A hybrid flow channel column and liquid chromatography system hybrid device

Abstract

The utility model discloses a kind of mixed flow channel column and liquid chromatography system mixing device, for mixer, belong to liquid chromatography instrument technical field, the surface of the mixed flow channel column is equipped with mixed flow channel groove, the mixed flow channel groove includes the front end face flow channel, column face flow channel and rear end face flow channel of intercommunication, the column face flow channel is helical line or is unidirectional square wave form or is the connection structure of first shunt and then confluence.The utility model can realize the purpose that multiple mobile phase mixes in mixed flow channel groove, simple structure, processing cost and processing difficulty are greatly reduced, and in the design stage of mixed flow channel groove, the dead volume of mixed flow channel groove can be better controlled.

Description

Technical Field

[0001] This utility model belongs to the field of liquid chromatography instrument technology, specifically relating to a mixing device for a mixed flow channel column and a liquid chromatography system. Background Technology

[0002] Currently, various mixers exist on the market, such as the porous sintered metal column mixing column from Waters Corporation in the United States, and the structure of multiple sets of stainless steel sheets with etched flow channels to achieve forced mixing from Shimadzu Corporation in Japan. A domestic patent, patent number "CN110787714B", discloses "A Miniature High-Pressure Static Mixer for Liquid Chromatography", which includes a main sleeve, a base, a support ring, a single-hole sealing gasket, a multi-hole sealing gasket, a mixing chamber, and an end sealing gasket. The main sleeve is connected to the base, and at least two sets of the mixing chambers are installed in series inside. The mixing chamber is composed of the support ring and the sealing gaskets at both ends. The sealing gaskets include: a single-hole sealing gasket, a multi-hole sealing gasket, and an end sealing gasket.

[0003] These mixing columns all involve the following problems: first, they have many parts, complex structures, and large dead volumes; second, the forced online distribution of multiple organic phases must pass through multiple levels of metal channels. During this process, the strongly corrosive organic phases will precipitate iron ions from the metal. However, in the analysis methods of clinical protein compounds, these precipitated iron ions from the metal will cause great interference to the analytical results. Therefore, this utility model urgently needs to design an online mixer with a simple structure and small dead volume of mixing channels to further avoid the precipitation of iron ions. Utility Model Content

[0004] In view of the shortcomings of the existing technology, the purpose of this utility model is to propose a mixing device for a mixing channel column and a liquid chromatography system that is simple in structure, has low processing cost and difficulty, and is easy to control dead volume.

[0005] Technical solution one of this utility model: This utility model provides a mixing channel column, the surface of which is provided with a mixing channel groove. The mixing channel groove includes a front face channel, a cylindrical face channel, and a rear face channel. The front face channel includes a liquid inlet end and a first connecting end. The cylindrical face channel includes an inlet end and an outlet end. The rear face channel includes a second connecting end and a liquid outlet end. The first connecting end is connected to the inlet end of the cylindrical face channel, and the second connecting end is connected to the outlet end of the cylindrical face channel.

[0006] Preferably, the front end flow channel is provided with an inlet end and a first connecting end, and the rear end flow channel is provided with an outlet end and a second connecting end. Both the front end flow channel and the rear end flow channel are spiral-shaped, and the cylindrical flow channel is spiral-shaped or has a unidirectional waveform. The two ends of the mixing flow channel column are provided with multiple connecting channels. The two ends of each flow channel group of the cylindrical flow channel are connected to the first connecting end of the front end flow channel and the second connecting end of the rear end flow channel through the connecting channels, respectively.

[0007] Preferably, the unidirectional square waveform is specifically a flow channel shape with a square wave-like curve that flows in one direction.

[0008] Preferably, the front end flow channel has an inlet end and multiple first connection ends; the rear end flow channel has an outlet end and multiple second connection ends; the cylindrical flow channel includes multiple independent flow channel groups, and each flow channel group has a connection structure of first splitting and then merging (also called a forced splitting mixing flow channel structure). The two ends of the mixing flow channel column are provided with multiple connection channels, and the two ends of each flow channel group of the cylindrical flow channel are connected to the first connection end of the front end flow channel and the second connection end of the rear end flow channel through the connection channels respectively.

[0009] Preferably, the front end flow channel includes one first flow channel and two second flow channels, which are joined together to form an "I" shape. The center of the first flow channel is the liquid inlet, and the two ends of the second flow channels are first connecting ends. The rear end flow channel includes one eighth flow channel and two ninth flow channels, which are joined together to form an "I" shape. The center of the eighth flow channel is the liquid outlet, and the two ends of the ninth flow channels are second connecting ends. Preferably, the connection structure of first splitting and then merging flows specifically includes a splitting channel, an intermediate channel and a merging channel connected in sequence. The splitting channel is one channel separated into multiple channels, the merging channel is multiple channels merged into one channel, and the intermediate channel includes multiple channels for connecting the splitting channel and the merging channel.

[0010] Preferably, the cylindrical flow channel includes four flow channel groups. In a single independent flow channel group, the branching flow channel includes one third flow channel, two fourth flow channels, one tenth flow channel, and two eleventh flow channels. The intermediate flow channel includes four fifth flow channels. The merging flow channel includes two sixth flow channels, one seventh flow channel, two twelfth flow channels, and one thirteenth flow channel. One end of the third flow channel is connected to the first connecting end through a connecting channel. The other end of the third flow channel is connected to two adjacent fourth flow channels through the tenth flow channel. The other end of each fourth flow channel is connected to two adjacent fifth flow channels through the eleventh flow channel. Each pair of adjacent fifth flow channels is connected to a sixth flow channel through the twelfth flow channel. Each pair of adjacent sixth flow channels is connected to a seventh flow channel through the thirteenth flow channel. The seventh flow channel is connected to the second connecting end through a connecting channel.

[0011] Preferably, the front end face, rear end face, and column surface of the mixing channel column are provided with turbulence grooves, which are disposed on the mixing channel.

[0012] Preferably, the diameter of the turbulent channel is greater than the width of the mixing channel, and the depth of the turbulent channel is greater than the depth of the mixing channel.

[0013] Preferably, the turbulence channels are arranged in an alternating vertical pattern along the axis of the mixing channel.

[0014] Preferably, the connecting channel includes a vertical section and a horizontal section, wherein the vertical section and the horizontal section are perpendicular to each other.

[0015] Preferably, the mixing dead volume of the mixing channel is 20-40 μL.

[0016] This invention also provides a mixing device for a liquid chromatography system, including the aforementioned mixing channel column.

[0017] This utility model also provides a mixing device for a liquid chromatography system, specifically, it further includes an inlet mounting seat, an outlet mounting seat, and a mixing column. The inlet mounting seat and the outlet mounting seat are sealed together to form a column with a accommodating cavity. The mixing column is placed in the accommodating cavity. The inlet mounting seat is provided with at least one inlet channel, and the outlet mounting seat is provided with an outlet channel. Preferably, the inlet mounting base and the outlet mounting base are connected by a thread.

[0018] The mixing column includes a mixing channel column, a sealing cap, and an inner liner. The sealing cap and the inner liner are sealed together to form a column with a mixing chamber. The mixing channel column is placed in the mixing chamber. The front end, cylindrical surface, and rear end of the mixing channel column are provided with interconnected mixing channels. The sealing cap has a liquid collection tank on the side away from the mixing channel column. The liquid collection tank is connected to the multiple inlet channels. The sealing cap is also provided with a first channel, which connects the liquid collection tank and the mixing channel on the front end of the mixing channel column. The bottom of the inner liner has a second channel, which connects to the mixing channel on the rear end of the mixing channel column.

[0019] Preferably, the mixing channel column and the mixing chamber are interference fit.

[0020] Furthermore, to address the problem of iron ion precipitation, the technical solution of this utility model is as follows: Preferably, the outer surface of the mixing channel column, the inner surface of the inner liner and the inner surface of the sealing cap are coated with stainless steel.

[0021] Preferably, the iron ion content of the mixed flow channel column is less than 0.3%.

[0022] Preferably, the material of the mixing channel column is selected from PEEK plastic materials, PI plastic materials, and titanium alloys.

[0023] Compared with the prior art, the advantages of this utility model are: This invention significantly reduces the manufacturing difficulty of precision mixers by setting a spiral, unidirectional square waveform, and / or forced flow splitting mixing channel structure on the surface of the mixing channel column, and enables the mixer to have a sample storage function similar to a quantitative ring.

[0024] This utility model has a simple structure, lower processing, manufacturing and assembly costs and difficulties, and lower replacement costs.

[0025] This invention further enhances the mixing effect by interleaving multiple turbulence channels within the mixing channel.

[0026] This invention effectively prevents the precipitation of iron ions when different organic phases flow through the mixing channel column by coating the surface of the mixing channel column or by directly selecting the material of the mixing channel column as PEEK, PI-type plastic materials or titanium alloys, etc., with an iron ion content of less than 0.04%. This avoids the serious interference of the precipitated iron ions on the results of downstream analysis and achieves inertization and residue-free operation.

[0027] The detailed structure of this utility model will be further described below with reference to the accompanying drawings and specific embodiments. Attached Figure Description

[0028] Figure 1 This is an isometric schematic diagram of the mixing channel column according to Embodiment 1 of this utility model; Figure 2 This is a front view of the mixing channel column according to Embodiment 1 of this utility model; Figure 3 This utility model Figure 1 Schematic diagram at point A; Figure 4 This is a cross-sectional view of the mixing channel column according to Embodiment 1 of this utility model; Figure 5 This is a three-dimensional schematic diagram of the mixing channel column in Embodiment 2 of this utility model; Figure 6 This is a cross-sectional view of the mixing channel column of Embodiment 2 of this utility model; Figure 7 This is an isometric schematic diagram of the mixing channel column in Embodiment 3 of this utility model; Figure 8 This is a front view of the mixing channel column according to Embodiment 3 of this utility model; Figure 9 This utility model Figure 7 Schematic diagram at point B; Figure 10 This is a cross-sectional view of the mixing channel column of Embodiment 3 of this utility model; Figure 11 This is an isometric schematic diagram of the mixing channel column of the mixing device in Embodiment 4 of this utility model; Figure 12 This is a front view of the mixing channel column in Embodiment 4 of this utility model; Figure 13 This utility model Figure 11 Schematic diagram at point C; Figure 14 This is an isometric schematic diagram of the mixing channel column of the mixing device in Embodiment 4 of this utility model; Figure 15 This is a front view of the mixing channel column in Embodiment 4 of this utility model; Figure 16 This utility model Figure 14 Schematic diagram at point D.

[0029] Figure 17 This is a schematic diagram of the overall appearance of the mixing device according to Embodiment 5 of this utility model; Figure 18 This is a cross-sectional view of the mixing device according to Embodiment 5 of this utility model; Figure 19 This is an exploded schematic diagram of the mixing device according to Embodiment 5 of this utility model; Figure 20 The data for Embodiment Six of this utility model are based on the curve graph; Figure 21This is a gradient curve diagram of Embodiment Six of this utility model.

[0030] Component names and corresponding serial numbers: 1. Inlet mounting base; 11. Inlet channel; 2. Sealing cap; 21. Liquid collection tank; 22. First channel; 3. Inner liner; 31. Second channel; 4. Outlet mounting base; 41. Outlet channel; 5. Mixing flow channel column; 51. Front face flow channel; 511. First flow channel; 512. Second flow channel; 513. Liquid inlet end; 514. First connection end; 52. Rear face flow channel; 521. Eighth flow channel; 522, Ninth flow channel; 523, Liquid outlet end; 524, Second connection end; 525, Tenth flow channel; 526, Eleventh flow channel; 527, Twelfth flow channel; 528, Thirteenth flow channel; 53, Cylindrical flow channel; 531, Third flow channel; 532, Fourth flow channel; 533, Fifth flow channel; 534, Sixth flow channel; 535, Seventh flow channel; 54, Turbulent channel; 55, Connecting channel; 551, Horizontal section; 552, Vertical section. Detailed Implementation

[0031] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. The components of the embodiments of this utility model described and shown in the accompanying drawings can be arranged and designed in various different configurations. The following detailed description of the embodiments of this utility model provided in the accompanying drawings is not intended to limit the scope of the claimed utility model, but merely to illustrate selected embodiments of the utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without inventive effort are within the scope of protection of this utility model.

[0032] Unless otherwise defined, the technical or scientific terms used in this disclosure shall have the ordinary meaning understood by a person skilled in the art to which this disclosure pertains. The words “comprising” or “including” and similar terms used in this disclosure mean that the element or object preceding the word covers the element or object listed after the word and its equivalents, without excluding other elements or objects. The words “connected” or “linked” and similar terms are not limited to physical or mechanical connections, but may also include electrical connections, whether direct or indirect. “Up,” “down,” “left,” “right,” etc., are used only to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly. Example

[0033] like Figures 1-4As shown, this utility model provides a mixing channel column 5. The surface of the mixing channel column 5 is provided with a mixing channel groove. The mixing channel groove includes a front face channel 51, a cylindrical face channel 53, and a rear face channel 52. The front face channel 51 includes an inlet end 513 and a first connecting end 514. The cylindrical face channel 53 includes an inlet end and an outlet end. The rear face channel 52 includes a second connecting end 524 and an outlet end 523. The first connecting end 514 is connected to the inlet end of the cylindrical face channel 53, and the second connecting end 524 is connected to the outlet end of the cylindrical face channel 53. By setting a mixing channel groove on the surface of the mixing channel column 5, the purpose of mixing multiple mobile phases in the mixing channel groove can be achieved. Moreover, during the design stage of the mixing channel groove, the dead volume of the design mixing channel groove can be better controlled.

[0034] Specifically, the front flow channel 51 is provided with an inlet end 513 and a first connecting end 514, and the rear flow channel 52 is provided with an outlet end 523 and a second connecting end 524. The front flow channel 51, the rear flow channel 52, and the cylindrical flow channel 53 are all spiral-shaped. Multiple mobile phases in the spiral-shaped flow channels, through centrifugal force, cause the fluid to collide with the channel walls. Due to the velocity difference between the fluid at the center of the channel and the channel walls, different mobile phases within the fluid continuously move back and forth between the center and the inner wall of the channel, colliding, converging, and then separating again, repeating this cycle multiple times to achieve the mixing of multiple mobile phases within the fluid. The mixing column 5 has multiple connecting channels 55 inside its two ends. The two ends of each group of cylindrical flow channels 53 are connected to the first connecting end 514 and the second connecting end 524 respectively through the connecting channels 55.

[0035] The interior of both ends of the mixing channel column 5 refers to the interior of the end of the mixing channel column 5 near the front end face or the interior of the end near the rear end face.

[0036] Specifically, the connecting channel 55 includes a vertical section 552 and a horizontal section 551. The vertical section 552 and the horizontal section 551 are perpendicular to each other. The right-angled connecting channel 55 is easy to process. When the end face section of the mobile phase in the mixing channel is transferred to the cylindrical channel 53, the various mobile phase components will also collide violently on the inner wall of the connecting channel 55, which enhances the mixing effect.

[0037] Specifically, the outer surface of the mixing column 5, the inner surface of the liner 3, and the inner surface of the sealing cap 2 are coated with stainless steel. This effectively prevents iron ions from precipitating from the mixing column and entering the mobile phase under high pressure, and then following the mobile phase into the chromatographic column and detector, thus affecting the analytical results.

[0038] Alternatively, the mixing column can also be manufactured using materials with an iron ion content of less than 0.04%, such as PEEK plastics, PI plastics, or titanium alloys. Example

[0039] like Figure 5 and Figure 6 As shown, this utility model provides another mixing device for a mixing channel column and a liquid chromatography system. Based on Embodiment 1, the shape of the column surface channel 53 is changed, making the column surface channel 53 a unidirectional square waveform surrounding the column surface. In this embodiment, the unidirectional square waveform of the column surface channel 53 allows multiple solutions to achieve a mixing effect at the channel corners through the velocity difference between the inner and outer fluids (the outer fluid flows slowly, and the inner fluid flows rapidly) and multiple collisions and fusions. This further increases the collision mixing intensity of the mobile phase in the column surface channel 53, enhancing the mixing effect. Multiple connecting channels 55 are provided inside both ends of the mixing channel column 53. The two ends of each group of channels in the column surface channel 53 are connected to the first connecting end 514 and the second connecting end 524 respectively through the connecting channels 55.

[0040] Specifically, the unidirectional square waveform refers to a flow channel shape with a square wave-like curve that flows in one direction. Example

[0041] like Figures 7-10 As shown, based on Embodiment 1, the shape of the mixing channel groove on the mixing channel column 5 is changed to form Embodiment 3. The front end channel 51 of Embodiment 3 is provided with an inlet end 513 and multiple first connection ends 514; the rear end channel 52 is provided with an outlet end 523 and multiple second connection ends 524; the cylindrical channel 53 includes multiple sets of independent channel groups, and each channel group has a connection structure of first splitting and then merging. Multiple connection channels 55 are provided inside both ends of the mixing channel column 5. The two ends of each group of channels of the cylindrical channel 53 are connected to the first connection end 514 and the second connection end 524 respectively through the connection channel 55.

[0042] The connection structure of the flow channel group is as follows: the flow channel is divided into upper and lower parts. The upper part is divided downward by a vertical direct current channel and connected to two vertical direct current channels. The two vertical direct current channels are then divided downward by themselves and connected to a total of four vertical direct current channels, forming a forced flow splitting structure where one channel becomes two channels and two channels become four channels. The lower part is symmetrical to the upper part, that is, a merging structure where four channels become two channels and two channels become one channel.

[0043] Specifically, in this embodiment, the front end flow channel 51 includes a first flow channel 511 and two second flow channels 512. The first flow channel 511 and the second flow channels 512 are joined to form an "I" shape. The center of the first flow channel 511 is the liquid inlet end 513, and the two ends of the second flow channels 512 are the first connecting ends 514. The rear end flow channel 52 includes an eighth flow channel 521 and two ninth flow channels 522. The eighth flow channel 521 and the ninth flow channels 522 are joined to form an "I" shape. The center of the eighth flow channel 521 is the liquid outlet end 523, and the two ends of the ninth flow channels 522 are the second connecting ends 524. The cylindrical flow channel 53 includes four sets of independent flow channels. Each set of independent flow channels includes one third flow channel 531, two fourth flow channels 532, four fifth flow channels 533, two sixth flow channels 534, one seventh flow channel 535, one tenth flow channel 525, two eleventh flow channels 526, two twelfth flow channels 527, and one thirteenth flow channel 528. One end of the third flow channel 531 is connected to the connection end of the second flow channel 512 through a connecting channel 55, and the other end of the third flow channel 531 is connected to both fourth flow channels 532 through the tenth flow channel 525. Each fourth flow channel 532, at the end furthest from the third flow channel 531, is simultaneously connected to two fifth flow channels 533 via the eleventh flow channel 526. The ends of each pair of fifth flow channels 533 furthest from the fourth flow channel 532 are connected to the same sixth flow channel 534 via the twelfth flow channel 527. The ends of the two sixth flow channels 534 furthest from the fifth flow channel 533 are merged via the thirteenth flow channel 528 and connected to the seventh flow channel 535. The end of the seventh flow channel 535 furthest from the sixth flow channel 534 is connected to the second connecting end 524 of the rear end flow channel 52 via the connecting channel 55. Fluid enters the first flow channel 511 from the inlet end 513, and is successively subjected to forced diversion through channels 1 to 2, 2 to 4, 4 to 8, and 8 to 16. Then, it undergoes forced merging through channels 16 to 8, 8 to 4, 4 to 2, and 2 to 1. Different mobile phases within the fluid are continuously dispersed and recombined within the flow channels, resulting in collisions and convergence of different mobile phases, leading to excellent mixing.

[0044] It is worth noting that, based on Embodiment 2 of this utility model, different shapes can be formed by increasing or decreasing the number of the first connecting end 514 in the front face flow channel 51 and / or the number of the second connecting segment in the rear face flow channel 52 as needed; increasing or decreasing the number of groups of cylindrical flow channels 53; and increasing or decreasing the number of times the flow splits and merges in each group of cylindrical flow channels 53. These changes in the flow channel structure are all variations of this technical solution and are all within the protection scope of this utility model.

[0045] In addition, to enhance the mixing effect of the mixing channel, the corners of the mixing channel can be set to right angles to enhance the collision and mixing effect of the fluid in the channel. Example

[0046] like Figures 11-16 As shown, based on Embodiment 1, Embodiment 2 and Embodiment 3, the end face and cylindrical surface of the mixing channel column 5 can also be provided with turbulence grooves 54, which are provided on the mixing channel.

[0047] Furthermore, the diameter of the turbulent channel 54 is greater than the width of the mixing channel, and the depth of the turbulent channel 54 is greater than the depth of the mixing channel; the turbulent channels 54 are arranged alternately up and down along the axis of the mixing channel; this can effectively achieve the turbulent effect of deceleration and re-acceleration of the liquid in the mixing channel, which is more conducive to the online mixing of different organic phases and greatly enhances the mixing effect. Example

[0048] like Figures 17-19 As shown: This utility model also provides a liquid chromatography system mixing device, including an inlet mounting seat 1, an outlet mounting seat 4, and a mixing channel column 5 of any one of Embodiments 1, 2, 3, and 4. The inlet mounting seat 1 and the outlet mounting seat 4 are sealed together to form a column with a accommodating cavity. The mixing channel column 5 is placed in the accommodating cavity. The inlet mounting seat is provided with at least one inlet channel 11, and the outlet mounting seat is provided with an outlet channel 41. In this embodiment, there are three inlet channels 11, which can be compatible with 1 inlet / 2 inlet / 3 inlet, three channel modes. Unused channels can be blocked with pressure plug screws.

[0049] Specifically, the outer surface of the mixing channel column 5 is also provided with an inner liner 3 and a sealing cap 2. The sealing cap 2 and the inner liner 3 cover each other to form a sealed chamber that can accommodate the mixing channel column 5. The side of the sealing cap 2 away from the mixing channel column 5 is provided with a liquid collection tank 21. The liquid collection tank 21 is connected to the plurality of inlet channels 11. The sealing cap 2 is also provided with a first channel 22. The first channel 22 connects the liquid collection tank 21 and the liquid inlet end 513 of the front end channel 51 of the mixing channel column 5. The bottom of the inner liner 3 is provided with a second channel 31. The second channel 31 connects to the liquid outlet end 523 in the rear end channel 52 of the mixing channel column 5. It is worth noting that the mixing channel column 5 and the inner liner 3 are press-fitted, the sealing cover 2 and the inner liner 3 are press-fitted, the mixing column and the outlet mounting seat 4 are also press-fitted, and the side of the sealing cover 2 away from the inner liner 3 is tightly fitted to the inlet mounting seat 1.

[0050] Working process and principle: During operation, multiple mobile phases enter the mixer through the inlet channel 11 on the inlet mounting base 1. The multiple mobile phases are initially mixed in the collection tank 21, and then enter the mixing chamber through the first channel 22. The mobile phase is first guided by the first channel 22 into the mixing channel on the end face of the mixing channel column 5. The mobile phase entering the mixing chamber moves in the mixing channel under the impetus of the subsequent mobile phase. During the movement, the mobile phase is continuously accelerated, decelerated, split, impacted and oscillated, and merged in the mixing channel to form a turbulent effect, thereby achieving the purpose of mixing multiple mobile phases. The mixed mobile phase is discharged through the second channel 31 and the outlet channel to enter the next process. Example

[0051] I. Experimental Objective The test was conducted to determine whether the mixing device using the mixed flow channel column of Example 1 met the requirement of gradient proportioning mixing accuracy ≤ ±0.5% (liquid chromatography industry standard). II. Instrument and Method Parameters Power unit: 1.5mm plunger infusion pump Mobile phase A: 0.2% pentoketone aqueous solution (as a marker) Mobile phase B: pure water Detector: Ultraviolet detector, wavelength 273nm III. Experimental Data Table 1. Raw data from online mixed test in Example 1

[0052] Table 2. Accuracy test data of gradient ratio mixing in Example 1

[0053] IV. Experimental Conclusions Combining Table 1 and Table 2, Figure 20 and Figure 21 It can be clearly seen that the gradient proportioning accuracy (gradient error) of the mixer using the mixing channel column of Example 1 is ≤ ±0.5%, which meets the standard of the liquid chromatography industry for mixers.

[0054] The mixing channel columns of Examples 2 and 3 are further improved products, with a gradient ratio mixing accuracy (gradient error) of ≤ ±0.5%, which will not be repeated here. They also meet the standards of the liquid chromatography industry for mixers.

[0055] The above description is a specific embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the technical scope disclosed in this utility model, based on the technical solution and concept of this utility model, should be covered within the protection scope of the claims of this utility model.

Claims

1. A mixing channel column for use in a mixer, characterized in that: The surface of the mixing channel column (5) is provided with a mixing channel groove, which includes a front face channel (51), a cylindrical face channel (53) and a rear face channel (52). The front face channel (51) includes an inlet end (513) and a first connecting end (514). The cylindrical face channel (53) includes an inlet end and an outlet end. The rear face channel (52) includes a second connecting end (524) and an outlet end (523). The first connecting end (514) is connected to the inlet end of the cylindrical face channel (53), and the second connecting end (524) is connected to the outlet end of the cylindrical face channel (53).

2. The hybrid flow channel column according to claim 1, characterized in that: The front end flow channel (51) is provided with an inlet end (513) and a first connecting end (514), and the rear end flow channel (52) is provided with an outlet end (523) and a second connecting end (524). The front end flow channel (51) and the rear end flow channel (52) are both spiral-shaped. The cylindrical flow channel (53) is spiral-shaped or has a unidirectional waveform. The two ends of the mixing flow channel column (5) are provided with multiple connecting channels (55). The two ends of each flow channel group of the cylindrical flow channel (53) are connected to the first connecting end (514) of the front end flow channel (51) and the second connecting end (524) of the rear end flow channel (52) respectively through the connecting channels (55).

3. A hybrid flow channel column according to claim 1, characterized in that: The front end flow channel (51) is provided with an inlet end (513) and multiple first connection ends (514); the rear end flow channel (52) is provided with an outlet end (523) and multiple second connection ends (524); the cylindrical flow channel (53) includes multiple independent flow channel groups, and each flow channel group has a connection structure of first splitting and then merging. The two ends of the mixing flow channel column (5) are provided with multiple connection channels (55). The two ends of each flow channel group of the cylindrical flow channel (53) are connected to the first connection end (514) of the front end flow channel (51) and the second connection end (524) of the rear end flow channel (52) respectively through the connection channels (55).

4. A hybrid flow channel column according to claim 3, characterized in that: The front end flow channel (51) includes a first flow channel (511) and two second flow channels (512). The first flow channel (511) and the second flow channel (512) are joined together to form an "I" shape. The center of the first flow channel (511) is the liquid inlet end (513), and the two ends of the second flow channel (512) are the first connecting ends (514). The rear end flow channel (52) includes an eighth flow channel (521) and two ninth flow channels (522). The eighth flow channel (521) and the ninth flow channel (522) are joined together to form an "I" shape. The center of the eighth flow channel (521) is the liquid outlet end (523), and the two ends of the ninth flow channel (522) are the second connecting ends (524).

5. A hybrid flow channel column according to claim 3, characterized in that: The connection structure of first splitting and then merging flows specifically includes a splitting channel, an intermediate channel, and a merging channel that are connected in sequence. The splitting channel is a channel that is separated into multiple channels, and the merging channel is a channel that is merged into a single channel. The intermediate channel includes multiple channels for connecting the splitting channel and the merging channel.

6. A hybrid flow channel column according to claim 5, characterized in that: The cylindrical flow channel (53) includes four flow channel groups. In each independent flow channel group, the branch flow channel includes one third flow channel (531), two fourth flow channels (532), one tenth flow channel (525), and two eleventh flow channels (526). The intermediate flow channel includes four fifth flow channels (533). The merging flow channel includes two sixth flow channels (534), one seventh flow channel (535), two twelfth flow channels (527), and one thirteenth flow channel (528). One end of the third flow channel (531) is connected to the first connecting end through a connecting channel (55). (514) Connected, the other end of the third flow channel (531) is connected to two adjacent fourth flow channels (532) through the tenth flow channel, the other end of each fourth flow channel (532) is connected to two adjacent fifth flow channels (533) through the eleventh flow channel, each pair of adjacent fifth flow channels (533) is connected to a sixth flow channel (534) through the twelfth flow channel, each pair of adjacent sixth flow channels is connected to a seventh flow channel (535) through the thirteenth flow channel, and the seventh flow channel (535) is connected to the second connecting end (524) through the connecting channel (55).

7. A hybrid flow channel column according to any one of claims 1-5, characterized in that: The front end face, rear end face and column surface of the mixing channel column (5) are provided with turbulence grooves (54), and the turbulence grooves (54) are provided on the mixing channel.

8. A hybrid flow channel column according to claim 7, characterized in that: The diameter of the turbulent channel (54) is greater than the width of the mixing channel, and the depth of the turbulent channel (54) is greater than the depth of the mixing channel.

9. A hybrid flow channel column according to any one of claims 1-5, characterized in that: The material of the mixed flow channel column (5) is selected from PEEK plastic materials, PI plastic materials, and titanium alloys.

10. A mixing device for a liquid chromatography system, characterized in that: Includes any one of the mixed flow channel columns described in claims 1-9.

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