A fixing device for mouse muscle injection

Abstract

The utility model discloses a fixing device for mouse muscle injection, containing fixed cylinder, one end of fixed cylinder is open, the other end inside fixed cylinder detachably installs the fixer, the door, the door is detachably installed in the opening of fixed cylinder through the connecting piece, and the door bottom is equipped with the canal. The size of the fixed cylinder is adjusted to be suitable for animals of different sizes, a head passage is opened from the front end of the fixed cylinder, a movable mounting head moves along the head passage to drive the fixer to move to fix the head of the animal, and an air hole is arranged at the fixer to enable the animal to breathe freely, a tail passage for fixing the tail of the animal is opened upward from the tail end of the fixed cylinder, and a door is additionally arranged at the tail of the fixed cylinder to expose and fix the hind limbs of the animal, so that the operator is prevented from being bitten, and one person can conveniently hold the fixer to operate.

Description

Technical Field

[0001] This utility model relates to the field of fixation devices, specifically to a fixation device for intramuscular injection in mice. Background Technology

[0002] Rodents such as rats and mice are widely used in pharmacokinetic studies of drugs. As a common route of administration, intramuscular injection allows for periodic sampling and analysis of drug concentration changes in plasma and tissues to assess drug absorption, distribution, metabolism, and excretion. There are two existing intramuscular injection methods: the first is a two-person operation, where one person manually restrains the animal while the other administers the injection; the second is a single-person operation, where the animal is anesthetized before administration. Two-person operations have several drawbacks: the stress from manual restraint may affect the animal's physiological parameters, thus influencing experimental data; furthermore, the animal's struggle may result in biting or scratching the restrainer. Single-person operations have two drawbacks: the anesthesia time prolongs the administration time and efficiency, and the recovery time after anesthesia is not conducive to blood collection within 3 minutes of administration; additionally, the anesthetic or anesthetic gas used may affect the drug's pharmacokinetic processes in the animal.

[0003] Currently available intramuscular injection devices are relatively complex in structure, requiring a support frame to hold the animal in place, which makes operation somewhat inconvenient. Existing cylindrical restraints are of a single size, and operators need to use their fingers to hold the animal's hind limbs and tail. Smaller animals may turn their heads and expose the restraints, potentially biting the operator. Therefore, it is necessary to modify existing devices and design a restraint that is easy to operate, safe, and suitable for intramuscular injection in animals. Utility Model Content

[0004] The technical problem this invention aims to solve is that existing intramuscular injection auxiliary devices are relatively complex in structure, requiring a support frame to hold the animal in place, which makes operation somewhat inconvenient. Existing cylindrical restraints are of a single size, and operators need to use their fingers to hold the animal's hind limbs and tail. Smaller animals may "turn their heads" and expose the restraints, posing a risk of biting the operator. This invention provides a restraint device for intramuscular injection in mice, adjusting the size of the restraint cylinder to suit animals of different sizes. A head channel is opened downwards from the front of the cylinder, and a movable mounting head moves along this head channel to move the restraint and secure the animal's head. An air vent is provided at the restraint to allow the animal to breathe freely. A tail channel is opened upwards from the rear of the cylinder to secure the animal's tail. A door is added at the rear of the cylinder to expose and secure the animal's hind limbs, preventing operator bites and facilitating single-person operation of the restraint, thus overcoming the shortcomings of existing technologies.

[0005] To solve the above-mentioned technical problems, this utility model provides the following technical solution:

[0006] A fixation device for intramuscular injection in mice, comprising a fixation cylinder, one end of which is open, and a fixator detachably installed inside the other end of the fixation cylinder;

[0007] A gate is detachably installed at the opening of the fixing cylinder via a connector. The bottom of the gate has a channel. Before use, the gate is separate from the fixing cylinder. When the mouse is placed into the fixing cylinder, the gate is used to fix the mouse.

[0008] The aforementioned fixation device for intramuscular injection in mice further includes an installation head. The fixation cylinder has a head channel, and the installation head is detachably connected to the fixator inside the fixation cylinder through the head channel. The installation head moves along the channel, causing the fixator to move. The installation head is preferably a screw.

[0009] The aforementioned fixation device for intramuscular injection in mice, wherein the fixator is a conical head fixator used to fix the mouse's head and prevent it from moving around.

[0010] The aforementioned fixation device for intramuscular injection in mice includes an air hole to allow the animal to breathe better.

[0011] The aforementioned fixation device for intramuscular injection in mice, wherein the length of the fixation cylinder is 10cm and the inner diameter is 3.5cm.

[0012] The aforementioned fixation device for intramuscular injection in mice includes a fixation hole on the fixation cylinder that matches the connector for connection.

[0013] The aforementioned fixation device for intramuscular injection in mice includes a tail channel on the fixation cylinder that communicates with the fixation hole to fix the mouse's tail.

[0014] In the aforementioned fixation device for intramuscular injection in mice, the connecting element is a screw.

[0015] The aforementioned fixation device for intramuscular injection in mice, wherein the orifice is semi-circular and the inner diameter of the orifice is 1 cm.

[0016] The specific usage process of the above-mentioned fixation device for intramuscular injection in mice is as follows:

[0017] The operator removes the animal from the cage and places it on the cage lid. Gently pressing down on the animal's body with the right hand, the operator uses the left hand to hold the restraint device, aligning it with the animal's head and guiding it into the device. The animal's tail is then placed into the tail passage, and the animal's hind limbs are secured with the door. The ankles are held in place with the left hand. The fur on the hind limbs is shaved to expose the quadriceps femoris muscle for intramuscular injection. The skin of the quadriceps femoris muscle and surrounding area is wiped with a cotton ball soaked in medical alcohol and then dried with a clean, dry cotton ball. The operator, holding a suitable syringe and needle, vertically inserts it into the quadriceps femoris muscle. After insertion, the syringe is slowly withdrawn. If negative pressure is observed, the needle has entered the muscle, and slow injection can begin. If fluid is observed leaking from the injection site during injection, the injection must be stopped immediately. The needle is reinserted into the muscle near the injection site, or the other hind limb is restrained and the medication is administered following the same procedure. After injection, the needle is slowly withdrawn, and a clean, dry cotton ball is used to apply pressure to the injection site to stop bleeding. The animal is then removed from the restraint device and returned to the cage.

[0018] The present invention provides a fixation device for intramuscular injection in mice with the following improvements:

[0019] Based on the original cylindrical restraint, its size has been adjusted to suit animals of different sizes (the restraint cylinder is 10cm long and has an inner diameter of 3.5cm);

[0020] A head channel (5cm long and 0.5cm wide) is opened from the front end of the fixing cylinder. A movable mounting head (threaded plug) is provided. Moving along this head channel will move the fixing device to fix the animal's head and block the animal's vision to calm it down. The fixing device is provided with two air holes with an inner diameter of 0.5cm so that the animal can breathe freely.

[0021] A tail channel is opened from the tail end of the fixing tube to fix the animal's tail (1cm in length and 0.2cm in width), and a gate is detachably installed at the opening of the fixing tube. The bottom of the gate has a channel for exposing and fixing the animal's hind limbs.

[0022] The above design modifications can prevent the animal's head from protruding from the restraint, thus avoiding biting or scratching the operator, and also make it convenient for a single person to hold the restraint and perform intramuscular injections.

[0023] Compared to single-person operation, the advantages of this simple intramuscular injection fixation device are as follows:

[0024] It allows for single-person restraint and administration, reducing the number of people required to administer the medication and improving efficiency; it avoids the risk of restraint personnel being bitten due to manual restraint; it avoids the stress and potential damage to animals caused by manual fixation, ensuring smooth administration.

[0025] Compared with animal anesthesia methods, the advantages of this simple intramuscular injection fixator are as follows:

[0026] Animals do not need anesthesia, which improves drug delivery efficiency; drug delivery in a normal physiological state better reflects the actual absorption, distribution, metabolism and excretion process of drugs in the animal's body.

[0027] The technical solution provided by the present invention, a fixation device for intramuscular injection in mice, has the following technical effects:

[0028] Based on the cylindrical restraint device, the size of the restraint cylinder has been adjusted to suit animals of different sizes. A head channel is opened from the front end of the restraint cylinder downwards. A movable mounting head moves along this head channel to move the restraint device to secure the animal's head. An air hole is provided at the restraint device to allow the animal to breathe freely. A tail channel is opened from the rear end of the restraint cylinder upwards to secure the animal's tail. A door is added to the rear end of the restraint cylinder to expose and secure the animal's hind limbs, preventing the operator from being bitten, and facilitating single-person operation of the restraint device, thus improving the efficiency of intramuscular injection. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the structure of a fixation device for intramuscular injection in mice according to the present invention;

[0030] Figure 2 This is a front view structural diagram of a fixation device for intramuscular injection in mice according to the present invention;

[0031] Figure 3 This is a top view of the fixation device for intramuscular injection in mice according to the present invention.

[0032] Figure 4 This is a side view of the fixation device for intramuscular injection in mice according to the present invention.

[0033] The reference numerals in the attached figures are as follows:

[0034] Fixed cylinder 100, gate 200, connector 300, opening 101, fixture 102, mounting head 103, head channel 104, air hole 105, fixing hole 106, tail channel 107, and channel 201. Detailed Implementation

[0035] In order to make the technical means, inventive features, objectives and effects of the utility model easy to understand, the technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to specific illustrations. Obviously, the described embodiments are some embodiments of the utility model, but not all embodiments.

[0036] Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0037] It should be noted that the structures, proportions, sizes, etc., shown in the accompanying drawings of this specification are only used to complement the content disclosed in the specification for those skilled in the art to understand and read, and are not intended to limit the conditions under which this utility model can be implemented. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in the proportional relationships, or adjustments to the size, without affecting the effects and purposes that this utility model can produce, should still fall within the scope of the technical content disclosed in this utility model.

[0038] Meanwhile, the terms such as "upper", "lower", "left", "right", "middle" and "one" used in this specification are only for clarity of description and are not intended to limit the scope of implementation of this utility model. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered as within the scope of implementation of this utility model.

[0039] A preferred embodiment of this utility model provides a fixation device for intramuscular injection in mice. The purpose is to adjust the size of the fixation cylinder to suit animals of different sizes. A head channel is opened downward from the front end of the fixation cylinder. A movable mounting head moves along this head channel to move the fixator to fix the animal's head. An air hole is provided at the fixator so that the animal can breathe freely. A tail channel is opened upward from the rear end of the fixation cylinder to fix the animal's tail. A door is added to the rear end of the fixation cylinder to expose and fix the animal's hind limbs, preventing the operator from being bitten and facilitating single-person operation of the fixator.

[0040] like Figure 1-4 As shown, a fixation device for intramuscular injection in mice includes a fixation cylinder 100, one end of which is an opening 101, and a fixator 102 is detachably installed inside the other end of the fixation cylinder 100.

[0041] like Figure 4 As shown, the barrier 200 is detachably installed at the opening 101 of the fixed cylinder 100 via the connector 300, and the bottom of the barrier 200 is provided with a channel 201.

[0042] like Figure 1-2 As shown, it also includes an installation head 103. A head channel 104 is provided on the fixing cylinder 100. The installation head 103 is detachably connected to the fixing device 102 inside the fixing cylinder 100 through the head channel 104. The installation head 103 moves on the channel, causing the fixing device 102 to move.

[0043] The restraint 102 is a conical head restraint 102, used to fix the mouse's head and prevent it from moving around; the restraint 102 has an air hole 105 so that the mouse can breathe better.

[0044] The length of the fixing cylinder 100 is 10cm and the inner diameter is 3.5cm. The fixing cylinder 100 is provided with a fixing hole 106 for matching the connector 300 so as to match and connect the connector 300. The fixing cylinder 100 is provided with a tail channel 107 communicating with the fixing hole 106 so as to fix the tail of the mouse. The connector 300 is a screw.

[0045] The channel 201 is semi-circular, and the inner diameter of the channel 201 is 1cm.

[0046] The specific usage process of the above-mentioned fixation device for intramuscular injection in mice is as follows:

[0047] The operator removes the animal from the cage and places it on the cage lid. The right hand gently presses down on the animal's body, while the left hand holds the restraint device, aligns it with the animal's head, and guides the animal into the device. The animal's tail is then placed into the tail passage 107, and the hind limbs are secured with the gate 200. The ankles are then secured with the left hand. The fur on the animal's hind limbs is shaved to expose the quadriceps femoris muscle for intramuscular injection. The skin of the quadriceps femoris muscle and surrounding area is wiped with a cotton ball soaked in medical alcohol and then dried with a clean, dry cotton ball. The operator holds a syringe and needle of appropriate size and inserts it vertically into the quadriceps femoris muscle. After insertion, the syringe is slowly withdrawn. If negative pressure is observed, the needle has entered the muscle, and slow injection can begin. If fluid is observed overflowing around the injection site during injection, the injection must be stopped immediately. The needle is reinserted into the muscle near the injection site, or the other hind limb is secured using the same procedure. After injection, the needle is slowly withdrawn, and a clean, dry cotton ball is used to apply pressure to the injection site to stop bleeding. Remove the animal from the restraints and return it to the cage.

[0048] The present invention provides a fixation device for intramuscular injection in mice with the following improvements:

[0049] Based on the original cylindrical restraint 102, its size has been adjusted to suit animals of different sizes (restraint cylinder 100 is 10cm long and 3.5cm in inner diameter).

[0050] A head channel 104 (5cm long and 0.5cm wide) is opened from the front end of the fixing cylinder 100 downwards. A movable mounting head 103 (threaded plug) is provided. Moving along this head channel 104 drives the fixing device 102 to move to fix the animal's head. Two air holes 105 with an inner diameter of 0.5cm are provided on the fixing device 102 so that the animal can breathe freely.

[0051] A tail passage 107 is opened from the tail end of the fixing tube 100 to fix the animal's tail (1cm in length and 0.2cm in width), and a gate 200 is detachably installed at the opening 101 of the fixing tube 100. The bottom of the gate 200 has a channel 201 for exposing and fixing the animal's hind limbs.

[0052] The above design modifications can prevent the animal's head from protruding from the restraint 102, thus avoiding biting or scratching the operator, and also facilitate single-person operation of intramuscular injection by holding the restraint 102.

[0053] In summary, this utility model provides a fixation device for intramuscular injection in mice. The size of the fixation cylinder has been adjusted to suit animals of different sizes. A head channel is opened downward from the front end of the fixation cylinder. A movable mounting head moves along this head channel to move the fixator and fix the animal's head. An air hole is provided at the fixator to allow the animal to breathe freely. A tail channel is opened upward from the rear end of the fixation cylinder to fix the animal's tail. A door is added at the rear end of the fixation cylinder to expose and fix the animal's hind limbs, preventing the operator from being bitten and facilitating single-person operation of the fixator.

[0054] The specific embodiments of the utility model have been described above. It should be understood that the utility model is not limited to the specific embodiments described above, and the devices and structures not described in detail should be understood as being implemented in a manner common to the art; those skilled in the art can make various modifications or alterations within the scope of the claims, and make several simple deductions, modifications or substitutions, which do not affect the substantive content of the utility model.

Claims

1. A fixation device for intramuscular injection in mice, characterized in that, It includes a fixing cylinder, one end of which is open, and a retainer is detachably installed inside the other end of the fixing cylinder; A gate is provided, which is detachably installed at the opening of the fixed cylinder via a connector, and the bottom of the gate is provided with a channel; It also includes an installation head, on which a head channel is provided. The installation head is detachably connected to the retainer inside the fixed cylinder through the head channel. The installation head moves along the channel, causing the retainer to move. The fixator is a conical head fixator; The fixing cylinder is provided with a fixing hole that matches the connector; the fixing cylinder is provided with a tail channel that communicates with the fixing hole.

2. The fixation device for intramuscular injection in mice as described in claim 1, characterized in that, The fixture has air holes.

3. The fixation device for intramuscular injection in mice as described in claim 1, characterized in that, The length of the fixed cylinder is 10cm and the inner diameter is 3.5cm.

4. The fixation device for intramuscular injection in mice as described in claim 1, characterized in that, The connector is a screw.

5. The fixation device for intramuscular injection in mice as described in claim 1, characterized in that, The channel is semi-circular.

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