An electrophysiological experimental system for auditory of primates

Abstract

The utility model belongs to the technical field of animal experiment equipment, specifically provides a kind of for primates's sense of hearing electro-physiological experiment system, including soundproof box, RZ6 processor, soundproof box is equipped with loudspeaker, loudspeaker is connected with RZ6 processor, soundproof box is also equipped with DP amplifier and ABR amplifier, DP amplifier and ABR amplifier are connected with RZ6 processor and loudspeaker respectively, ABR amplifier is also connected with electrode piece, still include the computer host connected with RZ6 processor, computer host connects display;Soundproof box is the double-layer structure of middle cavity setting, cavity is equipped with soundproofing cotton and copper mesh, back is equipped with threading hole and exhaust fan, box door is equipped with observation window, the middle of observation window is equipped with copper mesh.Double-layer soundproof box middle fills soundproofing cotton, can effectively insulate external noise, while the copper mesh of all-around coverage plays the role of shielding external signal, avoid to cause influence to experiment, exhaust fan can circulate the gas in box, maintain its inside more comfortable environment.

Description

Technical Field

[0001] This utility model belongs to the technical field of animal experimental equipment, and specifically relates to an auditory electrophysiological experimental system for primates. Background Technology

[0002] In recent years, with the development of new technologies such as cell and gene therapy, research into new drugs for ear diseases has entered a new chapter. Some ear diseases that previously lacked treatment options now offer methods and treatments that can restore hearing for patients. The emergence of these new treatment methods has also placed higher demands on non-clinical research and required newer evaluation methods.

[0003] First, precise local ototherapy is a crucial step in non-clinical research of otopathic drugs. Second, auditory electrophysiology (AEM) is an important tool for evaluating auditory system function and pathological mechanisms in non-clinical research, playing an irreplaceable role in basic research and clinical translation. AEM combined with precise local ototherapy strategies provides a multi-dimensional research platform for elucidating the mechanisms of auditory diseases and developing novel therapeutics. Auditory function assessment based on experimental animal models, combined with auditory brainstem evoked potentials and otoacoustic emission (OAE) detection techniques, can accurately analyze the electrophysiological characteristics of auditory conduction pathways. Primate AEM experiments provide model support for research on auditory function, disease mechanisms, and drug development.

[0004] Auditory electrophysiology refers to the method of assessing auditory function by recording electrical signals in the auditory pathway. During experiments, it is necessary to isolate the animals from noisy environments as much as possible to reduce experimental errors. At the same time, it is also necessary to provide the experimental animals with a comfortable experimental environment to avoid changes in various indicators caused by environmental changes. Therefore, it is necessary to design an auditory electrophysiological experimental system for primates to overcome the above-mentioned technical problems. Utility Model Content

[0005] Purpose of the utility model: In order to overcome the above deficiencies, the purpose of this utility model is to provide an auditory electrophysiological experimental system for primates, aiming to solve the above-mentioned technical problems.

[0006] Technical Solution: To achieve the above objectives, this utility model provides an auditory electrophysiological experimental system for primates, including a soundproof box, an RZ6 processor for auditory signal processing, a speaker for playing stimulus signals inside the soundproof box, the speaker being connected to the RZ6 processor, a DP amplifier and an ABR amplifier inside the soundproof box, the DP amplifier and ABR amplifier being connected to the RZ6 processor and the speaker respectively, the ABR amplifier being connected to electrode pads, and a computer host connected to the RZ6 processor, the computer host being connected to a monitor; The soundproof box is a double-layered structure with a cavity in the middle. The cavity is filled with sound insulation cotton and copper mesh. The front of the soundproof box has an openable door, and the back has a wire hole and an exhaust fan. The door has a double-layered observation window with a copper mesh in the middle.

[0007] The above method involves placing the animals in a soundproof box during the experiment. The double-layered soundproof box, filled with sound-absorbing cotton, effectively isolates external noise. Meanwhile, the all-around copper mesh acts as a shield against external signals, preventing them from affecting the experiment. The exhaust fan circulates the air inside the box, maintaining a relatively comfortable environment.

[0008] Furthermore, the inner layer of the soundproof box is a perforated metal mesh plate, and the exhaust fan is located on the outer plate of the soundproof box.

[0009] Furthermore, the soundproof enclosure is equipped with a workbench for placing instruments and experimental objects. An LED light and a UV lamp are located on the top inner side of the enclosure, and a dual switch for controlling the LED light and UV lamp is located on the surface of the enclosure. The LED light is used for illumination during experiments, and the UV lamp provides preliminary sterilization of the enclosure.

[0010] Furthermore, a sound-insulating plug is provided inside the wiring hole to allow wires to pass through. The sound-insulating plug includes an outer layer of rubber, a middle layer of sound-insulating cotton and copper mesh, and an inner layer of rubber. The wiring between the DP amplifier, ABR amplifier, and RZ6 processor passes through the sound-insulating plug. The sound-insulating plug not only allows the wiring to pass through smoothly but also effectively prevents external noise from entering the soundproof box.

[0011] Furthermore, the bottom of the soundproof box is equipped with omnidirectional casters, and the box door is equipped with a handle.

[0012] Furthermore, the observation window is made of double-layered tempered glass.

[0013] Furthermore, the DP amplifier and ABR amplifier are placed on a workbench, which is also equipped with a micro-injection pump.

[0014] As can be seen from the above technical solution, this utility model has the following beneficial effects: This invention provides an auditory electrophysiological experimental system for primates. During the auditory electrophysiological experiment, the experimental animals and the loudspeakers that generate the stimulation are placed in a soundproof box. The soundproof box has a double-layer structure with sound-insulating material filling the middle. At the same time, the soundproof box is provided with a wire hole with a sound-insulating plug, which not only meets the wiring requirements between the equipment, but also greatly reduces the interference of external noise, which is conducive to improving the reliability of the experiment.

[0015] In addition, the soundproof box is also equipped with a copper mesh covering the internal space. The copper mesh can not only provide support for the installation of sound insulation cotton, but also shield external interference signals, further improving the accuracy of the experiment. At the same time, the inner layer of the soundproof box uses metal mesh plates in conjunction with an exhaust fan to ensure air circulation and a suitable temperature inside the box, creating a comfortable experimental environment for the experimental animals. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the auditory electrophysiological experimental system for primates according to the present invention. Figure 2 This is a schematic diagram of the structure of the soundproof box described in this utility model; Figure 3 This is a rear view of the soundproof box described in this utility model; Figure 4 This is a cross-sectional view of the soundproof box described in this utility model.

[0017] In the picture: 1-Soundproof box, 2-Box door, 3-Wire hole, 4-Exhaust fan, 5-Observation window, 6-Double switch, 7-Universal casters. Detailed Implementation

[0018] It should be understood that the specific embodiments described herein are for illustrative purposes only and are not intended to limit the scope of the invention.

[0019] like Figures 1-4 As shown: An auditory electrophysiological experimental system for primates includes a soundproof box 1, an RZ6 processor for auditory signal processing, a speaker for playing stimulus signals inside the soundproof box 1, the speaker being connected to the RZ6 processor, a DP amplifier and an ABR amplifier inside the soundproof box 1, the DP amplifier and ABR amplifier being connected to the RZ6 processor and the speaker respectively, the ABR amplifier being connected to electrode pads, and a computer host connected to the RZ6 processor, the computer host being connected to a monitor; The soundproof box 1 is a double-layered structure with a cavity in the middle. The cavity contains sound insulation cotton and copper mesh. The front of the soundproof box 1 has an openable door 2, and the back has a wire hole 3 and an exhaust fan 4. The door 2 has a double-layered observation window 5, and the observation window 5 has a copper mesh in the middle. In this embodiment, the copper mesh completely covers the soundproof box 1. The copper mesh is sandwiched in the sound insulation cotton on the soundproof box 1, providing support for the sound insulation cotton while also shielding signals.

[0020] Specifically, the inner layer of the soundproof box 1 is a perforated metal mesh plate, which can improve the air permeability inside the soundproof box and provide support for the installation of sound insulation cotton. The exhaust fan 4 is located on the outer layer of the soundproof box 1.

[0021] Specifically, the soundproof box 1 has a workbench inside for placing instruments and experimental objects, an LED light and an ultraviolet light on the top inside the soundproof box 1, and a double switch 6 on the surface of the soundproof box 1 for controlling the LED light and the ultraviolet light.

[0022] Specifically, the wire hole 3 is provided with a sound insulation plug that can pass through the wire. The sound insulation plug includes an outer layer of rubber, a middle layer of sound insulation cotton and copper mesh, and an inner layer of rubber. The wiring between the DP amplifier, ABR amplifier and RZ6 processor passes through the sound insulation plug.

[0023] Specifically, the bottom of the soundproof box 1 is equipped with omnidirectional casters 7, and the door 2 is equipped with a handle. The soundproof box 1 can be flexibly moved using the omnidirectional casters 7. One side of the door 2 is rotatably connected to the soundproof box 1 via a hinge or hinge structure, and the handle facilitates opening or closing the door 2.

[0024] To further optimize the design, the observation window 5 is made of double-layered tempered glass. In order not to affect the observation, the aperture of the copper mesh in the middle of the observation window 5 can be adjusted appropriately.

[0025] Preferably, the DP amplifier and ABR amplifier are placed on a workbench, which is also equipped with a micro-injection pump. The micro-injection pump can inject a fixed amount of anesthetic into the experimental animal at regular intervals to maintain the animal's anesthesia.

[0026] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements can be made without departing from the principle of the present utility model, and these improvements should also be considered within the protection scope of the present utility model.

Claims

1. An auditory electrophysiological experimental system for primates, characterized in that, The device includes a soundproof enclosure (1), an RZ6 processor for auditory signal processing, a speaker for playing stimulus signals inside the soundproof enclosure (1), the speaker being connected to the RZ6 processor, a DP amplifier and an ABR amplifier inside the soundproof enclosure (1), the DP amplifier and the ABR amplifier being connected to the RZ6 processor and the speaker respectively, the ABR amplifier being connected to an electrode plate, and a computer host connected to the RZ6 processor, the computer host being connected to a monitor; The soundproof box (1) is a double-layer structure with a cavity in the middle. The cavity is provided with sound insulation cotton and copper mesh. The front of the soundproof box (1) is provided with an openable door (2), and the back is provided with a wire hole (3) and an exhaust fan (4). The door (2) is provided with a double-layer observation window (5), and the middle of the observation window (5) is provided with copper mesh.

2. The auditory electrophysiological experimental system for primates according to claim 1, characterized in that, The inner layer of the soundproof box (1) is a perforated metal mesh plate, and the exhaust fan (4) is located on the outer plate of the soundproof box (1).

3. The auditory electrophysiological experimental system for primates according to claim 1, characterized in that, The soundproof box (1) has a workbench inside for placing instruments and experimental objects. The top of the inner side of the soundproof box (1) is equipped with LED lighting and ultraviolet lamps. The surface of the soundproof box (1) is equipped with a double switch (6) for controlling the LED lighting and ultraviolet lamps.

4. The auditory electrophysiological experimental system for primates according to claim 1, characterized in that, The wire hole (3) is provided with a soundproof plug that can pass through the wire. The soundproof plug includes an outer layer of rubber, a middle layer of soundproof cotton and copper mesh, and an inner layer of rubber. The wiring between the DP amplifier, ABR amplifier and RZ6 processor passes through the soundproof plug.

5. The auditory electrophysiological experimental system for primates according to claim 1, characterized in that, The bottom of the soundproof box (1) is equipped with universal casters (7), and the door (2) is equipped with a handle.

6. The auditory electrophysiological experimental system for primates according to claim 1, characterized in that, The observation window (5) is made of double-layered tempered glass.

7. The auditory electrophysiological experimental system for primates according to claim 3, characterized in that, The DP amplifier and ABR amplifier are placed on a workbench, which is also equipped with a micro-injection pump for maintaining the anesthesia of the animals.

Images