A device for the preparation of pellets

Abstract

The utility model relates to the technical field of medicine primary processing, disclose a kind of pellet preparation device, including box and auxiliary material bin, the auxiliary material bin upper end surface with the box inner top surface fixed connection, and the stirring jar upper end surface with the auxiliary material bin lower end surface fixed connection, motor is fixedly connected in the stirring jar upper end surface, and motor shaft end fixedly connected with rotating shaft;The rotating shaft is through the upper end surface of the box and the stirring jar;Box inner bottom surface bearing is connected with No. 1 rotating rod, and the No. 1 rotating rod is fixedly connected with bevel gear;No. 2 rotating rod is provided in the left side of the No. 1 rotating rod, and the left and right ends of the No. 2 rotating rod are fixedly connected with bevel gear;Box left side inner bottom surface bearing is connected with No. 3 rotating rod.The utility model has realized the uniform mixing of auxiliary material in auxiliary material bin and the sufficient stirring of material in stirring jar, to ensure the uniformity of pellet preparation, and overall structure is simple and stable, easily implemented.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical primary processing technology, specifically to a micro-pellet preparation device. Background Technology

[0002] Microparticles are a form of drug formulation, typically composed of numerous small particles. They possess advantages such as good drug release characteristics, high bioavailability, and good stability. However, existing microparticle preparation devices still have certain shortcomings, such as: Application CN201810208438.7, entitled "A Heat Dissipation Type Sustained-Release Microcapsule Preparation Device," includes a main body, a coarse grinding device disposed within the main body, a coarse material conveying device disposed on the lower side of the main body, and a fine grinding device disposed on the right side of the main body. The coarse grinding device includes a feed hopper fixedly disposed at the middle position of the upper end face of the main body. A feed chamber is disposed within the main body, and a coarse grinding chamber communicating with the feed chamber is disposed within the upper inner wall of the feed chamber. A first coarse grinding motor fixing block is disposed near the left inner wall of the feed chamber and fixedly connected to the inner wall of the feed chamber by a fixed connecting frame. This device cannot uniformly pulverize the auxiliary stirring material before processing, which may lead to uneven quality of the prepared microcapsules, affecting the efficacy and failing to meet the usage requirements. In view of this, a microcapsule preparation device is proposed to solve the above problems. Utility Model Content

[0003] The purpose of this invention is to provide a micro-pellet preparation device to solve the problem mentioned in the background art that existing micro-pellet preparation devices cannot uniformly crush the auxiliary stirring material before processing, which may lead to uneven quality of the prepared micro-pellets and affect the efficacy of the drug.

[0004] To achieve the above objectives, this utility model provides the following technical solution: It includes a housing and an auxiliary material hopper. The upper surface of the auxiliary material hopper is fixedly connected to the top surface of the housing, and the upper surface of the mixing cylinder is fixedly connected to the lower surface of the auxiliary material hopper. A motor is fixedly connected to the upper surface of the mixing cylinder, and a rotating shaft is fixedly connected to the end of the motor shaft. The rotating shaft passes through the upper surfaces of the housing and the mixing cylinder. A first rotating rod is connected to a bearing on the bottom surface of the housing, and a helical gear is fixedly connected to the first rotating rod. A second rotating rod is provided to the left of the first rotating rod, and helical gears are fixedly connected to both ends of the second rotating rod. A third rotating rod is connected to a bearing on the bottom surface of the left side of the housing, and the upper surface of the third rotating rod is connected to a bearing on the top surface of the housing. A helical gear is fixedly connected to the third rotating rod. The first rotating rod and the second rotating rod, as well as the second rotating rod and the third rotating rod, are all driven by helical gear meshing.

[0005] The above technical solution facilitates the improvement of the efficiency and quality of micro-pellet preparation.

[0006] As a preferred embodiment of this utility model, the bearing on the second rotating rod is connected to a fixed seat, and the lower end face of the fixed seat is fixedly connected to the bottom surface of the box.

[0007] The above technical solution facilitates the improvement of the stability of the second rotating rod during rotation, prevents the second rotating rod from shaking or deviating when rotating at high speed, thereby ensuring more precise meshing transmission between helical gears and further improving the efficiency and quality of micro-pellet preparation.

[0008] As a preferred embodiment of this utility model, a crushing rod is connected to a bearing inside the auxiliary material bin, and the left end of the crushing rod passes through the auxiliary material bin; a helical gear is fixedly connected to the left end of the crushing rod, and the crushing rod is driven by meshing with the No. 3 rotating rod through the helical gear.

[0009] The above technical solution facilitates uniform mixing of excipients in the excipient silo, thereby improving the uniformity and quality of micro-pellet preparation.

[0010] As a preferred embodiment of this utility model, the auxiliary material bin, the second rotating rod, the third rotating rod, and the crushing rod are all symmetrically arranged about the center of the box.

[0011] By adopting the above technical solution, the force on the entire device becomes more balanced.

[0012] As a preferred embodiment of this utility model, the lower end of the rotating shaft passes through the lower end face of the stirring cylinder, and a hollow tube is fixedly connected to the lower end face of the rotating shaft; a pawl is fixedly connected inside the hollow tube by a torsion spring, and a ratchet is engaged with the hollow tube by the pawl; the lower end face of the ratchet is fixedly connected to the upper end face of the first rotating rod.

[0013] The above technical solution facilitates the improvement of the stability and durability of the entire device, while also further enhancing the efficiency of micro-pellet preparation and the quality of the finished product.

[0014] As a preferred embodiment of this utility model, a heater is fixedly connected to the lower end face of the mixing cylinder; a fan blade is fixedly connected to the rotating shaft; a feed hopper is fixedly connected to the auxiliary material bin; and a feed valve, a material removal valve, and a drain valve corresponding to the mixing cylinder are provided on the front end face of the housing.

[0015] The above technical solution facilitates the heating treatment of materials in the mixing tank to meet the temperature requirements of different micro-pellet preparation processes.

[0016] As a preferred embodiment of this utility model, an electromagnetic control valve is fixedly connected to the lower end face of the mixing cylinder, and the electromagnetic control valve is symmetrically arranged about the center of the housing; the lower end face of the electromagnetic control valve penetrates the upper end face of the mixing cylinder, and the upper end face of the electromagnetic control valve penetrates the lower end face of the auxiliary material bin; anti-seepage rubber rings are provided at the connection points between the rotating shaft and the mixing cylinder, and between the crushing rod and the auxiliary material bin; a mixing blade is fixedly connected to the rotating shaft.

[0017] The above technical solution is adopted to prevent material leakage at the joint.

[0018] Compared with the prior art, the beneficial effects of this utility model are: the utility model achieves uniform mixing of auxiliary materials in the auxiliary material silo and full stirring of materials in the mixing cylinder, thereby ensuring the uniformity of micro-pellet preparation, and the overall structure is simple, stable and easy to implement.

[0019] 1. When using, the staff first puts the auxiliary materials into the auxiliary material bin through the feeding hopper, and then injects the cleaning liquid into the mixing cylinder through the feeding valve set on the front side of the box. Then, the motor is started and rotated in the forward direction. The motor drives the rotating shaft to rotate in the forward direction. The motor drives the ratchet to rotate through the hollow tube. The ratchet drives the first rotating rod to rotate. The first rotating rod drives the second rotating rod to rotate through the helical gear. The second rotating rod drives the third rotating rod to rotate through the helical gear. The third rotating rod drives the crushing rod to rotate through the helical gear. 2. The crushing rod crushes the auxiliary mixing material in the auxiliary material bin, while the stirring blades on the rotating shaft drive the cleaning liquid to clean the mixing tank; then the motor is stopped, and the cleaning liquid in the mixing tank is discharged through the drain valve; and the preparation material of micro pellets is injected into the mixing tank through the feed valve. 3. At this time, the electromagnetic control valve opens, and the auxiliary stirring material in the auxiliary material hopper falls into the mixing cylinder under the action of gravity through the electromagnetic control valve. The motor is restarted, causing it to rotate in reverse. When the motor rotates in reverse, the ratchet does not drive the first rotating rod to rotate. At this time, the first, second, and third rotating rods remain stationary, and only the stirring blades on the rotating shaft stir the material in the mixing cylinder. During this process, the heater is started, and under the action of the fan blades on the rotating shaft, the material is heated evenly while being stirred, further improving the mixing effect and preparation quality of the material, and making the auxiliary stirring material and the material evenly mixed, thus completing the preparation of micro-pellets. After the preparation is completed, the motor is turned off, and the material discharge valve set in the box is opened to discharge the prepared micro-pellets. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the main cross-sectional structure of this utility model; Figure 2 This utility model Figure 1 Enlarged structural diagram at point A in the middle; Figure 3 This is a schematic diagram of the connection structure between the No. 1 rotating rod and the No. 2 rotating rod of this utility model; Figure 4 This is a schematic diagram of the connection structure between the rotating shaft and the stirring blade of this utility model; Figure 5 This is a schematic diagram of the main structure of this utility model; Figure 6 This is a schematic diagram of the connection structure between the hollow tube and the ratchet in this utility model.

[0021] In the diagram: 1. Box body; 2. Mixing cylinder; 3. Auxiliary material bin; 4. Motor; 5. Rotating shaft; 6. Rotating rod No. 1; 7. Rotating rod No. 2; 8. Rotating rod No. 3; 9. Crushing rod; 10. Hollow tube; 11. Ratchet; 12. Heater; 13. Feed hopper. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] Please see Figures 1-6 The present invention provides a micro-pellet preparation device, comprising a housing 1, a stirring cylinder 2, and an auxiliary material hopper 3. The upper end face of the auxiliary material hopper 3 is fixedly connected to the inner top surface of the housing 1, and the upper end face of the stirring cylinder 2 is fixedly connected to the lower end face of the auxiliary material hopper 3. A motor 4 is fixedly connected to the upper end face of the stirring cylinder 2, and a rotating shaft 5 is fixedly connected to the shaft end of the motor 4. The rotating shaft 5 passes through the upper end faces of the housing 1 and the stirring cylinder 2. A first rotating rod 6 is connected to a bearing on the inner bottom surface of the housing 1, and a helical gear is fixedly connected to the first rotating rod 6. A second rotating rod 7 is provided on the left side of the first rotating rod 6, and helical gears are fixedly connected to both ends of the second rotating rod 7. A third rotating rod 8 is connected to a bearing on the inner bottom surface of the left side of the housing 1, and the upper end face of the third rotating rod 8 is connected to a bearing on the inner top surface of the housing 1. A helical gear is fixedly connected to the third rotating rod 8. The first rotating rod 6 and the second rotating rod 7, as well as the second rotating rod 7 and the third rotating rod 8, are all driven by helical gear meshing, which facilitates improved efficiency and quality of micro-pellet preparation. The bearing on the second rotating rod 7 is connected to the fixed seat, and the lower end face of the fixed seat is fixedly connected to the inner bottom surface of the box 1. This facilitates the improvement of the stability of the second rotating rod 7 during rotation and prevents the second rotating rod 7 from shaking or deviating when rotating at high speed. This ensures that the meshing transmission between the helical gears is more precise and further improves the efficiency and quality of micro-pellet preparation. The auxiliary material hopper 3 is connected to a bearing with a crushing rod 9, and the left end of the crushing rod 9 passes through the auxiliary material hopper 3; the left end of the crushing rod 9 is fixedly connected to a helical gear, and the crushing rod 9 is driven by meshing with the No. 3 rotating rod 8 through the helical gear, which facilitates the uniform mixing of auxiliary materials in the auxiliary material hopper 3 and improves the uniformity and quality of micro pellet preparation. The auxiliary material bin 3, the second rotating rod 7, the third rotating rod 8 and the crushing rod 9 are all symmetrically arranged about the center of the box 1, so that the force on the whole device is more balanced; The lower end of the rotating shaft 5 passes through the lower end face of the stirring cylinder 2, and a hollow tube 10 is fixedly connected to the lower end face of the rotating shaft 5; a pawl is fixedly connected inside the hollow tube 10 by a torsion spring, and a ratchet 11 is engaged with the hollow tube 10 by the pawl; the lower end face of the ratchet 11 is fixedly connected to the upper end face of the first rotating rod 6, which facilitates the improvement of the stability and durability of the entire device, and also further improves the efficiency of micro-pellet preparation and the quality of the finished product; A heater 12 is fixedly connected to the lower end face of the mixing cylinder 2; a fan blade is fixedly connected to the rotating shaft 5; a feed hopper 13 is fixedly connected to the auxiliary material bin 3; a feed valve, a material removal valve and a drain valve corresponding to the mixing cylinder 2 are set on the front end face of the box body 1, so as to facilitate the heating treatment of the material in the mixing cylinder 2 to meet the temperature requirements of different micro-pellet preparation processes. An electromagnetic control valve is fixedly connected to the lower end face of the mixing cylinder 2, and the electromagnetic control valve is symmetrically arranged about the center of the housing 1; the lower end face of the electromagnetic control valve penetrates the upper end face of the mixing cylinder 2, and the upper end face of the electromagnetic control valve penetrates the lower end face of the auxiliary material bin 3; anti-seepage rubber rings are provided at the connection between the rotating shaft 5 and the mixing cylinder 2, and between the crushing rod 9 and the auxiliary material bin 3; the mixing blade is fixedly connected to the rotating shaft 5 to prevent material leakage at the connection; Working principle: When in use, the staff first puts the auxiliary materials into the auxiliary material bin 3 through the feed hopper 13, and then injects the cleaning liquid into the mixing cylinder 2 through the feed valve set on the front side of the box 1. Then, the motor 4 is started, so that the motor 4 rotates in the forward direction. The motor 4 drives the rotating shaft 5 to rotate in the forward direction. The motor 4 drives the ratchet 11 to rotate through the hollow tube 10. The ratchet 11 drives the first rotating rod 6 to rotate. The first rotating rod 6 drives the second rotating rod 7 to rotate through the helical gear. The second rotating rod 7 drives the third rotating rod 8 to rotate through the helical gear. The third rotating rod 8 drives the crushing rod 9 to rotate through the helical gear. The crushing rod 9 crushes the auxiliary mixing materials in the auxiliary material bin 3, while the stirring blades on the rotating shaft 5 drive the cleaning fluid to clean the mixing cylinder 2; then the motor 4 is stopped, and the drain valve is used to clean the inside of the mixing cylinder. The cleaning liquid in the mixing tank 2 is discharged; and the preparation material for the micro-particles is injected into the mixing tank 2 through the feed valve; At this time, the electromagnetic control valve opens, and the auxiliary stirring material in the auxiliary material bin 3 falls into the stirring cylinder 2 under the action of gravity through the electromagnetic control valve. The motor 4 is started again, causing the motor 4 to rotate in reverse. When the motor 4 rotates in reverse, the ratchet 11 does not drive the first rotating rod 6 to rotate. At this time, the first rotating rod 6, the second rotating rod 7, and the third rotating rod 8 all remain stationary. Only the stirring blades on the rotating shaft 5 stir the material in the stirring cylinder 2. During this process, the heater 12 is started. At the same time, under the action of the fan blades on the rotating shaft 5, the material is heated evenly while being stirred, further improving the mixing effect and preparation quality of the material, and making the auxiliary stirring material and the material evenly mixed, thereby completing the preparation of micro pellets. After the preparation is completed, the motor 4 is turned off, and the material discharge valve set in the box 1 is opened to discharge the prepared micro pellets.

[0024] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A microparticle preparation apparatus, comprising a housing (1), a stirring cylinder (2), and an auxiliary material hopper (3), wherein the upper end face of the auxiliary material hopper (3) is fixedly connected to the inner top surface of the housing (1), and the upper end face of the stirring cylinder (2) is fixedly connected to the lower end face of the auxiliary material hopper (3), characterized in that: A motor (4) is fixedly connected to the upper end face of the stirring cylinder (2), and a rotating shaft (5) is fixedly connected to the shaft end of the motor (4); the rotating shaft (5) passes through the upper end face of the box body (1) and the stirring cylinder (2); a first rotating rod (6) is connected to the bearing on the inner bottom surface of the box body (1), and a helical gear is fixedly connected to the first rotating rod (6); a second rotating rod (7) is provided on the left side of the first rotating rod (6), and helical gears are fixedly connected to both the left and right ends of the second rotating rod (7); a third rotating rod (8) is connected to the bearing on the inner bottom surface of the left side of the box body (1), and the upper end face of the third rotating rod (8) is connected to the bearing on the inner top surface of the box body (1); a helical gear is fixedly connected to the third rotating rod (8); the first rotating rod (6) and the second rotating rod (7), and the second rotating rod (7) and the third rotating rod (8) are all driven by helical gear meshing.

2. The microparticle preparation apparatus according to claim 1, characterized in that: The bearing on the second rotating rod (7) is connected to the fixed seat, and the lower end face of the fixed seat is fixedly connected to the inner bottom surface of the box (1).

3. The microparticle preparation apparatus according to claim 2, characterized in that: The auxiliary material bin (3) is connected to a bearing with a crushing rod (9), and the left end of the crushing rod (9) passes through the auxiliary material bin (3); the left end of the crushing rod (9) is fixedly connected to a helical gear, and the crushing rod (9) is driven by meshing with the third rotating rod (8) through the helical gear.

4. The microparticle preparation apparatus according to claim 3, characterized in that: The auxiliary material bin (3), the second rotating rod (7), the third rotating rod (8) and the crushing rod (9) are all symmetrically arranged about the center of the box (1).

5. The microparticle preparation apparatus according to claim 4, characterized in that: The lower end of the rotating shaft (5) passes through the lower end face of the stirring cylinder (2), and a hollow tube (10) is fixedly connected to the lower end face of the rotating shaft (5); a pawl is fixedly connected inside the hollow tube (10) by a torsion spring, and a ratchet (11) is engaged with the hollow tube (10) by the pawl; the lower end face of the ratchet (11) is fixedly connected to the upper end face of the first rotating rod (6).

6. The microparticle preparation apparatus according to claim 5, characterized in that: A heater (12) is fixedly connected to the lower end face of the mixing cylinder (2); a fan blade is fixedly connected to the rotating shaft (5); a feed hopper (13) is fixedly connected to the auxiliary material bin (3); and a feed valve, a take-up valve and a drain valve corresponding to the mixing cylinder (2) are provided on the front end face of the box body (1).

7. The microparticle preparation apparatus according to claim 6, characterized in that: The lower end face of the mixing cylinder (2) is fixedly connected to an electromagnetic control valve, and the electromagnetic control valve is symmetrically arranged about the center of the box (1); the lower end face of the electromagnetic control valve penetrates the upper end face of the mixing cylinder (2), and the upper end face of the electromagnetic control valve penetrates the lower end face of the auxiliary material bin (3); the connection between the rotating shaft (5) and the mixing cylinder (2), and between the crushing rod (9) and the auxiliary material bin (3) are all provided with anti-seepage rubber rings; the mixing blade is fixedly connected to the rotating shaft (5).

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