A device for detecting the delivery dose uniformity of dry powder inhalation formulations

Abstract

This invention discloses a device for detecting the uniformity of delivery dose of dry powder inhalation formulations, comprising a high-performance liquid chromatograph (HPLC). A PLC controller is fixedly installed on the right end of the front surface of the HPLC, and a working box is fixedly installed on the right side of the HPLC. A stepper motor is fixedly installed on the lower right end of the outer surface of the working box. This invention, through the design of the placement frame, allows personnel to place the solution bottle containing the mobile phase at a lower position when using the HPLC for detection, eliminating the need to lift arms or use a stool for high-level placement, thus improving the safety and convenience of operation. Furthermore, the design, including the working box, PLC controller, stepper motor, worm gear, worm wheel, rotating shaft, first synchronous pulley, synchronous belt, rotating rod, second synchronous pulley, and lifting plate, allows for adjustment of the height of the placement frame after the solution bottle is placed, greatly facilitating the detection operation.

Description

Technical Field

[0001] This utility model relates to the field of drug detection technology, specifically to a device for detecting the uniformity of delivery dose of dry powder inhaled formulations. Background Technology

[0002] In the testing of the delivery dose uniformity of dry powder inhalation formulations, high performance liquid chromatography (HPLC) is a key instrument. With its advantages of high sensitivity and high resolution, HPLC can accurately analyze the drug components and content in samples, thereby providing reliable data for assessing the delivery dose uniformity of dry powder inhalation formulations.

[0003] Currently, in practical use, high-performance liquid chromatographs are usually placed on the laboratory table. During the detection process, multiple sets of solution bottles often need to be placed on top of the instrument so that the solution bottles can be in a high position. This allows the gravitational potential energy to assist the flow of the mobile phase into the pump body and reduce the pump body's "suction resistance." However, due to the overall height, the operator often needs to lift their arms to place the solution bottles in place. This process is not only physically demanding, but also requires the use of a stool if the operator is short, increasing the risk of operator error. Utility Model Content

[0004] The purpose of this invention is to provide a device for detecting the delivery dose uniformity of dry powder inhalation preparations. This device allows for convenient operation by placing the solution bottle at a high position when using a high-performance liquid chromatograph to detect the delivery dose uniformity of dry powder inhalation preparations.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a device for detecting the uniformity of delivery dose of a dry powder inhalation preparation, comprising a high-performance liquid chromatograph (HPLC), a PLC controller fixedly mounted on the right end of the front surface of the HPLC, a working box fixedly mounted on the right side of the HPLC, a stepper motor fixedly mounted on the lower right end of the outer surface of the working box, an output terminal of the PLC controller electrically connected to an input terminal of the stepper motor, a worm gear fixedly mounted on the output terminal of the stepper motor, rotating rods movably connected to the upper ends of both sides of the inner cavity of the working box via bearings, a second synchronous pulley fixedly mounted on the middle end of the rotating rod, a rotating shaft movably connected to the lower end of the inner cavity of the working box via bearings, a worm wheel fixedly mounted on the middle end of the rotating shaft, the worm wheel meshing with the worm gear, a first synchronous pulley fixedly mounted on both ends of the rotating shaft, a synchronous belt drivingly connecting the middle ends of the first and second synchronous pulleys, a lifting plate fixedly mounted on the right side of the synchronous belt, and a placement frame fixedly connected between the right sides of the two lifting plates.

[0006] As a preferred embodiment, both ends of the right side of the work box are fixedly connected to guide vertical rods, the middle end of the lifting plate is slidably connected to the surface of the guide vertical rods, and guide balls are movably connected between the middle end of the lifting plate and the surface of the guide vertical rods.

[0007] As a preferred embodiment, a foam seat is placed inside the placement frame, and the surface of the foam seat has a receiving hole.

[0008] As a preferred embodiment, a support plate is fixedly connected to the middle of the bottom of the inner cavity of the working box. There are two support plates, and the upper end of the support plate is movably connected to the surface of the rotating shaft through a bearing.

[0009] As a preferred embodiment, a magnetic block is fixedly installed at the middle of the left side of the outer surface of the placement frame, and Hall sensors are fixedly installed at both ends of the right side of the high-performance liquid chromatograph. The output terminal of the Hall sensor is electrically connected to the input terminal of the PLC controller.

[0010] As a preferred embodiment, the left side of the worm gear is movably connected to the lower end of the left side of the working box cavity via a bearing.

[0011] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0012] This invention, through the design of a placement frame, allows personnel to place the solution bottle containing the mobile phase at a lower position when using a high-performance liquid chromatograph (HPLC), eliminating the need to lift arms or use a stool for placement. This improves the safety and convenience of personnel operation. Furthermore, the design incorporates a work box, PLC controller, stepper motor, worm gear, worm wheel, rotating shaft, first synchronous pulley, synchronous belt, rotating rod, second synchronous pulley, and lifting plate. After the solution bottle is placed, the height of the placement frame can be adjusted, greatly facilitating the personnel's testing operations. Attached Figure Description

[0013] Figure 1 This is a perspective view of the present utility model;

[0014] Figure 2 This is a schematic diagram of the left side structure of the working box of this utility model;

[0015] Figure 3 This is a front sectional view of the working box of this utility model;

[0016] Figure 4 This utility model Figure 3 Enlarged view of section A in the image;

[0017] Figure 5 This is a partial cross-sectional view of the right side of the working box of this utility model;

[0018] Figure 6This is a schematic diagram of the rotating shaft structure of this utility model.

[0019] In the diagram: 1. High-performance liquid chromatograph; 2. PLC controller; 3. Working box; 4. Stepper motor; 5. Hall sensor; 6. Placement frame; 7. Foam holder; 8. Magnetic block; 9. First synchronous pulley; 10. Guide vertical rod; 11. Synchronous belt; 12. Second synchronous pulley; 13. Lifting plate; 14. Guide ball; 15. Worm gear; 16. Worm wheel; 17. Support plate; 18. Rotating shaft; 19. Rotating rod. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] Secondly, the term "an embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that excludes other embodiments.

[0022] The high-performance liquid chromatograph 1, PLC controller 2, working box 3, stepper motor 4, Hall sensor 5, placement frame 6, foam seat 7, magnetic block 8, first synchronous pulley 9, guide vertical rod 10, synchronous belt 11, second synchronous pulley 12, lifting plate 13, guide ball 14, worm gear 15, worm wheel 16, support plate 17, rotating shaft 18, and rotating rod 19 of this application are all general standard parts or parts known to those skilled in the art. Their structure and principle can be learned by those skilled in the art through technical manuals or conventional experimental methods.

[0023] Example 1:

[0024] Please see Figures 1-6As shown, this utility model provides a device for detecting the delivery dose uniformity of dry powder inhalation preparations, including a high-performance liquid chromatograph 1 (HPLC). A PLC controller 2 is fixedly installed on the right end of the front surface of the HPLC 1. A working box 3 is fixedly installed on the right side of the HPLC 1. A stepper motor 4 is fixedly installed on the lower right end of the outer surface of the working box 3. The output terminal of the PLC controller 2 is electrically connected to the input terminal of the stepper motor 4. A worm gear 15 is fixedly installed on the output terminal of the stepper motor 4. The upper ends of both sides of the inner cavity of the working box 3 are connected by bearings. A rotating rod 19 is movably connected, and a second synchronous pulley 12 is fixedly installed at the middle end of the rotating rod 19. A rotating shaft 18 is movably connected to the lower end of the inner cavity of the working box 3 through a bearing. A worm gear 16 is fixedly installed at the middle end of the rotating shaft 18. The worm gear 16 meshes with the worm 15. A first synchronous pulley 9 is fixedly installed at both ends of the rotating shaft 18. A synchronous belt 11 is connected between the middle end of the first synchronous pulley 9 and the middle end of the second synchronous pulley 12. A lifting plate 13 is fixedly installed on the right side of the synchronous belt 11. A placement frame 6 is fixedly connected between the right sides of the two lifting plates 13.

[0025] In this technical solution, when the operator uses a high-performance liquid chromatograph 1 to test the delivery dose uniformity of dry powder inhalation preparations, the operator can place the solution bottle containing the mobile phase in the placement frame 6. Then, the stepper motor 4 is started by the PLC controller 2, which drives the worm gear 15 to rotate. The rotation of the worm gear 15 drives the worm wheel 16 and the rotating shaft 18 to rotate. The rotation of the rotating shaft 18 drives the two sets of first synchronous pulleys 9 to rotate. Under the action of the rotation of the first synchronous pulleys 9 and the interaction between the rotating rod 19 and the second synchronous pulley 12, the two sets of synchronous belts 11 can be driven to move. While the synchronous belts 11 are moving, they can drive the lifting plate 13 on the right and the placement frame 6 to move upward until the solution bottle placed in the placement frame 6 is in a higher position. This achieves the effect of adjusting the placement height of the solution bottle, allowing the operator to operate from a lower height, which greatly facilitates the operation.

[0026] It should be noted that the high performance liquid chromatograph 1 does not work alone during use, but is combined with an external delivery dose collection system. By analyzing the drug concentration collected by the delivery dose collection system and after solvent elution, the delivery dose uniformity test data of the dry powder inhalation formulation is obtained.

[0027] Example 2:

[0028] Based on Embodiment 1, this utility model is as follows: Figures 1-6As shown, guide rods 10 are fixedly connected to both ends of the right side of the work box 3. The middle end of the lifting plate 13 is slidably connected to the surface of the guide rod 10. Guide balls 14 are movably connected between the middle end of the lifting plate 13 and the surface of the guide rod 10. A foam seat 7 is placed in the inner cavity of the placement frame 6. The surface of the foam seat 7 has a receiving hole. A support plate 17 is fixedly connected to the middle end of the bottom of the inner cavity of the work box 3. There are two support plates 17. The upper end of the support plate 17 is movably connected to the surface of the rotating shaft 18 through a bearing. A magnetic block 8 is fixedly installed in the middle end of the left side of the outer surface of the placement frame 6. Hall sensors 5 are fixedly installed at both ends of the right side of the high performance liquid chromatograph 1. The output end of the Hall sensor 5 is electrically connected to the input end of the PLC controller 2. The left side of the worm gear 15 is movably connected to the lower end of the left side of the inner cavity of the work box 3 through a bearing.

[0029] In this technical solution, the guide rod 10 and guide ball 14 are used to guide the lifting plate 13 and the placement frame 6, preventing them from tilting due to force. The foam seat 7 and the receiving hole protect the solution bottles placed in the placement frame 6, preventing them from colliding and causing damage. The support plate 17 supports the rotating shaft 18, preventing it from tilting due to force. The Hall sensor 5 and the magnetic block 8 ensure that when the placement frame 6 moves to the highest or lowest position, the magnetic block 8 is positioned to the side of the Hall sensor 5. The Hall sensor 5 senses the magnetic block 8 and transmits the signal to the PLC controller 2 for processing and analysis. Simultaneously, the PLC controller 2 controls the stepper motor 4 to stop working.

[0030] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit the scope of protection of this utility model. Although this utility model has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this utility model without departing from the essence and scope of the technical solutions of this utility model.

Claims

1. A device for detecting the delivery dose uniformity of a dry powder inhalation formulation, comprising a high-performance liquid chromatograph (1), characterized in that: A PLC controller (2) is fixedly installed on the right end of the front surface of the high performance liquid chromatograph (1). A working box (3) is fixedly installed on the right side of the high performance liquid chromatograph (1). A stepper motor (4) is fixedly installed on the lower right side of the outer surface of the working box (3). The output terminal of the PLC controller (2) is electrically connected to the input terminal of the stepper motor (4). A worm gear (15) is fixedly installed on the output terminal of the stepper motor (4). Rotary rods (19) are movably connected to the upper ends of both sides of the inner cavity of the working box (3) through bearings. A second rotating rod (19) is fixedly installed at the middle end of the rotating rod (19). The lower end of the inner cavity of the work box (3) is movably connected to the rotating shaft (18) via a bearing. The middle end of the rotating shaft (18) is fixedly installed with a worm gear (16). The worm gear (16) meshes with the worm (15). Both ends of the rotating shaft (18) are fixedly installed with first synchronous pulleys (9). The middle end of the first synchronous pulley (9) and the middle end of the second synchronous pulley (12) are connected by a synchronous belt (11). The right side of the synchronous belt (11) is fixedly installed with a lifting plate (13). The right side of the two lifting plates (13) is fixedly connected with a placement frame (6).

2. The device for detecting the delivery dose uniformity of a dry powder inhalation formulation according to claim 1, characterized in that: Guide rods (10) are fixedly connected to both ends of the right side of the work box (3). The middle end of the lifting plate (13) is slidably connected to the surface of the guide rod (10). Guide balls (14) are movably connected between the middle end of the lifting plate (13) and the surface of the guide rod (10).

3. The device for detecting the delivery dose uniformity of a dry powder inhalation formulation according to claim 1, characterized in that: The inner cavity of the placement frame (6) is provided with a foam seat (7), and the surface of the foam seat (7) is provided with a receiving hole.

4. The device for detecting the delivery dose uniformity of a dry powder inhalation formulation according to claim 1, characterized in that: A support plate (17) is fixedly connected to the middle of the bottom of the inner cavity of the working box (3). There are two support plates (17). The upper end of the support plate (17) is movably connected to the surface of the rotating shaft (18) through a bearing.

5. The device for detecting the delivery dose uniformity of a dry powder inhalation formulation according to claim 1, characterized in that: A magnetic block (8) is fixedly installed at the middle of the left side of the outer surface of the placement frame (6), and Hall sensors (5) are fixedly installed at both ends of the right side of the high performance liquid chromatograph (1). The output end of the Hall sensor (5) is electrically connected to the input end of the PLC controller (2).

6. The device for detecting the delivery dose uniformity of a dry powder inhalation formulation according to claim 1, characterized in that: The left side of the worm (15) is movably connected to the lower end of the left side of the inner cavity of the working box (3) via a bearing.

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