A mobile phase membrane device for detecting alkaloids

Abstract

The utility model belongs to chromatographic analysis detection device technical field, concretely relates to a flowing phase membrane passing device for alkaloid detection, including filter cup, sand core hopper, vacuum cup cover and liquid collecting bottle, the lower end cup neck of filter cup upper and lower ends are all open, and the lower end cup neck is integrally connected with the compression ring no.

Description

Technical Field

[0001] This utility model belongs to the technical field of chromatographic analysis and detection devices, specifically relating to a mobile phase membrane-passing device for alkaloid detection. Background Technology

[0002] The determination of alkaloid content in cosmetics generally uses chromatographic analysis. To ensure that the liquid path is not blocked and the accuracy of the chromatographic examination is guaranteed, a membrane filter is often used to remove impurities in the mobile phase. In the existing technology, when using existing membrane filters for chromatographic analysis of alkaloids, if the filter membrane becomes blocked, the liquid remaining on the filter membrane cannot be removed quickly and effectively, and the filter membrane cannot be replaced quickly. Therefore, it often affects the progress of the test and may even cause the test to be interrupted. In addition, liquid leakage is likely to occur during the transfer process. Summary of the Invention

[0003] To address the above problems, the purpose of this invention is to provide a mobile phase membrane transfer device for alkaloid detection that can quickly and effectively divert and transfer the liquid above the filter membrane when blockage occurs during the mobile phase membrane transfer process, thereby facilitating quick replacement of the filter membrane by the testing personnel.

[0004] The objective of this invention is achieved through the following technical solution: a mobile phase membrane transfer device for alkaloid detection, comprising a filter cup, a sintered sand funnel, a vacuum cup, and a collection bottle. The filter cup is open at both ends, and a clamping ring is integrally connected to the neck of the lower end of the filter cup. A clamping ring 2, which cooperates with the clamping ring 1, is integrally connected to the top of the sintered sand funnel. A filter membrane is sandwiched between the clamping ring 1 and the clamping ring 2, and the clamping ring 1 and the clamping ring 2 are fixed together by a fixing clip. A drainage tube is located at the lower end of the sintered sand funnel. A vacuum cup is sealed to the outer wall. The vacuum cup has a vacuum port connected to the filtration device near its upper end. The lower end of the vacuum cup is detachably and sealed to the mouth of the collection bottle. A drainage groove for liquid transfer is radially opened on the pressing surface of the first pressing ring, and a drainage hole connected to the drainage groove is vertically opened on the second pressing ring. The end of the drainage groove away from the inner circle of the first pressing ring is located inside the outer circle of the first pressing ring. A short tube for drainage is sealed to the drainage hole, and a control valve is provided on the short tube.

[0005] Furthermore, the short tube is connected to a liquid addition bottle containing the mobile phase to be filtered via a pipetting line.

[0006] Furthermore, the filter cup is provided with a sealing cap at the upper end, and the sealing cap is provided with a liquid inlet funnel.

[0007] Furthermore, the clamping surface of the second clamping ring is provided with an annular groove that can accommodate the filter membrane. The drainage hole is located close to the edge of the annular groove and inside the clamping surface of the fixing clamp. When the fixing clamp is used to clamp and connect the first clamping ring and the second clamping ring, the short tube connected to the drainage hole will not cause inconvenience to the clamping operation of the fixing clamp.

[0008] Furthermore, the collection bottle is a conical flask or a reagent bottle, the drainage tube of the sand core funnel is inserted downward into the mouth of the conical flask, and the lower end of the vacuum cup cover is designed with a ground joint to match the mouth of the conical flask.

[0009] Furthermore, the lower end of the vacuum cup is threadedly sealed to the reagent bottle.

[0010] Furthermore, the vacuum port is connected to the filtration line of the filtration device via a rubber tube, and the filtration line is equipped with a vacuum gauge and a valve, and a buffer bottle is provided between the valve and the vacuum port to prevent liquid from being drawn into the filtration device.

[0011] In use, the mobile phase to be filtered enters the filter cup through the opening at the top of the filter cup, and is filtered through the filter membrane and the sintered sand funnel. The filtered liquid is then guided into the collection bottle through the guide tube at the bottom of the sintered sand funnel. Since the vacuum cup is equipped with a vacuum port near its upper end that connects to the filtration device, during filtration, to ensure smooth filtration and increase the filtration speed, the vacuum port can be connected to the filtration line of the filtration device via a rubber tube or pipe fitting. The filtration device is then activated to evacuate the gas inside the vacuum cup. In a vacuum environment, if the filter membrane becomes clogged during filtration, the control valve on the short tube used for drainage can be opened to allow the liquid above the filter membrane to be transferred sequentially through the drainage groove, drainage hole, and short tube to a suitable clean test tube, beaker, or addition bottle containing the mobile phase solvent to be filtered. The end of the drainage groove away from the inner circle of the clamping ring is located inside the outer circle of the clamping ring, which can prevent the drainage groove from penetrating the clamping surface of the clamping ring and causing leakage. After all the liquid above the filter membrane has been removed, the fixing clamp can be removed, the filter cup can be removed, and the filter membrane can be replaced.

[0012] Beneficial effects: This invention can quickly and effectively divert and transfer the liquid above the filter membrane when blockage occurs during the flow of the mobile phase through the membrane, thus facilitating quick replacement of the filter membrane by the testing personnel and preventing liquid leakage during the transfer process. Attached Figure Description

[0013] The present invention will now be described in more detail by way of example, with reference to the accompanying drawings, in which: Figure 1 : A schematic diagram of the structure of Embodiment 1 of this utility model.

[0014] Figure 2: A schematic diagram of the position of the drainage hole on the second clamping ring of this utility model embodiment 1.

[0015] Figure 3 : A schematic diagram of the structure of the upper drainage groove of the clamping ring in Embodiment 1 of this utility model.

[0016] Figure 4 : Schematic diagram of the installation structure of the liquid inlet funnel and buffer bottle in Embodiment 2 of this utility model.

[0017] In the diagram: 1. Mobile phase membrane transfer device; 2. Filter cup; 3. Sand core funnel; 4. Vacuum cup cover; 5. Collection bottle; 6. Filter membrane; 7. Fixing clamp; 8. Vacuum filtration device; 20. Opening; 201. Sealing cap; 202. Inlet funnel; 21. First clamping ring; 211. Clamping surface; 212. Drainage groove; 213. Inner circle of first clamping ring; 214. Outer circle of first clamping ring; 30. Sand core; 31. Second clamping ring; 32. Drainage tube; 311. Drainage hole; 312. Short tube; 313. Control valve; 41. Vacuum tube port; 411. Valve; 412. Buffer bottle; 61. Annular groove; 71. Clamping surface. Detailed Implementation

[0018] In this utility model, for ease of description, the relative positional relationships of each component are described according to the layout of the accompanying drawings. For example, the positional relationships of top, bottom, left, right, etc., are determined according to the layout direction in the accompanying drawings.

[0019] Example 1, referring to Figure 1 , Figure 2 , Figure 3 A mobile phase membrane transfer device 1 for alkaloid detection includes a filter cup 2, a sintered sand funnel 3, a vacuum cup 4, and a collection bottle 5. The filter cup 2 has openings 20 at both ends, and a clamping ring 21 is integrally connected to the neck of the lower end of the filter cup 2. A clamping ring 31, which cooperates with the clamping ring 21, is integrally connected to the top of the sintered sand funnel 3. A filter membrane 6 is sandwiched between the clamping rings 21 and 31, and the clamping rings 21 and 31 are connected and fixed by a fixing clip 7. A vacuum cup 4 is sealed to the outer wall of the drainage tube 32 at the lower end of the sintered sand funnel 3. The empty cup cover 4 is provided with a vacuum port 41 near the upper end, which is connected to the vacuum filtration device 8. The lower end of the vacuum cup cover 4 is detachably and sealed to the mouth of the collection bottle 5. The clamping surface 211 of the clamping ring 1 is provided with a radially opened drainage groove 212 for liquid transfer, and the clamping ring 21 is provided with a vertically opened drainage hole 311 connected to the drainage groove 212. The end of the drainage groove 212 away from the inner circle 213 of the clamping ring 1 is located inside the outer circle 214 of the clamping ring 1. A short drainage tube 312 is sealed and connected to the drainage hole 311, and a control valve 313 is provided on the short tube 312.

[0020] The clamping surface of the second clamping ring 31 is provided with an annular groove 61 that can accommodate the filter membrane 6. The drainage hole 311 is provided close to the edge of the annular groove 61 and the drainage hole 311 is located inside the clamping surface 71 of the fixing clamp 7. When the fixing clamp 7 is used to clamp and connect the first clamping ring 21 and the second clamping ring 31, the short tube 312 connected to the drainage hole 311 will not cause inconvenience to the clamping operation of the fixing clamp 7.

[0021] The collection bottle 5 is a conical flask or a reagent bottle. The drainage tube 32 of the sand core funnel 3 is inserted downward into the mouth of the conical flask, and the lower end of the vacuum cup 4 is designed with a ground joint to match the mouth of the conical flask.

[0022] In use, the mobile phase to be filtered enters the filter cup 2 through the opening at the top of the filter cup, and is filtered by the filter membrane 6 and the sand core 30 of the sand core funnel 3. The filtered liquid is then guided into the collection bottle 5 through the guide tube 32 at the bottom of the sand core funnel 3. Since the vacuum cup 4 has a vacuum port 41 connected to the filtration device 8 near its upper end, during filtration, to ensure smooth filtration and increase the filtration speed, the vacuum port 41 can be sealed and connected to the filtration line of the filtration device 8 through a rubber tube or pipe joint. The filtration device 8 is then activated to evacuate the gas inside the vacuum cup 4. During the filtration process... When the intermediate filter membrane 6 becomes blocked, the control valve 313 on the short tube 312 used for drainage can be opened to allow the liquid above the filter membrane 6 to be transferred sequentially through the drainage groove 212, drainage hole 311, and short tube 312 to a suitable clean test tube, beaker, or addition bottle containing the mobile phase solvent to be filtered. The end of the drainage groove 212 away from the inner circle 213 of the clamping ring 21 is located inside the outer circle 214 of the clamping ring 21, which can prevent the drainage groove 212 from penetrating the clamping surface of the clamping ring 21 and causing leakage. After all the liquid above the filter membrane 6 has been removed, the fixing clamp 7 is removed, the filter cup 2 is removed, and the filter membrane 6 is replaced.

[0023] Example 2, refer to Figure 4 As a further optimized design of Embodiment 1, the short tube 312 is connected to the liquid addition bottle containing the mobile phase to be filtered via a pipetting line, or the short tube 312 is connected to the secondary mobile phase membrane unit via a drainage tubing. The secondary mobile phase membrane unit has the same structure as the mobile phase membrane device 1 in Embodiment 1, and the outlet of the drainage tubing is connected to the upper opening of the filter cup 2 of the secondary mobile phase membrane unit.

[0024] The filter cup 2 is provided with a sealing cap 201 at the upper end, and a liquid inlet funnel 202 is provided on the sealing cap to reduce the evaporation of volatile organic solvents and air pollution. The lower end of the vacuum cup cover 4 is threadedly sealed to the reagent bottle.

[0025] The vacuum port 41 is connected to the filtration pipeline of the filtration device 8 via a rubber tube or pipe joint, and the filtration pipeline is equipped with a vacuum gauge and a valve 411, and a buffer bottle 412 is provided between the valve 411 and the vacuum port 41 to prevent liquid from being drawn into the filtration device 8.

[0026] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims

1. A mobile phase membrane transfer device for alkaloid detection, characterized in that, The system includes a filter cup, a sand core funnel, a vacuum cup cover, and a collection bottle. The filter cup is open at both ends, and a clamping ring is integrally connected to the neck of the lower end of the filter cup. A clamping ring 2, which mates with the clamping ring 1, is integrally connected to the top of the sand core funnel. A filter membrane is sandwiched between the clamping rings 1 and 2, and the clamping rings 1 and 2 are fixed together by a clamping clip. A vacuum cup cover is sealed to the outer wall of the drainage tube at the lower end of the sand core funnel. Near the upper end of the vacuum cup cover, a vacuum port communicating with a filtration device is provided. The lower end of the vacuum cup cover is detachably and sealed to the mouth of the collection bottle. A drainage groove for liquid transfer is radially formed on the clamping surface of the clamping ring 1, and a drainage hole communicating with the drainage groove is vertically formed on the clamping ring 2. The end of the drainage groove away from the inner circle of the clamping ring 1 is located inside the outer circle of the clamping ring 1. A short drainage tube is sealed to the drainage hole, and a control valve is provided on the short tube.

2. The mobile phase membrane transfer device for alkaloid detection as described in claim 1, characterized in that, The short tube is connected to the addition bottle containing the mobile phase to be filtered via a pipetting line.

3. A mobile phase membrane device for alkaloid detection as described in claim 1 or 2, characterized in that, The filter cup is provided with a sealing cap at the top, and the sealing cap is provided with a liquid inlet funnel.

4. The mobile phase membrane transfer device for alkaloid detection as described in claim 3, characterized in that, The clamping surface of the second clamping ring is provided with an annular groove that can accommodate the filter membrane. The drainage hole is located close to the edge of the annular groove and is located inside the clamping surface of the fixing clamp.

5. The mobile phase membrane transfer device for alkaloid detection as described in claim 1, characterized in that, The vacuum port is connected to the filtration line of the filtration device via a rubber tube, and the filtration line is equipped with a vacuum gauge and a valve. A buffer bottle is provided between the valve and the vacuum port to prevent liquid from being drawn into the filtration device.

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