A filtration device for the synthesis of pharmaceutical intermediates

Abstract

This utility model relates to the field of pharmaceutical intermediate synthesis technology, specifically a filtration device for pharmaceutical intermediate synthesis. A support ring is fixedly connected to the inner wall of the filter cylinder. A movable ring is positioned above the support ring, and a first filter canister is threadedly connected to the movable ring. A second filter canister is threadedly connected to the lower end of the first filter canister. A bracket is fixedly connected to the upper surface of the movable ring, and a vibration motor is fixedly connected to the bracket. This utility model, through the threaded connection structure between the movable ring and the first filter canister, and between the first and second filter canisters, allows for easy disassembly and assembly of the two filter canisters, facilitating subsequent cleaning or replacement. The vibration motor, driven by the bracket, vibrates the movable ring and the two filter canisters, effectively breaking up the adhesion between solid and liquid components in the pharmaceutical intermediate and preventing filter pore blockage.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical intermediate synthesis technology, specifically a filtration device for pharmaceutical intermediate synthesis. Background Technology

[0002] Pharmaceutical intermediate synthesis refers to the process of gradually transforming basic chemical raw materials into key intermediate products that can be used to produce active pharmaceutical ingredients (APIs) using chemical or biological methods. It is the core link connecting chemical raw materials and final drugs. It requires multiple reaction steps, separation and purification operations to ensure the purity and quality of intermediates to meet the requirements of subsequent API synthesis. When it is necessary to separate solid impurities in the reaction system, recover solid intermediate products, or perform solid-liquid separation of the reaction solution to obtain a clear filtrate for subsequent steps, appropriate filtration devices will be used.

[0003] A current authorized utility model patent with publication number CN221107226U discloses a multi-stage pressure filtration device for drug synthesis. After entering the housing, pharmaceutical intermediates sequentially pass through a first filter, a second filter, and a third filter. Impurities blocked by the first filter fall into a first collection trough, impurities blocked by the second filter fall into a second collection trough, and impurities filtered by the third filter fall into a third collection trough. This multi-stage filtration effectively improves the filtration efficiency of the pressure filtration device for pharmaceutical intermediates. This pressure filtration device has a simple structure, is easy to operate, and can perform multi-stage filtration of pharmaceutical intermediates. The filtered impurities and pharmaceutical intermediates are easily collected, effectively improving the practicality of the pressure filtration device.

[0004] While the above-mentioned technical solutions can achieve some filtration of pharmaceutical intermediates, they rely solely on the gravity flow of the mixture to achieve filtration. This lack of a high-efficiency filtration structure to improve filtration efficiency and effectiveness leads to a decrease in filtration efficiency due to adhesion between solid and liquid components. Therefore, there is a need to develop a filtration device for the synthesis of pharmaceutical intermediates that can improve filtration efficiency and effectiveness. Utility Model Content

[0005] To address the above technical problems, this utility model provides a filtration device for the synthesis of pharmaceutical intermediates that can improve filtration efficiency and effectiveness, thereby solving the problem that existing filtration devices rely on the gravity of the mixture itself for filtration, resulting in reduced filtration effect and efficiency.

[0006] To solve the above-mentioned technical problems, the present invention provides a filtration device for the synthesis of pharmaceutical intermediates, comprising a filter cylinder, a support ring fixedly connected to the inner wall of the filter cylinder, a movable ring disposed above the support ring, a guide rod fixedly connected to the bottom of the movable ring, the bottom end of the guide rod slidingly penetrating the support ring and fixedly connected to a limit plate, a first return spring and a second return spring respectively sleeved on the outer surface of the guide rod, a first filter canister threadedly connected to the movable ring, a coarse filter screen fixedly connected to the inner wall of the first filter canister, a second filter canister threadedly connected to the lower end of the first filter canister, a fine filter screen fixedly connected to the inner wall of the second filter canister, a bracket fixedly connected to the upper surface of the movable ring, a vibration motor fixedly connected to the bracket, and a control switch fixedly connected to the outer surface of the filter cylinder, the vibration motor being controlled by the control switch.

[0007] Furthermore, the two ends of the first return spring are in contact with the bottom surface of the movable ring and the upper surface of the support ring, respectively, and the two ends of the second return spring are in contact with the bottom surface of the support ring and the upper surface of the limiting plate, respectively.

[0008] Furthermore, a discharge pipe is fixedly connected to the bottom end of the filter cylinder, and a valve is fixedly connected to the discharge pipe.

[0009] Furthermore, an extension ring is fixedly connected to the outer surface of the filter cartridge, and four support legs are fixedly connected to the lower end of the extension ring.

[0010] Furthermore, two handle supports are fixedly connected to both sides of the outer surface of the filter cartridge, and a pull rod is fixedly connected to the inner wall of each handle support, with a grip rotatably connected to the pull rod.

[0011] Furthermore, a first anti-slip sleeve is fixedly connected to the outer surface of the first filter tank, and a plurality of first anti-slip protrusions are fixedly connected to the outer surface of the first anti-slip sleeve. A plurality of second anti-slip sleeves are fixedly connected to the outer surface of the second filter tank, and a plurality of second anti-slip protrusions are fixedly connected to the outer surface of the second anti-slip sleeves.

[0012] This utility model has the following advantages compared with the prior art:

[0013] This invention utilizes a threaded connection structure between a movable ring and the first filter tank, and between the first filter tank and the second filter tank, allowing for easy assembly and disassembly of the two filter tanks for subsequent cleaning or replacement. A vibration motor, driven by a bracket, vibrates the movable ring and the two filter tanks, effectively breaking up the adhesion between solid and liquid components in pharmaceutical intermediates and preventing filter pore blockage. A guide rod on the bottom of the movable ring slides in conjunction with a support ring, providing stable guidance for the vibration of the movable ring and filter tanks and preventing deviation during vibration. First and second return springs outside the guide rod ensure continuous and stable operation of the device. This device solves the problems of traditional filtration relying on gravity, poor filtration effect, and low efficiency. It avoids the problem that the lack of a high-efficiency filtration structure that can improve filtration efficiency and effect leads to poor filtration performance and low efficiency in pharmaceutical intermediates due to adhesion between solid and liquid components. Attached Figure Description

[0014] Figure 1 This is a three-dimensional overall structural diagram of the filtration device for the synthesis of pharmaceutical intermediates according to this utility model.

[0015] Figure 2 This is a cross-sectional three-dimensional structural diagram of the filter cartridge of this utility model.

[0016] Figure 3 This is a three-dimensional structural diagram of the bracket of this utility model.

[0017] Figure 4 This is a cross-sectional three-dimensional structural diagram of the first filter tank of this utility model.

[0018] Figure 5 This is a three-dimensional structural diagram of the second filter tank of this utility model, viewed from below.

[0019] Figure 6 This is a three-dimensional structural diagram of the filter cartridge of this utility model, viewed from below.

[0020] In the diagram: 1. Filter cylinder; 2. Support ring; 3. Movable ring; 4. Bracket; 5. Vibration motor; 6. Control switch; 7. First filter tank; 8. Second filter tank; 9. Coarse filter screen; 10. Fine filter screen; 11. Guide rod; 12. Limiting plate; 13. First return spring; 14. Second return spring; 15. Outer ring; 16. Support leg; 17. Discharge pipe; 18. Valve; 19. Handle support; 20. Pull rod; 21. Grip; 22. First anti-slip sleeve; 23. First anti-slip protrusion; 24. Second anti-slip sleeve; 25. Second anti-slip protrusion. Detailed Implementation

[0021] The present invention will be further described below with reference to the accompanying drawings.

[0022] like Figure 1-6The filter device for synthesizing pharmaceutical intermediates shown includes a filter cylinder 1. A support ring 2 is fixedly connected to the inner wall of the filter cylinder 1. A movable ring 3 is arranged above the support ring 2. An extension ring 15 is fixedly connected to the outer surface of the filter cylinder 1. Four support legs 16 are fixedly connected to the bottom surface of the extension ring 15. The extension ring 15 provides a stable mounting base for the support legs 16, allowing the four support legs 16 to be evenly distributed at the bottom of the filter cylinder 1. The support legs 16 can raise the entire device, preventing the filter cylinder 1 from directly contacting the ground. This prevents ground stains from contaminating the filter cylinder 1 and also leaves space below the discharge pipe 17 for placing a receiving container, ensuring smooth collection of filtered materials and improving the convenience and hygiene of the device during use.

[0023] The inner wall of the movable ring 3 is threadedly connected to a first filter tank 7, and the inner wall of the first filter tank 7 is threadedly connected to a second filter tank 8. A coarse filter screen 9 is fixedly connected to the inner wall of the first filter tank 7, and a fine filter screen 10 is fixedly connected to the inner wall of the second filter tank 8. The bottom end of the filter cylinder 1 is fixedly connected to a discharge pipe 17, and a valve 18 is fixedly installed on the outer surface of the discharge pipe 17. The discharge pipe 17 is a dedicated channel for the discharge of filtered materials, which can guide the materials to flow out in a directional manner. The valve 18 installed on the outer surface of the discharge pipe 17 can flexibly control the opening and closing of the discharge pipe 17. During the filtration process, the valve 18 can be closed to temporarily store materials. The discharge can be opened after filtration is completed or the receiving container is ready, so as to avoid the materials flowing out randomly and causing waste or pollution, realize the controllability of material discharge, and improve operational flexibility.

[0024] A bracket 4 is fixedly connected to the upper surface of the movable ring 3, and a vibration motor 5 is fixedly connected to the upper surface of the bracket 4. Two handle supports 19 are fixedly connected to the outer surface of the filter cylinder 1. A pull rod 20 is fixedly connected to the inner wall of each handle support 19. The handle support 19 is the mounting carrier of the pull rod 20, which can ensure that the pull rod 20 is stably fixed on the filter cylinder 1.

[0025] A control switch 6 is fixedly connected to the outer surface of the filter cartridge 1. Four guide rods 11 are fixedly connected to the bottom surface of the movable ring 3. The outer surface of each guide rod 11 is slidably connected to the inside of the support ring 2. The vibration motor 5 is electrically connected to the control switch 6 through a wire. Each handle support 19 has a grip 21 inside. The inner wall of each grip 21 is rotatably connected to the outer surface of the pull rod 20. The pull rod 20 provides rotational support for the grip 21, allowing the grip 21 to rotate around the pull rod 20. When the operator moves the device, they can hold the grip 21 to apply force. The cooperation between handle 9 and pull rod 20 ensures that handle 21 is firmly installed, preventing handle 21 from falling off during handling. At the same time, the rotatable handle 21 can adapt to different grip angles of the operator, reducing the difficulty of handling. When the operator holds handle 21 to carry the device, handle 21 can rotate flexibly with hand movements, avoiding excessive friction between the hand and handle 21 and reducing hand discomfort. At the same time, handle 21 provides the operator with a point of force application. Compared with directly carrying filter cartridge 1, holding handle 21 is less strenuous, further improving the comfort and convenience of the device during handling.

[0026] Each guide rod 11 is fixedly connected to a limiting plate 12 at its bottom end. A first anti-slip sleeve 22 is fixedly connected to the outer surface of the first filter canister 7. Several identical first anti-slip protrusions 23 are fixedly connected to the outer surface of the first anti-slip sleeve 22. The first anti-slip sleeve 22 can increase the friction between the hand and the first filter canister 7. Several first anti-slip protrusions 23 on the outer surface of the first anti-slip sleeve 22 can further enhance the anti-slip effect. When the operator disassembles or assembles the first filter canister 7, it is not easy to slip when holding the first anti-slip sleeve 22. The operator can rotate the first filter canister 7 more easily to complete the disassembly or assembly, avoiding the first filter canister 7 from falling and being damaged or causing hand injury due to hand slippage, thus improving the safety and convenience of the disassembly and assembly operation of the first filter canister 7.

[0027] Each guide rod 11 has a first return spring 13 and a second return spring 14 respectively fitted on its outer surface. The two ends of each first return spring 13 are in contact with the bottom surface of the movable ring 3 and the upper surface of the support ring 2, respectively. The two ends of each second return spring 14 are in contact with the bottom surface of the support ring 2 and the upper surface of the limiting plate 12, respectively. A second anti-slip sleeve 24 is fixedly connected to the outer surface of the second anti-slip sleeve 24. Several identical second anti-slip protrusions 25 are fixedly connected to the outer surface of the second anti-slip sleeve 24. The second anti-slip sleeve 24 can increase the contact friction between the hand and the second filter can 8. The several second anti-slip protrusions 25 on the outer surface of the second anti-slip sleeve 24 can further enhance the anti-slip performance. When the operator disassembles and assembles the second filter can 8, he / she can hold the second filter can 8 stably for rotation operation with the help of the second anti-slip sleeve 24 and the second anti-slip protrusions 25, preventing the hand from slipping and affecting the disassembly and assembly efficiency. At the same time, it can prevent the second filter can 8 from falling accidentally, ensuring the safety and convenience of the disassembly and assembly process of the second filter can 8.

[0028] The working principle of this embodiment is as follows:

[0029] In use, the vibration motor 5 is turned on by the control switch 6. After the vibration motor 5 starts, it generates vibration. The vibration is transmitted to the movable ring 3 through the bracket 4. The movable ring 3 drives the first filter tank 7 and the second filter tank 8, which are threaded to it, to vibrate together. At this time, the pharmaceutical intermediate material to be filtered is poured into the first filter tank 7. The material first passes through the coarse filter screen 9 fixed on the inner wall of the first filter tank 7. The coarse filter screen 9 performs preliminary filtration of larger particulate impurities in the material. The material after preliminary filtration falls into the second filter tank 8 and then undergoes secondary filtration through the fine filter screen 10 on the inner wall of the second filter tank 8 to remove fine impurities in the material. The double filtration can effectively improve the purity of the material.

[0030] During the vibration of the filter tank driven by the vibration motor 5, the guide rod 11 fixed on the bottom surface of the movable ring 3 slides along the inside of the support ring 2, providing stable guidance for the vibration of the movable ring 3 and the filter tank, preventing the filter tank from shifting during vibration, and ensuring the stable operation of the filtration process. At the same time, the first return spring 13 and the second return spring 14 sleeved on the outer surface of the guide rod 11 play their roles. The two ends of the first return spring 13 contact the bottom surface of the movable ring 3 and the upper surface of the support ring 2, respectively, and the two ends of the second return spring 14 contact the bottom surface of the support ring 2 and the upper surface of the limiting plate 12, respectively. The two return springs can make the vibration more stable and can also assist the movable ring 3 to reset during the vibration gap, ensuring that the vibration is continuous and effective.

[0031] After filtration, turn off the vibration motor 5 and open the valve 18 on the outer surface of the discharge pipe 17. The filtered material is discharged through the discharge pipe 17 and falls into the prepared receiving container below. If the filter canister needs to be cleaned or replaced, the operator can hold the first anti-slip sleeve 22 on the outer surface of the first filter canister 7 and rotate the first filter canister 7 to separate it from the movable ring 3. Then, hold the second anti-slip sleeve 24 on the outer surface of the second filter canister 8 and rotate the second filter canister 8 to separate it from the first filter canister 7. After disassembly and assembly, the filter canister can be cleaned or replaced. After reassembly, it can be used again. When the device needs to be moved, the operator can hold the handle 21 and easily move the device to the required position through the cooperation of the handle support 19 and the pull rod 20. The support leg 16 provides stable support for the device during use and transportation, ensuring the overall stability of the device.

Claims

1. A filtration device for the synthesis of pharmaceutical intermediates, comprising a filter cartridge (1), characterized in that: The inner wall of the filter cylinder (1) is fixedly connected to a support ring (2). A movable ring (3) is provided above the support ring (2). A guide rod (11) is fixedly connected to the bottom of the movable ring (3). The bottom end of the guide rod (11) slides through the support ring (2) and is fixedly connected to a limit plate (12). A first return spring (13) and a second return spring (14) are respectively sleeved on the outer surface of the guide rod (11). A first filter canister (7) is threadedly connected to the movable ring (3). A coarse filter screen (9) is fixedly connected to the inner wall of the first filter canister (7). A second filter canister (8) is threadedly connected to the lower end of the first filter canister (7). A fine filter screen (10) is fixedly connected to the inner wall of the second filter canister (8). A bracket (4) is fixedly connected to the upper surface of the movable ring (3). A vibration motor (5) is fixedly connected to the bracket (4). A control switch (6) is fixedly connected to the outer surface of the filter cylinder (1). The vibration motor (5) is controlled by the control switch (6).

2. The filtration device for synthesizing pharmaceutical intermediates according to claim 1, characterized in that: The two ends of the first return spring (13) are in contact with the bottom surface of the movable ring (3) and the upper surface of the support ring (2), respectively. The two ends of the second return spring (14) are in contact with the bottom surface of the support ring (2) and the upper surface of the limiting plate (12), respectively.

3. The filtration device for synthesizing pharmaceutical intermediates according to claim 1, characterized in that: The bottom end of the filter cylinder (1) is fixedly connected to a discharge pipe (17), and a valve (18) is fixedly connected to the discharge pipe (17).

4. The filtration device for synthesizing pharmaceutical intermediates according to claim 1, characterized in that: An extension ring (15) is fixedly connected to the outer surface of the filter cylinder (1), and four support legs (16) are fixedly connected to the lower end of the extension ring (15).

5. The filtration device for synthesizing pharmaceutical intermediates according to claim 4, characterized in that: Two handle supports (19) are fixedly connected to both sides of the outer surface of the filter cylinder (1). A pull rod (20) is fixedly connected to the inner wall of each handle support (19), and a handle (21) is rotatably connected to the pull rod (20).

6. The filtration device for synthesizing pharmaceutical intermediates according to claim 1, characterized in that: The outer surface of the first filter tank (7) is fixedly connected to a first anti-slip sleeve (22), and the outer surface of the first anti-slip sleeve (22) is fixedly connected to a plurality of first anti-slip protrusions (23). The outer surface of the second filter tank (8) is fixedly connected to a plurality of second anti-slip sleeves (24), and the outer surface of the second anti-slip sleeves (24) is fixedly connected to a plurality of second anti-slip protrusions (25).

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