter. Any filter in the prior art that has bidirectional filtration capability and meets the requirement of bidirectional flow of inert gas can be used.

[0025] Of course, there may be other embodiments of this utility model. Without departing from the spirit and essence of this utility model, those skilled in the art can make various corresponding changes and modifications based on this utility model, but these corresponding changes and modifications should all fall within the protection scope of the appended claims of this utility model.

Claims

1. A liquid medicine protection device, characterized in that: The medicine storage tank (1) is provided with an air inlet, a liquid inlet and a pressure relief port at the top and a liquid outlet at the bottom. The air inlet is connected to the output end of the air inlet pipe (2) and an air inlet valve (3) is provided on the air inlet pipe (2). The liquid inlet is connected to the output end of the liquid inlet pipe (4) and an liquid inlet valve (5) is provided on the liquid inlet pipe (4). The liquid outlet is connected to the output end of the liquid outlet pipe (6) and an liquid outlet valve (7) is provided on the liquid outlet pipe (6). The pressure relief port is connected to a buffer bag (9) through a bidirectional flow pipe (8). The buffer bag (9) is connected to an air outlet pipe (10) and an air outlet valve (11) is provided on the air outlet pipe (10). The buffer bag (9) has a retractable gas-containing cavity.

2. The liquid medicine protection device according to claim 1, characterized in that: A filter (12) is connected between the pressure relief port and the bidirectional flow pipe (8).

3. The liquid medicine protection device according to claim 1, characterized in that: The cushioning bag (9) is made of elastic material.

4. The liquid medicine protection device according to claim 1, characterized in that: The exhaust valve (11) is a one-way valve.

5. The liquid medicine protection device according to claim 1, characterized in that: The medicine storage tank (1) is equipped with an oxygen detector.

6. The liquid medicine protection device according to claim 1, characterized in that: The buffer bag (9) is equipped with a pressure detector.

7. The liquid medicine protection device according to claim 1, characterized in that: The inert gas supplied by the intake pipe (2) is nitrogen.

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