Fixing device and adapter for small animal brain function imaging

Abstract

The utility model discloses a fixing device and adapter for small animal brain function imaging, including head fixing frame and probe fixed assembly, probe fixed assembly installs on head fixing frame, the head fixing frame is equipped with detection hole, the side of head fixing frame away from probe fixed assembly is located the edge of detection hole and is integrally connected with the fixed part of downward extension, the fixed part is equipped with the fixed groove of adapting to the shape of animal head, the fixed groove forms and has the open mouth of opening downward, through the side of head fixing frame away from probe fixed assembly is located the edge of detection hole and is integrally connected with the fixed part of downward extension, the fixed part is equipped with the fixed groove of adapting to the shape of animal head, and the fixed groove forms and has the open mouth of opening downward, realize the fixed of mouse headskull fast, solve the problem of low experiment efficiency.

Description

Technical Field

[0001] This utility model relates to the technical field of ultrasonic imaging detection experimental equipment, specifically to a fixation device and adapter for small animal brain functional imaging. Background Technology

[0002] To study brain function, mice are usually used as experimental subjects. When conducting experiments on mice, anesthesia is used to perform brain imaging. However, because anesthetics inhibit brain function and reduce physiological signals, it is difficult to observe brain function under normal physiological conditions.

[0003] Existing animal in vivo brain functional imaging fixation devices do not conform to the orientation of the mouse skull. It is necessary to use a metal sheet to form a suitable shape according to the size of the mouse's head, then attach the metal sheet to the animal in vivo brain functional imaging fixation device, and finally use dental cement to fix the mouse's head. This operation is very complicated, and it takes skilled operators at least 1.5-2 hours to complete the operation, resulting in low experimental efficiency.

[0004] Based on this, our research group conducted research on the utility model content, which was funded by the Ningxia Hui Autonomous Region Key Research and Development Program or the Achievement Transformation Project; the funded project title is: Research on the mechanism of hypothalamic-medial prefrontal cortex neural circuit regulating depression and its application in drug intervention; project number: 2023BEG03009. Utility Model Content

[0005] This invention addresses the deficiencies in existing technologies by providing a fixation device and adapter for small animal brain functional imaging. It features a downwardly extending fixation part integrally connected to the edge of the detection hole on the side of the head fixation frame away from the probe fixation assembly. The fixation part has a fixation groove adapted to the shape of the animal's head, forming an open-faced opening. This eliminates the need for additional metal plates, enabling rapid fixation of the mouse's head and solving the problem of low experimental efficiency.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A fixation device and adapter for small animal brain functional imaging includes a head fixation frame and a probe fixation assembly. The probe fixation assembly is mounted on the head fixation frame, which has a detection hole. A downwardly extending fixation part is integrally connected to the edge of the detection hole on the side of the head fixation frame away from the probe fixation assembly. The fixation part has a fixation groove adapted to the shape of the animal's head, and the fixation groove forms a downward-opening opening. By having a downwardly extending fixation part integrally connected to the edge of the detection hole on the side of the head fixation frame away from the probe fixation assembly, and the fixation part having a fixation groove adapted to the shape of the animal's head with a downward-opening opening, no additional metal plate is required, enabling rapid fixation of the mouse's head and solving the problem of low experimental efficiency.

[0008] As a preferred embodiment, the probe fixing assembly includes a first mounting plate and a second mounting plate. The first mounting plate has a clearance hole corresponding to the detection hole. The first mounting plate has a plurality of mounting positions for mounting the second mounting plate around the clearance hole. The second mounting plate has a third mounting plate that can move along the length direction of the second mounting plate. The third mounting plate has a probe fixing bracket. The third mounting plate is vertically mounted on the second mounting plate.

[0009] As a preferred embodiment, the first mounting plate has a first fixing ear on both sides, and the first fixing ear has a first mounting hole. The head fixing bracket has a second fixing ear corresponding to the first fixing ear, and the second fixing ear has a second mounting hole corresponding to the first mounting hole. The first mounting plate and the head fixing bracket are fixed by screws or bolts passing through the first mounting hole and the second mounting hole.

[0010] As a preferred embodiment, the first mounting plate and the head fixing bracket are magnetically connected.

[0011] As a preferred embodiment, the second mounting plate is provided with a slide rail along its length, the slide rail is provided with a slide block, and the third mounting plate is disposed on the slide block.

[0012] As a preferred embodiment, the third mounting plate is provided with a plurality of third mounting holes along its length, and the probe fixing bracket is provided with a fourth mounting hole corresponding to the third mounting holes. The probe fixing bracket is fixed to the third mounting plate by screws or bolts passing through the third mounting holes and the fourth mounting holes.

[0013] As a preferred embodiment, the second mounting plate has a fifth mounting hole, and the mounting position has a sixth mounting hole. The second mounting plate is mounted on the mounting position by screws or bolts passing through the fifth mounting hole and the sixth mounting hole.

[0014] As a preferred embodiment, the head fixing bracket is further provided with at least one glue inlet through hole that connects to the fixing groove.

[0015] As a preferred embodiment, the inner side of the detection hole is provided with a step facing the probe fixing assembly.

[0016] As a preferred embodiment, the width of the opening gradually increases from top to bottom.

[0017] Compared with the prior art, this utility model has obvious advantages and beneficial effects. Specifically, by integrally connecting a downwardly extending fixing part to the edge of the detection hole on the side of the head fixing frame away from the probe fixing component, and providing a fixing groove that is adapted to the shape of the animal's head in the fixing part, an opening facing downward is formed at the fixing groove. During use, no additional metal sheet is required, which can realize the quick fixing of the head fixing frame, greatly reducing the difficulty of operation for the experimenter, improving the fixing efficiency, and thus improving the experimental efficiency.

[0018] To more clearly illustrate the structural features, technical means, and specific objectives and functions achieved by this utility model, the following detailed description is provided in conjunction with the accompanying drawings and specific embodiments: Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the assembly structure of an embodiment of the present utility model;

[0020] Figure 2 This is an exploded structural diagram of an embodiment of the present utility model;

[0021] Figure 3 This is a side view of an embodiment of the present utility model.

[0022] Explanation of reference numerals in the attached diagram:

[0023] 10-First mounting plate; 11-Lean-out hole; 12-Mounting position; 13-Sixth mounting hole; 14-First fixing lug; 15-First mounting hole;

[0024] 20-Second mounting plate; 21-Slide rail; 22-Fifth mounting hole; 23-Third mounting plate; 24-Slide block; 25-Third mounting hole; 26-Probe mounting bracket; 27-Fourth mounting hole;

[0025] 30-Head fixing bracket; 31-Inspection hole; 32-Step; 33-Glue inlet hole; 34-Fixing part; 35-Fixing groove; 36-Second fixing ear; 37-Second mounting hole. Detailed Implementation

[0026] In the description of this utility model, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the utility model and simplifying the description, and do not indicate or imply that the position or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0027] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0028] like Figure 1-3 As shown, this utility model discloses a fixation device and adapter for small animal brain functional imaging, including a head fixation frame 30 and a probe fixation assembly. The probe fixation assembly is mounted on the head fixation frame 30. The head fixation frame 30 has a detection hole 31. On the side of the head fixation frame 30 away from the probe fixation assembly, a downwardly extending fixing part 34 is integrally connected to the edge of the detection hole 31. The fixing part 34 has a fixing groove 35 adapted to the shape of the animal's head. The fixing groove 35 forms an opening facing downwards. The width of the opening gradually increases from top to bottom. The head fixation frame 30 also has two glue inlet holes 33 communicating with the fixing groove 35. The inner side of the detection hole 31 A step 32 facing the probe fixing assembly is provided; dental cement is injected through the glue inlet 33 to fill the gap between the head fixation frame 30 and the animal head, and to bond and fix the head fixation frame 30 and the animal head, thus completing the fixation of the head fixation frame 30; after the craniotomy is completed, the biofilm can be quickly adhered to the step 32; a downwardly extending fixing part 30 is integrally connected to the edge of the detection hole on the side of the head fixation frame 30 away from the probe fixing assembly. The fixing part has a fixing groove 35 adapted to the shape of the animal head. The fixing groove 35 forms an open opening facing downwards, eliminating the need for additional metal plates, thus achieving rapid fixation of the mouse skull and solving the problem of low experimental efficiency.

[0029] The probe fixing assembly includes a first mounting plate 10 and a second mounting plate 20. The first mounting plate 10 has a clearance hole 11 corresponding to the detection hole 31. The first mounting plate 10 has multiple mounting positions 12 for mounting the second mounting plate 20 around the clearance hole 11. The second mounting plate 20 has a third mounting plate 23 that can move along the length of the second mounting plate 20. The third mounting plate 23 has a probe fixing bracket 26 and is vertically arranged on the second mounting plate 20. By setting multiple mounting positions 12, the second mounting plate 12 can be installed on mounting positions 12 at different positions as needed, improving imaging quality and range. By moving the third mounting plate 23, the sagittal and coronal planes can be measured.

[0030] The first mounting plate 10 has first fixing ears 14 on both sides, and first fixing ears 14 have first mounting holes 15. The head fixing frame 30 has second fixing ears 36 corresponding to the first fixing ears 14, and second fixing ears 36 have second mounting holes 37 corresponding to the first mounting holes 15. The first mounting plate 10 and the head fixing frame 30 are fixed by screws or bolts passing through the first mounting holes 15 and the second mounting holes 37. The connection is reliable and will not shake during use, thus improving the imaging quality.

[0031] The first mounting plate and the head fixing frame are magnetically connected; by providing grooves for fixing magnets at the first fixing ear 14 and the second fixing ear 36, the magnets can be fixed on the first mounting plate 10 and the head fixing frame 30.

[0032] It should be understood that the fixed position of the magnet can be selected as needed.

[0033] It should be understood that magnets can be provided on both the first mounting plate 10 and the head fixing frame 30, or magnets can be provided on either the first mounting plate 10 or the head fixing frame 30, while the other is made of a material that can be attracted by magnets.

[0034] This should be understood as meaning that, in order to secure it more quickly, snap-fit ​​or other methods can be used for connection, so that it does not shake or fall off during use.

[0035] The second mounting plate 20 is provided with a slide rail 21 along its length direction, and a slide seat 24 is provided on the slide rail 21. The third mounting plate 23 is disposed on the slide seat 24. Through the cooperation of the slide seat 24 and the slide rail 21, the third mounting plate 23 can be moved along the length direction of the second mounting plate 20, thereby realizing the movement of the probe along the coronal axis and realizing the measurement of the coronal plane.

[0036] In this invention, the slide block 24 is provided with a fixing hole. By inserting a screw into the through hole and abutting against the slide rail 21, the slide block 24 can be fixed on the slide rail 21, thereby improving imaging stability.

[0037] The third mounting plate 23 has multiple third mounting holes 25 along its length, and the probe mounting bracket 26 has a fourth mounting hole 27 corresponding to the third mounting holes 25. The probe mounting bracket 26 is fixed to the third mounting plate 23 by screws or bolts passing through the third mounting holes 25 and the fourth mounting holes 27. By providing multiple third mounting holes 25, the probe mounting bracket 26 can be installed in different positions as needed, so that the distance between the probe and the detection hole 31 can be adjusted, thereby improving the imaging range.

[0038] In this utility model, the number of the third mounting holes 25 is 3. It should be understood that the number of the third mounting holes 25 can be increased or decreased according to the needs of use. In addition, the probe fixing frame 26 and the third mounting plate 23 can also be connected by a slide rail 21 and a slide block 24, so that the probe fixing frame 26 can be moved along the length direction of the third mounting plate 23 to adjust the distance between it and the detection hole 31.

[0039] The second mounting plate 20 has a fifth mounting hole 22, and the mounting position 12 has a sixth mounting hole 13. The second mounting plate 20 is mounted on the mounting position 12 by screws or bolts passing through the fifth mounting hole 22 and the sixth mounting hole 13. There are two fifth mounting holes 22, which are located at opposite ends of the second mounting plate 20. By improving the stability of the connection between the first mounting plate 10 and the second mounting plate 20, the stability of the probe is ensured and the imaging quality is improved.

[0040] It should be understood that the first mounting plate 10 and the second mounting plate 20 can be connected by snap-fit ​​or other fixed methods to achieve a stable connection between the first mounting plate 10 and the second mounting plate 20.

[0041] In this invention, the probe holder 26 can be made of stainless steel, the slide rail 21 can be made of POM material, and the remaining parts can be made of 6161 aluminum alloy or 7075 aluminum alloy. By using the above materials, the fixing device is made lighter and lighter. When this fixing device is used to fix mice, its weight is 3g-3.5g.

[0042] The method of using this utility model is as follows: Place the head fixation frame 30 on the animal's head, and inject dental cement along the glue inlet hole 33 to fill the gap between the head fixation frame 30 and the animal's head, so that the head fixation frame 30 and the animal's head are bonded and fixed. After the craniotomy is completed, the biofilm is adhered to the step 32, and the first mounting plate 10 is connected to the head fixation frame 30. Then, the probe fixing assembly is installed on the first mounting plate 10. During use, the position of the probe fixing frame 26 can be adjusted according to the needs, and the probe fixing assembly can be installed on the mounting position 12 at different positions as needed.

[0043] In summary, this invention improves the detection and imaging range by mounting the probe on a probe holder and providing a slide rail 21 and a slide block 24, allowing the probe holder to be movably mounted on the third mounting plate 23. Multiple mounting positions 12 enable the probe to measure both the sagittal and coronal planes. Furthermore, a downwardly extending fixing part 34 is integrally connected to the edge of the detection hole 31 on the side of the head holder 30 away from the probe fixing assembly. The fixing part 34 has a fixing groove 35 adapted to the shape of the animal's head, forming a downward-facing opening. This allows for rapid fixation of the head holder 30 during use, significantly reducing the operator's difficulty, improving fixation efficiency, and ultimately enhancing experimental efficiency.

[0044] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model. Therefore, any modifications, equivalent substitutions, improvements, etc., made to the above embodiments based on the actual technical aspects of the present utility model shall still fall within the scope of the technical solution of the present utility model.

Claims

1. A fixation device and adapter for small animal brain functional imaging, characterized in that: The device includes a head fixation frame and a probe fixation assembly. The probe fixation assembly is mounted on the head fixation frame. The head fixation frame has a detection hole. On the side of the head fixation frame away from the probe fixation assembly, a downwardly extending fixing part is integrally connected to the edge of the detection hole. The fixing part has a fixing groove adapted to the shape of the animal's head, and the fixing groove forms an opening facing downwards.

2. The fixation device and adapter for small animal brain functional imaging according to claim 1, characterized in that, The probe fixing assembly includes a first mounting plate and a second mounting plate. The first mounting plate has a clearance hole corresponding to the detection hole. The first mounting plate has a plurality of mounting positions for mounting the second mounting plate around the clearance hole. The second mounting plate has a third mounting plate that can move along the length direction of the second mounting plate. The third mounting plate has a probe fixing bracket. The third mounting plate is vertically mounted on the second mounting plate.

3. The fixation device and adapter for small animal brain functional imaging according to claim 2, characterized in that, The first mounting plate has a first fixing ear on both sides, and a first mounting hole is provided on the first fixing ear. The head fixing bracket has a second fixing ear corresponding to the first fixing ear, and a second mounting hole corresponding to the first mounting hole is provided on the second fixing ear. The first mounting plate and the head fixing bracket are fixed by screws or bolts passing through the first mounting hole and the second mounting hole.

4. The fixation device and adapter for small animal brain functional imaging according to claim 2, characterized in that, The first mounting plate and the head fixing bracket are magnetically connected.

5. A fixation device and adapter for small animal brain functional imaging according to claim 2, characterized in that, The second mounting plate is provided with a slide rail along its length, and a slide block is provided on the slide rail. The third mounting plate is disposed on the slide block.

6. The fixation device and adapter for small animal brain functional imaging according to claim 5, characterized in that, The third mounting plate is provided with a plurality of third mounting holes along its length, and the probe fixing bracket is provided with a fourth mounting hole corresponding to the third mounting holes. The probe fixing bracket is fixed to the third mounting plate by screws or bolts passing through the third mounting holes and the fourth mounting holes.

7. A fixation device and adapter for small animal brain functional imaging according to claim 2, characterized in that, The second mounting plate has a fifth mounting hole, and the mounting position has a sixth mounting hole. The second mounting plate is installed on the mounting position by screws or bolts passing through the fifth mounting hole and the sixth mounting hole.

8. The fixation device and adapter for small animal brain functional imaging according to claim 1, characterized in that, The head fixing bracket is also provided with at least one glue inlet through hole that connects to the fixing groove.

9. A fixation device and adapter for small animal brain functional imaging according to claim 1, characterized in that, The inside of the detection hole is provided with a step facing the probe fixing assembly.

10. A fixation device and adapter for small animal brain functional imaging according to claim 1, characterized in that, The width of the opening gradually increases from top to bottom.

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