Cryobox and cryo device

Abstract

The application relates to a cryopreservation box and a cryopreservation device. The cryopreservation box comprises a box cover, a box body movably connected with the box cover through a pivot, a box body main plate, a bottom plate, a first side plate and a second side plate, wherein the bottom plate, the first side plate and the second side plate are located on the inner side of the box body main plate and connected with the box body main plate, the first side plate and the second side plate are arranged in parallel and at intervals, the bottom plate is located between the first side plate and the second side plate, the extension direction of the bottom plate intersects with the extension directions of the first side plate and the second side plate, a fixing frame is located in a first containing groove and arranged in parallel and at intervals with the bottom plate between the first side plate and the second side plate, a plurality of storage through holes are arranged in the fixing frame, and a plurality of positioning structures are arranged on the surface of the bottom plate and correspond to the storage through holes one by one. The positioning structure can position and fix the cryopreservation tube, fix the direction of the placed cryopreservation tube, avoid collision between adjacent cryopreservation tubes and avoid damage of the cryopreservation tube.

Description

Technical Field

[0001] This application relates to the field of cell cryopreservation technology, and in particular to a cryopreservation box and cryopreservation device. Background Technology

[0002] Cell cryopreservation is a continuation of cell culture. It utilizes cryopreservation technology and corresponding equipment or devices to store cells in liquid nitrogen for extended periods, maintaining their viability and functional integrity. When these cells are needed, they are then thawed. Cell cryopreservation typically involves placing cryovials into cryopreservation boxes. However, most existing cryovials have rounded bottoms, and the base of the cryopreservation box supporting the cryovials is also flat. This makes it impossible to fix the orientation of the cryovials after they are placed in the cryopreservation box, increasing the risk of collision and even breakage between adjacent cryovials. Utility Model Content

[0003] Therefore, it is necessary to provide a cryopreservation box and cryopreservation device to address the problems in the relevant technology.

[0004] To achieve the above objectives, in a first aspect, this application provides a cryopreservation box, the cryopreservation box comprising:

[0005] Box lid;

[0006] The box body is pivotally connected to the box lid; the box body includes a main box body, a bottom plate, a first side plate, and a second side plate; the bottom plate, the first side plate, and the second side plate are all located inside the main box body and connected to the main box body to form a first receiving groove inside the box body; the first side plate and the second side plate are arranged in parallel and spaced apart, and the bottom plate is located between the first side plate and the second side plate, and the extension direction of the bottom plate intersects the extension direction of the first side plate and the extension direction of the second side plate;

[0007] A fixing frame is located within the first receiving groove and between the first side plate and the second side plate, and is arranged parallel to and spaced apart from the bottom plate; the fixing frame is provided with a plurality of storage through holes;

[0008] Several positioning structures are located on the surface of the base plate and are configured to correspond one-to-one with the storage through holes.

[0009] In some embodiments, the lid includes: a main lid panel, a third side panel, a fourth side panel, and a fifth side panel; wherein,

[0010] The third, fourth, and fifth side plates are all located inside the main body of the lid and connected to the main body of the lid to form a second receiving groove inside the lid; the third and fourth side plates are arranged in parallel and spaced apart, with the third side plate located outside the first side plate and the fourth side plate located outside the second side plate; the fifth side plate is located between the third and fourth side plates and is connected to the ends of the third and fourth side plates away from the bottom plate.

[0011] In some embodiments, the pivot includes a first pivot and a second pivot; the first pivot movably connects the first side plate to the third side plate; and the second pivot movably connects the second side plate to the fourth side plate.

[0012] In some embodiments, the fifth side plate is provided with a plurality of observation holes, and the observation holes are provided in a one-to-one correspondence with the storage through holes.

[0013] In some embodiments, the positioning structure includes a triangular pyramid positioning structure.

[0014] In some embodiments, the lid is an aluminum alloy lid, and the body is an aluminum alloy body.

[0015] In some embodiments, the number of storage through holes in the fixing frame is 5 to 10.

[0016] In some embodiments, the housing has an opening that exposes a portion of the mounting bracket.

[0017] In some embodiments, the cryopreservation box further includes a raised structure located outside the first side plate and outside the second side plate.

[0018] Secondly, this application also provides a cryopreservation device, the cryopreservation device comprising:

[0019] The cryopreservation box as described in the first aspect;

[0020] A cryopreservation tube, comprising: a tube body and a tube cap; the tube cap is located at the top of the tube body; the bottom of the tube body is provided with a groove that matches the positioning structure; the cryopreservation tube is placed in the storage through hole.

[0021] In the aforementioned cryopreservation box, several positioning structures are set on the bottom plate surface of the box body, each corresponding to a storage through hole for storing cryopreservation tubes. After the cryopreservation tubes are placed into the storage through holes of the cryopreservation box, the positioning structures can fix the position of the cryopreservation tubes, thereby fixing the direction of the placed cryopreservation tubes, preventing collisions between adjacent cryopreservation tubes, and preventing damage to the cryopreservation tubes. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this application or the conventional technology, the drawings used in the description of the embodiments or the conventional technology will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a front view of the cryopreservation box provided in one embodiment of this application when it is in the open state;

[0024] Figure 2 This is a side view of the cryopreservation box provided in one embodiment of this application when it is in the open state;

[0025] Figure 3 This is a top view of the cryopreservation box provided in one embodiment of this application when it is in a snap-fit ​​state;

[0026] Figure 4 This is a bottom view of the cryopreservation box provided in one embodiment of this application when it is in a snap-fit ​​state;

[0027] Figure 5 This is a side view of the cryopreservation box provided in one embodiment of this application when it is in a snap-fit ​​state;

[0028] Figure 6 This is a schematic diagram of the cryopreservation device provided in another embodiment of this application.

[0029] Explanation of reference numerals in the attached drawings: 1. Cryopreservation box; 10. Box body; 101. Opening; 102. Main body plate; 103. Bottom plate; 104. First side plate; 105. Second side plate; 106. First receiving slot; 11. Box lid; 111. Main body plate of box lid; 112. Third side plate; 113. Fourth side plate; 114. Fifth side plate; 115. Second receiving slot; 12. Fixing frame; 121. Storage through hole; 13. Positioning structure; 14. Pivot; 15. Protruding structure; 2. Cryopreservation tube; 20. Tube body; 201. Groove; 21. Tube cap. Detailed Implementation

[0030] To make the objectives, technical solutions, and advantages of this application clearer, the following detailed description is provided in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application.

[0031] In one embodiment, see Figures 1 to 5This application provides a cryopreservation box 1, which may include: a lid 11, a body 10, a fixing frame 12, and a plurality of positioning structures 13; wherein, the body 10 and the lid 11 are movably connected by a pivot 14; the body 10 may include a main body plate 102, a bottom plate 103, a first side plate 104, and a second side plate 105; the bottom plate 103, the first side plate 104, and the second side plate 105 are all located inside the main body plate 102 and connected to the main body plate 102 to form a first receiving groove 106 on the inner side of the body 10; the first side plate 104 and the second side plate 105 are connected to the main body plate 102. The side plates 105 are arranged in parallel at intervals. The bottom plate 103 is located between the first side plate 104 and the second side plate 105. The extending direction of the bottom plate 103 intersects the extending directions of the first side plate 104 and the second side plate 105. The fixing frame 12 is located in the first receiving groove 106 and between the first side plate 104 and the second side plate 105, and is arranged in parallel at intervals with the bottom plate 103. The fixing frame 12 is provided with a plurality of storage through holes 121. A plurality of positioning structures 13 are located on the surface of the bottom plate 103 and are arranged in a one-to-one correspondence with the storage through holes 121.

[0032] In the aforementioned cryopreservation box 1, several positioning structures 13 are provided on the surface of the bottom plate 103 of the box body 10, which correspond one-to-one with the storage through holes 121 for storing cryopreservation tubes. After the cryopreservation tubes are placed into the storage through holes 121 of the cryopreservation box 1, the positioning structures 13 can play the role of positioning and fixing the cryopreservation tubes, thereby fixing the direction of the placed cryopreservation tubes, avoiding collisions between adjacent cryopreservation tubes, and preventing the cryopreservation tubes from being damaged.

[0033] As an example, the base plate 103 may be perpendicular to the first side plate 104 and the second side plate 105; the base plate 103, the first side plate 104 and the second side plate 105 may all be perpendicular to the main body 102 of the box.

[0034] As an example, the main body 102, the bottom plate 103, the first side plate 104 and the second side plate 105 can be an integrally formed structure.

[0035] As an example, please continue reading Figure 1The box cover 11 may include: a main box cover 111, a third side plate 112, a fourth side plate 113, and a fifth side plate 114; wherein the third side plate 112, the fourth side plate 113, and the fifth side plate 114 are all located inside the main box cover 111 and connected to the main box cover 111 to form a second receiving groove 115 on the inner side of the box cover 11; the third side plate 112 and the fourth side plate 113 are arranged in parallel and spaced apart, the third side plate 112 is located outside the first side plate 104, and the fourth side plate 113 is located outside the second side plate 105; the fifth side plate 114 is located between the third side plate 112 and the fourth side plate 113, and is connected to the end of the third side plate 112 and the fourth side plate 113 away from the bottom plate 103.

[0036] As an example, the main body 111 of the box cover, the third side plate 112, the fourth side plate 113 and the fifth side plate 114 can be an integrally formed structure.

[0037] As an example, the fifth side plate 114 may be perpendicular to both the third side plate 112 and the fourth side plate 113; the third side plate 112, the fourth side plate 113 and the fifth side plate 114 may all be perpendicular to the main cover plate 111.

[0038] As an example, the lid 11 may include an aluminum alloy lid, and the body 10 may include an aluminum alloy body. That is, the lid 11 can be any existing aluminum alloy lid, and the body 10 can be any existing aluminum alloy body. Aluminum alloy is more robust than plastic. The cryopreservation box 1 of this application is not easily broken or deformed during long-term freezing or use, thus preventing damage or loss of the cryopreservation tubes stored inside.

[0039] As an example, the fixing frame 12 can also be an aluminum alloy fixing frame, the positioning structure 13 can also be an aluminum alloy positioning structure, and the pivot 14 can also be an aluminum alloy pivot.

[0040] As an example, the pivot 14 includes a first pivot (not shown) and a second pivot (not shown); the first pivot movably connects the first side plate 104 to the third side plate 112; the second pivot movably connects the second side plate 105 to the fourth side plate 113.

[0041] Of course, in other examples, the lid 11 and the body 10 can also be connected in any other way that allows them to open and close.

[0042] As an example, the positioning structure 13 may include a triangular pyramid positioning structure; specifically, the positioning structure 13 includes an isosceles triangular pyramid positioning structure. Of course, in other examples, the shape of the positioning structure 13 can also be set according to actual needs; for example, the positioning structure 13 may be a conical positioning structure or a cubic positioning structure, etc.

[0043] As an example, the number of storage through holes 121 within the fixing frame 12 can be set according to actual needs; in this embodiment, the number of storage through holes 121 within the fixing frame 12 can be 5 to 10; specifically, the number of storage through holes 121 can be 5, 6, 7, 8, 9, or 10, etc. Of course, in other examples, the number of storage through holes 121 can also be 1, 2, 3, or 4. The cryopreservation box 1 of this application can store batches with a small number of cryopreservation tubes, greatly reducing the risk of confusion in single-box storage.

[0044] As an example, the arrangement of the storage through holes 121 within the fixing frame 12 can be set according to actual needs. For example, it can be arranged in multiple rows and columns, or in a single row. Figure 1 The storage through holes 121 are arranged in a single row within the fixing frame 12 as an example.

[0045] As an example, please continue reading Figure 1 and Figure 3 The box body 10 is provided with an opening 101, which exposes a part of the fixing frame 12.

[0046] As an example, the fifth side plate 114 is provided with a plurality of observation holes (not shown), and the observation holes are provided in a one-to-one correspondence with the storage through holes.

[0047] By setting the opening 101 and the observation hole, when cryopreservation tubes are placed in the cryopreservation box 1, the markings (e.g., labels) and barcodes on the side of the cryopreservation tubes can be observed through the opening 101, and the top markings (e.g., QR codes) on the top of the cryopreservation tubes can be viewed through the observation hole, which facilitates the retrieval of cryopreservation tubes and has strong convenience. It can reduce the exposure time of frozen cells in cryopreservation tubes at room temperature and reduce damage to cells.

[0048] As an example, please continue reading Figure 2 The cryopreservation box 1 may further include a protruding structure 15, which is located on the outer side of the first side plate 104 and the outer side of the second side plate 105. When the box body 10 is fastened to the box lid 11, the friction between the protruding structure 15 and the box lid 11 can be used to lock the cryopreservation box 1, thereby achieving the locking of the cryopreservation box 1.

[0049] In another embodiment, please refer to Figures 1 to 5 See Figure 6 This application also provides a cryopreservation device, which may include: a cryopreservation box 1 and cryopreservation tubes 2; wherein, the cryopreservation box 1 is as described in the previous embodiment. Figures 1 to 5 The cryopreservation box 1 is described in the previous embodiment, and the specific structure of the cryopreservation box is not similar here; the cryopreservation tube 2 includes: tube body 20 and tube cap 21; the tube cap 21 is located at the top of the tube body 20; the bottom of the tube body 20 is provided with a groove 201 that matches the positioning structure 13; the cryopreservation tube 2 is placed in the storage through hole 121.

[0050] In the above-mentioned cryopreservation device, after the cryopreservation tube 2 is placed into the storage through hole 121 of the cryopreservation box 1, the positioning structure 13 is inserted into the groove 201 at the bottom of the tube body 20, which can play the role of positioning and fixing the cryopreservation tube 2, thereby fixing the direction of the placed cryopreservation tube 2, avoiding collision between adjacent cryopreservation tubes 2, and preventing the cryopreservation tube 2 from being damaged.

[0051] As an example, the top outer surface of the tube body 20 may be provided with external threads, and the tube cap 21 may be provided with internal threads. The tube cap 21 can be connected to the tube body 20 through the internal threads and the external threads. Of course, in other examples, the tube cap 21 can also be connected to the tube body 20 in other ways, such as plug-in connection, etc.

[0052] As an example, the side of the cryopreservation tube 2 may be provided with side markings (not shown), such as markings (labels) and barcodes, etc.; the side markings may be, but are not limited to, being affixed to the side of the cryopreservation tube 2.

[0053] As an example, the top of the cryopreservation tube 2 (i.e., the top of the tube cap 21) may be provided with a top label, which may include, but is not limited to, a QR code. The top label may be, but is not limited to, affixed to the top of the tube cap 21. By identifying the side label and the top label, relevant information about the frozen cells inside the cryopreservation tube 2 can be obtained.

[0054] As an example, the cryopreservation tube 2 of this application is first cooled to -80°C and stored for 24 hours before being placed in the cryopreservation box 1, which is a cryopreservation box pre-cooled with liquid nitrogen. Specifically: the box cover 11 is opened, and the cryopreservation tube 2 is placed into the storage through hole 121, with the side markings of the cryopreservation tube 2 facing outwards; the positioning structure 13 is embedded in the groove 201 at the bottom of the cryopreservation tube 2 to achieve positioning and fixation of the cryopreservation tube 2. The technical features of the above embodiments can be combined arbitrarily. For the sake of brevity, not all possible combinations of the technical features of the above embodiments are described. However, as long as the combination of these technical features does not contradict each other, it should be considered to be within the scope of this specification.

[0055] The above embodiments merely illustrate several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A cryopreservation box, characterized in that, include: Box lid; The box body is pivotally connected to the box lid; the box body includes a main box body, a bottom plate, a first side plate, and a second side plate; the bottom plate, the first side plate, and the second side plate are all located inside the main box body and connected to the main box body to form a first receiving groove inside the box body; the first side plate and the second side plate are arranged in parallel and spaced apart, and the bottom plate is located between the first side plate and the second side plate, and the extension direction of the bottom plate intersects the extension direction of the first side plate and the extension direction of the second side plate; A fixing frame is located within the first receiving groove and between the first side plate and the second side plate, and is arranged parallel to and spaced apart from the bottom plate; the fixing frame is provided with a plurality of storage through holes; Several positioning structures are located on the surface of the base plate and are configured to correspond one-to-one with the storage through holes.

2. The cryopreservation box according to claim 1, characterized in that, The box cover includes: a main box cover, a third side panel, a fourth side panel, and a fifth side panel; wherein... The third, fourth, and fifth side plates are all located inside the main body of the lid and connected to the main body of the lid to form a second receiving groove inside the lid; the third and fourth side plates are arranged in parallel and spaced apart, with the third side plate located outside the first side plate and the fourth side plate located outside the second side plate; the fifth side plate is located between the third and fourth side plates and is connected to the ends of the third and fourth side plates away from the bottom plate.

3. The cryopreservation box according to claim 2, characterized in that, The pivot includes a first pivot and a second pivot; the first pivot movably connects the first side plate to the third side plate; the second pivot movably connects the second side plate to the fourth side plate.

4. The cryopreservation box according to claim 2, characterized in that, The fifth side plate is provided with a number of observation holes, and the observation holes are arranged one-to-one with the storage through holes.

5. The cryopreservation box according to claim 1, characterized in that, The positioning structure includes a triangular pyramid positioning structure.

6. The cryopreservation box according to claim 1, characterized in that, The lid is an aluminum alloy lid, and the body is an aluminum alloy body.

7. The cryopreservation box according to claim 1, characterized in that, The number of storage through holes in the fixing frame is 5 to 10.

8. The cryopreservation box according to claim 1, characterized in that, The box body has an opening that exposes a portion of the mounting bracket.

9. The cryopreservation box according to any one of claims 1 to 8, characterized in that, The cryopreservation box also includes a raised structure located on the outside of the first side plate and the outside of the second side plate.

10. A cryopreservation device, characterized in that, include: Cryopreservation box as described in any one of claims 1 to 9; A cryopreservation tube, comprising: a tube body and a tube cap; the tube cap is located at the top of the tube body; the bottom of the tube body is provided with a groove that matches the positioning structure; the cryopreservation tube is placed in the storage through hole.

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