A 24 hour urine biomarker sample collector

Abstract

This utility model discloses a 24-hour urine biological sample collector, relating to the field of urine collection. It includes a collection bucket, a discharge assembly, a waste liquid collection assembly, a filter assembly, a biological sample collection assembly, and a support ring. The collection bucket has an internal groove for installing the support ring, which is detachably snapped into the groove. The biological sample collection assembly is detachably installed inside the support ring and is located at the bottom of the collection bucket. The filter assembly is detachably installed inside the collection bucket and is located above the biological sample collection assembly. One end of the discharge assembly is connected to the bottom of the collection bucket, and the other end is detachably connected to the waste liquid collection assembly. This utility model integrates collection, filtration, and separation functions, is easy to operate, reduces patient error, requires no preservatives, and allows cell preservation solution to directly act on the biological sample, ensuring cell morphology integrity and improving detection accuracy.

Description

Technical Field

[0001] This invention belongs to the field of urine collection, specifically a 24-hour urine biological sample collector. Background Technology

[0002] In clinical disease diagnosis, urine biological sample analysis is one of the important diagnostic methods. For example, detecting cancer cells in urine can help diagnose malignant diseases such as bladder cancer and renal pelvis cancer, while analyzing components such as urine protein and red blood cells can help determine kidney diseases and urinary tract infections. 24-hour urine collection is a crucial method for obtaining sufficient biological samples, and the completeness of the process and the quality of sample preservation directly affect the accuracy of diagnostic results.

[0003] Current standard operating procedures require patients to collect all urine within 24 hours using large-capacity containers. This process is not only cumbersome but also highly susceptible to omissions due to patient negligence or recording errors, affecting the accuracy of total sample calculation. To inhibit urine spoilage during prolonged collection, chemical preservatives such as toluene and hydrochloric acid are typically added to the containers. However, these chemicals may adversely affect the integrity of cell morphology in the urine, interfering with subsequent microscopic analysis. More critically, biological sample extraction relies entirely on centrifugation. After collection, the urine sample must be sent to the laboratory for centrifugation to separate the precipitate. This process is not only time-consuming but also prone to causing fragile cell structures (such as cancer cells) to rupture due to centrifugal force. Furthermore, impurities in the urine may co-precipitate with the target biological sample, increasing interference during microscopic examination. In addition, the limited capacity of conventional centrifuge tubes may result in insufficient cell counts in a single collection, posing a high risk of missed detection for diseases requiring substantial cytological evidence. Utility Model Content

[0004] The purpose of this invention is to provide a 24-hour urine biological sample collector to solve the problems of cumbersome operation, need to add preservatives, reliance on centrifugation for biological sample extraction, and easy missed detection in the existing technology.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a 24-hour urine biological sample collector, comprising a collection bucket, a discharge assembly, a waste liquid collection assembly, a filter assembly, a biological sample collection assembly, and a support ring;

[0006] The inside of the collection bucket is provided with a groove for installing a support ring, and the support ring can be detachably snapped into the groove;

[0007] The biological sample collection assembly is detachably installed inside the support ring, and the biological sample collection assembly is located at the bottom of the collection bucket;

[0008] The filter assembly is detachably installed inside the collection bucket, and the filter assembly is located above the biological sample collection assembly;

[0009] One end of the discharge assembly is connected to the bottom of the collection tank, and the other end is detachably connected to the waste liquid collection assembly.

[0010] Preferably, the collection bucket includes a cylindrical body, a base, and a lid;

[0011] The cylinder has an open structure at both the top and bottom. The bottom support is detachably connected to the lower end of the cylinder via a rotating locking structure or a snap-fit ​​structure. The groove is located on the inner wall of the cylinder near the bottom support. The cylinder cover is detachably connected to the upper end of the cylinder via a rotating locking structure or a flip-top structure.

[0012] Preferably, the side of the collection bucket is also provided with a negative pressure connection pipe for connecting to a negative pressure source. The negative pressure connection pipe is connected to the inside of the collection bucket. One end of the negative pressure connection pipe is fixedly connected to and connected to the side of the base, and the other end is provided with a quick-connect interface.

[0013] Preferably, the discharge assembly includes a first valve, a guide pipe, and a quick connector A;

[0014] One end of the guide tube is fixedly connected to and communicates with the bottom of the base, and the other end is fixedly connected to quick connector A. The first valve is installed in series in the middle of the guide tube to control the opening and closing of the guide tube.

[0015] Preferably, the waste liquid collection assembly includes a storage bag, a second valve, a quick connector B, and a connecting pipe;

[0016] One end of the connecting pipe is fixedly connected to and communicates with the opening end of the storage bag, and the other end is fixedly connected to quick connector B. The second valve is installed in series in the middle of the connecting pipe. Quick connector B is adapted to quick connector A to realize the detachable connection between the discharge component and the waste liquid collection component.

[0017] Preferably, the filtration assembly includes a filter membrane support, a filter cartridge plate, and a filter membrane;

[0018] The filter membrane support is a frame structure and can be detachably installed inside the cylinder through a snap-fit ​​structure. The filter cylinder plate is fixedly installed on the filter membrane support, and filter holes are opened on the side wall and bottom of the filter cylinder plate. The filter membrane is fixedly installed on the filter membrane support, and the filter membrane is located on the outside of the filter cylinder plate.

[0019] Preferably, the biological sample collection assembly includes a collection cup, a fixing ring, and a collection filter membrane;

[0020] The collecting cup is a cup-shaped structure with openings at both ends. The upper end is provided with a flared mouth for interference fit with the inner ring surface of the support ring to achieve a detachable connection. The fixing ring is detachably connected to the upper end of the collecting cup through a rotational locking structure or a snap-fit ​​structure. The collecting filter membrane is located between the fixing ring and the upper end of the collecting cup.

[0021] Preferably, a handle is fixedly installed in the middle of the outer side wall of the cylinder. The handle has a U-shaped structure and is used for moving the collection bucket.

[0022] Preferably, both the guide tube and the connecting tube are made of medical elastic tubing, and both quick connector A and quick connector B are Luer connectors.

[0023] Preferably, both the collection membrane and the filter membrane are made of food-grade or pharmaceutical-grade PET material, and the micropore size of the collection membrane can be changed according to the type of target biological sample.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] 1. This utility model, through the cooperation of a collection bucket, a discharge component, a waste liquid collection component, a filtration component, and a biological sample collection component, eliminates the need for a special large-capacity collection container and the addition of preservatives. The device integrates collection, filtration, separation, and preservation functions. Patients only need to urinate, open and close the valve, and add preservation solution, reducing operation steps and effectively reducing problems such as urine leakage or incorrect addition of preservatives caused by cumbersome operation.

[0026] 2. This utility model uses a customized collection filter membrane to accurately retain target biological samples and avoid interference from impurities; the specially formulated cell preservation solution acts directly on the sample to ensure the integrity of cell morphology. Compared with traditional preservatives, it improves the pass rate of biological samples, eliminates the need for centrifugation, reduces cell rupture, improves the sample activity retention rate, and reduces the risk of missed detection.

[0027] 3. This utility model improves the urine separation speed through negative pressure assisted filtration and avoids urine retention; the collection filter membrane can be directly "stamped" to transfer samples, eliminating steps such as centrifugation and smearing, shortening the pre-test processing time and saving valuable time for clinical diagnosis.

[0028] 4. This utility model allows for flexible replacement of different pore sizes of the collection filter membrane via a fixing ring, adapting to the detection needs of various diseases such as bladder cancer, renal pelvis cancer, and kidney diseases. Attached Figure Description

[0029] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this utility model. For those skilled in the art, other drawings can be obtained based on these drawings.

[0030] Figure 1 This is a first-view perspective three-dimensional structural diagram of an embodiment of the present utility model;

[0031] Figure 2 This is a second-view perspective three-dimensional structural diagram provided for an embodiment of the present utility model;

[0032] Figure 3 A third-view perspective three-dimensional structural schematic diagram provided for an embodiment of this utility model;

[0033] Figure 4 This is a schematic diagram of the exploded structure provided for an embodiment of the present utility model.

[0034] In the picture:

[0035] 1. Collection bucket; 101. Cylinder body; 102. Base support; 103. Cylinder cover; 2. Discharge assembly; 201. First valve; 202. Guide tube; 203. Quick connector A; 3. Waste liquid collection assembly; 301. Storage bag; 302. Second valve; 303. Quick connector B; 304. Connecting pipe; 4. Negative pressure connection pipe; 5. Filter assembly; 501. Filter membrane support; 502. Filter cylinder plate; 503. Filter membrane; 6. Biological sample collection assembly; 601. Collection cup; 602. Fixing ring; 603. Collection filter membrane; 7. Support ring; 8. Handle. Detailed Implementation

[0036] To enable those skilled in the art to better understand the technical solution of this utility model, the present utility model will be further described in detail below with reference to the accompanying drawings.

[0037] As attached Figure 1 To be continued Figure 4 As shown:

[0038] This utility model provides a 24-hour urine biological sample collector, including a collection bucket 1, a discharge assembly 2, a waste liquid collection assembly 3, a filter assembly 5, a biological sample collection assembly 6, and a support ring 7. The collection bucket 1 is made of medical-grade transparent polypropylene and has an internal groove for installing the support ring 7. The groove is an annular recess with a width adapted to the thickness of the support ring 7. The support ring 7 is made of medical-grade polyethylene and is detachably snapped into the groove via an interference fit to ensure no shaking after installation. The biological sample collection assembly 6 is detachably installed inside the support ring 7 and is located at the lower part of the collection bucket 1. The bottom of the collection bucket 1 has a reserved space to facilitate the smooth flow of urine waste liquid to the discharge component 2; the filter component 5 is made of food-grade PET material and can be detachably installed inside the collection bucket 1 through a rotating snap-fit ​​structure, and the filter component 5 is located above the biological sample collection component 6 to avoid mutual interference between the filter component 5 and the biological sample collection component 6; the guide tube 202 of the discharge component 2 is made of medical elastic silicone tube, one end of which is connected to the bottom of the collection bucket 1 through a threaded connection, and a sealing ring is provided at the connection to prevent leakage, and the other end is detachably connected to the waste liquid collection component 3 through a quick connector A203, which facilitates the replacement of the waste liquid collection component 3 in the future.

[0039] During operation, the operator first engages the support ring 7 into the groove of the collection bucket 1, then installs the biological sample collection component 6 inside the support ring 7. Next, the filter component 5 is secured inside the collection bucket 1 with clips and positioned above the biological sample collection component 6. Finally, one end of the discharge component 2 is connected to the bottom of the collection bucket 1, and the other end is connected to the waste liquid collection component 3. When the patient urinates, the urine first flows into the filter component 5 for preliminary filtration, then enters the biological sample collection component 6 to complete biological sample retention. The remaining waste liquid flows into the waste liquid collection component 3 through the discharge component 2. The detachable design of each component facilitates subsequent cleaning and maintenance. The transparent collection bucket 1 allows for easy observation of the internal urine. The stable installation of the support ring 7 ensures the stability of the biological sample collection component 6 during use, improving the overall reliability of the device.

[0040] As attached Figure 2 To be continued Figure 4As shown, in one embodiment of this utility model, the collection bucket 1 includes a cylindrical body 101, a base 102, and a lid 103. The cylindrical body 101 is a cylindrical structure with openings at both ends, made of medical-grade transparent polypropylene. The base 102 is a disc-shaped structure with the same diameter as the cylindrical body 101, made of medical-grade polyethylene. It is detachably connected to the lower end of the cylindrical body 101 via a rotating locking structure (i.e., the outer side of the base 102 has external threads, and the inner side of the lower end of the cylindrical body 101 has internal threads), ensuring a tight connection and no leakage. The groove is set at the connection between the inner wall of the cylindrical body 101 and the base 102. The lid 103 is circular and is detachably connected to the upper end of the cylindrical body 101 using a threaded structure. The inner side of the lid 103 has a sealing gasket, which can effectively isolate external pollution after closing.

[0041] During operation, the staff first installs the base 102 on the lower end of the cylinder 101 using the rotating locking structure, ensuring that the threads are properly engaged. Then, the cylinder cover 103 is opened or closed according to the usage requirements. When it is necessary to clean the collection bucket 1, the base 102 can be rotated in the opposite direction to remove it, making it easy to take out the internal biological sample collection component 6. This also prevents external dust and impurities from entering the collection bucket 1, ensuring that the urine sample is not contaminated.

[0042] As attached Figure 1 To be continued Figure 2 As shown, in one embodiment of this utility model, the side of the collection bucket 1 is also provided with a negative pressure connection pipe 4 for connecting to a negative pressure source. The negative pressure connection pipe 4 is made of medical PVC pipe. The negative pressure connection pipe 4 is connected to the inside of the collection bucket 1. The connection is made by hot melt welding process to ensure a tight seal without leakage. One end of the negative pressure connection pipe 4 is fixedly connected to and connected to the side of the base 102, and the other end is provided with a quick-connect interface (using Luer connector) to facilitate quick connection to a negative pressure pump, syringe or hospital negative pressure system. The quick-connect interface is provided with a dust cap to prevent dust from entering when not in use.

[0043] During operation, the operator first connects the quick-connect interface of the negative pressure connection pipe 4 to the negative pressure source, turns on the negative pressure source switch, and adjusts the negative pressure value. When the patient urinates into the collection bucket 1, the negative pressure accelerates the passage of urine through the filter assembly 5 and the biological sample collection assembly 6, preventing urine from stagnating in the collection bucket 1. Negative pressure assists in improving urine filtration and separation efficiency, reducing deterioration caused by prolonged contact between biological samples and urine. The quick-connect design of the Luer connector facilitates rapid connection to the negative pressure source, while the dust cap ensures the pipe remains clean when not in use.

[0044] As attached Figure 1 To be continued Figure 4As shown, in one embodiment of this utility model, the discharge assembly 2 includes a first valve 201, a guide tube 202, and a quick connector A203; the first valve 201 is a medical shut-off valve, which is convenient for manual opening and closing; the guide tube 202 is a medical elastic silicone tube, which has good aging resistance and elasticity; one end of the guide tube 202 is fixedly connected to the bottom of the base 102 by a threaded connection and communicates with it, and the thread is wrapped with Teflon tape to enhance the sealing; the other end is fixedly connected to the quick connector A203 by adhesive, and the quick connector A203 is a Luer male connector made of medical stainless steel; the first valve 201 is installed in series in the middle of the guide tube 202 to control the opening and closing of the guide tube 202. When the valve is closed, it can completely block the flow of urine without leakage.

[0045] During operation, the operator first checks whether the first valve 201 is closed, then connects the guide pipe 202 to the base 102 and the quick connector A203. When there is waste liquid in the collection tank 1 that needs to be discharged, the first valve 201 is opened, and the waste liquid flows through the guide pipe 202 to the waste liquid collection assembly 3. After discharge, the first valve 201 is closed. The first valve 201 is designed to precisely control the discharge of waste liquid and prevent it from flowing randomly. The guide pipe 202 of the medical elastic silicone tube is easy to adjust its position, and the quick connector A203 of the Luer connector ensures a tight connection with the waste liquid collection assembly 3.

[0046] As attached Figure 1 To be continued Figure 4 As shown, in one embodiment of this utility model, the waste liquid collection assembly 3 includes a storage bag 301, a second valve 302, a quick connector B303, and a connecting pipe 304. The storage bag 301 is made of medical-grade PE material, has a capacity of 3-4L, and has graduations printed on its surface for easy observation of the waste liquid volume. The top of the storage bag 301 has a hanging hole for easy hanging. The second valve 302 has the same structure as the first valve 201 to ensure flow matching. The quick connector B303 is a Luer female connector, compatible with quick connector A203, and is made of medical-grade stainless steel. The connecting pipe 304 is a medical-grade PVC pipe. One end of the connecting pipe 304 is fixedly connected to the open end of the storage bag 301 by a heat sealing process, ensuring a firm connection and no leakage. The other end is fixedly connected to the quick connector B303 by adhesive. The second valve 302 is installed in series in the middle of the connecting pipe 304, 10-15cm away from the open end of the storage bag 301, and is used to control the opening and closing of the connecting pipe 304.

[0047] During operation, the operator first connects quick connector B303 to quick connector A203, ensuring a tight connection. Then, the second valve 302 and the first valve 201 are opened, allowing the waste liquid in collection tank 1 to flow into storage bag 301 through guide pipe 202 and connecting pipe 304. Once storage bag 301 is full, the second valve 302 and the first valve 201 are closed, quick connector A203 is disconnected from quick connector B303, and a new storage bag 301 is installed. The large-capacity design of storage bag 301 meets the needs of 24-hour waste liquid collection, the graduations facilitate recording the waste liquid volume, the Luer connector adaptation design enables quick replacement of storage bag 301, and the second valve 302 prevents waste liquid leakage during replacement.

[0048] As attached Figure 1 To be continued Figure 4 As shown, in one embodiment of this utility model, the filter assembly 5 includes a filter membrane support 501, a filter cartridge plate 502, and a filter membrane 503. The filter membrane support 501 is a cylindrical frame structure made of medical-grade polyethylene. The filter cartridge plate 502 is a circular plate made of food-grade PET or stainless steel and is fixedly installed on the filter membrane support 501 by a snap-fit ​​structure or screws. Filter holes are provided on the side walls and bottom of the filter cartridge plate 502, with uniformly distributed pore sizes to ensure filtration efficiency. The filter membrane 503 is circular with a diameter consistent with the outer diameter of the filter cartridge plate 502. It is made of food-grade PET material and is fixedly installed on the filter membrane support 501 by an adhesive process. The filter membrane 503 is located outside the filter cartridge plate 502, and the micropore size of the filter membrane 503 is 5-10 μm, which can effectively filter large particulate impurities in urine.

[0049] During operation, the operator first fixes the filter membrane 503 onto the filter membrane support 501, then installs the filter cartridge plate 502 onto the filter membrane support 501 using clips, and covers it with the filter membrane 503. The assembled filter assembly 5 is then installed into the collection container 1 using clips. After urine flows into the filter assembly 5, it is initially dispersed by the filter holes of the filter cartridge plate 502, and then large particles are filtered out by the filter membrane 503. The frame structure of the filter membrane support 501 ensures smooth urine flow, while the filter holes of the filter cartridge plate 502 disperse the urine, preventing it from concentrating and impacting the filter membrane 503. The specific pore size of the filter membrane 503 precisely filters impurities, providing pure urine for subsequent biological sample collection. When the sample collection volume is small, it is filtered through the filter membrane 503 at the bottom of the filter cartridge plate 502. When the sample collection volume is large, it is filtered through the filter membranes 503 at the bottom and side walls of the filter cartridge plate 502, accelerating the filtration effect.

[0050] As attached Figure 1 To be continued Figure 4As shown, in one embodiment of this utility model, the biological sample collection assembly 6 includes a collection cup 601, a fixing ring 602, and a collection filter membrane 603. The collection cup 601 is a cup-shaped structure with openings at both ends, made of medical-grade polyethylene, and has a flared opening at the upper end. The flared opening is press-fitted with the inner ring surface of the support ring 7 to achieve a detachable connection, ensuring a tight connection and easy disassembly. The fixing ring 602 is annular, with a diameter matching the inner diameter of the upper end of the collection cup 601, and is also made of medical-grade polyethylene. It is designed to be rotated... A snap-fit ​​structure (with external threads on the outer side of the fixing ring 602 and internal threads on the inner side of the upper end of the collection cup 601) is detachably connected to the upper end of the collection cup 601. The collection filter membrane 603 is circular, with the same diameter as the fixing ring 602, and is made of food-grade or pharmaceutical-grade PET material. It is positioned between the fixing ring 602 and the upper end of the collection cup 601 for fixation. The upper surface of the collection filter membrane 603 is flush with the upper surface of the fixing ring 602, facilitating the direct transfer of biological samples onto a glass slide in a stamping motion through the collection filter membrane 603. The pore size of the collection filter membrane 603 can be changed according to the type of target biological sample; for example, a pore size of 10-30 μm is used for cancer cell detection, and a pore size of 0.22-0.45 μm is used for protein detection.

[0051] During operation, the operator first selects a collection filter membrane 603 with the appropriate pore size according to the testing requirements, places it on the upper surface of the collection cup 601, and then clamps and fixes the collection filter membrane 603 using a rotating locking structure and a fixing ring 602. Next, the collection cup 601 is installed inside the support ring 7 through its upper flared opening. Urine treated by the filtration assembly 5 flows to the collection cup 601, where the biological sample in the urine is trapped by the collection filter membrane 603, and the remaining waste liquid flows out from the lower end of the collection cup 601. The replaceable collection filter membrane 603 meets different testing needs, and the rotating locking structure and fixing ring 602 ensure that the collection filter membrane 603 is securely installed, preventing displacement of the filter membrane due to urine impact.

[0052] As attached Figure 1 To be continued Figure 2 As shown, in one embodiment of the present invention, a handle 8 is fixedly installed in the middle of the outer side wall of the cylindrical body 101 of the collection bucket 1. The handle 8 has a U-shaped structure and is made of medical silicone material with anti-slip texture on the surface to prevent slipping during handling.

[0053] During operation, the operator first holds the silicone sleeve of the handle 8 with both hands to move the collection bucket 1 to the designated location; when it is necessary to move the collection bucket 1, the operator also holds the handle 8. The U-shaped handle 8 is ergonomically designed for easy application of force, the medical-grade stainless steel material ensures strength, and the anti-slip texture of the silicone sleeve enhances handling safety and prevents the collection bucket 1 from falling during handling.

[0054] As attached Figure 2 To be continued Figure 4 As shown, in one embodiment of this utility model, the guide pipe 202 of the discharge assembly 2 and the connecting pipe 304 of the waste liquid collection assembly 3 are both made of medical elastic tubing. The guide pipe 202 is made of silicone, which has good elasticity and aging resistance, while the connecting pipe 304 is made of PVC, which has good chemical resistance and can withstand corrosion from various components in urine. The quick connectors A203 and B303 are both Luer connectors, ensuring a tight connection between the two without leakage. The connectors are equipped with sealing gaskets inside to further enhance the sealing performance.

[0055] During operation, the operator first inserts quick connector A203 (Luer male connector) into quick connector B303 (Luer female connector) and rotates it 1 / 4 turn to lock it in place, ensuring a tight connection. To disconnect, rotate it 1 / 4 turn in the opposite direction to separate them. The medical flexible tubing's guide tube 202 and connecting tube 304 are easy to bend and place, adapting to different usage scenarios. The standardized design of the Luer connector ensures reliable connection, and the sealing gasket prevents urine leakage at the connection point, improving the overall sealing of the device.

[0056] As attached Figure 2 To be continued Figure 3 As shown, in one embodiment of this utility model, the collection filter membrane 603 of the biological sample collection component 6 and the filter membrane 503 of the filtration component 5 are both made of food-grade or pharmaceutical-grade PET material. This material has good biocompatibility and will not react with the components in urine, ensuring that the biological sample is not contaminated. The PET material has good high-temperature resistance. The micropore size of the collection filter membrane 603 can be changed according to the type of target biological sample. For example, a pore size of 3-5 μm is used to detect red blood cells in urine, a pore size of 5-8 μm is used to detect white blood cells, and a pore size of 10-30 μm is used to detect cancer cells. When changing, it is only necessary to remove the fixing ring 602, remove the old filter membrane, replace the new filter membrane, and then reinstall the fixing ring 602.

[0057] During operation, staff first determine the required pore size of the collection filter membrane 603 based on the testing requirements, select the appropriate membrane, and install it into the biological sample collection assembly 6. When urine passes through the collection filter membrane 603, the target biological sample is retained, while other small molecules and water pass through. After testing, the retaining ring 602 is removed, and the collection filter membrane 603 is taken off for subsequent testing. Food-grade or pharmaceutical-grade PET material ensures the purity of biological samples, the replaceable pore size design makes the device suitable for various testing needs, and the easily removable retaining ring 602 simplifies the membrane replacement process and improves work efficiency.

[0058] Working principle: The support ring 7 is snapped into the groove inside the cylinder 101. The collecting cup 601 is then snapped into the inner ring surface of the support ring 7 via the upper protrusion. The collecting filter membrane 603 is then placed on the upper surface of the flared opening of the collecting cup 601 and tightened by the fixing ring 602. The filter cartridge plate 502 is fixed to the upper end of the filter membrane support 501, and the filter membrane 503 covers and lies on the surface of the filter cartridge plate 502. The filter membrane support 501 is then installed inside the cylinder 101 via snap-fit, positioned above the collecting cup 601.

[0059] The base support 102 is installed at the lower end of the cylinder 101 via a threaded connection. One end of the guide pipe 202 is connected to the bottom outlet of the base support 102, and the other end is fitted with a quick connector A203. The first valve 201 is connected in series in the middle of the guide pipe 202. One end of the negative pressure connection pipe 4 is connected to the side interface of the base support 102, and the other end is connected to the hospital negative pressure source. The negative pressure regulating valve is adjusted to a suitable negative pressure value.

[0060] Connect one end of the connecting pipe 304 to the liquid storage bag 301, and install the quick connector B303 on the other end. Connect the second valve 302 in series in the middle of the connecting pipe 304. Connect the discharge assembly 2 and the waste liquid collection assembly 3 by connecting the quick connector A203 and the quick connector B303. Cover the cylinder with the cover 103 to complete the assembly of the device.

[0061] During collection: Select 7:00 AM as the starting time for collection. After the patient urinates, discard the urine sample and open the cap 103 to directly discharge subsequent urine into the collection container 1.

[0062] After urine enters the collection bucket 1, it first passes through the filter membrane 503 and the filter plate 502 to filter out fine impurities. The pre-filtered urine flows to the collection cup 601, where the collection filter membrane 603 retains biological samples in the urine. The filtered urine waste liquid flows through the outside of the collection cup 601 to the base tray 102. The first valve 201 and the second valve 302 are opened, and the waste liquid flows into the storage bag 301 through the guide pipe 202 and the connecting pipe 304.

[0063] After a single urination, close the first valve 201, open the cap 103, and add an appropriate amount of special cell preservation solution to the collection container 1. As the cell preservation solution flows through the collection filter membrane 603, it fixes and preserves the retained biological sample. Before the second urination, disconnect quick connectors A203 and B303, remove the storage bag 301, open the second valve 302 to dispose of the waste liquid, reinstall the storage bag 301, open the first valve 201, and drain the cell preservation solution into the storage bag 301. Close the first valve 201 to prepare for the second urine collection. Repeat the above operations until 7:00 AM the next morning, when the patient urinates and the urine is discharged into the collection container 1. Repeat the above filtration and preservation steps; disconnect quick connectors A203 and B303, and remove the storage bag 301 to dispose of the waste liquid.

[0064] Open the cap 103, remove the filter membrane holder 501, and then remove the collection cup 601. Transfer the biological sample on the upper surface of the collection filter membrane 603 directly onto the glass slide by "stamping" and send it directly to the microscope for examination.

[0065] The foregoing description only illustrates certain exemplary embodiments of the present invention. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A 24-hour urine biological sample collector, characterized in that: It includes a collection bucket (1), a discharge assembly (2), a waste liquid collection assembly (3), a filter assembly (5), a biological sample collection assembly (6), and a support ring (7); The collection bucket (1) has a groove for installing a support ring (7) inside, and the support ring (7) can be detachably snapped into the groove; The biological sample collection assembly (6) is detachably installed inside the support ring (7), and the biological sample collection assembly (6) is located at the lower part of the collection bucket (1); The filter assembly (5) is detachably installed inside the collection bucket (1), and the filter assembly (5) is located above the biological sample collection assembly (6); One end of the discharge assembly (2) is connected to the bottom of the collection bucket (1), and the other end is detachably connected to the waste liquid collection assembly (3).

2. The 24-hour urine biological sample collector according to claim 1, characterized in that: The collection bucket (1) includes a cylindrical body (101), a base (102), and a lid (103); The cylinder (101) has an open structure at both the top and bottom. The bottom support (102) is detachably connected to the lower end of the cylinder (101) by a rotating locking structure or a snap-fit ​​structure. The groove is located on the inner wall of the cylinder (101) near the bottom support (102). The cylinder cover (103) is detachably connected to the upper end of the cylinder (101) by a rotating locking structure or a flip-top structure.

3. A 24-hour urine biological sample collector according to claim 2, characterized in that: The side of the collection bucket (1) is also provided with a negative pressure connection pipe (4) for connecting a negative pressure source. The negative pressure connection pipe (4) is connected to the inside of the collection bucket (1). One end of the negative pressure connection pipe (4) is fixedly connected to and connected to the side of the base (102), and the other end is provided with a quick-connect interface.

4. A 24-hour urine biological sample collector according to claim 3, characterized in that: The discharge assembly (2) includes a first valve (201), a guide pipe (202), and a quick connector A (203); One end of the guide pipe (202) is fixedly connected to the bottom of the base (102) and communicates with it, and the other end is fixedly connected to the quick connector A (203). The first valve (201) is installed in series in the middle of the guide pipe (202) to control the opening and closing of the guide pipe (202).

5. A 24-hour urine biological sample collector according to claim 4, characterized in that: The waste liquid collection assembly (3) includes a storage bag (301), a second valve (302), a quick connector B (303), and a connecting pipe (304); One end of the connecting pipe (304) is fixedly connected to and communicates with the opening end of the liquid storage bag (301), and the other end is fixedly connected to the quick connector B (303). The second valve (302) is installed in series in the middle of the connecting pipe (304). The quick connector B (303) is adapted to the quick connector A (203) to realize the detachable connection between the discharge assembly (2) and the waste liquid collection assembly (3).

6. A 24-hour urine biological sample collector according to claim 1, characterized in that: The filtration assembly (5) includes a filter membrane support (501), a filter cartridge plate (502), and a filter membrane (503); The filter membrane support (501) is a frame structure and can be detachably installed inside the cylinder (101) by means of a snap-fit ​​structure. The filter cylinder plate (502) is fixedly installed on the filter membrane support (501), and filter holes are provided on the side wall and bottom of the filter cylinder plate (502). The filter membrane (503) is fixedly installed on the filter membrane support (501), and the filter membrane (503) is located outside the filter cylinder plate (502).

7. A 24-hour urine biological sample collector according to claim 1, characterized in that: The biological sample collection assembly (6) includes a collection cup (601), a fixing ring (602), and a collection filter membrane (603); The collecting cup (601) is a cup-shaped structure with openings at both ends. Its upper end is provided with a flared mouth for interference fit with the inner ring surface of the support ring (7) to achieve detachable connection. The fixing ring (602) is detachably connected to the upper end of the collecting cup (601) through a rotational snap-fit ​​structure or a snap-fit ​​structure. The collecting filter membrane (603) is located between the fixing ring (602) and the upper end of the collecting cup (601).

8. A 24-hour urine biological sample collector according to claim 2, characterized in that: A handle (8) is fixedly installed in the middle of the outer side wall of the cylinder (101). The handle (8) has a U-shaped structure and is used to move the collection bucket (1).

9. A 24-hour urine biological sample collector according to claim 5, characterized in that: The guide tube (202) and the connecting tube (304) are both made of medical elastic tubing, and the quick connector A (203) and quick connector B (303) are both Luer connectors.

10. A 24-hour urine biological sample collector according to claim 7, characterized in that: Both the collection filter membrane (603) and the filter membrane (503) are made of food-grade or pharmaceutical-grade PET material. The micropore size of the collection filter membrane (603) can be changed according to the type of target biological sample.

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