An extraction device for the preparation of novel pharmaceutical intermediates

Abstract

The utility model belongs to the field of medicine extraction technology, and disclose a kind of extraction device of preparation new drug intermediate, including cylinder, cylinder bottom is fixed with discharge pipe, valve is installed on the discharge pipe, through the mutual cooperation of mixing disc, ring groove, toothed disc, L-shaped edge leaf and center leaf and other structures, two solutions are bifurcated first through ring groove, discharge into two sides, then meet and mix with opposite solution at the discharge port and discharge, complete preliminary mixing, again by cambered surface sliding block constantly extruding in the hole groove of reciprocating groove sleeve, make stirring rod do reciprocating movement and rotate simultaneously, inside area is stirred by toothed disc, L-shaped edge leaf then scrape off material in the inner cavity edge of cylinder, again cooperate with the center leaf of middle part continuous rotation, effectively cover the cross-sectional range of inner cavity of cylinder, even re-mix, extraction solution is doubly mixed after initial mixing and re-mixing, contact sufficiently, effectively improve extraction effect.

Description

Technical Field

[0001] This invention belongs to the field of drug extraction technology, specifically an extraction device for preparing novel drug intermediates. Background Technology

[0002] When preparing novel drug intermediates, laboratories typically use separatory funnels to extract the desired substance. By utilizing the different solubilities of the substance to be separated in two immiscible or slightly soluble solvents, the desired compound is extracted from one solvent, such as an aqueous phase, into another solvent, such as an organic phase, thereby separating it from impurities.

[0003] Existing technology document CN104001561A discloses a separatory funnel for extraction and an extraction instrument based on the separatory funnel. The separatory funnel includes a funnel body with a bottle mouth at the top. Its characteristic is that an outer auxiliary funnel body covers the funnel body, forming a cavity for the flow of a heating medium between the funnel body and the outer auxiliary funnel body. At least two heat medium inlets are provided on the outer auxiliary funnel body, and these inlets communicate with the cavity. This not only solves the problem of difficult extraction of petroleum products but also improves extraction efficiency. Although this device improves upon the traditional separatory funnel, during the extraction process, the experimenter still needs to manually shake the solution for extraction. It is difficult to achieve a highly consistent degree of mixing between the two phases in each experiment, which may lead to experimental errors and is detrimental to the stable preparation of intermediates for novel drugs. Utility Model Content

[0004] To address the problem in the aforementioned background technology that manual shaking of the solution for extraction makes it difficult to achieve a highly consistent degree of mixing between the two phases in each experiment, which may lead to experimental errors, this invention provides an extraction device for preparing novel pharmaceutical intermediates.

[0005] To achieve the above objectives, this utility model provides the following technical solution: an extraction device for preparing novel pharmaceutical intermediates, comprising a cylinder, wherein a discharge pipe is fixedly connected to the bottom of the cylinder, and a valve is installed on the discharge pipe, and further comprising: A double-blade stirring mechanism is located on the cylinder; A primary mixing mechanism, which is connected to a double-blade stirring mechanism; The initial mixing mechanism first performs primary mixing of the drug solution, and then, in conjunction with the double-blade stirring mechanism, stirs the inner and outer blades to complete the extraction of the drug.

[0006] Preferably, the double-blade stirring mechanism includes an electric motor fixed to the top of the cylinder, a main gear fixed to the output end of the electric motor, a secondary gear meshing with the outer wall of the main gear, and a reciprocating groove sleeve rotatably connected to the side wall of the secondary gear.

[0007] Preferably, the outer wall of the reciprocating groove sleeve is fixed to the top of the cylinder, and the inner cavity of the reciprocating groove sleeve is movably fitted with a stirring rod, which is slidably disposed in the groove of the reciprocating groove sleeve via an arc-shaped slider.

[0008] Preferably, the top of the stirring rod is provided with several vertical grooves, and the top of the stirring rod is slidably connected to the center of the auxiliary gear through the vertical grooves.

[0009] Preferably, a toothed disc and a central blade are fixedly connected to the bottom of the stirring rod, and a pair of L-shaped side blades are fixedly connected to the outer wall of the toothed disc, with the edges of the L-shaped side blades abutting against the inner cavity of the cylinder.

[0010] Preferably, a pair of liquid inlet pipes are fixedly connected to the top of the cylinder, and a mixing disc is fixedly connected to the inner side of the pair of liquid inlet pipes.

[0011] Preferably, the mixing disc has an annular groove in the middle, which is connected to the liquid inlet pipe, and a pair of discharge ports are provided at the bottom of the mixing disc.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: This invention utilizes the coordinated structure of a mixing disc, annular groove, toothed disc, L-shaped side blades, and central blades. Two solutions are introduced into the mixing disc through two inlet pipes. First, the solutions branch off through the annular groove, flowing to both sides. Then, they meet and mix with the opposite solution at the discharge port, exiting together and completing the initial mixing. Next, an arc-shaped slider continuously presses the solutions into the grooves of the reciprocating sleeve, causing the stirring rod to move up and down and rotate simultaneously. The toothed disc stirs the area closest to the stirring rod, while the L-shaped side blades scrape away any adhering substances from the inner cavity of the cylinder. Combined with the continuously rotating central blades, this effectively covers the cross-sectional area of ​​the inner cavity, uniformly remixing the two solutions within the cylinder. The extraction solution undergoes both mechanically driven initial and remixing, ensuring thorough contact and effectively improving the extraction effect. No manual shaking is required, thus increasing the accuracy of the extraction. Attached Figure Description

[0013] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is a schematic diagram showing the structural fit between the L-shaped side blade and the cylinder of this utility model; Figure 3 This is a schematic diagram showing the structural fit between the mixing disc and the reciprocating groove sleeve of this utility model; Figure 4 This is a schematic diagram showing the structural fit between the auxiliary gear and the stirring rod of this utility model; Figure 5 This is a schematic diagram showing the structural fit between the arc-shaped slider and the reciprocating groove sleeve of this utility model; Figure 6This is a schematic diagram showing the structural fit between the annular groove and the mixing disk of this utility model.

[0014] In the diagram: 1. Cylinder; 2. Valve; 3. Discharge pipe; 4. Double-blade stirring mechanism; 401. Motor; 402. Main gear; 403. Secondary gear; 404. Stirring rod; 405. Vertical groove; 406. L-shaped side blade; 407. Gear disc; 408. Central blade; 409. Reciprocating sleeve; 4010. Arc-shaped slider; 5. Initial mixing mechanism; 501. Liquid inlet pipe; 502. Mixing disc; 503. Discharge port; 504. Annular groove. Detailed Implementation

[0015] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0016] like Figures 1 to 6 As shown, this utility model provides an extraction device for preparing novel pharmaceutical intermediates, including a cylinder 1, with a discharge pipe 3 fixedly connected to the bottom of the cylinder 1, and a valve 2 installed on the discharge pipe 3, and further including: The double-blade stirring mechanism 4 is located on the cylinder 1; The primary mixing mechanism 5 is connected to the double-blade stirring mechanism 4; The primary mixing mechanism 5 first performs primary mixing of the drug solution, and then, in conjunction with the double-blade stirring mechanism 4, stirs the inner and outer blades to complete the extraction of the drug.

[0017] The above scheme utilizes a two-stage synergistic effect of pre-mixing mechanism 5 and double-blade stirring mechanism 4 to achieve efficient and uniform extraction of the drug solution. The cylinder 1 provides the container space for mixing and separation. After clear stratification, the operator can precisely and controllably discharge the lower liquid phase through valve 2 on the discharge pipe 3 located at the bottom of the cylinder 1, ensuring clear and complete separation of the two phases, thereby efficiently collecting the extract phase rich in the target drug intermediate.

[0018] like Figures 2 to 4As shown, the double-blade stirring mechanism 4 includes a motor 401 fixed to the top of the cylinder 1. A main gear 402 is fixed to the output end of the motor 401. A secondary gear 403 meshes with the outer wall of the main gear 402. A reciprocating sleeve 409 is rotatably connected to the side wall of the secondary gear 403. The outer wall of the reciprocating sleeve 409 is fixed to the top of the cylinder 1. A stirring rod 404 is movably fitted inside the reciprocating sleeve 409. The stirring rod 404 slides in the slot of the reciprocating sleeve 409 through an arc-shaped slider 4010. Several vertical slots 405 are opened on the top of the stirring rod 404. The top of the stirring rod 404 is slidably connected to the center of the secondary gear 403 through the vertical slots 405. A gear disk 407 and a central blade 408 are fixed to the bottom of the stirring rod 404. A pair of L-shaped side blades 406 are fixed to the outer wall of the gear disk 407. The edges of the L-shaped side blades 406 abut against the inner cavity of the cylinder 1.

[0019] The above scheme employs a method where the constant rotational speed provided by the electric motor 401 is transmitted to the stirring rod 404 via the main gear 402, generating a basic rotational shear force that efficiently breaks up liquid clumps and promotes liquid convection. Simultaneously, a specific curved groove on the fixed reciprocating sleeve 409 engages with the arc-shaped slider 4010 mounted on the stirring rod 404, adding a regular axial reciprocating stroke to the rotational motion of the stirring rod 404. The engagement of the vertical groove 405 with the secondary gear 403 critically restricts the circumferential freedom of the stirring rod 404, ensuring that it can only slide axially while rotating synchronously with the main gear 402, preventing torsional failure or disengagement from the drive system. This superposition of rotation and reciprocating motion allows the end of the stirring rod 404 to trace a constantly changing trajectory within the cylinder 1, thereby generating partial eddies, shearing, and axial pumping effects in the solution, improving mass transfer efficiency and extraction rate.

[0020] like Figures 3 to 6 As shown, a pair of liquid inlet pipes 501 are fixedly connected to the top of the cylinder 1, and a mixing disc 502 is fixedly connected to the inner side of the pair of liquid inlet pipes 501; an annular groove 504 is opened in the middle of the mixing disc 502, the annular groove 504 is connected to the liquid inlet pipes 501, and a pair of discharge ports 503 are opened at the bottom of the mixing disc 502.

[0021] The above scheme utilizes an annular groove 504 within the mixing disc 502 to effectively disperse and guide the two liquid streams to the disc edge, forcing them to flow along an annular path. During this process, the kinetic energy of the liquid streams is partially dissipated, and the flow velocity tends to be balanced, avoiding violent splashing or excessively high local concentrations that might result from direct collision. When the two liquid streams finally converge at their respective discharge ports 503, they collide and initially mix at a relatively gentle speed and with a large contact area, laying a good foundation for subsequent deep homogenization reactions within the cylinder 1.

[0022] Working principle and usage process of this utility model: Firstly, the laboratory preparation of novel drug intermediates typically employs extraction. Two solutions are introduced into a mixing dish 502 through two separate inlet pipes 501. The solutions first branch off through an annular groove 504, flowing to opposite sides. Then, they meet and mix with the opposite solution at the discharge port 503, and both are discharged from the discharge port 503. Figure 5 As indicated by the arrow, the two solutions are initially mixed in this way, and when they fall into the inner cavity of cylinder 1, they can be evenly distributed, which is beneficial for sufficient contact during remixing. After initial mixing, the motor 401 drives the main gear 402 to rotate, which in turn drives the centrally positioned stirring rod 404 to rotate synchronously. As the stirring rod 404 rotates, it is continuously pressed into the groove of the reciprocating sleeve 409 by the arc-shaped slider 4010. Since the reciprocating sleeve 409 is stationary, the arc-shaped slider 4010 drives the stirring rod 404 to move up and down reciprocally. The vertical groove 405 ensures that the stirring rod 404 does not slip off the secondary gear 403. While the stirring rod 404 moves up and down and rotates simultaneously, the gear disc 407 stirs the area closest to the stirring rod 404, and the L-shaped side blades 406 scrape away any solution adhering to the inner cavity of the cylinder 1. Combined with the continuously rotating central blade 408, this effectively covers the cross-sectional area of ​​the inner cavity of the cylinder 1, uniformly mixing the two solutions within the cylinder 1 and improving the extraction effect. After mixing is complete, the intermediate solution can be extracted, typically resulting in stratification. After standing for a period of time until the solution has completely separated into layers, valve 2 can be opened to allow the lower layer solution to drain first, thus completing the extraction and separation process.

[0023] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0024] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An extraction apparatus for preparing novel pharmaceutical intermediates, comprising a cylindrical body (1), wherein a discharge pipe (3) is fixedly connected to the bottom of the cylindrical body (1), and a valve (2) is installed on the discharge pipe (3), characterized in that, Also includes: A double-blade stirring mechanism (4) is located on the cylinder (1); The initial mixing mechanism (5) is connected to the double-blade stirring mechanism (4); The initial mixing mechanism (5) first mixes the drug solution, and then the double-blade stirring mechanism (4) stirs the inner and outer blades to complete the extraction of the drug.

2. The extraction apparatus for preparing novel pharmaceutical intermediates according to claim 1, characterized in that: The double-blade stirring mechanism (4) includes an electric motor (401) fixed to the top of the cylinder (1). The output end of the electric motor (401) is fixed to a main gear (402). The outer wall of the main gear (402) is meshed with a secondary gear (403). The side wall of the secondary gear (403) is rotatably connected to a reciprocating sleeve (409).

3. The extraction apparatus for preparing novel pharmaceutical intermediates according to claim 2, characterized in that: The outer wall of the reciprocating sleeve (409) is fixed to the top of the cylinder (1). The inner cavity of the reciprocating sleeve (409) is movably fitted with a stirring rod (404). The stirring rod (404) is slidably disposed in the slot of the reciprocating sleeve (409) through an arc-shaped slider (4010).

4. The extraction apparatus for preparing novel pharmaceutical intermediates according to claim 3, characterized in that: The top of the stirring rod (404) is provided with several vertical grooves (405), and the top of the stirring rod (404) is slidably connected to the center of the auxiliary gear (403) through the vertical grooves (405).

5. The extraction apparatus for preparing novel pharmaceutical intermediates according to claim 4, characterized in that: The bottom of the stirring rod (404) is fixedly connected to a toothed disc (407) and a central blade (408). A pair of L-shaped side blades (406) are fixedly connected to the outer wall of the toothed disc (407). The edges of the L-shaped side blades (406) abut against the inner cavity of the cylinder (1).

6. The extraction apparatus for preparing novel pharmaceutical intermediates according to claim 5, characterized in that: The top of the cylinder (1) is fixedly connected to a pair of liquid inlet pipes (501), and a mixing disc (502) is fixedly connected to the inner side of the pair of liquid inlet pipes (501).

7. The extraction apparatus for preparing novel pharmaceutical intermediates according to claim 6, characterized in that: The mixing disc (502) has an annular groove (504) in the middle, which is connected to the liquid inlet pipe (501). The bottom of the mixing disc (502) has a pair of discharge ports (503).

Images