A pharmaceutical experimental dissolving device

Abstract

The utility model discloses a kind of pharmaceutical experiment dissolving devices, it is related to experimental dissolving equipment technical field.The lower side inner wall of equipment frame is fixedly connected with power supply and control module, the upper side inner wall of support frame is fixedly connected with auxiliary motor, the output end of auxiliary motor is through the upper side wall of support frame and is connected with bottom support mechanism, and the upper portion of the bottom mechanism is provided with dissolving bottle and top limiting mechanism.Dissolving bottle is supported and bottom limiting by being provided with bottom support mechanism in device, while the upper end position of dissolving bottle is limited by using top limiting mechanism, then cooperate auxiliary motor to realize the shaking operation of dissolving bottle, and then medicament dissolving operation can be carried out;The present device uses conical flask as dissolving bottle, without replacing dissolving container after dissolving, and then effectively solve the problem that traditional device needs to frequently transfer solution, reduce sample loss, pollution risk and concentration deviation, improve experimental result accuracy.

Description

Technical Field

[0001] This utility model relates to the field of experimental dissolution equipment technology, and in particular to a pharmaceutical experimental dissolution device. Background Technology

[0002] In drug development and testing, drug dissolution is a fundamental and crucial step, directly impacting the accuracy and reliability of subsequent experimental results such as efficacy evaluation, component analysis, and dosage form development. Whether it's solvent dissolution of solid drugs, dilution and mixing of liquid drugs, or homogenization of suspensions, all processes must be carried out under stable and controllable conditions to ensure that the solute is fully dissolved and forms a homogeneous solution system.

[0003] Currently, existing drug dissolving devices have certain limitations in practical applications. Most traditional dissolving devices are equipped with dedicated dissolving cylinders as containers, but they are poorly adapted to Erlenmeyer flasks commonly used in pharmaceutical experiments. In experimental operations, researchers often prefer to use Erlenmeyer flasks as dissolving containers for ease of sampling, transfer, and compatibility with other experimental instruments. However, existing dissolving devices cannot directly and stably fix Erlenmeyer flasks for efficient dissolution. This forces researchers to first dissolve the drug in a dedicated dissolving cylinder and then transfer the solution to the Erlenmeyer flask. This process not only increases the complexity of the operation and prolongs the experimental time, but more importantly, frequent solution transfers can easily lead to sample loss, increased risk of contamination, and concentration deviations, adversely affecting the accuracy of experimental results.

[0004] Therefore, this application proposes a pharmaceutical experimental dissolution device to solve the above problems. Utility Model Content

[0005] The purpose of this invention is to provide a pharmaceutical experimental dissolution device that solves the technical problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a pharmaceutical experimental dissolution device, comprising an equipment frame, the equipment frame being L-shaped, a power supply and a control module being fixedly connected to the lower inner wall of the equipment frame, a support frame being provided above the power supply, the rear end of the upper side wall of the support frame being fixedly connected to the rear inner wall of the equipment frame, an auxiliary motor being fixedly connected to the upper inner wall of the support frame, the output end of the auxiliary motor penetrating through the upper side wall of the support frame and connected to a bottom support mechanism, a dissolution bottle and a top limiting mechanism being provided above the bottom support mechanism, and an operation screen being provided at the front end of the support frame; The bottom support mechanism includes a fixed frame and a telescopic rod. The telescopic rod is L-shaped, and its horizontal bar extends into the fixed frame. The lower end of the fixed frame is fixedly connected to the output end of the auxiliary motor. A locking bolt is provided on the outside of the fixed frame. The end of the locking bolt near the fixed frame passes through the side wall of the fixed frame and abuts against the side wall of the telescopic rod. The locking bolt is threadedly connected to the side wall of the fixed frame.

[0007] Preferably, the telescopic rod is L-shaped, and a support cylinder is fixedly connected to the upper end of the longitudinal side wall of the telescopic rod. The lower end of the dissolving bottle extends to the inner side of the support cylinder, and the lower side wall of the support cylinder is inclined downward on the side near the output end of the auxiliary motor.

[0008] Preferably, an electric heating plate is provided inside the lower side wall of the support cylinder, and several abutment rubber rings are fixedly connected to the inner side wall of the support cylinder.

[0009] Preferably, the top limiting mechanism includes a sliding plate and two auxiliary plates. The rear end of the sliding plate is located between the two auxiliary plates. A limiting slide is provided on the rear side wall of the equipment frame. The limiting slide is located between the two auxiliary plates. The front end of the sliding plate passes through the limiting slide and is hinged to a connecting plate. A rubber band is fixedly connected to the end of the connecting plate away from the sliding plate. A limiting outer ring is fixedly connected to the front end of the rubber band. The upper end of the dissolving bottle extends to the inner side of the limiting outer ring. An abutting rubber ring is rotatably connected to the lower end of the limiting outer ring. The inner diameter of the abutting rubber ring is smaller than the inner diameter of the limiting outer ring. The inner wall of the abutting rubber ring abuts against the outer wall of the dissolving bottle.

[0010] Preferably, a limiting slide rod is fixedly connected to the upper end of the lower auxiliary plate. The upper end of the limiting slide rod passes through the sliding plate and is connected to the lower end of the top auxiliary plate. An abutment spring is sleeved on the limiting slide rod. The upper and lower ends of the abutment spring are fixedly connected to the lower end of the upper auxiliary plate and the upper end of the sliding plate, respectively.

[0011] Preferably, the control module includes a controller and a temperature regulation module. The temperature regulation module is electrically connected to the operation panel, and a temperature detection sensor is provided at the position of the electric heating plate. The temperature detection sensor is electrically connected to the controller.

[0012] Compared with related technologies, the pharmaceutical experimental dissolution device provided by this utility model has the following beneficial effects: 1. This utility model provides a pharmaceutical experimental dissolution device. The device is equipped with a bottom support mechanism to support and limit the bottom of the dissolution bottle, and a top limiting mechanism to limit the upper position of the dissolution bottle. In addition, an auxiliary motor is used to shake the dissolution bottle, thereby enabling the dissolution of the reagent. This device uses a conical flask as the dissolution bottle, eliminating the need to change the dissolution container after dissolution. This effectively solves the problem of frequent solution transfer required by traditional devices, reduces sample loss, risk of contamination and concentration deviation, and improves the accuracy of experimental results.

[0013] 2. This utility model provides a pharmaceutical experimental dissolution device. The distance between the support cylinder and the output end of the auxiliary motor is adjusted by adjusting the position of the fixed frame and the telescopic rod in the bottom support mechanism, thereby adjusting the amplitude of shaking of the dissolution bottle; at the same time, the setting of the top limiting mechanism ensures the stability of the dissolution bottle during shaking.

[0014] 3. This utility model provides a pharmaceutical experimental dissolution device, which has an electric heating plate at the bottom of the support cylinder. During the dissolution process, the temperature of the dissolution bottle is raised and controlled to increase the dissolution speed. At the same time, the device is also equipped with an auxiliary stirring rod. When the dissolution bottle is accelerated by shaking, the auxiliary stirring rod is put into the dissolution bottle. The collision between the liquid and the auxiliary stirring rod further increases the dissolution speed. Attached Figure Description

[0015] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is a cross-sectional structural diagram of the present invention; Figure 3 for Figure 2 Enlarged view of a portion of point A in the middle; Figure 4 This is a three-dimensional structural diagram of the top limiting mechanism of this utility model; Figure 5 This is a schematic diagram of the planar structure of the bottom support mechanism of this utility model; Figure 6 This is a cross-sectional three-dimensional structural diagram of the bottom support mechanism of this utility model.

[0016] In the diagram: 1. Equipment frame; 2. Support frame; 3. Operation panel; 4. Power supply; 5. Control module; 6. Auxiliary motor; 7. Bottom support mechanism; 71. Fixed frame; 72. Telescopic rod; 73. Locking bolt; 74. Support cylinder; 75. Abutting rubber ring; 8. Dissolving bottle; 9. Limiting slide; 10. Top limiting mechanism; 101. Auxiliary plate; 102. Sliding plate; 103. Limiting slide rod; 104. Abutting spring; 105. Connecting plate; 106. Rubber belt; 107. Limiting outer ring; 108. Contact rubber ring; 11. Spring rope; 12. Auxiliary stirring rod; 13. Electric heating plate. Detailed Implementation

[0017] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the protection scope of the present utility model.

[0018] Please see Figures 1-6 This utility model provides a technical solution: a pharmaceutical experimental dissolution device, including a device frame 1, which is L-shaped. A power supply 4 and a control module 5 are fixedly connected to the lower inner wall of the device frame 1. A support frame 2 is provided above the power supply 4. The rear end of the upper side wall of the support frame 2 is fixedly connected to the rear inner wall of the device frame 1. An auxiliary motor 6 is fixedly connected to the upper inner wall of the support frame 2. The output end of the auxiliary motor 6 passes through the upper side wall of the support frame 2 and is connected to a bottom support mechanism 7. A dissolution bottle 8 and a top limiting mechanism 10 are provided above the bottom support mechanism 7. The dissolution bottle 8 is an experimental conical flask. An operation screen 3 is provided at the front end of the support frame 2. The bottom support mechanism 7 includes a fixed frame 71 and a telescopic rod 72. The telescopic rod 72 is L-shaped, and its horizontal bar extends into the fixed frame 71. The lower end of the fixed frame 71 is fixedly connected to the output end of the auxiliary motor 6. A locking bolt 73 is provided on the outside of the fixed frame 71. One end of the locking bolt 73 near the fixed frame 71 passes through the side wall of the fixed frame 71 and abuts against the side wall of the telescopic rod 72. The locking bolt 73 is threadedly connected to the side wall of the fixed frame 71. By adjusting the position of the telescopic rod 72 and the fixed frame 71, the distance between the support cylinder 74 and the output end of the auxiliary motor 6 can be adjusted, thereby adjusting the amplitude of shaking of the dissolving bottle 8. The telescopic rod 72 is L-shaped, and a support cylinder 74 is fixedly connected to the upper end of the longitudinal side wall of the telescopic rod 72. The lower end of the dissolving bottle 8 extends to the inner side of the support cylinder 74, and the lower side wall of the support cylinder 74 is inclined downward on the side near the output end of the auxiliary motor 6. An electric heating plate 13 is installed inside the lower side wall of the support cylinder 74. During the dissolution process, the temperature of the dissolution bottle 8 is raised and controlled, thereby increasing the dissolution speed. Several abutting rubber rings 75 are fixedly connected to the inner side wall of the support cylinder 74. When the dissolution bottle 8 is placed inside the support cylinder 74, the inner end of the abutting rubber ring 75 abuts against the outer side wall of the dissolution bottle 8, thereby cooperating with the top limiting mechanism 10 to improve the stability of the dissolution bottle 8. The top limiting mechanism 10 includes a sliding plate 102 and two auxiliary plates 101. The rear end of the sliding plate 102 is located between the two auxiliary plates 101. A limiting slide 9 is provided on the rear side wall of the equipment frame 1, located between the two auxiliary plates 101. The front end of the sliding plate 102 passes through the limiting slide 9 and is hinged to a connecting plate 105. A rubber band 106 is fixedly connected to the end of the connecting plate 105 away from the sliding plate 102. A limiting outer ring 107 is fixedly connected to the front end of the rubber band 106. The upper end of the dissolving bottle 8 extends to the inner side of the limiting outer ring 107. A rubber abutment ring 75 is rotatably connected to the lower end of the limiting outer ring 107. The inner diameter of the rubber abutment ring 75 is smaller than the inner diameter of the limiting outer ring 107. The inner wall of the rubber abutment ring 75 abuts against the outer wall of the dissolving bottle 8. The upper end of the lower auxiliary plate 101 is fixedly connected to the limiting slide rod 103. The upper end of the limiting slide rod 103 passes through the sliding plate 102 and is connected to the lower end of the top auxiliary plate 101. The limiting slide rod 103 is fitted with an abutment spring 104. The upper and lower ends of the abutment spring 104 are fixedly connected to the lower end of the upper auxiliary plate 101 and the upper end of the sliding plate 102, respectively. The limiting outer ring 107 and the contact rubber ring 108 are fitted on the upper end of the dissolving bottle 8. The inner end of the contact rubber ring 108 abuts against the outer wall of the dissolving bottle 8. Under the action of the abutment spring 104, the contact rubber ring 108 and the limiting outer ring 107 apply a downward force to the dissolving bottle 8. In conjunction with the bottom support mechanism 7, the position of the dissolving bottle 8 is restricted, thereby ensuring the stability of the dissolving bottle 8 during shaking. A spring rope 11 is fixedly connected to the upper end of the limiting outer ring 107. An auxiliary stirring rod 12 is fixedly connected to the end of the spring rope 11 away from the limiting outer ring 107. The lower end of the auxiliary stirring rod 12 extends into the dissolving bottle 8. When the auxiliary motor 6 drives the bottom support mechanism 7 to shake, the auxiliary stirring rod 12 is inserted into the dissolving bottle 8. During the shaking process to accelerate dissolution, the solution collides with the auxiliary stirring rod 12 to further increase the dissolution speed. The control module 5 includes a controller and a temperature regulation module. The temperature regulation module is electrically connected to the operation panel 3. A temperature detection sensor is installed at the position of the electric heating plate 13, and the temperature detection sensor is electrically connected to the controller.

[0019] Working principle: In use, place the material to be dissolved into the dissolving bottle 8, loosen the locking bolt 73, and adjust the position of the telescopic rod 72 and the fixing frame 71 to adjust the distance between the support cylinder 74 and the output end of the auxiliary motor 6, thereby adjusting the shaking amplitude of the dissolving bottle 8; after position adjustment, tighten the locking bolt 73, place the dissolving bottle 8 containing the reagent to be dissolved into the support cylinder 74, with the lower end of the dissolving bottle 8 abutting against the lower inner wall of the support cylinder 74, and several abutting rubber rings 75 abutting against the outer wall of the dissolving bottle 8, while simultaneously setting the limiting outer ring 107 and the contact rubber ring 108. The rubber ring 108, fitted onto the upper end of the dissolving bottle 8, abuts against the outer wall of the dissolving bottle 8. Under the action of the abutment spring 104, the rubber ring 108 and the limiting outer ring 107 apply a downward force to the dissolving bottle 8. This, in conjunction with the bottom support mechanism 7, restricts the position of the dissolving bottle 8, ensuring its stability during shaking. Simultaneously, when the bottom support mechanism 7 is shaken by the auxiliary motor 6, the auxiliary stirring rod 12 is inserted into the dissolving bottle 8. During the shaking process, the solution collides with the auxiliary stirring rod 12, further increasing the dissolving speed. The shaking time and the rotation speed of the auxiliary motor 6 are set on the operation screen 3. During shaking, the auxiliary motor 6 operates by rotating in both forward and reverse directions. The liquid in the dissolving bottle 8 is more easily agitated during the rotation of the auxiliary motor 6, facilitating the dissolution of the reagent. An electric heating plate 13 is installed at the bottom of the support cylinder 74. During the dissolution process, the temperature of the dissolving bottle 8 is raised and controlled, thereby increasing the dissolution speed.

[0020] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A pharmaceutical experimental dissolution apparatus, comprising an apparatus frame (1), characterized in that: The device frame (1) is L-shaped. A power supply (4) and a control module (5) are fixedly connected to the lower inner wall of the device frame (1). A support frame (2) is provided above the power supply (4). The rear end of the upper side wall of the support frame (2) is fixedly connected to the rear inner wall of the device frame (1). An auxiliary motor (6) is fixedly connected to the upper inner wall of the support frame (2). The output end of the auxiliary motor (6) passes through the upper side wall of the support frame (2) and is connected to a bottom support mechanism (7). A dissolving bottle (8) and a top limiting mechanism (10) are provided above the bottom support mechanism (7). An operation screen (3) is provided at the front end of the support frame (2). The bottom support mechanism (7) includes a fixed frame (71) and a telescopic rod (72). The telescopic rod (72) is L-shaped, and the horizontal bar of the telescopic rod (72) extends into the fixed frame (71). The lower end of the fixed frame (71) is fixedly connected to the output end of the auxiliary motor (6). A locking bolt (73) is provided on the outside of the fixed frame (71). The end of the locking bolt (73) near the fixed frame (71) passes through the side wall of the fixed frame (71) and abuts against the side wall of the telescopic rod (72). The locking bolt (73) is threadedly connected to the side wall of the fixed frame (71).

2. The pharmaceutical experimental dissolution apparatus according to claim 1, characterized in that: The telescopic rod (72) is L-shaped. A support cylinder (74) is fixedly connected to the upper end of the longitudinal side wall of the telescopic rod (72). The lower end of the dissolving bottle (8) extends to the inner side of the support cylinder (74). The lower side wall of the support cylinder (74) is inclined downward on the side near the output end of the auxiliary motor (6).

3. The pharmaceutical experimental dissolution apparatus according to claim 2, characterized in that: An electric heating plate (13) is provided inside the lower side wall of the support cylinder (74), and several abutting rubber rings (75) are fixedly connected to the inner side wall of the support cylinder (74).

4. The pharmaceutical experimental dissolution apparatus according to claim 1, characterized in that: The top limiting mechanism (10) includes a sliding plate (102) and two auxiliary plates (101). The rear end of the sliding plate (102) is located between the two auxiliary plates (101). A limiting slide (9) is provided on the rear side wall of the equipment frame (1). The limiting slide (9) is located between the two auxiliary plates (101). The front end of the sliding plate (102) passes through the limiting slide (9) and is hinged to a connecting plate (105). The connecting plate (105) is away from the sliding plate (102). One end of the 02) is fixedly connected to a rubber band (106), and the front end of the rubber band (106) is fixedly connected to a limiting outer ring (107). The upper end of the dissolving bottle (8) extends to the inner side of the limiting outer ring (107). The lower end of the limiting outer ring (107) is rotatably connected to an abutting rubber ring (75). The inner diameter of the abutting rubber ring (75) is smaller than the inner diameter of the limiting outer ring (107). The inner wall of the abutting rubber ring (75) abuts against the outer wall of the dissolving bottle (8).

5. A pharmaceutical experimental dissolution apparatus according to claim 4, characterized in that: A limiting slide rod (103) is fixedly connected to the upper end of the lower auxiliary plate (101). The upper end of the limiting slide rod (103) passes through the sliding plate (102) and is connected to the lower end of the top auxiliary plate (101). An abutment spring (104) is sleeved on the limiting slide rod (103). The upper and lower ends of the abutment spring (104) are fixedly connected to the lower end of the upper auxiliary plate (101) and the upper end of the sliding plate (102), respectively.

6. A pharmaceutical experimental dissolution apparatus according to claim 3, characterized in that: The control module (5) includes a controller and a temperature regulation module. The temperature regulation module is electrically connected to the operation screen (3). A temperature detection sensor is provided at the position of the electric heating plate (13). The temperature detection sensor is electrically connected to the controller.

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