A plasma-assisted transport device

Abstract

This application relates to a plasma-assisted transmission device, comprising: a working tip having a jet contraction cavity extending axially along the working tip; the working tip including an input end and an output end, the inner diameter of the input end being larger than the inner diameter of the output end; the input end being used to connect to a plasma therapy device; and a needle body connected to the output end of the working tip, with the cavity of the needle body communicating with the jet contraction cavity; and an output hole communicating with the cavity of the needle body at the end away from the output end. The end of the needle body with the output hole can be inserted into the gingival sulcus of a mouse through the tip of the needle body. Because the working tip is connected to the plasma therapy device, the plasma jet sent by the plasma therapy device can reduce the output diameter of the plasma jet through the jet contraction cavity until the plasma jet contracts to a diameter sufficient to penetrate the gingival sulcus before entering the cavity of the needle body. The reduced-diameter plasma jet can then be injected into the gingival sulcus of the mouse from the output hole of the needle body.

Description

Technical Field

[0001] This application relates to the fields of plasma mechanism research and plasma therapy technology, specifically to a plasma-assisted transmission device. Background Technology

[0002] Currently, in domestic and international research, plasma is primarily used on bacterial models, in vitro cells, in vivo cells, and large animals. While experiments on bacterial models or large animals are easy to perform, they also suffer from drawbacks such as long experimental cycles, high costs, and limited sample sizes. Mice, due to their physiological similarities to humans, are excellent models for studying human diseases; their ease of reproduction facilitates the provision of large sample sizes; and the mature transgenic technology for mice provides a valuable tool for studying molecular mechanisms of action. Therefore, mice are a superior animal model for in-depth research into the mechanisms of plasma action. In related techniques, plasma is typically introduced into the gingival sulcus of mice to study its effects on antibacterial, anti-inflammatory, and tissue regeneration promotion. However, due to the small size of mice, their shallow gingival sulcus, and thin tissue, current plasma equipment struggles to deliver plasma directly into the gingival sulcus. Summary of the Invention

[0003] This application provides a plasma-assisted transmission device that can solve the technical problem in the related art that, due to the small size of mice, shallow gingival sulcus, and thin tissue, current plasma devices are difficult to deliver plasma to the gingival sulcus of mice.

[0004] In a first aspect, embodiments of this application provide a plasma-assisted transmission device, comprising: a working tip having a jet contraction cavity extending axially along the working tip, the working tip including an input end and an output end, the inner diameter of the input end being larger than the inner diameter of the output end, the input end being used to connect to a plasma therapy device; and a needle body connected to the output end of the working tip, the cavity of the needle body communicating with the jet contraction cavity, and an output hole communicating with the cavity of the needle body being opened at one end of the needle body away from the output end.

[0005] In conjunction with the first aspect, in one embodiment, the working tip includes: a handle connecting section, the input end being disposed on the handle connecting section, the handle connecting section having a first cavity extending axially along the handle connecting section; an airflow contraction section connected to the handle connecting section, the airflow contraction section having a second cavity extending axially along the airflow contraction section; a needle body connecting section connected to one end of the airflow contraction section away from the handle connecting section, and the output end being disposed on one end of the needle body connecting section away from the airflow contraction section, the needle body connecting section having a third cavity extending axially along the needle body connecting section, the first cavity, the second cavity, and the third cavity communicating with each other to form the jet contraction cavity, the inner diameter of the first cavity being larger than the inner diameter of the third cavity.

[0006] In conjunction with the first aspect, in one embodiment, the airflow contraction section includes: a buffer section, one end of which is connected to the handle connection section, and the outer diameter of the buffer section is larger than the outer diameter of the handle connection section; and a contraction section, the other end of which is connected to the buffer section, and the end of the contraction section away from the buffer section is connected to the needle body connection section.

[0007] In conjunction with the first aspect, in one embodiment, the outer diameter of the contraction segment gradually decreases from the point of connection with the buffer segment toward the end closer to the needle body connection segment.

[0008] In conjunction with the first aspect, in one embodiment, the inner diameter of the first cavity remains unchanged along its axial direction.

[0009] In conjunction with the first aspect, in one embodiment, the inner diameter of the second cavity gradually decreases along the axial direction of the second cavity, and the inner diameter of the second cavity at the end closer to the first cavity is greater than the inner diameter of the second cavity at the end farther away from the first cavity.

[0010] In conjunction with the first aspect, in one embodiment, the inner diameter of the third cavity remains unchanged along its axial direction.

[0011] In conjunction with the first aspect, in one embodiment, the needle body includes: a fixed section, the outer wall of which is fitted to the inner sidewall of the needle body connecting section; a tip section, which is connected to the fixed section, the output hole being opened at the end of the tip section away from the fixed section, the tip section extending axially along the fixed section, and the outer diameter of the tip section gradually decreasing from the connection point with the fixed section toward the side away from the fixed section.

[0012] In conjunction with the first aspect, in one embodiment, the sidewall of the tip has a notch that communicates with the output hole.

[0013] In conjunction with the first aspect, in one embodiment, the working tip is made of thermoplastic resin.

[0014] The beneficial effects of the technical solutions provided in this application include:

[0015] The needle tip can be inserted into the gingival sulcus of a mouse by inserting the end of the needle with the output hole. Since the working tip is connected to the plasma therapy device, the plasma jet sent by the plasma therapy device can reduce the output diameter of the plasma jet through the jet contraction cavity until the plasma jet is contracted to a diameter large enough to penetrate the gingival sulcus before entering the cavity of the needle. The plasma jet with a reduced diameter can then be injected into the gingival sulcus of the mouse from the output hole of the needle, which solves the technical problem in related technologies that it is difficult for plasma devices to deliver plasma to the gingival sulcus of mice. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 A cross-sectional view of the working tip provided in an embodiment of this application;

[0018] Figure 2 This is a schematic diagram of the front view structure of the working tip provided in an embodiment of this application;

[0019] Figure 3 A bottom view of the working tip structure provided in an embodiment of this application;

[0020] Figure 4 A cross-sectional view of the needle body provided in an embodiment of this application;

[0021] Figure 5 This is a side view of the needle body provided in an embodiment of this application.

[0022] In the picture:

[0023] 1. Working tip; 11. Handle connecting section; 111. First chamber; 12. Airflow contraction section; 121. Second chamber; 122. Buffer section; 123. Contraction section; 13. Needle body connecting section; 131. Third chamber;

[0024] 2. Needle body; 21. Fixed segment; 22. Tip segment; 221. Notch. Detailed Implementation

[0025] To enable those skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present application, and not all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present application.

[0026] This application provides a plasma-assisted transport device that can solve the technical problem in the related art that, due to the small size of mice, shallow gingival sulcus, and thin tissue, current plasma devices are difficult to deliver plasma to the gingival sulcus of mice.

[0027] See Figure 1 and Figure 3 The image shows a plasma-assisted transmission device provided in an embodiment of this application. It may include: a working tip 1, which has a jet contraction cavity extending axially along the working tip 1; the working tip 1 includes an input end and an output end, the inner diameter of the input end being larger than the inner diameter of the output end; the input end being used to connect to a plasma therapy device; and a needle body 2, connected to the output end of the working tip 1, with its cavity communicating with the jet contraction cavity. An output hole communicating with the cavity of the needle body 2 is provided at the end of the needle body 2 away from the output end. The output end of the working tip 1 can be connected to the handle of the plasma therapy device. The communication between the cavity of the needle body 2 and the jet contraction cavity allows the jet drawn into the jet contraction cavity from the plasma therapy device to enter the cavity of the needle body 2 and ultimately exit from the output hole at the end of the needle body 2.

[0028] In this embodiment, the tip of the needle body 2 can be inserted into the gingival sulcus of a mouse by inserting the end of the needle body 2 with the output hole. Since the working tip 1 is connected to the plasma therapy device, the plasma jet sent by the plasma therapy device can reduce the output diameter of the plasma jet through the jet contraction cavity until the plasma jet is contracted to a diameter sufficient to penetrate the gingival sulcus before entering the cavity of the needle body 2. The plasma jet with a reduced diameter can be injected into the gingival sulcus of the mouse from the output hole of the needle body 2. In related technologies, the plasma jet usually uses helium as a carrier to output to the gingival sulcus of the mouse. In addition to reducing the diameter of the plasma jet when it is input into the gingival sulcus of the mouse, the jet contraction cavity can also increase the jet pressure, improve the penetration depth and concentration of the plasma in the gingival sulcus of the mouse, and solve the technical problem that it is difficult for plasma devices to deliver plasma to the gingival sulcus of mice in related technologies.

[0029] In some optional embodiments, the working tip 1 may include: a handle connecting section 11, the input end being disposed on the handle connecting section 11, the handle connecting section 11 having a first cavity 111 extending axially along the handle connecting section 11; an airflow contraction section 12 connected to the handle connecting section 11, the airflow contraction section 12 having a second cavity 121 extending axially along the airflow contraction section 12; a needle body connecting section 13 connected to one end of the airflow contraction section 12 away from the handle connecting section 11, and the output end being disposed at one end of the needle body connecting section 13 away from the airflow contraction section 12, the needle body connecting section 13 having a third cavity 131 extending axially along the needle body connecting section 13, the first cavity 111, the second cavity 121 and the third cavity 131 communicating with each other to form the jet contraction cavity, the inner diameter of the first cavity 111 being larger than the inner diameter of the third cavity 131. Preferably, the handle connecting section 11, the airflow contraction section 12, and the needle body connecting section 13 can be integrally formed. The inner walls of the interconnected first cavity 111, second cavity 121, and third cavity 131 are also relatively smooth. The needle body 2 is connected to the needle body connecting section 13. When the plasma jet enters the first cavity 111 from the input end, it then enters the second cavity 121 and the third cavity 131 in sequence, and finally enters the cavity of the needle body connecting section 13. In this embodiment, by setting the handle connecting section 11, the airflow contraction section 12, and the needle body connecting section 13, the jet contraction cavity can form a stepped contraction flow channel, reducing turbulence caused by sudden changes in airflow and improving the stability of the plasma jet.

[0030] See Figure 2 As shown, in some optional embodiments, the airflow contraction section 12 may include: a buffer section 122, one end of which is connected to the handle connecting section 11, and the outer diameter of the buffer section 122 is larger than the outer diameter of the handle connecting section 11; and a contraction section 123, the other end of which is connected to the buffer section 122, and the end of the contraction section 123 away from the buffer section 122 is connected to the needle body connecting section 13. In this embodiment, setting the outer diameter of the buffer section 122 to be larger than the outer diameter of the handle connecting section 11 allows the handle connecting section 11 to be directly inserted into the handle when connected to the handle. After the handle connecting section 11 has extended a certain length into the handle, it can be blocked by the buffer section 122 from further extension, making it easier to control the positional relationship between the working tip 1 and the handle, thus enhancing ease of use.

[0031] In some optional embodiments, the outer diameter of the contraction section 123 gradually decreases from its connection with the buffer section 122 toward the end near the needle body connecting section 13. Preferably, the outer diameter of the needle body connecting section 13 remains constant along its axial direction, and the outer diameter of the buffer section 122 near the needle body connecting section 13 is the same as the outer diameter of the needle body connecting section 13. In this embodiment, the outer diameter of the contraction section 123 gradually decreases, and the outer diameter of the needle body connecting section 13 connected to it is also smaller. This arrangement can increase the field of view during actual operation and improve the visibility of the plasma therapy device.

[0032] In some alternative embodiments, the inner diameter of the first cavity 111 remains constant along its axial direction. By setting the inner diameter of the first cavity 111 to remain constant along its axial direction, a transition phase can be provided for the plasma jet after entering the first cavity 111 and before entering the second cavity 121, thereby enhancing the stability of the plasma jet transmission in the jet contraction cavity.

[0033] In some optional embodiments, the inner diameter of the second cavity 121 gradually decreases along the axial direction of the second cavity 121, and the inner diameter of the second cavity 121 at the end closer to the first cavity 111 is larger than the inner diameter of the second cavity 121 at the end farther from the first cavity 111. Preferably, the inner diameter of the buffer section 122 can contract more gently than the inner diameter of the contraction section 123, that is, the change in the inner diameter of the buffer section 122 can be smaller, so as to enhance the smoothness of the plasma jet contraction. The inner diameter of the end of the buffer section 122 closer to the handle connecting section 11 is set to be the same as the inner diameter of the first cavity 111, so that the transition between the first cavity 111 and the second cavity 121 is smoother, thereby achieving gradual control of the plasma jet.

[0034] Preferably, the inner diameter of the third cavity 131 remains unchanged along its axial direction. This arrangement allows the plasma jet to transition within the third cavity 131 before entering the needle body 2. In the second cavity 121, the plasma jet may have significant pressure after its diameter is compressed. The smooth transition through the third cavity 131 effectively reduces this pressure and lowers the possibility of damaging mouse tissue.

[0035] See Figure 4As shown, in some optional embodiments, the needle body 2 may include: a fixed section 21, the outer wall of which is fitted to the inner sidewall of the needle body connecting section 13; and a tip 22 connected to the fixed section 21. The output hole is located at the end of the tip 22 away from the fixed section 21. The tip 22 extends axially along the fixed section 21, and its outer diameter gradually decreases from the point of connection with the fixed section 21 toward the side away from the fixed section 21. The connection between the fixed section 21 and the needle body connecting section 13 can be achieved by curing with a light-curing adhesive, ensuring good sealing between the needle body connecting section 13 and the fixed section 21. Preferably, the entire needle body 2 is made of 304 stainless steel. The smaller diameter of the tip 22 at the end away from the fixed section 21 facilitates insertion into the mouse gingival sulcus through the gap, reducing the possibility of damage to mouse tissue. It should be understood that the thickness of the needle body 2 can be customized according to the target gap.

[0036] See Figure 5 As shown, in some optional embodiments, the sidewall of the tip 22 has a notch 221, which communicates with the output hole. The notch 221 of the tip 22 can be symmetrically arranged along the axial direction of the tip 22. The communication between the notch 221 and the output hole allows the plasma jet to pass through both the end and the side of the tip 22. When the output hole of the needle body 2 is blocked by soft tissue or other obstacles, the jet can pass through the notch 221 on the side of the tip 22, continuing to exert its effect or pushing away the soft tissue, relieving the blocked state at the end, and increasing the reliability of the test.

[0037] In some optional embodiments, the working tip 1 is made of thermoplastic resin, that is, the handle connecting section 11, the airflow contraction section 12, and the needle body connecting section 13 are all made of thermoplastic resin, giving the working tip 1 a certain degree of toughness and good airtightness when connected to the handle. Preferably, the working tip 1 is manufactured by 3D printing, which has low manufacturing cost, can be mass-produced, and meets the needs of frequent scientific research and medical work.

[0038] In the description of this application, it should be noted that the terms "upper," "lower," etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application. Unless otherwise expressly specified and limited, the terms "installed," "connected," and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication between two elements. For those skilled in the art, the specific meaning of the above terms in this application can be understood according to the specific circumstances.

[0039] It should be noted that in this application, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0040] The above description is merely a specific embodiment of this application, enabling those skilled in the art to understand or implement this application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of this application. Therefore, this application is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features claimed herein.

Claims

1. A plasma assisted transport device, characterized by, It includes: The working tip (1) has a jet contraction cavity that extends along the axial direction of the working tip (1). The working tip (1) includes an input end and an output end. The inner diameter of the input end is larger than the inner diameter of the output end. The input end is used to connect to a plasma therapy device. The needle body (2) is connected to the output end of the working tip (1), and the cavity of the needle body (2) is connected to the jet contraction cavity. The end of the needle body (2) away from the output end is provided with an output hole that is connected to the cavity of the needle body (2).

2. The plasma-assisted transport device of claim 1, wherein, The working tip (1) includes: A handle connecting section (11) is provided with an input end located on the handle connecting section (11). The handle connecting section (11) has a first cavity (111) that extends along the axial direction of the handle connecting section (11). An airflow contraction section (12) is connected to the handle connection section (11), and the airflow contraction section (12) has a second cavity (121) that extends along the axial direction of the airflow contraction section (12). The needle body connecting section (13) is connected to the end of the airflow contraction section (12) away from the handle connecting section (11), and the output end is located at the end of the needle body connecting section (13) away from the airflow contraction section (12). The needle body connecting section (13) has a third cavity (131) extending axially along the needle body connecting section (13). The first cavity (111), the second cavity (121) and the third cavity (131) are interconnected to form the jet contraction cavity. The inner diameter of the first cavity (111) is larger than the inner diameter of the third cavity (131).

3. The plasma assisted transport device of claim 2, wherein, The airflow contraction section (12) includes: A buffer section (122) is provided, one end of which is connected to the handle connecting section (11), and the outer diameter of the buffer section (122) is larger than the outer diameter of the handle connecting section (11). A contraction section (123) is connected to the other end of the buffer section (122), and the end of the contraction section (123) away from the buffer section (122) is connected to the needle body connecting section (13).

4. The plasma-assisted transport device as described in claim 3, characterized in that: The outer diameter of the contraction section (123) gradually decreases from the point of connection with the buffer section (122) toward the end closer to the needle body connection section (13).

5. The plasma-assisted transport device as described in claim 2, characterized in that: The inner diameter of the first cavity (111) remains unchanged along the axial direction.

6. The plasma-assisted transport device as described in claim 5, characterized in that: The inner diameter of the second cavity (121) gradually decreases along the axial direction of the second cavity (121), and the inner diameter of the second cavity (121) at the end closer to the first cavity (111) is greater than the inner diameter of the second cavity (121) at the end farther away from the first cavity (111).

7. The plasma-assisted transport device as described in claim 2, characterized in that: The inner diameter of the third cavity (131) remains unchanged along its axial direction.

8. The plasma assisted transport device of claim 2, wherein, The needle body (2) includes: The outer wall of the fixed section (21) is attached to the inner wall of the needle body connecting section (13); A pointed segment (22) is connected to the fixed segment (21). The output hole is opened at the end of the pointed segment (22) away from the fixed segment (21). The pointed segment (22) extends axially along the fixed segment (21), and the outer diameter of the pointed segment (22) gradually decreases from the connection point with the fixed segment (21) toward the side away from the fixed segment (21).

9. The plasma-assisted transport device as described in claim 8, characterized in that: The side wall of the tip (22) has a notch (221) that communicates with the output hole.

10. The plasma-assisted transport device as described in claim 1, characterized in that: The working tip (1) is made of thermoplastic resin.

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