Punch for animal wound modeling

Abstract

The puncher for animal wound modeling is characterized in that the punch head is provided with a punch head, the first silica gel ring is sleeved on the punch head, and the first silica gel ring is in abutment with the upper epidermis when the punch head goes down; the base is further provided with a positioning table for limiting the punch head from going down, the top surface of the positioning table is provided with the second silica gel ring coaxially arranged with the punch head; the opposite surfaces of the first silica gel ring and the second silica gel ring are provided with adhesive layers, and the adhesive layers are covered with isolation paper; and the mounting seat and the positioning table are left with a reserved area for positioning the experimental animals. The first silica gel ring is sleeved on the punch head, the second silica gel ring is coaxially arranged with the punch head on the top surface of the positioning table, the first silica gel ring on the punch head is transferred to the upper epidermis during the downward process in the single wound cutting, the upper epidermis and the lower epidermis are respectively adhered with the first silica gel ring and the second silica gel ring during the punching, so as to replace the complicated manual punching and ring pasting operation, and the shrinkage phenomenon in the healing process of the animal skin is avoided to the greatest extent.

Description

Technical Field

[0001] This utility model patent relates to the field of animal wound modeling technology, and in particular to a puncher for animal wound modeling. Background Technology

[0002] Animal wound scaffolds are often used in the creation of laboratory animal models. They are the most widely used full-thickness skin excision wound modeling tool in traditional animal wound repair experiments.

[0003] The following is the standard procedure for animal wound modeling:

[0004] 1) Anesthesia: Anesthetizing experimental animals using appropriate methods.

[0005] 2) Wound preparation: First, fix the anesthetized experimental animal ventrally on the board and fix its limbs. Trim the hair and prepare the skin on its back, preferably towards the back, to prevent the experimental animal from scratching and affecting the experiment. Then, perform routine disinfection. Use tweezers to pick up a 2cm diameter filter paper soaked in iodine and stick it to the trimmed area. Press the paper lightly to imprint one or more pairs of marked areas on the experimental animal's back that are the same size and shape as the paper. Then, use a traditional handheld wound punch to punch a circular wound on the skin of the experimental animal's back or use scissors to cut off the epidermis of the marked area along the edge of the mark. Finally, manually fix a ring-shaped adhesive band to the circular wound.

[0006] 3) Post-modeling observation: Experimental animals should be kept separately after modeling, and the bedding should be changed frequently to keep the environment dry and clean. After modeling, the diameter of the circular wound should be measured every two days, the wound area should be calculated, and the data should be recorded.

[0007] Circular rubber bands are used to prevent wrinkling of open wounds. Compared to metal bands, they are lighter and avoid secondary pressure injury to the wound. However, existing skin harvesting tools only have a single function of harvesting skin or punching holes, requiring punching and manual banding to be performed in separate steps. Animal skin is prone to wrinkling during the operation intervals, and circular wounds usually have one or more pairs of bands. Due to the extensibility of animal skin, it is difficult to maintain the target wound surface in a circular shape during banding, increasing the difficulty of manual banding. Therefore, a convenient and stable punching tool for modeling animal wounds is needed. Utility Model Content

[0008] The purpose of this invention is to solve existing technical problems by proposing a punch for modeling animal wounds.

[0009] To achieve the above objectives, the present invention adopts the following technical solution: a punch for modeling animal wounds, comprising a mounting base, a punch connected to the upper part of the mounting base for vertical reciprocating punching operations, and a base connected to the mounting base below the punch; a punching cutter head is provided at the bottom of the punching cutter head, and a first silicone ring is fitted on the punching cutter head, and the first silicone ring abuts against the upper epidermis when the punching cutter head moves downward; a positioning platform is also provided on the base for limiting the downward movement of the punching cutter head, and a second silicone ring is provided on the top surface of the positioning platform coaxially with the punching head; an adhesive layer is provided on the opposite surfaces of the first silicone ring and the second silicone ring, and a release paper is covered on the adhesive layer; an empty area for positioning experimental animals is left between the mounting base and the positioning platform.

[0010] Preferably, the mounting base is equipped with a motor for driving the punch to perform vertical reciprocating motion, and the mounting base is also equipped with a switch button, which is connected to the motor via wired or wireless connection to control the start / stop of the punch.

[0011] Preferably, the outer wall of the punch head is engraved with a marking line for marking the upper limit of the height of the first silicone ring, and the distance from the marking line to the bottom of the punch head is a; the top surface of the positioning stage is recessed to form a positioning hole, the diameter of the positioning hole is larger than the diameter of the punch head, and the depth of the positioning hole is b; b>a, so that when the punch head moves downward, the adhesive layer of the first silicone ring is in contact with the upper skin, and the adhesive layer of the second silicone ring is in contact with the lower skin.

[0012] Preferably, the top surface of the positioning platform is also provided with an annular mark for positioning the second silicone ring, and the diameter of the positioning hole is smaller than the outer ring diameter of the annular mark.

[0013] Preferably, the first silicone ring and the second silicone ring have the same shape and are equal in size.

[0014] Preferably, the positioning platform is also equipped with a lighting device for auxiliary positioning, which is a lamp fixed to the bottom wall of the positioning hole or an inter-ring lighting strip located within the ring marking.

[0015] Preferably, both the punching head and the positioning table are made of die steel by stamping.

[0016] The beneficial effects of this invention are as follows: By fitting a first silicone ring onto the punching head and a second silicone ring coaxially arranged with the punch on the top surface of the positioning platform, the first silicone ring on the punching head is transferred to the upper epidermis as the wound is cut, and the upper and lower epidermis are respectively adhered to the first and second silicone rings during punching. This replaces the tedious manual punching and ring-attaching operations, minimizes the wrinkling phenomenon during the healing process of animal skin, reduces systematic errors caused by the ring-attaching operation during the experiment, and facilitates precise wound repair.

[0017] This product uses the principle of machine tool stamping to model wounds on laboratory animals, ensuring the stability of wound modeling, effectively reducing experimental errors, improving the accuracy of experimental results, and reducing the waste of experimental materials due to operational errors. Attached Figure Description

[0018] Figure 1 This is a partial structural diagram of the hole punch of this utility model;

[0019] Figure 2 This is a diagram showing the fit between the punching head and the positioning table of this utility model.

[0020] Figure 3 This is a schematic diagram of the punching positions in a mouse (with the skin on its back stretched) according to this invention.

[0021] Figure 4 This is a schematic diagram of the mouse perforation results of this invention (excluding the first and second silicone rings);

[0022] Figure 5 The results of pigskin molding according to this utility model. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0024] In conjunction with the embodiments and appendices Figure 1-5 A punch for modeling animal wounds includes a mounting base 2. A punch 21, which moves vertically back and forth to perform punching operations, is connected to the upper part of the mounting base 2. A base 22, connected to the mounting base 2, is located below the punch 21. A punching head 3 is located at the bottom of the punch 21, and a first silicone ring 51 is fitted onto the punching head 3, abutting against the upper epidermis as the punching head 3 moves downwards. A positioning platform 4, used to limit the downward movement of the punching head 3, is also provided on the base 22. A second silicone ring 52, coaxially arranged with the punch 21, is located on the top surface of the positioning platform 4. An adhesive layer 50 is provided on the opposing surfaces of the first silicone ring 51 and the second silicone ring 52, and a release paper is covered on the adhesive layer 50. A clearance area 1 for positioning experimental animals is left between the mounting base 2 and the positioning platform 4.

[0025] Furthermore, the outer wall of the punch head is provided with a frosted area for fitting the first silicone ring, and the inner wall of the first silicone ring is provided with several anti-slip ridges. The anti-slip ridges are arranged along the axial direction of the first silicone ring to prevent it from detaching from the punch head during the up and down stroke. The punch head and the positioning table can have one or more first and second silicone rings. With the help of the release paper, multiple first and second silicone rings can be stacked axially.

[0026] Procedure for animal wound modeling:

[0027] The mice were anesthetized and their back hair was shaved to expose the back epidermis 12 for later use. Before drilling, the first silicone ring was attached to the drilling head and the second silicone ring was placed on the positioning stage. After confirming that the first and second silicone rings were aligned, the release paper was removed to expose the adhesive layer.

[0028] By pinching the skin at the cervical and caudal vertebrae of the mouse with both hands, allowing its limbs to hang naturally, and then lifting it to create a double-folded back skin, the folded skin 11 is placed horizontally between the positioning table and the punching head. At this point, the mouse... Figure 3 The mouse lies on its side on the base; the folded skin 11 has an upper epidermis facing the punch and a lower epidermis facing the positioning platform. After determining the punching position, the folded skin 11 is lowered to ensure the lower epidermis is in contact with the second silicone ring. The punching operation is then performed. As the punch descends, it drives the punching head through the folded skin (the skin on the mouse's back is in a state of tension throughout the entire penetration), forming a pair of identical circular wounds 10. The first and second silicone rings are respectively adhered to the circumference of the circular wounds, completing the punching and ringing operation in one step. To facilitate handling and positioning confirmation, the mouse can be positioned with its limbs facing away from the open area 1.

[0029] The puncher used for animal wound modeling has a mounting base 2 containing a motor for driving the punch to perform vertical reciprocating motion. The mounting base 2 also has a switch button 20, which controls the start / stop of the punch 21 via a wired or wireless connection to the motor. The punch, mounting base, and base can be obtained by modifying conventional lifting and stamping components or punchers. Modification of the lifting and stamping component only requires adapting the corresponding punching head and positioning table according to the outer diameter of the hole. The modification cost is low and it is easy to promote.

[0030] Furthermore, the punch head 3 is screwed to the punch 2, and the base 22 is provided with a fixing post coaxial with the punch 2. The bottom of the positioning table 4 has a mounting hole that matches the fixing post. The punch head and the punch, as well as the positioning table and the base, are all detachably connected, making it easy to replace punch heads and positioning tables of different sizes according to punching requirements.

[0031] A punching tool for animal wound modeling has a punching head 3 with a marking line 30 on its outer wall to indicate the upper limit of the height of the first silicone ring. The distance from the marking line 30 to the bottom of the punching head 3 is 'a'. A positioning platform 4 has a recessed top surface forming a positioning hole 41. The diameter of the positioning hole 41 is larger than the diameter of the punching head 3, and the depth of the positioning hole 41 is 'b'. Since 'b' > 'a', when the punching head 3 moves downward, the adhesive layer 50 of the first silicone ring 51 adheres to the upper epidermis, and the adhesive layer 50 of the second silicone ring 52 adheres to the lower epidermis. The adhesive layer can be 3M adhesive or bio-adhesive. Through the strong adhesive effect of the adhesive layer, the first silicone ring adheres to the epidermis around the wound ring after it comes into contact with the upper epidermis.

[0032] The puncher used for animal wound modeling has a ring mark on the top surface of the positioning platform 4 for positioning the second silicone ring. The diameter of the positioning hole 41 is smaller than the outer ring diameter of the ring mark.

[0033] A punch for modeling animal wounds, with the first and second silicone rings being identical in shape and equal in size.

[0034] The punching tool used for animal wound modeling, and the positioning platform 4 are also equipped with a lighting device for auxiliary positioning. The lighting device is a lamp fixed to the bottom wall of the positioning hole or an inter-ring lighting strip located in the ring mark. By changing the light transmittance, the position of the second silicone ring is determined, avoiding the phenomenon of slippage of the second silicone ring due to accidental contact.

[0035] The puncher used for animal wound modeling has a punch head and positioning platform made of die steel by stamping, which facilitates sterilization operations in the laboratory.

[0036] Another implementation of the punch for animal wound modeling involves simply removing the second silicone ring from the top surface of the positioning platform to perform simultaneous punching and ring application of a single layer of skin, such as... Figure 5 The simulation results of pigskin modeling shown demonstrate that, through the combination of positioning holes and punching heads, the modeling wound has a regular shape and smooth cut edges.

[0037] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A punch for modeling animal wounds, comprising a mounting base, a punch for vertically reciprocating drilling operations connected to the upper part of the mounting base, and a base connected to the mounting base below the punch; a punching cutter is provided at the bottom of the punch, characterized in that, A first silicone ring is fitted on the punch head, and the first silicone ring abuts against the upper skin as the punch head moves downward; the base is also provided with a positioning platform for limiting the downward movement of the punch head, and a second silicone ring is provided on the top surface of the positioning platform, which is coaxially arranged with the punch head; the opposing surfaces of the first silicone ring and the second silicone ring are provided with an adhesive layer, and the adhesive layer is covered with release paper; a clearance area for positioning experimental animals is left between the mounting base and the positioning platform.

2. The punch for animal wound modeling according to claim 1, characterized in that: The mounting base contains a motor for driving the punch to perform vertical reciprocating motion. The mounting base also has a switch button, which is connected to the motor via wired or wireless connection to control the start / stop of the punch.

3. The punch for animal wound modeling according to claim 1, characterized in that: The outer wall of the punch head is engraved with a marking line to indicate the upper limit of the height of the first silicone ring. The distance from the marking line to the bottom of the punch head is a. The top surface of the positioning stage is recessed to form a positioning hole. The diameter of the positioning hole is larger than the diameter of the punch head, and the depth of the positioning hole is b. b > a, so that when the punch head moves downward, the adhesive layer of the first silicone ring is in contact with the upper skin, and the adhesive layer of the second silicone ring is in contact with the lower skin.

4. The punch for animal wound modeling according to claim 3, characterized in that: The top surface of the positioning platform is also provided with an annular mark for positioning the second silicone ring, and the diameter of the positioning hole is smaller than the outer ring diameter of the annular mark.

5. The punch for animal wound modeling according to claim 1 or 3, characterized in that: The first and second silicone rings are identical in shape and equal in size.

6. The punch for animal wound modeling according to claim 3, characterized in that: The positioning platform is also equipped with lighting devices for auxiliary positioning. The lighting devices are lamps fixed to the bottom wall of the positioning hole or inter-ring lighting strips located within the circular markings.

7. The punch for animal wound modeling according to claim 1, characterized in that: Both the punching head and the positioning table are made of die steel by stamping.

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