A multi-channel crystallization process rapid screening device combined with a particle size particle shape instrument

Abstract

This invention discloses a multi-channel crystallization process rapid screening device combined with a particle size and shape analyzer, including a crystallization screening unit and an image analysis system, with the image analysis system located next to the crystallization screening unit. The crystallization screening unit includes a main unit housing, an upper cover, a six-channel crystallization unit, a temperature control system, a six-point magnetic stirrer, and an automatic sampling system. The top of the main unit housing is connected to the upper cover. The six-channel crystallization unit is placed on top of the main unit housing and connected to the temperature control system. The six-point magnetic stirrer is located below the six-channel crystallization unit. The automatic sampling system connects the six-channel crystallization unit to the image analysis system. The image analysis system includes a particle size and shape analyzer and a computer. The particle size and shape analyzer is used for high-definition imaging of particles, analyzing particle size, shape, and other related parameters, and is connected to the computer via a data cable. This invention enables high automation, integration of crystallization and detection processes, and rapid screening of optimal crystallization process conditions.

Description

Technical Field

[0001] This utility model relates to the chemical industry, and in particular to a rapid screening device for multi-channel crystallization processes that incorporates a particle size and shape analyzer. Background Technology

[0002] Crystallization is a crucial step in chemical production, and its process conditions directly affect product quality and yield. Traditional methods for screening crystallization processes typically employ single-batch experiments. This approach is not only time-consuming but also struggles to comprehensively assess the impact of various parameters on the crystallization process. Furthermore, due to limitations in experimental conditions, traditional methods also have significant limitations in parameter adjustment and optimization.

[0003] In recent years, with the development of automation technology and high-throughput experimental equipment, multi-channel crystallization process screening has gradually become a research hotspot. This method can significantly improve experimental efficiency and shorten the process development cycle by performing multiple experiments simultaneously. However, existing multi-channel crystallization technologies still face some challenges, such as how to precisely control the experimental conditions of each channel and how to quickly and accurately evaluate the quality of the crystallized products.

[0004] In the field of particle size and shape detection, traditional laser diffraction methods suffer from several drawbacks, including the inability to directly observe particle morphology, the need to provide the refractive index and absorption index of the material, difficulty in distinguishing transparent particles, and the inability to analyze samples with reflective properties. While conventional microscopic imaging methods can observe particle morphology, they suffer from a small field of view, complex operation, limited data volume, and a lack of statistical significance.

[0005] Currently, there are few devices on the market that combine multi-channel crystallization with particle size and shape detection technology, and there is a lack of integrated systems that can achieve online automatic sampling and detection, making it difficult to meet the needs of rapid screening and real-time monitoring of crystallization processes. Utility Model Content

[0006] The purpose of this invention is to address the shortcomings of existing crystallization process screening methods by providing a multi-channel crystallization process rapid screening device that combines a particle size and shape analyzer, thereby solving the technical problems of low efficiency, insufficient real-time monitoring capability, and low degree of automation in existing multi-channel crystallization screening methods.

[0007] This utility model achieves the above objectives through the following technical solutions:

[0008] This invention provides a multi-channel crystallization process rapid screening device that combines a particle size and shape analyzer, including a crystallization screening unit and an image analysis system, with the image analysis system located next to the crystallization screening unit.

[0009] The crystallization screening unit of this utility model, which combines a particle size and shape analyzer with a multi-channel crystallization process rapid screening device, includes a main unit housing, an upper cover, a six-channel crystallization unit, a temperature control system, a six-point magnetic stirrer, and an automatic sampling system. The top of the main unit housing is connected to the upper cover. The six-channel crystallization unit is placed on top of the main unit housing and connected to the temperature control system. The six-point magnetic stirrer is located below the six-channel crystallization unit. The automatic sampling system connects the six-channel crystallization unit to the image analysis system.

[0010] As a preferred embodiment of this utility model, the main unit housing adopts a frame structure design, including upper and lower platforms. The upper platform is a temperature control tank area for placing the six-channel crystallization unit, and the lower platform is a tray to support the six-channel crystallization unit above. At the same time, the area under the lower platform is used to protect and store the internal motor and electrical circuits. The six crystallization containers are evenly distributed in the temperature control tank, and each container is connected to the piping of the temperature measurement and sampling system.

[0011] In a preferred embodiment of this invention, the upper cover is supported by two liftable brackets and positioned directly above the crystallization tank. The feeding ports and sampling ports are located on the upper cover; there are four feeding ports and one sampling port, arranged in a 2-1-2 configuration (solvent feeding port, sampling port, and antisolvent feeding port). The upper cover is raised and lowered by a stepper motor, integrated into the overall control program. These feeding and sampling ports allow for the addition of solvent or sampling during the experiment without affecting the stability of the crystallization environment. A liquid material zone is also located next to the upper cover, supplying solvent and antisolvent to the six-channel crystallization unit.

[0012] As a preferred embodiment of this invention, the six-channel crystallization unit includes six crystallizer tanks and a temperature control tank. The crystallizer tanks are used to hold standard-sized crystallization glass beakers, and the temperature control tank has a jacketed structure and is connected to the temperature control system. The crystallizers of the six-channel crystallization unit come in various sizes, all of which are equipped with a top cover. A magnetic stirring paddle is suspended from the top cover through a central perforation and is driven by a bottom magnetic stirrer.

[0013] As a preferred embodiment of this invention, the temperature control system includes a high-low temperature circulator and a temperature measuring unit. The high-low temperature circulator includes a control panel, a temperature control housing, and a temperature control medium delivery pipeline. The control panel is mounted on the temperature control housing, which delivers the temperature control medium to the temperature control tank via the temperature control medium delivery pipeline. The high-low temperature circulator is connected to the temperature control tank via an external circulation system to control the internal temperature of the crystallizer, with a control temperature range from room temperature to 90°C. The temperature measuring unit includes a temperature measuring probe placed inside the crystallizer tank, which transmits the temperature signal to the temperature control housing.

[0014] As a preferred embodiment of this invention, the six-point magnetic stirrer is placed below the temperature control tank and is driven by six independent motors, each capable of different speed adjustments, with integrated control within the main control program. The six-point magnetic stirrer is used to control the magnetic stirring paddle to stir the crystallizer in the crystallization unit.

[0015] As a preferred embodiment of this invention, the automatic sampling system connects the six-channel crystallization unit with the image analysis system to form a complete integrated system. The automatic sampling system includes two alternating injection pumps (main pump and auxiliary pump), an eight-way solenoid switching valve, sampling tubing, and a waste container. One end of the sampling tubing connects to the sampling port on the upper cap, and the other end connects to the image analysis system via the eight-way switching valve for wet particle size and shape detection of the crystallized samples from each channel. The eight-way solenoid switching valve is a high-precision electromagnetically driven eight-channel switching valve, with six ports connected to six crystallization units, responsible for switching the extraction from different crystallizers; the seventh port connects to cleaning fluid for cleaning residual substances in the tubing; and the eighth port connects to the waste container. Through programmed control, the sample flow direction of different channels is precisely switched, ensuring that samples do not mix or cross-contaminate, with a switching time of <100ms.

[0016] As a preferred embodiment of this invention, the two injection pumps of the automatic sampling system work alternately to achieve uninterrupted liquid extraction, thereby ensuring the fluidity of the sample during wet optical particle size analysis. After the analysis is completed, the excess mother liquor is pushed back into the crystallizer.

[0017] As a preferred embodiment of this invention, the image analysis system includes a particle size and shape analyzer and a computer. The particle size and shape analyzer is used to perform high-definition imaging of particles, analyze relevant parameters such as particle size and shape, and is connected to the computer via a data cable. The computer is used for data analysis, storage, and display of relevant parameter content.

[0018] As a preferred embodiment of this invention, the particle size and shape analyzer includes a liquid pool assembly, a high-precision telecentric zoom lens, a blue pulse light source, and a high-resolution CMOS camera. The liquid pool assembly is positioned between the high-resolution CMOS camera and the blue pulse light source. The high-precision telecentric zoom lens and the high-resolution CMOS camera are combined to perform high-definition imaging of the particles. The entire system is housed inside the particle size and shape analyzer. The bottom and side of the liquid pool assembly are provided with an inlet and an outlet. The inlet is connected to an eight-way switching valve, and the outlet is connected to an injection pump.

[0019] As a preferred embodiment of this invention, the liquid pool assembly includes replaceable clips, available in five different thicknesses: 50μm, 100μm, 200μm, 400μm, and 600μm, suitable for particle detection in different particle size ranges. The liquid pool assembly is the module for the imaging area; the thickness of the clips within the liquid pool assembly determines the maximum size of the particles passing through. Particles larger than the thickness of the clips in the liquid pool assembly cannot pass through the imaging area.

[0020] As a preferred embodiment of this invention, a computer is equipped with dedicated software to control the particle size and shape analyzer. This software includes data acquisition and processing functions, capable of processing acquired images and extracting particle size and shape parameters. The software's data processing function can perform image binarization, identify particle outlines, and then calculate physical parameters such as particle diameter and roundness for each particle according to a certain equivalent model. It can generate various types of analysis reports and supports multi-report comparison, allowing for comparative analysis of morphology results under different experimental conditions.

[0021] As a preferred embodiment of this invention, the dedicated software includes a custom command control module, a real-time data display module, a particle morphology analysis module, and a report generation module. The custom command control module supports various commands, including PUMP, CLEAN, RESET, and VALVE commands. The real-time data display module displays particle quantity, particle size distribution, online statistics, and concentration distribution information. The particle morphology analysis module processes the acquired images, extracting and analyzing over 30 particle size and shape parameters.

[0022] The beneficial effects of this utility model are:

[0023] 1. Achieve a high degree of automation, with programmable operation of full experimental temperature magnetic control and sampling process. The six-channel combination of automation can greatly improve the efficiency of screening experimental conditions.

[0024] 2. It can be directly connected to online particle size detection equipment to realize the integration of crystallization and detection processes. This can avoid changes in the crystal during sampling and observation, obtain the initial crystal growth morphology data, and facilitate accurate and rapid judgment of the experimental process.

[0025] 3. By integrating a high-precision telecentric zoom lens and a high-resolution CMOS camera, it achieves high-definition imaging of particles ranging from 300 nanometers to 1000 micrometers, covering a wide testing range;

[0026] 4. The six-position magnetic stirrer can stir the crystallizer at different positions in each channel, and the stirring of different channels is independent of each other;

[0027] 5. The dual injection pump alternating operation system enables uninterrupted liquid extraction and detection, improving analysis efficiency;

[0028] 6. The image analysis system can extract various particle size and shape parameters to meet complex analysis needs; the multi-report comparison function can compare and analyze the morphology results under different experimental conditions and quickly screen the optimal crystallization process conditions. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0030] Figure 2 This is a schematic diagram of the crystallization screening unit of this utility model;

[0031] Figure 3 This is a schematic diagram showing the connection between the crystallization screening unit and the image analysis system of this utility model;

[0032] Figure 4 This is a schematic diagram of the upper cover structure of this utility model.

[0033] In the diagram: 1-solvent feed port, 2-sampling port, 3-antisolvent feed port, 4-crystallizer tank, 5-stepper motor, 6-top cover, 7-eight-way switching valve, 8-injection pump, 9-liquid material zone, 10-magnetic stirrer, 11-control panel, 12-temperature control cabinet, 13-temperature control medium delivery pipeline, 14-sampling pipeline, 15-waste liquid tank, 16-liquid pool assembly, 17-CMOS camera, 18-particle size and shape analyzer, 19-magnetic stirring paddle. Detailed Implementation

[0034] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. The components of the embodiments of this utility model described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0035] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0036] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0037] In the description of this utility model, it should be understood that the terms "upper", "lower", "inner", "outer", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship that the utility model product is usually placed in during use, or the orientation or positional relationship that is commonly understood by those skilled in the art. They are only used to facilitate the description of this utility model and to simplify the description, and are not intended to indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0038] Furthermore, the terms "first," "second," etc., are used only to distinguish descriptions and should not be interpreted as indicating or implying relative importance.

[0039] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, terms such as "set" and "connection" should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0040] The specific embodiments of this utility model will now be described in detail with reference to the accompanying drawings.

[0041] As attached Figure 1-3 As shown, this embodiment provides a multi-channel crystallization process rapid screening device combined with a particle size and shape analyzer, including a crystallization screening unit and an image analysis system, with the image analysis system located next to the crystallization screening unit. Figure 1 As shown, the crystallization screening unit of the multi-channel crystallization process rapid screening device combined with a particle size and shape analyzer of this utility model includes a main unit housing, an upper cover 6, a six-channel crystallization unit, a temperature control system, a six-point magnetic stirrer 10, and an automatic sampling system. The top of the main unit housing is connected to the upper cover 6. The six-channel crystallization unit is placed on the top of the main unit housing and connected to the temperature control system. The six-point magnetic stirrer 10 is located below the six-channel crystallization unit. The automatic sampling system connects the six-channel crystallization unit to the image analysis system.

[0042] As a preferred embodiment of this utility model, the main unit housing adopts a frame structure design, including upper and lower platforms. The upper platform is a temperature control tank area for placing the six-channel crystallization unit, and the lower platform is a tray to support the six-channel crystallization unit above. At the same time, the area under the lower platform is used to protect and store the internal motor and electrical circuits. The six crystallization containers are evenly distributed in the temperature control tank, and each container is connected to a pipeline of a temperature measurement and sampling system.

[0043] In a preferred embodiment of this utility model, the upper cover 6 is supported by two liftable brackets and placed directly above the crystallization tank. The feeding port and sampling port are located on the upper cover 6. There are four feeding ports and one sampling port, arranged in a 2-1-2 pattern (solvent feeding port 1, sampling port 2, antisolvent feeding port 3). The upper cover 6 is raised and lowered by a stepper motor 5, integrated into the overall control program. Through these feeding ports and sampling ports, solvent can be added or samples taken during the experiment without affecting the stability of the crystallization environment. A liquid material zone 9 is also provided next to the upper cover 6, which supplies solvent and antisolvent to the six-channel crystallization unit.

[0044] In a preferred embodiment of this utility model, the six-channel crystallization unit includes six crystallizer tanks 4 and a temperature control tank. The crystallizer tanks 4 are used to hold standard-sized crystallization glass beakers, and the temperature control tank has a jacketed structure and is connected to the temperature control system. The crystallizers of the six-channel crystallization unit are available in various sizes, and all are equipped with an upper cover 6. A magnetic stirring paddle 19 is suspended from the upper cover 6 through a central perforation and is driven by a bottom magnetic stirrer 10.

[0045] In a preferred embodiment of this utility model, the temperature control system includes a high-low temperature circulator and a temperature measuring unit. The high-low temperature circulator includes a control panel 11, a temperature control housing 12, and a temperature control medium delivery pipeline 13. The control panel 11 is mounted on the temperature control housing 12, and the temperature control housing 12 delivers the temperature control medium to the temperature control tank through the temperature control medium delivery pipeline 13. The high-low temperature circulator is connected to the temperature control tank via an external circulation system to control the internal temperature of the crystallizer. The temperature measuring unit includes a temperature measuring probe placed inside the crystallizer tank 4, which transmits the temperature signal to the temperature control housing 12.

[0046] In a preferred embodiment of this utility model, the six-position magnetic stirrer 10 is placed below the temperature control tank and is driven by six independent motors, each capable of different speed adjustments, with integrated control within the main control program. The six-position magnetic stirrer 10 is used to control the magnetic stirring paddle 19 to stir the crystallizer in the crystallization unit.

[0047] In a preferred embodiment of this utility model, the automatic sampling system connects the six-channel crystallization unit with the image analysis system to form a complete integrated system. The automatic sampling system includes two alternating injection pumps 8 (main pump and auxiliary pump), an eight-way solenoid switching valve, a sampling pipeline 14, and a waste liquid tank 15. One end of the sampling pipeline 14 is connected to the sampling port on the upper cover 6, and the other end is connected to the image analysis system via the eight-way switching valve 7 for wet particle size and shape detection of the crystallized samples from each channel. The eight-way solenoid switching valve is a high-precision electromagnetically driven eight-channel switching valve, with six ports connected to six crystallization units to switch between different crystallizers, a seventh port connected to cleaning fluid for cleaning residual substances in the pipeline, and an eighth port connected to the waste liquid tank 15. Through programmed control, the sample flow direction of different channels is precisely switched, ensuring that samples do not mix or cross-contaminate, with a switching time of <100ms.

[0048] As a preferred embodiment of this utility model, the two injection pumps 8 of the automatic sampling system work alternately to achieve uninterrupted liquid extraction, so as to ensure the fluidity of the sample during wet optical particle size detection. After the detection is completed, the excess mother liquor will be pushed back into the crystallizer.

[0049] like Figure 3 As shown, the image analysis system includes a particle size and shape analyzer 18 and a computer. The particle size and shape analyzer 18 is used to perform high-definition imaging of particles, analyze relevant parameters such as particle size and shape, and is connected to the computer via a data cable. The computer is used for data analysis, storage, and display of relevant parameter content.

[0050] In a preferred embodiment of this utility model, the particle size and shape analyzer 18 includes a liquid pool assembly 16, a high-precision telecentric zoom lens, a blue pulse light source, and a high-resolution CMOS camera 17. The liquid pool assembly 16 is positioned between the high-resolution CMOS camera 17 and the blue pulse light source. The high-precision telecentric zoom lens and the high-resolution CMOS camera 17 are combined to perform high-definition imaging of the particles. The entire system is housed inside the particle size and shape analyzer 18. The bottom and side of the liquid pool assembly 16 are provided with an inlet and an outlet. The inlet is connected to an eight-way switching valve 7, and the outlet is connected to an injection pump 8.

[0051] In a preferred embodiment of this utility model, the liquid pool assembly 16 includes replaceable clips with five different thicknesses available: 50μm, 100μm, 200μm, 400μm, and 600μm, each suitable for particle detection within a different particle size range. The liquid pool assembly 16 is the module for the imaging area. The thickness of the clips in the liquid pool assembly 16 determines the maximum size of the particles that can pass through; particles larger than the thickness of the clips in the liquid pool assembly 16 cannot pass through the imaging area.

[0052] In a preferred embodiment of this utility model, the computer is equipped with dedicated software to control the particle size and shape analyzer 18. This software includes data acquisition and processing functions, capable of processing acquired images and extracting particle size and shape parameters. The software's data processing function can binarize the images, identify particle outlines, and then calculate the physical parameters such as particle diameter and roundness of each particle according to a certain equivalent pattern.

[0053] The software interface will be Figure 4 The software, as shown in the image, includes a custom command control module, a real-time data display module, a particle morphology analysis module, and a report generation module. The custom command control module supports various commands, including PUMP, CLEAN, RESET, and VALVE commands. The real-time data display module shows particle quantity, particle size distribution, online statistics, and concentration distribution information. The particle morphology analysis module processes the acquired images, extracting and analyzing over 30 particle size and shape parameters.

[0054] The working process of this utility model is as follows:

[0055] Cooling crystallization experiment operation steps: (1) Raise the upper cover 6, put in six crystallization glass beakers, and add the raw materials and solvents into their respective beakers; (2) Lower the upper cover 6, connect the external circulation of the high and low temperature circulator to the temperature control tank, and start the six-position magnetic stirrer 10 and temperature control system through program control to start dissolution; (3) After the dissolution is completed, lower the temperature through the temperature control system to achieve cooling crystallization; (4) After the crystals precipitate, turn on the automatic sampling system to perform wet particle size and shape detection on the recrystallized crystal samples of each channel to obtain the morphology results under different experimental conditions.

[0056] Dissolution crystallization experiment operation steps: (1) Raise the upper cover 6, put in six crystallization glass beakers, and add the raw materials and solvents into their respective beakers; (2) Lower the upper cover 6, connect the external circulation of the high and low temperature circulator to the temperature control tank, and start the six-position magnetic stirrer 10 and temperature control system through program control to start dissolution; (3) After the dissolution is completed, add the unsuitable solvent through the feeding port on the upper cover 6 to achieve dissolution crystallization; the reverse addition process can also be realized, that is, first place the anti-solvent, and after the stirring temperature is stable, add the clear good solvent solution through the feeding port; (4) After the crystals precipitate, turn on the automatic sampling system and perform wet particle size and shape detection on the crystal recrystallization sample of each channel to obtain the morphology results under different experimental conditions.

[0057] This invention provides a multi-channel rapid screening device for crystallization processes, integrating a particle size and shape analyzer. By combining a six-channel crystallization unit with online wet particle size and shape detection technology, it achieves real-time monitoring of particle morphology and parallel screening under multiple conditions during crystallization, significantly improving the screening efficiency of the crystallization process. The device achieves automation, speed, stability, and accuracy for the user. Direct connection with the particle size and shape detection system avoids changes in the crystals during sampling and observation, obtaining initial crystal growth morphology data, which is beneficial for accurate and rapid judgment of the experimental process. It is suitable for crystallization research and quality control in fields such as pharmaceuticals, chemicals, and materials.

[0058] Although the present invention has been described herein with reference to illustrative embodiments, the above embodiments are merely preferred embodiments of the present invention, and the implementation of the present invention is not limited to the above embodiments. It should be understood that those skilled in the art can design many other modifications and implementations, which will fall within the scope and spirit of the principles disclosed in this application.

Claims

1. A rapid screening device for a multi-channel crystallization process combined with a particle size and shape analyzer, characterized in that, It includes a crystallization screening unit and an image analysis system. The image analysis system is located next to the crystallization screening unit. The crystallization screening unit includes a main unit housing, an upper cover (6), a six-channel crystallization unit, a temperature control system, a six-point magnetic stirrer (10), and an automatic sampling system. The top of the main unit housing is connected to the upper cover (6). The six-channel crystallization unit is placed on the top of the main unit housing and connected to the temperature control system. The six-point magnetic stirrer (10) is located below the six-channel crystallization unit. The automatic sampling system connects the six-channel crystallization unit to the image analysis system.

2. The rapid screening device for multi-channel crystallization process combined with a particle size and shape analyzer according to claim 1, characterized in that, The main unit housing adopts a frame structure design, including upper and lower platforms. The upper platform is a temperature control tank area for placing the six-channel crystallization unit, and the lower platform is a tray to support the six-channel crystallization unit. At the same time, the area under the lower platform is used to protect and store the internal motor and electrical circuits. The six crystallization containers are evenly distributed in the temperature control tank, and each container is connected to the pipeline of the temperature measurement and sampling system.

3. The rapid screening device for multi-channel crystallization process combined with a particle size and shape analyzer according to claim 2, characterized in that, The top cover (6) is supported by two liftable supports and placed directly above the crystallization tank. The feeding port and sampling port are located on the top cover (6). There are four feeding ports and one sampling port, arranged in a 212 pattern, namely two solvent feeding ports (1), one sampling port (2), and two antisolvent feeding ports (3). The top cover (6) is raised and lowered by a stepper motor (5). Through these feeding ports and sampling ports, solvents can be added or samples can be taken during the experiment without affecting the stability of the crystallization environment. A liquid material area (9) is also set up next to the top cover (6). The liquid material area (9) is used to supply solvents and antisolvents to the six-channel crystallization unit.

4. The rapid screening device for multi-channel crystallization process combined with a particle size and shape analyzer according to claim 3, characterized in that, The six-channel crystallization unit includes six crystallizer tanks (4) and a temperature control tank. The crystallizer tanks (4) are used to place standard-sized crystallization glass beakers. The temperature control tank is a jacket structure and is connected to the temperature control system. The crystallizers of the six-channel crystallization unit are of various specifications and are all matched with an upper cover (6). The upper cover (6) is suspended by a magnetic stirring paddle (19) through a central perforation and is driven by a bottom magnetic stirrer (10).

5. The rapid screening device for multi-channel crystallization process combined with a particle size and shape analyzer according to claim 4, characterized in that, The temperature control system includes a high and low temperature circulator and a temperature measuring unit. The high and low temperature circulator includes a control panel (11), a temperature control box (12), and a temperature control medium delivery pipeline (13). The control panel (11) is installed on the temperature control box (12). The temperature control box (12) delivers the temperature control medium to the temperature control tank through the temperature control medium delivery pipeline (13). The high and low temperature circulator is connected to the temperature control tank through an external circulation to control the internal temperature of the crystallizer. The temperature measuring unit includes a temperature measuring probe placed inside the crystallizer tank (4) to transmit the temperature signal to the temperature control box (12).

6. The rapid screening device for multi-channel crystallization process combined with a particle size and shape analyzer according to claim 5, characterized in that, The six-position magnetic stirrer (10) is placed below the temperature control tank and is driven by six independent motors. Each motor can adjust its own speed and is integrated into the overall control program. The six-position magnetic stirrer (10) is used to control the magnetic stirring paddle (19) to stir the crystallizer in the crystallization unit.

7. The rapid screening device for multi-channel crystallization process combined with a particle size and shape analyzer according to claim 6, characterized in that, The automatic sampling system includes two alternating injection pumps (8), an eight-way solenoid switching valve, a sampling pipeline (14), and a waste liquid tank (15). One end of the sampling pipeline (14) is connected to the sampling port on the upper cover (6), and the other end is connected to the image analysis system through the eight-way switching valve (7) for wet particle size and shape detection of the crystallized samples in each channel. The eight-way switching valve (7) is driven by high-precision electromagnetics. Six ports are connected to six crystallization units to switch the extraction for different crystallizers. The seventh port is connected to cleaning fluid for cleaning residual substances in the pipeline. The eighth port is connected to the waste liquid tank (15).

8. The rapid screening device for multi-channel crystallization process combined with a particle size and shape analyzer according to claim 7, characterized in that, The two injection pumps (8) of the automatic sampling system work alternately to achieve uninterrupted liquid extraction, so as to ensure the fluidity of the sample during wet optical particle size detection. After the detection is completed, the excess mother liquor will be pushed back into the crystallizer.

Images