Amphotericin B liposome preparation microfiltration filter device

Abstract

The utility model relates to liposome preparation filter device technical field especially is a kind of amphotericin B liposome preparation and uses microfiltration filter device, including filter bucket, the top of filter bucket is provided with cover plate, cover plate and filter bucket between are provided with sealing ring, the outside of filter bucket is evenly provided with several openings, the fast detachable assembly for quick replacement filter unit is provided in opening, the bottom of filter bucket is fixedly connected with discharge gate. The utility model is driven third connecting block and first connecting plate together to rotate outward by outward wrenching second connecting plate, in turn drive the cam of third connecting block both ends together to rotate, the principle of cam mechanism is second connecting plate missing extrusion pressure to sealing plate at this time to make sealing plate loose, by pulling out the one end of connecting rod in first connecting block and rotating sealing plate outward to expose opening, move ring sleeve in opening and the filter membrane of inboard fixed connection outward and replace or flush.

Description

Technical Field

[0001] This utility model relates to the technical field of lipid system filtration devices, and in particular to a backup microfiltration device for amphotericin B lipid system. Background Technology

[0002] Liposome amphotericin B is an antifungal drug that works by disrupting the fungal cell membrane. It is mainly used to treat severe systemic fungal infections, especially for patients with renal insufficiency or those who are intolerant to conventional amphotericin B treatment. The core objective is to significantly reduce its severe toxic side effects while maintaining strong antibacterial efficacy. The drug reduces nephrotoxicity through liposome encapsulation.

[0003] Existing technologies typically use only a single filtration unit to filter lipids, which not only fails to ensure stable filtration results, but also requires a significant amount of time and manpower to disassemble when the filtration unit becomes clogged, severely impacting production efficiency. Utility Model Content

[0004] This utility model addresses the shortcomings of existing technologies by providing the following technical solution:

[0005] A microfiltration device for the preparation of amphotericin B lipid system includes a filter barrel, a cover plate on the top of the filter barrel, a sealing ring between the cover plate and the filter barrel, a plurality of openings evenly distributed on the outer side of the filter barrel, a quick-release assembly for quick replacement of the filter unit being provided in the opening, and a discharge port fixedly connected to the bottom of the filter barrel.

[0006] As an improvement to the above technical solution, the quick-release assembly includes a fixing plate fixedly connected to the outside of the filter barrel, a fourth connecting block fixedly connected to one end of the fixing plate, the fourth connecting block being rotatably connected to the inner side of one end of the fixing member, a rotating shaft being provided between the fourth connecting block and the fixing member, and the same fourth connecting block being rotatably connected to the other end of the fixing member, the fourth connecting block being fixedly connected to one end of the sealing plate.

[0007] As an improvement to the above technical solution, a second connecting block is fixedly connected to the other end of the sealing plate. Cams are symmetrically rotatably connected to both ends of the second connecting block. A first connecting plate is fixedly connected to the outer side of the cams. A third connecting block is fixedly connected to the other end of the first connecting plate. A second connecting plate is fixedly connected to the outer side of the third connecting block. A first connecting rod is fixedly connected to both ends of the third connecting block. The other end of the first connecting rod is disposed inside the first connecting block. The first connecting block is fixedly connected to the other end of the fixing plate.

[0008] As an improvement to the above technical solution, a flow guide line is provided on the inner side of the filter barrel, and a temperature control pipe is provided inside the filter barrel.

[0009] As an improvement to the above technical solution, a buffer cavity is fixedly connected to the top of the cover plate, a feed inlet is fixedly connected to the top of the buffer cavity, and arc-shaped baffles are fixedly connected at equal intervals on the inner circumference of the buffer cavity.

[0010] As an improvement to the above technical solution, the quick-release assembly is provided with a ring sleeve, a first filter membrane is provided inside the ring sleeve, a second filter membrane is provided below the first filter membrane, and a third filter membrane is provided below the second filter membrane.

[0011] The beneficial effects of this utility model are:

[0012] When any filter membrane needs to be replaced, the second connecting plate is moved outward, causing the third connecting block and the first connecting plate to rotate outward together. This causes the cams at both ends of the third connecting block to rotate as well. The cams and the connection structure of the first connecting plate, the second connecting block, the third connecting block, and the second connecting plate form a cam mechanism. Utilizing the principle of the cam mechanism, the second connecting plate lacks the squeezing force on the sealing plate, causing the sealing plate to loosen. The end of the connecting rod that is engaged in the first connecting block is pulled outward, and the sealing plate is rotated outward to expose the opening. The ring and the filter membrane fixedly connected to the inner side of the opening are moved outward for replacement or flushing. After reinstalling the filter membrane, the reverse operation is performed: first, the connecting rod is engaged in the first connecting block, then the second connecting plate is pressed inward, causing the second connecting plate to rotate together with the third connecting block. Utilizing the cam principle, the second connecting plate squeezes the sealing plate, making it fit tightly against the opening to ensure a tight seal and fix the filter membrane. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the structure of this utility model;

[0014] Figure 2 This is a schematic diagram of the flow guide line in this utility model;

[0015] Figure 3 This is a schematic diagram of the quick-release component in this utility model;

[0016] Figure 4 This is a schematic diagram of the structure of the fixing component in this utility model;

[0017] Figure 5 This is a schematic diagram of the arc-shaped baffle in this utility model;

[0018] Figure 6 This is a schematic diagram of the ring sleeve in this utility model.

[0019] Reference numerals: 1. Filter barrel; 2. Cover plate; 3. Sealing ring; 4. Feed inlet; 5. Buffer chamber; 6. Discharge outlet; 7. Fixing plate; 8. First connecting block; 9. Connecting rod; 10. Cam; 11. Sealing plate; 12. Second connecting block; 13. First connecting plate; 14. Second connecting plate; 15. Third connecting block; 16. Fixing component; 17. Fourth connecting block; 18. Rotating shaft; 19. Opening; 20. Guide line; 21. Temperature control tube; 22. Arc-shaped baffle; 23. Ring sleeve; 24. First filter membrane; 25. Second filter membrane; 26. Third filter membrane. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of this utility model clearer, the following provides a more detailed description of the utility model. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of the utility model.

[0021] Please refer to Figures 1-6 A microfiltration device for the preparation of amphotericin B lipid system includes a filter barrel 1, a cover plate 2 on the top of the filter barrel 1, a sealing ring 3 between the cover plate 2 and the filter barrel 1, a plurality of openings 19 evenly opened on the outside of the filter barrel 1, a quick-release component for quick replacement of the filter unit is provided in the opening 19, and a discharge port 6 is fixedly connected to the bottom of the filter barrel 1.

[0022] Specifically, the cover plate 2 strengthens the sealing between itself and the filter barrel 1 through the externally set sealing ring 3. The filter unit can be quickly replaced through the quick-release assembly, which enhances the production effect and reduces downtime. The discharge port 6 at the bottom of the filter barrel 1 is an inverted cone shape, so that the liquid can flow completely to the outlet along the conical slope and avoid dead corners.

[0023] Please refer to Figures 1-6 The quick-release assembly includes a fixing plate 7 fixedly connected to the outside of the filter barrel 1. A fourth connecting block 17 is fixedly connected to one end of the fixing plate 7. The fourth connecting block 17 is rotatably connected to the inside of one end of the fixing member 16. A rotating shaft 18 is provided between the fourth connecting block 17 and the fixing member 16. The same fourth connecting block 17 is rotatably connected to the other end of the fixing member 16. The fourth connecting block 17 is fixedly connected to one end of the sealing plate 11. A second connecting block 12 is fixedly connected to the other end of the sealing plate 11. Cams 10 are symmetrically rotatably connected to both ends of the second connecting block 12. A first connecting plate 13 is fixedly connected to the outside of the cam 10. A third connecting block 15 is fixedly connected to the other end of the first connecting plate 13. A second connecting plate 14 is fixedly connected to the outside of the third connecting block 15. A first connecting rod 9 is fixedly connected to both ends of the third connecting block 15. The other end of the first connecting rod 9 is located inside the first connecting block 8. The first connecting block 8 is fixedly connected to the other end of the fixing plate 7.

[0024] Specifically, by pulling the second connecting plate 14 outward, the third connecting block 15 and the first connecting plate 13 rotate outward together, which in turn drives the cams 10 at both ends of the third connecting block 15 to rotate together. The connection structure of the cams 10, the first connecting plate 13, the second connecting block 12, the third connecting block 15, and the second connecting plate 14 forms a cam mechanism. Utilizing the principle of the cam mechanism, the second connecting plate 14 lacks the pressure on the sealing plate 11, causing the sealing plate 11 to loosen. By pulling the connecting rod 9 outward, it engages with the first connecting block. One end of the connecting rod 9, which is engaged with the first connecting block 8, is made of a material that can deform to a certain extent. The sealing plate 11 is rotated outward to expose the opening 19. The filter unit in the opening 19 is replaced and installed. Then, the reverse operation is performed. First, the connecting rod 9 is engaged in the first connecting block 8. Then, the second connecting plate 14 is pressed inward and the second connecting plate 14 drives the third connecting block 15 to rotate together. With the help of the cam principle, the sealing plate 11 is squeezed by the second connecting plate 14 to make it fit tightly with the opening 19 to ensure the seal.

[0025] Please refer to Figures 1-6 A flow guide line 20 is provided inside the filter barrel 1, and a temperature control pipe 21 is provided inside the filter barrel 1.

[0026] Specifically, the spiral guide line 20 allows the liposome feed solution to flow evenly along the guide line 20 to the surface of the filter unit, avoiding local blockage of the filter unit caused by excessively high local feed concentration and improving filtration uniformity. At the same time, the temperature control pipe 21 set inside the filter tank 1 maintains the stable temperature of the feed solution inside the filter tank 1, avoiding liposome demulsification caused by temperature fluctuations. Circulating low-temperature water is introduced into the temperature control pipe 21.

[0027] Please refer to Figures 1-6 A buffer chamber 5 is fixedly connected to the top of the cover plate 2, and a feed inlet 4 is fixedly connected to the top of the buffer chamber 5. Arc-shaped baffles 22 are fixedly connected at equal intervals on the inner circumference of the buffer chamber 5.

[0028] Specifically, the buffer chamber 5 has a spherical structure, and several arc-shaped baffles 22 are evenly arranged inside the buffer chamber 5. The flow rate of the feed liquid is slowed down by the combination of the buffer chamber 5 and the arc-shaped baffles 22, thereby reducing the shear damage to the liposome bilayer membrane caused by high-speed feeding.

[0029] Please refer to Figures 1-6 The quick-release assembly is provided with a ring 23, a first filter membrane 24 is provided inside the ring 23, a second filter membrane 25 is provided below the first filter membrane 24, and a third filter membrane 26 is provided below the second filter membrane 25.

[0030] Specifically, the first filter membrane 24 is a pre-filtration membrane that removes any trace amounts of larger particles or crystals that may be present. The second filter membrane 25 is the main filter membrane, used for core sterilization and determining the final particle size. The third filter membrane 26 is a safety device for the second filter membrane 25, used to ensure the filtration results.

[0031] The above embodiments are only used to illustrate the technical solution of this utility model, and are not intended to limit it.

Claims

1. A microfiltration device for the preparation of amphotericin B lipid system, comprising a filter barrel (1), characterized in that: The top of the filter barrel (1) is provided with a cover plate (2), and a sealing ring (3) is provided between the cover plate (2) and the filter barrel (1). Several openings (19) are evenly opened on the outside of the filter barrel (1). A quick-release assembly for quick replacement of the filter unit is provided in the opening (19). The bottom of the filter barrel (1) is fixedly connected with a discharge port (6).

2. The microfiltration device for the amphotericin B lipid system according to claim 1, characterized in that: The quick-release assembly includes a fixing plate (7) fixedly connected to the outside of the filter barrel (1). A fourth connecting block (17) is fixedly connected to one end of the fixing plate (7). The fourth connecting block (17) is rotatably connected to the inner side of one end of the fixing member (16). A rotating shaft (18) is provided between the fourth connecting block (17) and the fixing member (16). The same fourth connecting block (17) is rotatably connected to the other end of the fixing member (16). The fourth connecting block (17) is fixedly connected to one end of the sealing plate (11).

3. The microfiltration device for the amphotericin B lipid system according to claim 2, characterized in that: The other end of the sealing plate (11) is fixedly connected to a second connecting block (12). The two ends of the second connecting block (12) are symmetrically rotatably connected to cams (10). The outer side of the cam (10) is fixedly connected to a first connecting plate (13). The other end of the first connecting plate (13) is fixedly connected to a third connecting block (15). The outer side of the third connecting block (15) is fixedly connected to a second connecting plate (14). Both ends of the third connecting block (15) are fixedly connected to a first connecting rod (9). The other end of the first connecting rod (9) is located inside the first connecting block (8). The first connecting block (8) is fixedly connected to the other end of the fixing plate (7).

4. The microfiltration device for the amphotericin B lipid system according to claim 1, characterized in that: The filter barrel (1) is provided with a flow guide line (20) on the inside and a temperature control tube (21) is provided inside the filter barrel (1).

5. The microfiltration device for the amphotericin B lipid system according to claim 1, characterized in that: The top of the cover plate (2) is fixedly connected to a buffer cavity (5), the top of the buffer cavity (5) is fixedly connected to a feed inlet (4), and the inner circumference of the buffer cavity (5) is fixedly connected to an arc-shaped baffle (22).

6. The microfiltration device for the amphotericin B lipid system according to claim 1, characterized in that: The quick-release assembly is provided with a ring (23), a first filter membrane (24) is provided inside the ring (23), a second filter membrane (25) is provided below the first filter membrane (24), and a third filter membrane (26) is provided below the second filter membrane (25).

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