A pretreatment device for detecting a tianeptine preparation

Abstract

The utility model discloses a kind of preparation detection of tipepidone pretreatment device, it is related to reagent processing equipment technical field, including equipment shell, the inside of equipment shell is equipped with bearing platform, the upper surface middle part of bearing platform is fixedly installed with fixed seat, the inside of fixed seat is equipped with reagent bottle, the inside top of equipment shell is fixedly installed with ultrasonic generator.The utility model is by setting movable cover in the bottom of ultrasonic generator, the end of ultrasonic generator is inserted into reagent bottle after the sleeve of movable cover middle part is penetrated, movable cover can be covered with the opening of reagent bottle, aerosol suspended in movable cover due to high-frequency vibration in ultrasonic dissolving process, by setting exhaust fan and filter, exhaust fan can extract aerosol suspended in movable cover and air to filter inside, aerosol is handled by filter, to avoid aerosol leakage caused by mixed solvent processing process to cause pollution.

Description

Technical Field

[0001] This utility model relates to the field of reagent processing equipment technology, and in particular to a pretreatment device for the detection of teprenone preparations. Background Technology

[0002] Teprenone is a gastric mucosal protectant, primarily used clinically to treat gastric ulcers and acute and chronic gastritis. It possesses tissue repair properties, particularly enhancing its anti-ulcer effect. Its mechanism of action includes: promoting gastric mucosal epithelial cell regeneration and accelerating damage repair; increasing prostaglandin synthesis and mucus secretion; and improving gastric mucosal microcirculation and reducing inflammatory responses. Teprenone should be stored under nitrogen-filled, sealed conditions at 2-8°C. This indicates that teprenone is prone to oxidation during storage, producing impurities that affect its content and thus its efficacy. To ensure drug quality and public safety, effective control of related substances in teprenone preparations is necessary.

[0003] In the prior art, when detecting related substances in teprenone formulations, the teprenone formulation is usually dissolved in n-hexane solvent, and the teprenone formulation in the n-hexane solvent is dissolved using an ultrasonic processor. Then, the mixed solution is measured using a UV lamp. Before the measurement, the mixed solvent needs to be pretreated by the ultrasonic processor. However, when the ultrasonic processor in the prior art processes the mixed solvent, the mixed solvent is prone to generating aerosols due to the high-frequency vibration generated by the ultrasound. The aerosols diffuse in the air, causing leakage and pollution, and may even induce experimental accidents.

[0004] Therefore, it is necessary to invent a pretreatment device for the detection of teprenone preparations to solve the above problems. Summary of the Invention

[0005] The purpose of this invention is to provide a pretreatment device for the detection of teprenone preparations, so as to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a pretreatment device for teprenone preparation detection, comprising a housing, an inner platform, a fixed seat fixedly installed on the upper surface of the platform, a reagent bottle inside the fixed seat, an ultrasonic generator fixedly installed at the top of the inner surface of the housing, a movable cover at the bottom of the ultrasonic generator, a sleeve fixedly installed in the middle of the movable cover, the sleeve being located outside the bottom of the ultrasonic generator, an exhaust fan fixedly installed on the inner side of the housing, a flexible hose fixedly installed at the input end of the exhaust fan, one end of the flexible hose being connected to the inside of the movable cover, a filter fixedly installed at the output end of the exhaust fan, positioning rings fixedly installed at the top of both sides of the movable cover, positioning screws penetrating the interior of both positioning rings, and both positioning screws fixedly installed inside the housing, two positioning nuts threadedly installed at the bottom of the positioning screws, the two positioning nuts being located on both sides of the positioning rings respectively.

[0007] Preferably, a rubber sleeve is fixedly provided at the bottom end of the movable cover, and the inner diameter of the rubber sleeve is larger than the outer diameter of the reagent bottle.

[0008] Preferably, a base is fixedly installed at the bottom of the inner part of the equipment housing, a support arm is rotatably installed on one end of the upper surface of the base via a pin, a slide rod is fixedly installed at the top of the support arm, a fixed frame is fixedly installed on one end of the lower surface of the platform, and the slide rod is slidably installed inside the fixed frame.

[0009] Preferably, a movable arm is rotatably mounted on the lower surface of the support platform away from the fixed frame via a pin, and a movable rod is rotatably mounted on the inner bottom end of the movable arm via a pin, and the movable rod is slidably disposed above the base.

[0010] Preferably, a threaded sleeve is fixedly provided in the middle of the movable rod, and an adjusting screw is installed inside the threaded sleeve by means of threads, and the adjusting screw is rotatably installed inside the base by means of a bearing.

[0011] Preferably, the outer bottom of the device housing is hinged with a movable door.

[0012] Preferably, the bottom of the outer wall of the device housing is provided with multiple air outlet slots, and the filter is located at the opening of the air outlet slot.

[0013] The technical effects and advantages of this utility model are as follows: 1. This utility model features a movable cover at the bottom of an ultrasonic generator. The end of the ultrasonic generator passes through the sleeve in the middle of the movable cover and is inserted into a reagent bottle. When the teprenone preparation and n-hexane solvent in the reagent bottle are ultrasonically dissolved, the movable cover can cover the opening of the reagent bottle. The aerosol generated by high-frequency vibration during the ultrasonic dissolution process is suspended inside the movable cover. By setting up an exhaust fan and a filter, the exhaust fan can draw the suspended aerosol and air inside the movable cover into the filter, and the aerosol is treated by the filter to avoid leakage of aerosol generated during the mixed solvent treatment process and causing pollution. 2. This utility model features a support platform that can move up and down inside the equipment casing. When placing or removing reagent bottles, the platform's position can be adjusted to move it closer to or further away from the ultrasonic generator, thus preventing collisions between the ultrasonic generator and the reagent bottles. Furthermore, a fixing seat on the upper surface of the platform positions the reagent bottles, ensuring they are accurately placed directly below the ultrasonic generator. This prevents the end of the ultrasonic generator from colliding with the reagent bottle and causing equipment damage. This combination of structures facilitates the placement and removal of reagent bottles while ensuring effective ultrasonic dissolution of the solution. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0015] Figure 2 This is a schematic diagram of the overall structure of this utility model.

[0016] Figure 3 This is a schematic diagram of the ultrasonic generator and movable cover structure of this utility model.

[0017] Figure 4 This is a schematic diagram of the support structure of this utility model.

[0018] In the diagram: 1. Equipment casing; 2. Support platform; 3. Fixed base; 4. Reagent bottle; 5. Ultrasonic generator; 6. Movable cover; 7. Sleeve; 8. Exhaust fan; 9. Hose; 10. Filter; 11. Positioning ring; 12. Positioning screw; 13. Positioning nut; 14. Rubber sleeve; 15. Base; 16. Support arm; 17. Slide rod; 18. Fixed frame; 19. Movable arm; 20. Movable rod; 21. Threaded sleeve; 22. Adjusting screw; 23. Movable door; 24. Air outlet duct. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0020] This utility model provides, for example Figure 1-4 The device shown is a pretreatment device for the detection of teprenone preparations. It includes a housing 1, a support 2 inside the housing 1, a fixing seat 3 fixedly installed in the middle of the upper surface of the support 2, and a reagent bottle 4 inside the fixing seat 3. The reagent bottle 4 can be directly inserted into the fixing seat 3. When the reagent bottle 4 is a beaker, the fixing seat 3 has a flat bottom ring structure. When the reagent bottle 4 is a test tube or flask, the fixing seat 3 has a concave bottom ring structure. The reagent bottle 4 can be stably inserted into the fixing seat 3 to complete the placement. An ultrasonic generator 5 is fixedly installed at the top of the inner part of the equipment housing 1. A movable cover 6 is provided at the bottom of the ultrasonic generator 5. A sleeve 7 is fixedly installed in the middle of the movable cover 6, and the sleeve 7 is located outside the bottom of the ultrasonic generator 5. An exhaust fan 8 is fixedly installed on the inner side of the equipment housing 1. A hose 9 is fixedly installed at the input end of the exhaust fan 8, and one end of the hose 9 is connected to the inside of the movable cover 6. A filter 10 is fixedly installed at the output end of the exhaust fan 8. Positioning rings 11 are fixedly installed at the top of both sides of the movable cover 6. Positioning screws 12 are passed through the inside of both positioning rings 11, and both positioning screws 12 are fixedly installed inside the equipment housing 1. Two positioning nuts 13 are threadedly installed at the bottom of the positioning screws 12, and the two positioning nuts 13 are located on both sides of the positioning rings 11. By adjusting the position of the positioning nuts 13 on the positioning screws 12, the height of the positioning rings 11 can be adjusted, and thus the height of the movable cover 6 can be adjusted so that the movable cover 6 can be adapted to reagent bottles 4 of different heights. A rubber sleeve 14 is fixedly provided at the bottom of the movable cover 6, and the inner diameter of the rubber sleeve 14 is larger than the outer diameter of the reagent bottle 4. The rubber sleeve 14 is used to extend the coverage area of ​​the movable cover 6 around the mouth of the reagent bottle 4, and further reduce the diffusion range of aerosol. A base 15 is fixedly installed at the bottom of the inner part of the equipment housing 1. A support arm 16 is rotatably installed on one end of the upper surface of the base 15 via a pin. A slide rod 17 is fixedly installed at the top of the support arm 16. A fixed frame 18 is fixedly installed on one end of the lower surface of the platform 2. The slide rod 17 is slidably installed inside the fixed frame 18. A movable arm 19 is rotatably installed on the lower surface of the platform 2 away from the fixed frame 18 via a pin. A movable rod 20 is rotatably installed on the bottom inner side of the movable arm 19 via a pin. The movable rod 20 is slidably mounted on the base 15. A threaded sleeve 21 is fixedly provided in the middle of the movable rod 20. An adjusting screw 22 is installed inside the threaded sleeve 21 via a thread. The adjusting screw 22 is rotatably installed inside the base 15 via a bearing. The adjusting screw 22 is used to adjust the position of the movable rod 20 and the movable arm 19, thereby realizing the adjustment of the height of the platform 2. A movable door 23 is hinged to the bottom outer side of the equipment housing 1. Multiple air outlet slots 24 are provided through the bottom outer side wall of the equipment housing 1. The filter 10 is located at the slot opening of the air outlet slot 24. It should be noted that the filter 10 adopts the corresponding structure in the prior art, which includes a housing and a filter element. The filter element is selected to be a type that can filter and adsorb aerosols generated by teprenone preparation and n-hexane solvent. The aerosols can be filtered and adsorbed when passing through the filter element.

[0021] Working principle of this utility model: When using this device, first open the movable door 23 and rotate the adjusting screw 22. The adjusting screw 22 drives the movable rod 20 to slide horizontally through the thread and threaded sleeve 21. The movable rod 20 drives the movable arm 19 to move, so that the bottom end of the movable arm 19 slides along the upper surface of the base 15. At this time, the movable arm 19 drives the support platform 2 to move downward. At this time, the support platform 2 moves away from the ultrasonic generator 5. When the support platform 2 moves to the lowest point, the reagent bottle 4 above the support platform 2 can be removed from the fixed seat 3. Then, an appropriate amount of teprenone preparation and n-hexane solvent are dripped into the reagent bottle 4. Then, the reagent bottle 4 is placed in the fixed seat 3, and the adjusting screw 22 is rotated in the opposite direction, so that the support platform 2 drives the reagent bottle 4 to move upward until the top of the reagent bottle 4 is inserted into the rubber sleeve 14. At this time, the output end of the ultrasonic generator 5 is inserted into the mixed solvent in the reagent bottle 4. At this time, the solvent can be dissolved by ultrasonic treatment. During solvent processing, the ultrasonic waves generated by the ultrasonic generator 5 drive the mixed solvent to vibrate at high frequency, causing the teprenone preparation to dissolve in the hexane solution. During this process, the mixed solvent generates aerosols due to the high-frequency vibration. The aerosols are suspended in the space between the movable hood 6 and the reagent bottle 4. At this time, the exhaust fan 8 is started. The exhaust fan 8 draws out the aerosols and air in the movable hood 6 through the hose 9 and delivers them to the filter 10. The filter 10 can filter and separate the aerosols in the air, and then discharge the pure air through the air outlet slot 24 to achieve the treatment of aerosols during solvent processing, thereby avoiding aerosol pollution of the surrounding environment. It should be noted that the ultrasonic generator 5 in this embodiment adopts the corresponding structure in the prior art, and its model is not limited while ensuring the normal implementation of this embodiment; It should be further noted that the amounts of teprenone preparation and n-hexane solvent used in this embodiment are selected according to the testing standards. There is no limit to the amount used as long as the ratio of the two is appropriate. The ultrasonic dissolution time of teprenone preparation and n-hexane solution is proportional to the amount of mixed solvent used. For example, when the mixed solvent is 5 ml, ultrasonic treatment for 5 minutes can ensure that the two solvents are completely dissolved.

[0022] Finally, the following points should be noted: First, in the description of this application, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection", and "linkage" should be interpreted broadly, and can be mechanical or electrical connections, or internal connections between two components, or direct connections. "Up", "down", "left", "right", etc. are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may change. Secondly: The accompanying drawings of the embodiments disclosed in this utility model only involve the structures involved in the embodiments disclosed in this utility model. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this utility model can be combined with each other. Finally: The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A pretreatment device for detecting teprenone preparations, comprising a housing (1), characterized in that: The equipment housing (1) has a support platform (2) inside. A fixed seat (3) is fixedly installed in the middle of the upper surface of the support platform (2). A reagent bottle (4) is installed inside the fixed seat (3). An ultrasonic generator (5) is fixedly installed at the top inside the equipment housing (1). A movable cover (6) is provided at the bottom of the ultrasonic generator (5). A sleeve (7) is fixedly installed in the middle of the movable cover (6), and the sleeve (7) is located outside the bottom of the ultrasonic generator (5). An exhaust fan (8) is fixedly installed on the inner side of the equipment housing (1). The input end of the exhaust fan (8) is... A flexible hose (9) is fixedly installed, and one end of the flexible hose (9) is connected to the inside of the movable cover (6). A filter (10) is fixedly installed at the output end of the exhaust fan (8). Positioning rings (11) are fixedly installed at the top of both sides of the movable cover (6). Positioning screws (12) are inserted through the inside of both positioning rings (11). Both positioning screws (12) are fixedly installed inside the equipment housing (1). Two positioning nuts (13) are installed at the bottom of the positioning screws (12) by threads. The two positioning nuts (13) are located on both sides of the positioning rings (11).

2. The pretreatment device for detecting teprenone preparations according to claim 1, characterized in that: The bottom end of the movable cover (6) is fixedly provided with a rubber sleeve (14), and the inner diameter of the rubber sleeve (14) is larger than the outer diameter of the reagent bottle (4).

3. The pretreatment device for detecting teprenone preparations according to claim 2, characterized in that: A base (15) is fixedly installed at the bottom of the inner side of the equipment housing (1). A support arm (16) is rotatably installed on one end of the upper surface of the base (15) via a pin. A slide rod (17) is fixedly installed at the top of the support arm (16). A fixed frame (18) is fixedly installed on one end of the lower surface of the support platform (2). The slide rod (17) is slidably installed inside the fixed frame (18).

4. The pretreatment device for detecting teprenone preparations according to claim 3, characterized in that: A movable arm (19) is rotatably mounted on the lower surface of the support (2) away from the fixed frame (18) via a pin. A movable rod (20) is rotatably mounted on the inner bottom end of the movable arm (19) via a pin, and the movable rod (20) is slidably located above the base (15).

5. The pretreatment device for detecting teprenone preparations according to claim 4, characterized in that: The movable rod (20) is fixedly provided with a threaded sleeve (21) in the middle. An adjusting screw (22) is installed inside the threaded sleeve (21) by means of threads. The adjusting screw (22) is rotatably installed inside the base (15) by means of a bearing.

6. The pretreatment device for detecting teprenone preparations according to claim 1, characterized in that: The outer bottom of the equipment housing (1) is hinged with a movable door (23).

7. The pretreatment device for detecting teprenone preparations according to claim 6, characterized in that: The bottom of the outer wall of the device housing (1) is provided with multiple air outlet slots (24), and the filter (10) is located at the opening of the air outlet slots (24).

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