A mouse intranasal instillation needle and device

Abstract

The utility model relates to the technical field of experimental apparatus, more particularly to a mouse intranasal instillation needle and device, the needle head is equipped with the spacing structure that can butt with mouse nose head, the one end of needle head for instilling liquid is injection end, the other end is mounting end, the spacing structure is set on the needle head and with mounting end detachable connection, the injection end is equipped with the plugging part, one end of plugging part with injection end fixed connection, the other end is hemispherical, the lateral wall of injection end is equipped with the injection hole that links injection end inner chamber and outside. The needle head of the utility model can control the length of needle head that stretches into mouse nasal cavity inside through spacing structure, ensure when carrying out repeated experiment, can make the intranasal instillation depth of every mouse same, play the role of controlling variable. Meanwhile, one end of the plugging part of needle injection end is hemispherical, the end face of hemispherical can avoid the needle head in the process of stretching into mouse nasal cavity inside, scratch mouse's nasal mucosa.

Description

Technical Field

[0001] This utility model relates to the technical field of experimental equipment, and more specifically, to an intranasal drip device for mice. Background Technology

[0002] When infecting mice with lung disease, a syringe is used to inject the virus or bacteria into the mice's lungs via intranasal drip to complete the lung infection, so as to carry out subsequent treatment and control observation.

[0003] When administering intranasal drops to mice using a syringe, the nasal cavity diameter is only 0.5mm-1mm, making it difficult for current syringe needles to accurately penetrate the narrow nasal cavity. Even when the needle is inserted, the sharp tip can easily scratch the nasal mucosa, leading to nasal bleeding or inflammation. Furthermore, controlling the insertion length is challenging, resulting in inconsistent drop placement for each mouse and affecting experimental reproducibility. Utility Model Content

[0004] The purpose of this invention is to overcome the shortcomings of the syringe needle when using a syringe to infect the lungs of mice by intranasal dripping. This invention provides an intranasal dripping needle and device for mice. During the dripping process in the mouse nasal cavity, this solution can not only control the length of the needle inserted into the mouse nasal cavity, but also avoid scratching the nasal mucosa of the mouse during the insertion of the needle into the mouse nasal cavity.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by this utility model is as follows:

[0006] A mouse intranasal drip needle is provided, comprising a needle and a limiting structure that can abut against the tip of a mouse nose. One end of the needle for dripping liquid is an injection end, and the other end is an installation end. The limiting structure is sleeved on the needle and detachably connected to the installation end. A plug is fixedly provided at the end of the injection end. The plug is hemispherical. The side wall of the injection end is provided with an injection hole that communicates the inner cavity of the injection end with the outside.

[0007] When the drip needle of this invention is in operation, the limiting structure is sleeved on the needle and installed at the mounting end of the needle. Then, the injection end of the needle is inserted into the nasal cavity of the mouse until the limiting structure abuts against the tip of the mouse's nose, and then intranasal drip is performed on the mouse.

[0008] The intranasal drip needle of this invention can control the length of the needle inserted into the mouse nasal cavity through a limiting structure, ensuring that the intranasal drip depth is the same for each mouse in repeated experiments, thus controlling for variables. At the same time, one end of the plug at the injection end of the needle is hemispherical, which can prevent the needle from scratching the nasal mucosa of the mouse during insertion into the nasal cavity.

[0009] Furthermore, the limiting structure includes a connecting part, a fixing part, and an abutting part that can abut against the mouse's nose. The connecting part is sleeved on the needle and detachably connected to the mounting end. The abutting part is sleeved on the needle and connected to the connecting part. The position of the abutting part on the connecting part is adjustable. The fixing part is installed on the connecting part and connected to the abutting part to fix the abutting part on the connecting part.

[0010] When installing the limiting structure on the needle tip, first, slip the connecting part onto the needle tip and install it at the mounting end to secure the connecting part to the needle tip. Then, slip the abutment part onto the needle tip and connect it to the connecting part. The abutment part can be threaded or slidably connected to the connecting part. During the connection process, adjust the position of the abutment part on the connecting part so that the length of the needle extending beyond the abutment part is the target length for the needle to enter the mouse's nasal cavity. After adjusting the position of the abutment part on the connecting part, secure it to the connecting part using the fixing part. The fixing part can be threaded, snap-fitted, or plugged into the abutment part, ensuring that the abutment part is secured to the connecting part after connection.

[0011] Furthermore, the outer wall of the mounting end is provided with a first protrusion and a positioning plate; when the connecting part is sleeved on the needle tip, the first protrusion is interference-fitted with the inner cavity of the connecting part; the positioning plate is provided with a positioning groove, and the side wall of the inner cavity of the connecting part is provided with a second protrusion that can extend into the inner cavity of the positioning groove and a third protrusion that can abut against the side of the positioning plate, the second protrusion and the third protrusion being fixed sequentially on the side wall of the inner cavity of the connecting part. The first protrusion makes the mounting end and the connecting part interference-fitted, which can complete the fixation of the connecting part on the mounting end. Alternatively, the first protrusion can be set in the inner cavity of the connecting part, and similarly, the positioning plate can be set in the inner cavity of the connecting part, and the second and third protrusions can be set on the outer wall of the mounting end.

[0012] Furthermore, the fixing part is provided with a scale. The displacement distance of the abutment part can be intuitively obtained by changing the alignment position of the end face of the abutment part with the scale on the fixing part.

[0013] Furthermore, the axis of the injection hole forms an angle of 15°-20° with the axis of the needle, and one end of the sidewall of the injection hole away from the inner cavity of the needle is inclined towards the blocking part. The outer wall of the needle is also provided with a guide groove, the two ends of which are hemispherical, connecting the injection hole and the blocking part respectively. The downward inclination of the injection hole and the guide groove serve to guide the liquid inside the needle, guiding it to form droplets and move downwards.

[0014] Furthermore, the sidewall of the needle is 0.1mm-0.15mm thick, the inner diameter is 0.3mm-0.4mm, and the diameter of the injection hole is 0.3mm-0.4mm. There are two injection holes, both located on the guide groove. The sidewall thickness of the needle (0.1mm-0.15mm) and the inner diameter (0.3mm-0.4mm) allow the needle to be smoothly inserted into the mouse nasal cavity. The diameter of the injection hole (0.3mm-0.4mm) allows control over the size of the dripped liquid.

[0015] This invention also provides a mouse intranasal drip device, including a syringe and a needle, wherein the needle is a mouse intranasal drip needle as described above, and the syringe is connected to the mounting end.

[0016] The syringe of this invention not only controls the length of the needle inserted into the mouse's nasal cavity, ensuring that the intranasal instillation depth is the same for each mouse during repeated experiments, but also avoids scratching the mouse's nasal mucosa during the insertion of the needle into the mouse's nasal cavity.

[0017] Compared with the prior art, the beneficial effects of this utility model are:

[0018] The present invention uses a limiting structure on the needle tip to control the length of the needle insertion into the mouse nasal cavity, ensuring that the intranasal instillation depth is the same for each mouse during repeated experiments, thus controlling for variables. Simultaneously, one end of the plugging portion of the needle injection tip is hemispherical, which prevents the needle from scratching the mouse's nasal mucosa during insertion. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of a mouse intranasal drip needle;

[0020] Figure 2 A schematic diagram of the needle structure for an intranasal drip needle for mice;

[0021] Figure 3 for Figure 2 Enlarged view of part A;

[0022] Figure 4 This is a schematic diagram of the internal structure of a portion of the injection tip of a mouse intranasal drip needle.

[0023] Figure 5 This is a schematic diagram of the contact part of an intranasal drip needle for mice;

[0024] Figure 6 This is a schematic diagram of the connection and fixation parts of a mouse intranasal drip needle;

[0025] Figure 7 This is a schematic diagram of the connection and fixation parts of a mouse intranasal drip needle from another angle.

[0026] Figure 8 This is a schematic diagram of a mouse intranasal drip device.

[0027] In the attached diagram: 1. Needle; 2. Blocking part; 3. Connecting part; 4. Fixing part; 5. Abutting part; 6. First protrusion; 7. Positioning plate; 8. Second protrusion; 9. Third protrusion; 10. Syringe; 101. Mounting end; 102. Injection hole; 103. Guide groove; 301. Threaded section; 302. Receiving hole; 401. Positioning protrusion; 402. Pressing protrusion; 501. Positioning groove; 701. Positioning recess. Detailed Implementation

[0028] The present invention will be further described below with reference to specific embodiments. The accompanying drawings are for illustrative purposes only, representing schematic diagrams rather than actual physical objects, and should not be construed as limiting the scope of this patent. To better illustrate the embodiments of the present invention, some components in the drawings may be omitted, enlarged, or reduced, and do not represent the actual dimensions of the product. It is understandable to those skilled in the art that some well-known structures and their descriptions may be omitted in the drawings.

[0029] In the accompanying drawings of this utility model, the same or similar reference numerals correspond to the same or similar components. In the description of this utility model, it should be understood that if terms such as "upper," "lower," "left," and "right" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, they are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, the terms used to describe positional relationships in the drawings are only for illustrative purposes and should not be construed as limiting this patent. For those skilled in the art, the specific meaning of the above terms can be understood according to the specific circumstances.

[0030] Example 1

[0031] This embodiment is a first embodiment of a mouse intranasal drip needle, such as... Figures 1-4As shown, it includes a needle 1 and a limiting structure that can contact the nose of a mouse. One end of the needle 1 for dripping liquid is the injection end, and the other end is the mounting end 101. The limiting structure is sleeved on the needle 1 and detachably connected to the mounting end 101. The end of the injection end is fixedly provided with a plug 2, which is hemispherical. The side wall of the injection end is provided with an injection hole 102 that connects the inner cavity of the injection end to the outside.

[0032] The working principle or working process of this embodiment is as follows:

[0033] The limiting structure is fitted onto the needle 1 and installed at the mounting end 101 of the needle 1. Then, the injection end of the needle 1 is inserted into the nasal cavity of the mouse until the limiting structure contacts the tip of the mouse's nose. Then, intranasal instillation is performed on the mouse.

[0034] The beneficial effects of this implementation are as follows:

[0035] In this embodiment, the length of the intranasal drip needle 1 inserted into the mouse nasal cavity can be controlled by a limiting structure, ensuring that the intranasal drip depth is the same for each mouse during repeated experiments, thus controlling the variable. Simultaneously, one end of the plug 2 at the injection end of the needle 1 is hemispherical, which prevents the needle 1 from scratching the mouse's nasal mucosa during insertion into the nasal cavity.

[0036] Example 2

[0037] This embodiment is a second embodiment of a mouse intranasal drip needle. Based on the first embodiment, this embodiment further limits the limiting structure.

[0038] Specifically, such as Figure 1 As shown, the limiting structure includes a connecting part 3, a fixing part 4, and an abutting part 5 that can abut against the nose of a mouse. The connecting part 3 is sleeved on the needle 1 and detachably connected to the mounting end 101. The abutting part 5 can be sleeved on the needle 1 and connected to the connecting part 3. The position of the abutting part 5 on the connecting part 3 is adjustable. The fixing part 4 is installed on the connecting part 3 and connected to the abutting part 5 to fix the abutting part 5 on the connecting part 3.

[0039] The working distance or working process in this embodiment is:

[0040] When installing the limiting structure on the needle 1, first, the connecting part 3 is sleeved on the needle 1 and installed on the mounting end 101, thus fixing the connecting part 3 on the needle 1. Then, the abutment part 5 is sleeved on the needle 1 and connected to the connecting part 3. The abutment part 5 can be threaded or slidably connected to the connecting part 3. During the connection process, the position of the abutment part 5 on the connecting part 3 is adjusted so that the length of the needle 1 extending beyond the abutment part 5 is the target length for the needle 1 to enter the mouse's nasal cavity. After adjusting the position of the abutment part 5 on the connecting part 3, the fixing part 5 is fixed to the connecting part 3 by the fixing part 4. The fixing part 4 can be threaded, snap-fitted, or plugged into the abutment part 5, achieving the purpose of fixing the abutment part 5 to the connecting part 3 after the fixing part 4 is connected to the abutment part 5.

[0041] Example 3

[0042] This embodiment is a third embodiment of a mouse intranasal drip needle. Based on embodiment two, this embodiment further defines the connection method between the mounting end 101 and the needle 1.

[0043] Specifically, such as Figure 2 and Figure 6 As shown, a first protrusion 6 is provided on the outer wall of the mounting end 101. When the connecting part 3 is sleeved on the needle 1, the first protrusion 6 is interference-fitted with the inner cavity of the connecting part 3. The outer wall of the mounting end 101 is also provided with a positioning plate 7, which has a positioning groove 701. The inner wall of the connecting part 3 is also provided with a second protrusion 8 that can extend into the inner cavity of the positioning groove 701 and a third protrusion 9 that can abut against the side of the positioning plate 7. The second protrusion 8 and the third protrusion 9 are fixed to the inner wall of the connecting part 3 in sequence.

[0044] Specifically, there are multiple first protrusions 6, which are arranged equidistantly in a circle around the axis of the needle tip 1 on the outer wall of the mounting end 101. Figure 2 In the middle, the first protrusion 6 has four.

[0045] Specifically, the end face of the first protrusion 6 that is away from the mounting end 101 can fit tightly against the inner cavity sidewall of the connecting part 3.

[0046] Specifically, when the second protrusion 8 extends into the inner cavity of the positioning groove 701, the second protrusion 8 fits into the inner cavity of the positioning groove 701, while the third protrusion 9 abuts against the end face of the positioning plate 7.

[0047] Specifically, there are two second protrusions 8 and two third protrusions 9, which are arranged symmetrically with the axis of the needle 1 as the center; there are four positioning plates 7 on the mounting end 101, which are arranged equidistantly in a circle with the axis of the needle 1 as the center.

[0048] The working principle or process of this embodiment is as follows:

[0049] In use, insert the second protrusion 8 and the third protrusion 9 into the gap between two adjacent mounting plates, then insert the connecting part 3 into the inner cavity of the mounting end 101, and then rotate the needle 1 or the connecting part 3 until the second protrusion 8 is engaged in the positioning groove 701 and the third protrusion 9 abuts against the end face of the positioning plate 7. At this time, the connecting part 3 is installed in place on the mounting end 101.

[0050] The beneficial effects of this embodiment are as follows:

[0051] The first protrusion 6 ensures an interference fit between the mounting end 101 and the connecting part 3, thus securing the connecting part 3 to the mounting end 101. The second protrusion 8 and the third protrusion 9 prevent relative rotation between the connecting part 3 and the needle 1, indicating to the operator that the connecting part 3 is properly installed on the needle 1.

[0052] Example 4

[0053] This embodiment is the fourth embodiment of a mouse intranasal drip needle. Based on the third embodiment, this embodiment further limits the limiting structure.

[0054] Specifically, such as Figure 5 and Figure 7 As shown, the outer surface of the connecting part 3 is provided with a threaded section 301, the abutting part 5 is threadedly connected to the threaded section 301, the side wall of the connecting part 3 is also provided with a receiving hole 302, the side wall of the abutting part 5 is provided with a positioning groove 501, the fixing part 4 is located in the receiving hole 302, one end of the fixing part 4 near the injection end is fixedly connected to the side wall of the receiving hole 302, and one end of the fixing part 4 away from the injection end is provided with a positioning protrusion 401 that can extend into the positioning groove 501.

[0055] Specifically, such as Figure 6 and Figure 7 As shown, the fixing part 4 is a long strip elastic sheet, the receiving hole 302 is a long strip through hole, and the positioning groove 501 is a through groove.

[0056] Specifically, the positioning protrusion 401 is arc-shaped, and the end of the fixing part 4 connected to the side wall of the receiving hole 302 is provided with a pressing protrusion 402, which is also arc-shaped. The tops of the positioning protrusion 401 and the pressing protrusion 402 both protrude from the receiving hole 302.

[0057] Specifically, there are two positioning grooves 501 on the contact part 5, and the two positioning grooves 501 are arranged equidistantly in a circle with the axis of the needle 1 as the center.

[0058] Specifically, when the abutment 5 rotates 180° on the connecting part 3, the displacement of the abutment 5 on the connecting part 3 along the axis of the needle 1 is 0.75 mm.

[0059] Specifically, the top surface of the fixing part 4 is also provided with a scale.

[0060] The working distance or working process in this embodiment is as follows:

[0061] When it is necessary to adjust the position of the abutment 5 on the connecting part 3, the operator presses the pressing protrusion 402 of the fixing part 4 to cause the fixing part 4 to bend downwards. At this time, the positioning protrusion 401 on the fixing part 4 moves downwards until it disengages from the positioning groove 501 of the abutment 5. The abutment 5 can be rotated to slide back and forth on the connecting part 3 to adjust its position. After the position adjustment of the abutment 5 is completed, the abutment 5 is rotated until the positioning groove 501 is aligned with the fixing part 4. At this time, the pressing protrusion 402 is released, the fixing part 4 returns to its original position, and the positioning protrusion 401 re-enters the positioning groove 501, preventing the abutment 5 from sliding on the connecting part 3.

[0062] The beneficial effects of this embodiment are as follows:

[0063] The displacement distance of the abutment part 5 can be intuitively obtained by changing the alignment position of the end face of the abutment part 5 with the scale on the fixed part 4.

[0064] Example 5

[0065] This embodiment is the fifth embodiment of a mouse intranasal drip needle. This embodiment is based on embodiment four, as follows: Figure 3 and Figure 4 As shown, the injection hole 102 and the plug 2 are further defined.

[0066] Specifically, the plugging part 2 is a soft plugging part 2, such as a silicone plug or a soft plastic plugging part 2.

[0067] Specifically, the angle between the axis of the injection hole 102 and the axis of the needle 1 is 15°-20°, and the end of the side wall of the injection hole 102 away from the inner cavity of the needle 1 is inclined towards the blocking part 2.

[0068] Specifically, the outer wall of the needle 1 is also provided with a flow guide groove 103, and the two ends of the flow guide groove 103 are respectively connected to the injection hole 102 and the hemisphere of the plug 2.

[0069] Specifically, the sidewall of the needle 1 is 0.1mm thick, the inner diameter is 0.3mm-0.4mm, the diameter of the injection hole 102 is 0.3mm-0.4mm, there are two injection holes 102, both of which are located on the guide groove 103.

[0070] The beneficial effects of this embodiment are as follows:

[0071] The downward tilt of the injection orifice 102 and the function of the guide groove 103 are to guide the liquid inside the needle 1, directing it to form droplets and move downwards. The sidewall of the needle 1 is 0.1mm-0.15mm thick, and the inner diameter is 0.3mm-0.4mm, allowing the needle 1 to be smoothly inserted into the mouse's nasal cavity. The diameter of the injection orifice 102 is 0.3mm-0.4mm, which allows control over the size of the dripping droplets. There are two injection orifices 102, which can improve the droplet formation rate.

[0072] Example 6

[0073] This embodiment is an example of a mouse intranasal drip device, such as... Figure 8 As shown, it includes a syringe 10 and a needle 1. The needle 1 is a mouse intranasal drip needle as described in any one of Examples 1 to 5. The syringe 10 is connected to the mounting end 101.

[0074] The beneficial effects of this embodiment are as follows:

[0075] In this embodiment, the needle 1 in the syringe 10 can not only control the length of the needle 1 inserted into the mouse's nasal cavity to ensure that the intranasal instillation depth is the same for each mouse when repeating the experiment, but also avoid scratching the mouse's nasal mucosa during the insertion of the needle 1 into the mouse's nasal cavity.

[0076] In the specific implementation of the above embodiments, the technical features can be combined in any non-contradictory way. For the sake of brevity, not all possible combinations of the above technical features are described. However, as long as the combination of these technical features is not contradictory, it should be considered to be within the scope of this specification.

[0077] Obviously, the above embodiments of this utility model are merely examples for clearly illustrating this utility model, and are not intended to limit the implementation of this utility model. Those skilled in the art can make other variations or modifications based on the above description. It is neither necessary nor possible to exhaustively describe all embodiments here. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this utility model should be included within the protection scope of the claims of this utility model.

Claims

1. A mouse intranasal drip needle, characterized in that, The device includes a needle (1) and a limiting structure that can contact the nose of a mouse. One end of the needle (1) for dripping liquid is the injection end, and the other end is the mounting end (101). The limiting structure is sleeved on the needle (1) and detachably connected to the mounting end (101). A plug (2) is fixedly provided at the end of the injection end. The plug (2) is hemispherical. The side wall of the injection end is provided with an injection hole (102) that connects the inner cavity of the injection end to the outside.

2. The intranasal drip needle for mice according to claim 1, characterized in that, The limiting structure includes a connecting part (3), a fixing part (4), and an abutting part (5) that can abut against the nose of a mouse. The connecting part (3) is sleeved on the needle (1) and detachably connected to the mounting end (101). The abutting part (5) can be sleeved on the needle (1) and connected to the connecting part (3). The position of the abutting part (5) on the connecting part (3) is adjustable. The fixing part (4) is installed on the connecting part (3) and connected to the abutting part (5) to fix the abutting part (5) on the connecting part (3).

3. The intranasal drip needle for mice according to claim 2, characterized in that, The outer wall of the mounting end (101) is provided with a first protrusion (6) and a positioning plate (7). When the connecting part (3) is sleeved on the needle (1), the first protrusion (6) and the inner cavity of the connecting part (3) are interference fit.

4. The intranasal drip needle for mice according to claim 3, characterized in that, The positioning plate (7) is provided with a positioning groove (701), and the side wall of the inner cavity of the connecting part (3) is provided with a second protrusion (8) that can extend into the inner cavity of the positioning groove (701) and a third protrusion (9) that can abut against the side of the positioning plate (7). The second protrusion (8) and the third protrusion (9) are fixed to the side wall of the inner cavity of the connecting part (3) in sequence.

5. A mouse intranasal drip needle according to claim 2, characterized in that, The outer surface of the connecting part (3) is provided with a threaded section (301), the abutting part (5) is threadedly connected to the threaded section (301), the side wall of the connecting part (3) is also provided with a receiving hole (302), the side wall of the abutting part (5) is provided with a positioning groove (501), the fixing part (4) is located in the receiving hole (302), one end of the fixing part (4) near the injection end is fixedly connected to the side wall of the receiving hole (302), and one end of the fixing part (4) away from the injection end is provided with a positioning protrusion (401) that can extend into the positioning groove (501).

6. The intranasal drip needle for mice according to claim 5, characterized in that, The fixing part (4) is provided with a scale.

7. The intranasal drip needle for mice according to claim 1, characterized in that, The axis of the injection hole (102) forms an angle of 15°-20° with the axis of the needle (1), and one end of the side wall of the injection hole (102) away from the inner cavity of the needle (1) is inclined toward the blocking part (2).

8. The intranasal drip needle for mice according to claim 7, characterized in that, The outer wall of the needle (1) is also provided with a flow guide groove (103), and the two ends of the flow guide groove (103) are respectively connected to the injection hole (102) and the plug (2).

9. A mouse intranasal drip needle according to claim 8, characterized in that, The sidewall of the needle (1) is 0.1mm-0.15mm and the inner diameter is 0.3mm-0.4mm. The diameter of the injection hole (102) is 0.3mm-0.4mm. There are two injection holes (102), and both injection holes (102) are located on the guide groove (103).

10. A mouse intranasal drip device, characterized in that, It includes a syringe (10) and a needle (1), wherein the needle (1) is a mouse intranasal drip needle as described in any one of claims 1-9, and the syringe (10) is connected to the mounting end (101).

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