A multilayer sustained-release transdermal patch with a drug reservoir

Abstract

This invention belongs to the field of sustained-release transdermal patch technology, specifically a multi-layer sustained-release transdermal patch with a drug reservoir, including a backing layer; a drug layer is disposed at the bottom of the backing layer, and drug-carrying holes are evenly distributed from left to right at the bottom of the drug layer; a sustained-release layer is disposed at the bottom of the drug layer; and an adhesive layer is disposed at the bottom of the sustained-release layer. Through the structural design of the first, second, and third permeable layers, and the successively decreasing pore size, the evaporation and release of the drug effect are buffered, allowing it to be slowly and effectively delivered to the body, making the treatment more comfortable and long-lasting. The drug layer and drug-carrying holes increase the drug loading capacity, expanding the range of applications. In use, the protective film is torn off, and the patch is fixed to the patient's skin using the adhesive strip. The first, second, and third through-holes buffer the evaporation and release of the drug effect, allowing it to be slowly and effectively delivered to the body, making the treatment more comfortable and long-lasting.

Description

Technical Field

[0001] This utility model relates to the field of sustained-release transdermal patch technology, specifically a multilayer sustained-release transdermal patch with a drug reservoir. Background Technology

[0002] Transdermal patches are long-acting formulations that deliver medication through the skin. Their core feature is the ability to control the release of drugs at a slow, constant rate, thereby maintaining effective blood drug concentrations over a longer period of time, reducing the frequency of administration and improving patient compliance.

[0003] Traditional percutaneous patches are limited by the liquid absorption capacity and thickness of the matrix, and can usually only carry low doses of drugs, resulting in rapid drug release and short treatment time. Therefore, a multilayer sustained-release percutaneous patch with a drug reservoir is proposed to address the above problems. Utility Model Content

[0004] The technical problem to be solved by this invention is that the existing technology usually can only load low doses of drugs, and the drug release is fast and the treatment time is short. To this end, we propose a multilayer sustained-release transdermal patch with a drug reservoir.

[0005] The technical solution adopted by this utility model to solve its technical problem is: a multilayer sustained-release transdermal patch with a drug reservoir, including a backing layer; a drug layer is provided at the bottom of the backing layer, drug loading holes are uniformly provided at the bottom of the drug layer from left to right, a sustained-release layer is provided at the bottom of the drug layer, an adhesive layer is provided at the bottom of the sustained-release layer, and a protective film is provided at the bottom of the adhesive layer.

[0006] Preferably, the sustained-release layer includes a first permeation layer, a second permeation layer, and a third permeation layer. The bottom of the backing layer is provided with the first permeation layer, the bottom of the first permeation layer is provided with the second permeation layer, and the bottom of the second permeation layer is provided with the third permeation layer. The bottom of the first permeation layer has a first through hole, and the diameter of the first through hole is smaller than that of the drug-carrying hole. The bottom of the second permeation layer has a second through hole, and the diameter of the second through hole is smaller than that of the first through hole. The bottom of the third permeation layer has a third through hole, and the diameter of the third through hole is smaller than that of the second through hole.

[0007] Preferably, an adhesive strip is provided at the bottom of the adhesive layer.

[0008] Preferably, the protective film is made of siliconized polyester material, and the thickness of the protective film is between 20-50 μm.

[0009] Preferably, the backing layer is made of polyurethane material and the thickness of the backing layer is between 20-100 μm.

[0010] Preferably, the drug layer is made of silicone rubber.

[0011] The beneficial effects of this utility model are: This invention, through its structural design of a first permeable layer, a second permeable layer, and a third permeable layer, uses progressively smaller pore sizes to buffer the evaporation and release of the drug's effects, allowing it to be delivered to the body slowly and for a longer duration, resulting in more comfortable and longer-lasting treatment. The drug layer and drug-carrying pores also increase the drug loading capacity, making it applicable to a wider range of conditions. Attached Figure Description

[0012] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0013] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a separation diagram of the sustained-release layer structure of this utility model; Figure 3 This is a bottom view of the adhesive layer structure of this utility model.

[0014] In the diagram: 1. Backing layer; 2. Drug layer; 3. Drug-carrying pores; 4. Sustained-release layer; 41. First permeable layer; 42. Second permeable layer; 43. Third permeable layer; 5. Adhesive layer; 6. Protective film; 7. Adhesive strip. Detailed Implementation

[0015] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present utility model.

[0016] The following is in conjunction with the appendix Figure 1-3 This application will be described in further detail. This application discloses a multilayer sustained-release transdermal patch with a drug reservoir. (Refer to...) Figure 1 and Figure 2A multilayer sustained-release transdermal patch with a drug reservoir includes a backing layer 1; a drug layer 2 is disposed at the bottom of the backing layer 1, drug loading holes 3 are uniformly disposed from left to right at the bottom of the drug layer 2, a sustained-release layer 4 is disposed at the bottom of the drug layer 2, an adhesive layer 5 is disposed at the bottom of the sustained-release layer 4, and a protective film 6 is disposed at the bottom of the adhesive layer 5; this increases the drug loading capacity and broadens the range of applications.

[0017] Reference Figure 1 and Figure 2 The sustained-release layer 4 includes a first permeable layer 41, a second permeable layer 42, and a third permeable layer 43. The bottom of the backing layer 1 is provided with the first permeable layer 41, the bottom of the first permeable layer 41 is provided with the second permeable layer 42, and the bottom of the second permeable layer 42 is provided with the third permeable layer 43. The bottom of the first permeable layer 41 has a first through hole, and the diameter of the first through hole is smaller than that of the drug-carrying hole 3. The bottom of the second permeable layer 42 has a second through hole, and the diameter of the second through hole is smaller than that of the first through hole. The bottom of the third permeable layer 43 has a third through hole, and the diameter of the third through hole is smaller than that of the second through hole. By successively decreasing the pore size, the volatilization and release of the drug effect is buffered, so that it is slowly and long-lastingly delivered to the human body, making the treatment more comfortable and long-lasting.

[0018] Reference Figure 1 and Figure 3 An adhesive strip 7 is provided at the bottom of the adhesive layer 5; after being fixed to the skin, it does not hinder the release of the drug.

[0019] Reference Figure 1 The protective film 6 is made of silicone polyester material, and its thickness ranges from 20-50um. It is applied to the surface of the adhesive layer before use to prevent the patch from sticking together. It needs to be removed before use.

[0020] Reference Figure 1 The backing layer 1 is made of polyurethane material, and the thickness of the backing layer 1 ranges from 20-100um; its main function is to prevent drug leakage and block the external environment, protecting the drug storage layer from damage.

[0021] Reference Figure 1 The drug layer 2 is made of silicone rubber.

[0022] Working principle: When using, tear off the protective film 6 and fix the patch to the patient's skin with the adhesive strip 7. The first, second and third through holes buffer the volatilization and release of the drug effect, so that it is slowly and effectively delivered to the human body, making the treatment more comfortable and long-lasting.

[0023] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model.

Claims

1. A multilayer sustained-release transdermal patch with a drug reservoir, characterized in that: Includes a backing layer (1); a drug layer (2) is provided at the bottom of the backing layer (1), drug loading holes (3) are uniformly provided at the bottom of the drug layer (2) from left to right, a sustained-release layer (4) is provided at the bottom of the drug layer (2), an adhesive layer (5) is provided at the bottom of the sustained-release layer (4), and a protective film (6) is provided at the bottom of the adhesive layer (5). The sustained-release layer (4) includes a first permeation layer (41), a second permeation layer (42), and a third permeation layer (43). The bottom of the backing layer (1) is provided with the first permeation layer (41), the bottom of the first permeation layer (41) is provided with the second permeation layer (42), and the bottom of the second permeation layer (42) is provided with the third permeation layer (43). The bottom of the first permeation layer (41) is provided with a first through hole, and the diameter of the first through hole is smaller than that of the drug-carrying hole (3). The bottom of the second permeation layer (42) is provided with a second through hole, and the diameter of the second through hole is smaller than that of the first through hole. The bottom of the third permeation layer (43) is provided with a third through hole, and the diameter of the third through hole is smaller than that of the second through hole.

2. The multilayer sustained-release transdermal patch with a drug reservoir according to claim 1, characterized in that: An adhesive strip (7) is provided at the bottom of the adhesive layer (5).

3. The multilayer sustained-release transdermal patch with a drug reservoir according to claim 1, characterized in that: The protective film (6) is made of siliconized polyester material, and the thickness of the protective film (6) is between 20-50 μm.

4. A multilayer sustained-release transdermal patch with a drug reservoir according to claim 1, characterized in that: The backing layer (1) is made of polyurethane material and the thickness of the backing layer (1) ranges from 20 to 100 μm.

5. A multilayer sustained-release transdermal patch with a drug reservoir according to claim 1, characterized in that: The drug layer (2) is made of silicone rubber.

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