Monitoring device and experimental perfusion system

Abstract

The application is suitable for the field of medical devices, and discloses a monitoring device and an experimental perfusion system. The monitoring device comprises a pressure transmission assembly and a monitoring assembly. The pressure transmission assembly comprises a main body and a movable sealing piece. The main body is provided with a fluid channel. The fluid channel is communicated with the experimental perfusion system. The movable sealing piece is slidably arranged in the fluid channel. The monitoring assembly is used for monitoring displacement change of the movable sealing piece or pressure change in the fluid channel, so as to determine blood pressure change of the experimental perfusion system, and further determine the state of the experimental perfusion system. The monitoring device of the application can timely monitor the risk of blood coagulation, ensure that the perfusion experiment can be smoothly carried out, improve the efficiency of the perfusion experiment, and has simple structure, safety and reliability.

Description

Technical Field

[0001] This application relates to the field of medical devices, and more particularly to a monitoring device and an experimental perfusion system. Background Technology

[0002] Hemoperfusion (HP) is a commonly used blood purification method in clinical practice. It involves drawing blood from the patient's body through methods such as puncture and circulating it extracorporeally. The adsorbent in the extracorporeal perfusion device removes exogenous and endogenous toxins. To evaluate the safety and effectiveness of blood adsorption materials, animal perfusion experiments are necessary to simulate clinical conditions and conduct relevant studies.

[0003] However, in animal perfusion experiments, if blood clots appear in the experimental model, the perfusion device will become blocked. In this case, the perfusion must be stopped by unloading the device, which affects the efficiency of the experiment. Utility Model Content

[0004] The purpose of this application is to provide a monitoring device and an experimental irrigation system that aim to improve the efficiency of irrigation experiments.

[0005] To achieve the above objectives, this application provides a monitoring device for use in an experimental perfusion system, comprising: A pressure transmission assembly includes a body and a movable seal. The body has a fluid channel that communicates with the experimental perfusion system, and the movable seal is slidably disposed on the fluid channel. A monitoring component is used to monitor the displacement change of the movable seal or the pressure change within the fluid channel to determine the blood pressure change of the experimental perfusion system, and thus determine the state of the experimental perfusion system.

[0006] In the monitoring device of this application, the movable seal has a first end along a first direction away from the fluid channel, the first end extends out of the body, and the monitoring component is used to monitor the displacement change of the first end; Wherein, the first direction is the sliding direction of the movable seal.

[0007] In the monitoring device of this application, the pressure transmission component is a syringe, the main body is the sleeve of the syringe, and the movable seal is the piston rod of the syringe.

[0008] In the monitoring device of this application, the monitoring components include one or a combination of contact sensors, pressure sensors, distance sensors, and Hall sensors.

[0009] In the monitoring device of this application, the fluid channel contains an anticoagulant, and the monitoring device further includes an injection assembly. The injection assembly includes a driving device and a pushing assembly. The pushing assembly has a pushing part, and the pushing part and the first end of the movable seal are disposed opposite each other. The driving device is connected to the pushing assembly to drive the pushing assembly to move along a first direction. The monitoring assembly is disposed on the pushing part.

[0010] In the monitoring device of this application, the injection assembly further includes a lead screw, the pushing assembly includes a slider, a connecting rod and the pushing part, the connecting rod connects the slider and the pushing part, the driving device is connected to the lead screw, and the slider is connected to the lead screw. In the monitoring device of this application, the injection assembly further includes a displacement sensor for monitoring the position of the pushing part; the displacement sensor includes an electrode plate and a potentiometer, the electrode plate is disposed on the pushing assembly, and the electrode plate and the potentiometer are in electrical contact.

[0011] The monitoring device of this application further includes a control component, which is connected to both the monitoring component and the drive device. The control component is used to receive electrical signals from the monitoring component and control the drive device to operate according to the electrical signals.

[0012] In the monitoring device of this application, the fluid channel includes a connecting channel, and the fluid channel is connected to the experimental perfusion system through the connecting channel. The flow cross-sectional area of ​​the connecting channel is smaller than the flow cross-sectional area of ​​the fluid channel. The monitoring device also includes a replenishment component and an injection solenoid valve. The fluid channel contains an anticoagulant. The replenishment component includes a reservoir, a replenishment pump, a replenishment pipeline, and a replenishment solenoid valve. The reservoir stores the anticoagulant and is connected to the fluid channel through the replenishment pipeline. The replenishment pump and the replenishment solenoid valve are both located on the replenishment pipeline, and the injection solenoid valve is located on the connecting channel.

[0013] This application also provides an experimental perfusion system, comprising: Irrigation circuit; An irrigation device, wherein the irrigation device is disposed on the irrigation circuit; The monitoring device described in any of the above embodiments is connected to the irrigation circuit and located at the inlet and / or outlet of the irrigation device.

[0014] The monitoring device and experimental perfusion system provided in this application, when the monitoring component detects a change in the displacement of the movable seal or a change in the pressure within the fluid channel, indicates a change in the fluid pressure within the fluid channel. Since the fluid channel is connected to the experimental perfusion system, it can be determined that the blood pressure within the experimental perfusion system has changed. This allows for the identification of whether the blood flow resistance within the experimental perfusion system has increased, whether coagulation has occurred, or whether there are signs of precoagulation, enabling the timely release of an anticoagulant into the experimental perfusion system to alleviate coagulation. Therefore, the monitoring device of this application can monitor the risk of coagulation in a timely manner, ensuring the smooth conduct of the perfusion experiment, thereby improving the efficiency of the perfusion experiment. Furthermore, it is simple in structure and safe and reliable. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0016] Figure 1 This is a schematic diagram of the monitoring device provided in the embodiments of this application; Figure 2 This is a connection diagram of the control components provided in an embodiment of this application; Figure 3 This is a schematic diagram of the experimental irrigation system provided in the embodiments of this application.

[0017] Explanation of icon numbers: 1000: Experimental irrigation system; 100: Monitoring device; 101: First monitoring device; 102: First monitoring device; 10: Pressure transmission assembly; 11: Body; 111: Fluid passage; 112: Connection passage; 1121: Injection solenoid valve; 12: Movable seal; 121: First end; 20: Monitoring components; 30: Injection assembly; 31: Drive unit; 32: Lead screw; 33: Push assembly; 331: Slider; 332: Connecting rod; 333: Pushing part; 34: Displacement sensor; 341: Electrode plate; 342: Potentiometer; 40: Liquid replenishment assembly; 41: Liquid storage tank; 42: Liquid replenishment pump; 43: Liquid replenishment pipeline; 44: Liquid replenishment solenoid valve; 50: Bracket; 200: Irrigation circuit; 300: Irrigation device; 400: Blood pump; 500: Heater; 600: Temperature sensor; 701: First tee connector; 702: Second tee connector; 900: Control component. Detailed Implementation

[0018] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0019] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of this application are only used to explain the relative positional relationship and movement of each component in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0020] It should also be noted that when a component is referred to as being "fixed to" or "set on" another component, it can be directly on the other component or may be connected to an intermediary component. When a component is referred to as being "connected to" another component, it can be directly connected to the other component or indirectly connected to the other component through an intermediary component.

[0021] Furthermore, the use of terms such as "first" and "second" in this application is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. Additionally, the technical solutions of the various embodiments can be combined with each other, but only on the basis of being achievable by those skilled in the art. When the combination of technical solutions is contradictory or impossible to implement, such a combination of technical solutions should be considered non-existent and not within the scope of protection claimed in this application.

[0022] like Figure 1As shown in the illustration, an embodiment of this application provides a monitoring device 100 applied to an experimental perfusion system 1000. The monitoring device 100 includes a pressure transmission component 10 and a monitoring component 20. The pressure transmission component 10 includes a main body 11 and a movable seal 12. The main body 11 is provided with a fluid channel 111, which is connected to the experimental perfusion system 1000. The movable seal 12 is slidably disposed in the fluid channel 111. The monitoring component 20 is used to monitor the displacement change of the movable seal 12 or the pressure change within the fluid channel 111 to determine the blood pressure change of the experimental perfusion system 1000, and thus determine the state of the experimental perfusion system 1000.

[0023] In the pressure transmission assembly 10, when transmitting pressure from the experimental irrigation system 1000, its fluid channel 111 is only connected to the experimental irrigation system 1000. The movable seal 12 can slide in the fluid channel 111, but it remains sealed to prevent external air pressure from affecting the accuracy of the monitoring device 100. For example, the movable seal 12 has a piston at one end inside the fluid channel 111 to ensure a seal between it and the inner wall of the fluid channel 111.

[0024] In the animal perfusion experiment, the blood pressure in the experimental perfusion system 1000 remained essentially constant. When the fluid channel 111 was connected to the experimental perfusion system 1000, the fluid pressure in the fluid channel 111 also remained essentially constant in the absence of coagulation. The fluid in the fluid channel 111 would not flow into the experimental perfusion system 1000, and blood would not flow into the fluid channel 111 either.

[0025] In the monitoring device 100 of this application embodiment, when the monitoring component 20 detects a change in the displacement of the movable seal 12 or a change in the pressure within the fluid channel 111, it indicates a change in the fluid pressure within the fluid channel 111. Since the fluid channel 111 is connected to the experimental perfusion system 1000, it can be determined that the blood pressure in the experimental perfusion system 1000 has changed. This allows for identification of whether the blood flow resistance within the experimental perfusion system 1000 has increased, whether coagulation has occurred, or whether there are signs of precoagulation, enabling timely release of an anticoagulant into the experimental perfusion system 1000 to alleviate coagulation. Therefore, the monitoring device 100 of this application can monitor the risk of coagulation in a timely manner, ensuring the smooth conduct of the perfusion experiment, thereby improving the efficiency of the perfusion experiment. Furthermore, it has a simple structure and is safe and reliable. In addition, this method can provide data support for anticoagulant dosage studies, providing favorable support for projects that require animal perfusion to conduct relevant efficacy and safety studies. Simultaneously, parameter optimization is also used as a supplementary means for the anticoagulation evaluation of the perfusion device 300 product.

[0026] Specifically, when the monitoring component 20 detects that the movable seal 12 is moving away from the fluid channel 111 or that the pressure within the fluid channel 111 increases, it indicates an increase in fluid pressure within the fluid channel 111. Since the fluid channel 111 is connected to the experimental perfusion system 1000, it can be determined that the blood pressure in the experimental perfusion system 1000 has increased, thereby identifying an increase in blood flow resistance within the experimental perfusion system 1000, i.e., coagulation or precoagulation precursors have occurred. It should be noted that when coagulation or precoagulation precursors occur in the experimental perfusion system 1000, the user can actively inject an anticoagulant, or the monitoring device 100 can automatically release the anticoagulant to alleviate the coagulation situation; there are no restrictions.

[0027] like Figure 1 As shown, in some embodiments, the fluid channel 111 includes a connecting channel 112, through which the fluid channel 111 is connected to the experimental perfusion system 1000. The flow cross-sectional area of ​​the connecting channel 112 is smaller than that of the fluid channel 111. In this way, in the absence of coagulation, the fluid in the fluid channel 111 and the blood in the experimental perfusion system 1000 can be prevented from flowing and exchanging with each other.

[0028] In some embodiments, the monitoring component 20 is disposed on the connection channel 112 to monitor the pressure of the connection channel 112, thereby accurately knowing the blood pressure changes within the experimental perfusion system 1000, and thus determining the state of the experimental perfusion system 1000.

[0029] For example, the monitoring component 20 includes a pressure gauge that allows for a visual assessment of the pressure value in the connection channel 112. For instance, the pressure gauge may be positioned on the side of the injection solenoid valve 1121 away from the fluid channel.

[0030] like Figure 1 As shown, in some embodiments, the movable seal 12 has a first end 121 along a first direction that is away from the fluid channel 111. The first end 121 extends out of the body 11, and the monitoring component 20 is used to monitor the displacement change of the first end 121. The first direction is the sliding direction of the movable seal 12. By monitoring the displacement change of the first end 121, the monitoring component 20 can determine the sliding status of the movable seal 12 along the first direction, thereby determining the fluid pressure change within the fluid channel 111 and ultimately determining the state of the experimental perfusion system 1000.

[0031] In other embodiments, the monitoring component 20 can also detect the displacement change of the movable seal 12 by monitoring other parts of the movable seal 12. For example, the monitoring component 20 can detect the displacement change of the movable seal 12 by monitoring one end of the movable seal 12 located within the fluid channel 111.

[0032] like Figure 1As shown, in some embodiments, the main body 11, the fluid channel 111, and the connecting channel 112 all extend along a first direction. Since the sliding direction of the movable seal 12 is also along the first direction, the fluid flow direction of the fluid channel 111 and the connecting channel 112 is also along the first direction. In this way, the sensitivity and accuracy of pressure transmission of the pressure transmission assembly 10 can be improved.

[0033] like Figure 1 As shown, in some embodiments, the pressure transmission component 10 is a syringe, the main body 11 is the syringe sleeve, and the movable seal 12 is the syringe piston rod. The needle of the syringe forms the aforementioned connection channel 112. Syringes are a common structure; in this application, using a syringe as the pressure transmission component 10 reduces costs and facilitates the application of the monitoring device 100 in actual experiments.

[0034] In the syringe, the piston rod is located at one end inside the sleeve, which can seal with the inner wall of the sleeve. The piston rod as a whole can slide relative to the sleeve. The first end 121 of the piston rod away from the fluid channel 111 is the handle. The handle has an increased area relative to other positions in the middle of the piston rod, which is beneficial for the monitoring component 20 to monitor its displacement changes and is also convenient to press, which is beneficial for liquid injection and return.

[0035] In some embodiments, the monitoring component 20 includes one or more of a contact sensor, a pressure sensor, a distance sensor, and a Hall sensor.

[0036] When the movable seal 12 undergoes displacement, the contact sensor can detect whether the movable seal 12 has been displaced by detecting whether it is in contact with the movable seal 12, thereby determining the fluid pressure change in the fluid channel 111 and thus determining the state of the experimental irrigation system 1000.

[0037] For example, a contact sensor is disposed at a position opposite to the first end 121 along a first direction. When the movable seal 12 slides along the first direction, its first end 121 will contact the contact sensor, the contact sensor will detect a contact signal, and thus know that the movable seal 12 has been displaced.

[0038] When the movable seal 12 undergoes displacement, the pressure sensor can detect the displacement of the movable seal 12 by measuring the pressure change generated by its contact with the movable seal 12, thereby determining the fluid pressure change within the fluid channel 111 and ultimately the state of the experimental perfusion system 1000. The pressure sensor may include a strain gauge pressure sensor or a capacitive pressure sensor.

[0039] For example, a pressure sensor is disposed at a position opposite to the first end 121 along a first direction. When the movable seal 12 slides along the first direction, its first end 121 comes into contact with the pressure sensor, thus generating a pressure change.

[0040] When the piston seal undergoes displacement, the ranging sensor can directly determine the displacement change of the movable seal 12, thereby determining whether the movable seal 12 has shifted, thus determining the fluid pressure change within the fluid channel 111, and consequently determining the state of the experimental irrigation system 1000. The ranging sensor may include a laser ranging sensor.

[0041] For example, the ranging sensor is positioned opposite the first end 121 along the first direction. For instance, when the ranging sensor is a laser ranging sensor, both its transmitting end and receiving end are positioned towards the first end 121 along the first direction. Thus, when the movable seal 12 slides along the first direction, the distance between its first end 121 and the ranging sensor will change accordingly, thereby allowing it to be determined whether the movable seal 12 has been displaced.

[0042] When the movable seal 12 undergoes displacement, the Hall sensor can detect whether the movable seal 12 has shifted by changing the magnetic field, thereby determining the fluid pressure change in the fluid channel 111 and thus the state of the experimental irrigation system 1000.

[0043] For example, a Hall sensor is disposed at a position opposite to the first end 121 along a first direction. A magnet may be disposed at the first end 121. When the movable seal 12 slides along the first direction, the Hall sensor detects the change in the magnetic field, and thus can determine whether the movable seal 12 has been displaced.

[0044] In this application, the monitoring component 20 can be one or a combination of the above-mentioned sensors, without limitation. Furthermore, this application is not limited to the sensors listed above; that is, any sensor capable of detecting changes in the displacement of the movable seal 12 can be used in this application.

[0045] like Figure 1As shown, in some embodiments, the fluid channel 111 contains an anticoagulant. The anticoagulant is used to alleviate clotting and prevent blood flow obstruction within the experimental perfusion system 1000 due to clotting. When clotting or pre-clotting occurs in the experimental perfusion system 1000, the anticoagulant in the fluid channel 111 can be injected into the experimental perfusion system 1000 by pushing the movable seal 12, thus alleviating clotting and ensuring unobstructed blood flow. Integrating the anticoagulant injection into the monitoring device 100 allows for simultaneous monitoring and clotting relief, improving the efficiency of the perfusion experiment. The user can actively push the movable seal 12, for example, by pressing the first end 121 of the movable seal 12, to inject the anticoagulant in the fluid channel 111 into the experimental perfusion system 1000. Alternatively, the movable seal 12 can be automatically pushed by the injection assembly 30 to inject the anticoagulant in the fluid channel 111 into the experimental perfusion system 1000.

[0046] For example, the anticoagulant includes heparinized saline, wherein the concentration of heparin is 0.02 mg / mL. Heparinized saline can effectively alleviate coagulation, ensuring that the perfusion experiment can be performed smoothly and thus improving the efficiency of the perfusion experiment.

[0047] like Figure 1 As shown, in some embodiments, the monitoring device 100 further includes an injection assembly 30, which includes a driving device 31 and a pushing assembly 33. The pushing assembly 33 has a pushing part 333, which is disposed opposite to the first end 121 of the movable seal 12. The driving device 31 is connected to the pushing assembly 33 to drive the pushing assembly 33 to move along a first direction. When it is necessary to inject anticoagulant into the experimental perfusion system 1000, the driving device 31 can drive the pushing assembly 33 to move towards the movable seal 12 along the first direction. The pushing part 333 of the pushing assembly 33 can push the first end 121 of the movable seal 12, so that the movable seal 12 can slide within the fluid channel 111, thereby compressing the volume of the fluid channel 111, so that the anticoagulant in the fluid channel 111 can be injected into the experimental perfusion system 1000 to relieve coagulation through antigel and ensure smooth blood flow in the experimental perfusion system 1000. By injecting anticoagulants in this automated manner, manpower can be reduced and operational efficiency can be improved, so as to alleviate the coagulation situation within the experimental perfusion system in a timely manner and improve the efficiency of perfusion experiments.

[0048] For example, the drive device 31 includes a stepper motor. The stepper motor can stably and precisely drive the push component 33 to move, ensuring that the distance the push component 33 moves meets the requirements.

[0049] like Figure 1As shown, in some embodiments, the injection assembly 30 further includes a lead screw 32, and the pushing assembly 33 includes a slider 331, a connecting rod 332, and a pushing part 333. The connecting rod 332 connects the slider 331 and the pushing part 333. The driving device 31 is connected to the lead screw 32, and the slider 331 is connected to the lead screw 32. It should be noted that the lead screw 32 also extends along the first direction, and the slider 331 is connected to the lead screw 32. That is, the slider 331 has a threaded groove inside, which can cooperate with the thread on the outer surface of the lead screw 32. The output shaft of the driving device 31 is connected to the lead screw 32 and can drive the lead screw 32 to rotate. When the output shaft of the driving device 31 rotates the lead screw 32, the slider 331 can translate along the length direction of the lead screw 32 and drive the connecting rod 332 to move, thereby allowing the pushing part 333 to move along the first direction, so as to push the movable seal 12 when needed and inject the anticoagulant into the experimental perfusion system 1000.

[0050] like Figure 1 As shown, in some embodiments, the monitoring device 100 further includes a bracket 50, which supports the injection assembly 30 and the pressure transmission assembly 10, enabling the monitoring device 100 to be integrated and quickly installed onto the experimental perfusion system 1000. Specifically, the bracket 50 has a mounting cavity and a fixing hole, the fixing hole communicating with the mounting cavity, the pressure transmission assembly 10 passing through the fixing hole, the main body 11 being fixedly installed in the fixing hole, one end of the main body 11 extending out of the fixing hole and used to connect with the experimental perfusion system 1000, and the portion of the movable seal 12 near the first end 121 extending out of the fixing hole and placed in the mounting cavity. The lead screw 32 is located in the mounting cavity, with one end rotatably connected to the inner wall of the bracket 50, and the other end extending out of the bracket 50 and connected to the output shaft of the drive device 31. The push assembly 33 is located in the mounting cavity, and the slider 331 is connected to the lead screw 32. The push part 333 and the first end 121 are arranged along a first direction.

[0051] For example, a locking ring is provided on the periphery of the main body 11, and a locking groove is provided on the inner wall of the fixing hole. The locking ring is locked in the locking groove so that the main body 11 is fixedly installed in the fixing hole and will not move relative to the fixing hole.

[0052] For example, the drive device 31 is fixedly installed on the outer wall of the bracket 50, and the output shaft of the drive device 31 is connected to the lead screw 32 so that the injection assembly 30 is stably integrated and installed on the bracket 50.

[0053] like Figure 1As shown, in some embodiments, the monitoring component 20 is disposed on the pushing part 333. It should be noted that the monitoring component 20 disposed on the pushing part 333 is the same as the monitoring component 20 described above for monitoring the displacement change of the movable seal 12, and it includes a pressure sensor, a distance sensor, and a Hall sensor. Disposing the monitoring component 20 on the pushing part 333 allows for precise monitoring of the displacement change of the first end 121 of the movable seal 12. Furthermore, it simplifies the placement of the monitoring component 20, thereby simplifying the overall structure of the monitoring device 100.

[0054] For example, the monitoring component 20 is a contact sensor, which is located on the surface of the push part 333 facing the first end 121. When the movable seal 12 is displaced, the first end 121 will contact the contact sensor, generating a corresponding electrical signal, thereby allowing the state within the experimental perfusion system 1000 to be determined.

[0055] like Figure 1 As shown, in some embodiments, the injection assembly 30 further includes a displacement sensor 34 for monitoring the position of the pusher 333. The displacement sensor 34 can visually confirm the current position of the pusher 333 so that the monitoring device 100 can perform corresponding functional operations, such as returning to the initial position so that the monitoring assembly 20 can perform the next monitoring.

[0056] Of course, in some other embodiments, the operation of the drive device 31 can also be recorded in the control component 900 to determine the position of the pusher 333. Specifically, when the device is determined to be a stepper motor, the control component 900 can record the speed and running time of the stepper motor to determine the moving distance of the pusher 33 based on its speed and running time, and thus determine the current position of the pusher 333 so that the monitoring device 100 can perform corresponding functional operations.

[0057] like Figure 1 As shown, in some embodiments, the displacement sensor 34 includes an electrode plate 341 and a potentiometer 342. The electrode plate 341 is disposed on the pushing assembly 33, and the electrode plate 341 and the potentiometer 342 are in electrical contact. One end of the potentiometer 342 and the electrode plate 341 are respectively connected to a circuit. When the pushing assembly 33 moves along a first direction, the electrode plate 341 also moves relative to the potentiometer 342, and the contact position between the electrode plate 341 and the potentiometer 342 changes. The resistance of the displacement sensor 34 in the circuit also changes. Therefore, the current position of the electrode plate 341 can be determined by the electrical signal in the circuit, thereby obtaining the position of the pushing assembly 33 and its pushing part 333.

[0058] For example, potentiometer 342 extends along a first direction and is fixed to the inner wall of bracket 50. For instance, potentiometer 342 is fixed to the bottom inner wall of bracket 50.

[0059] For example, electrode 341 is disposed on the side wall of the pushing part 333 so that the electrode 341 moves when the pushing part 333 moves. For example, electrode 341 is disposed at the bottom of the pushing part 333 so as to contact the potentiometer 342 at the bottom.

[0060] Of course, in other embodiments, a distance sensor may also be provided on the inner wall of the bracket 50 to detect the current position of the pushing assembly 33 and its pushing part 333.

[0061] like Figure 2 As shown, in some embodiments, the monitoring device 100 further includes a control component 900, which is connected to the monitoring component 20 and the drive device 31 respectively. The control component 900 is used to receive electrical signals from the monitoring component 20 and control the drive device 31 to operate according to the electrical signals. When coagulation or precoagulation signs occur in the experimental perfusion system 1000, the pressure within the experimental perfusion system 1000 is transmitted to the pressure transmission component 10. The monitoring component 20 can then detect changes in the displacement of the movable seal 12 or changes in the pressure within the fluid channel 111. An electrical signal is then transmitted to the control component 900. Upon receiving the electrical signal, the control component 900 sends a control signal to the drive device 31. The drive device 31 then drives the push component 33 to move, causing the push part 333 to move along the first direction toward the first end 121. The push part 333 then pushes the first end 121 of the movable seal 12 to inject the anticoagulant from the fluid channel 111 into the experimental perfusion system 1000, thereby alleviating the coagulation situation in a timely manner, ensuring the smooth progress of the perfusion experiment, and improving the efficiency of the perfusion experiment.

[0062] In some preferred embodiments, the monitoring device 100 is a contact sensor and is located on the side of the pushing part 333 facing the first end 121. Under normal circumstances, the pushing part 333 is in its initial position, and there is a gap between the pushing part 333 and the first end 121 of the movable seal 12. When coagulation or signs of precoagulation occur in the experimental perfusion system 1000, the movable seal 12 moves toward the pushing part 333 until it contacts the contact sensor. After receiving the signal from the contact sensor, the control component 900 controls the drive device 31 to drive the pushing component 33 to move, and the pushing part 333 can then push the first end 121 of the movable seal 12 to move. Since the pushing part 333 is in contact with the first end 121 when the monitoring device 100 detects coagulation, this arrangement can immediately control the pushing part 333 to push the movable seal 12 when coagulation is detected, improving the efficiency of relieving coagulation, simplifying the injection process, and enabling precise control of the amount of anticoagulant injected.

[0063] like Figure 2As shown, in some embodiments, the control component 900 is connected to the displacement sensor 34. The displacement sensor 34 can know the current position of the pusher 333 in real time, for example, it can determine the initial position and the injection position of the pusher 333. During the process of the pusher 333 pushing the movable seal 12 to inject anticoagulant, the amount of advancement of the displacement sensor 34 can be determined by the displacement sensor 34, and then the control component 900 can control the drive device 31 to control the volume of anticoagulant pushed into the experimental perfusion system 1000. This is to provide certain data support for anticoagulant dosage research.

[0064] like Figure 1 As shown, in some embodiments, the monitoring device 100 further includes a replenishment assembly 40 and an injection solenoid valve 1121. The replenishment assembly 40 includes a storage tank 41, a replenishment pump 42, a replenishment pipeline 43, and a replenishment solenoid valve 44. The storage tank 41 stores anticoagulant and is connected to the fluid channel 111 via the replenishment pipeline 43. The replenishment pump 42 and the replenishment solenoid valve 44 are both mounted on the replenishment pipeline 43, and the injection solenoid valve 1121 is mounted on the connection channel 112. The replenishment assembly 40 can replenish the anticoagulant in the fluid channel 111 to prepare for the next injection of anticoagulant into the experimental perfusion system 1000 by the monitoring device 100. In this way, it can be ensured that the monitoring device 100 can inject anticoagulant into the experimental perfusion system 1000 multiple times, ensuring that the entire perfusion experiment can proceed smoothly and improving the efficiency of the perfusion experiment. Specifically, when fluid replenishment is needed, the injection solenoid valve 1121 is closed to prevent the anticoagulant from directly entering the experimental perfusion system 1000 during the fluid replenishment process. Then, the fluid replenishment solenoid valve 44 is opened, and the fluid replenishment pump 42 is started to replenish the anticoagulant in the storage tank 41 into the fluid channel 111.

[0065] like Figure 2 As shown, in some embodiments, the control component 900 is connected to the replenishment component 40 and the injection solenoid valve 1121 so that when replenishment is needed, the control component 900 controls the operation of the injection solenoid valve 1121, the replenishment solenoid valve 44, and the replenishment pump 42 to achieve automatic replenishment.

[0066] In some embodiments, after the control component 900 controls the injection component 30 to inject the anticoagulant, the control component 900 controls the drive device 31 to reverse, so as to drive the push component 33 to move away from the movable seal 12. At the same time, the control component 900 controls the injection solenoid valve 1121 to close and the replenishment solenoid valve 44 to open, and starts the replenishment pump 42 to replenish the anticoagulant into the syringe. During this process, the movable seal 12 will slide away from the fluid channel 111 along the first direction, and the volume of the fluid channel 111 will gradually increase until the monitoring component 20 detects that the first end 121 of the movable seal 12 is in the first position, or the pressure of the fluid channel 111 is at the first pressure. At this time, the control component 900 receives a signal, that is, controls the replenishment pump 42 to stop, closes the replenishment solenoid valve 44, and opens the injection solenoid valve 1121. The first position is the position of the first end 121 of the movable seal 12 when the monitoring device 100 is initially not filled with liquid, and the first pressure is the pressure of the fluid channel 111 when the monitoring device 100 is initially not filled with liquid. In order to facilitate the next liquid injection operation of the injection component 30, the control component 900 will also control the drive device 31 to reverse, so that the push component 33 returns to the initial position.

[0067] In some preferred embodiments, the monitoring device 100 is a contact sensor and has a pushing part 333 facing the first end 121. After the control component 900 controls the injection component 30 to inject the anticoagulant, the control component 900 controls the drive device 31 to reverse, so as to drive the pushing component 33 to move away from the movable seal 12, so that the pushing part 333 moves to the replenishment position. At the same time, the control component 900 controls the injection solenoid valve 1121 to close and the replenishment solenoid valve 44 to open, and starts the replenishment pump 42 to replenish the anticoagulant into the syringe. During this process, the movable seal 12 will slide away from the fluid channel 111 along the first direction, and the volume of the fluid channel 111 will gradually increase until the first end 121 of the movable seal 12 contacts the contact sensor. The control component 900 receives the signal, that is, controls the replenishment pump 42 to stop, closes the replenishment solenoid valve 44, and opens the injection solenoid valve 1121. Then, in order to facilitate the next injection operation of the injection component 30, the control component 900 will also control the drive device 31 to reverse, so that the push component 33 returns to the initial position.

[0068] like Figure 3 As shown in the illustration, this application also provides an experimental irrigation system 1000, including an irrigation circuit 200, an irrigation device 300, and a monitoring device 100. The monitoring device 100 is connected to the irrigation circuit 200 and is located at the inlet and / or outlet of the irrigation device 300.

[0069] The experimental perfusion system 1000 can be an animal perfusion system or other perfusion system model, without limitation, and its purpose is to simulate the therapeutic effect of human blood perfusion.

[0070] In the experimental perfusion system 1000 of this application embodiment, the blood changes in the perfusion circuit 200 can be monitored by the monitoring device 100 at the inlet and / or outlet of the perfusion device 300, and the device can identify whether the blood flow resistance in the perfusion circuit 200 has increased, so as to determine whether coagulation has occurred or there are signs of precoagulation. This allows for the timely release of an anticoagulant into the experimental perfusion system 1000 to alleviate the coagulation situation. Therefore, the monitoring device 100 of this application can monitor the risk of coagulation in a timely manner, ensuring that the perfusion experiment can be carried out smoothly, thereby improving the efficiency of the perfusion experiment. Furthermore, it is simple in structure and safe and reliable.

[0071] For example, the monitoring device 100 of this application can ensure that the irrigation experiment can be carried out smoothly for 2 hours or more.

[0072] It should be noted that the monitoring device 100 of this application is not limited to being installed at the inlet and / or outlet of the irrigation device 300, but can also be installed at other locations in the irrigation circuit 200 without limitation. Furthermore, the number of monitoring devices 100 is not limited to one, but can be two or more.

[0073] like Figure 3 As shown, in some embodiments, the monitoring device 100 includes a first monitoring device 101 and a second monitoring device 102. The first monitoring device 101 is located at the inlet end of the perfusion device 300, and the second monitoring device 102 is located at the outlet end of the perfusion device 300. It should be noted that the inlet end of the perfusion device 300 is located at the arterial end of the perfusion circuit 200, and the outlet end of the perfusion device 300 is located at the venous end of the perfusion circuit 200. If coagulation or signs of precoagulation occur at the arterial end (i.e., at the inlet end of the perfusion device 300), the first monitoring device 101 will detect a change in the displacement of its movable seal 12 or a change in the pressure within the fluid channel 111. In this case, the movable seal 12 can be pushed to inject the anticoagulant within it into the arterial end and the perfusion device 300 to alleviate the coagulation and prevent blockage. If coagulation or signs of precoagulation occur at the venous end (i.e., at the outlet end of the perfusion device 300), the second monitoring device 102 will detect a change in the displacement of its movable seal 12 or a change in the pressure within the fluid channel 111. In this case, the movable seal 12 can be pushed to inject the anticoagulant within it into the venous end and the perfusion device 300 to alleviate the coagulation and prevent blockage.

[0074] like Figure 3As shown, in some embodiments, a first tee connector 701 is provided at the arterial end of the perfusion circuit 200. A branch connector of the first tee connector 701 is used to connect to the first monitoring device 101, for example, to connect to the connection channel 112. And / or, a second tee connector 702 is provided at the venous end of the perfusion circuit 200. A branch connector of the second tee connector 702 is used to connect to the second monitoring device 102, for example, to connect to the connection channel 112. This allows the first monitoring device 101 and / or the second monitoring device 102 to be stably positioned in the experimental perfusion system 1000.

[0075] like Figure 3 As shown, in some embodiments, the experimental perfusion system 1000 further includes: an arterial indwelling needle, a blood pump 400, a heater 500, a temperature sensor 600, and a venous indwelling needle. Along the direction of blood flow, the arterial indwelling needle, blood pump 400, first monitoring device 101, perfusion device 300, second monitoring device 102, heater 500, temperature sensor 600, and venous indwelling needle are sequentially arranged in the perfusion circuit 200. The blood pump 400 provides the driving force for blood circulation in the tubing, the temperature sensor 600 detects the temperature of the blood to be returned to the rabbit, and the heater 500 maintains the blood temperature within a suitable range.

[0076] The above description is merely a preferred embodiment of this application and does not limit the patent scope of this application. Any equivalent structural transformations made based on the content of this application's specification and drawings under the concept of this application, or direct / indirect applications in other related technical fields, are included within the patent protection scope of this application.

Claims

1. A monitoring device applied to an experimental irrigation system, characterized in that, include: A pressure transmission assembly includes a body and a movable seal. The body has a fluid channel that is connected to the experimental perfusion system, and the movable seal is slidably disposed in the fluid channel. A monitoring component is used to monitor the displacement change of the movable seal or the pressure change within the fluid channel to determine the blood pressure change of the experimental perfusion system, and thus determine the state of the experimental perfusion system.

2. The monitoring device as described in claim 1, characterized in that, The movable seal has a first end along a first direction away from the fluid channel, the first end extending out of the body, and the monitoring component is used to monitor the displacement change of the first end; Wherein, the first direction is the sliding direction of the movable seal.

3. The monitoring device as described in claim 1, characterized in that, The pressure transmission component is a syringe, the main body is the sleeve of the syringe, and the movable seal is the piston rod of the syringe.

4. The monitoring device as described in claim 1, characterized in that, The monitoring components include one or more of the following: contact sensors, pressure sensors, distance sensors, and Hall sensors.

5. The monitoring device according to any one of claims 1 to 4, characterized in that, The fluid channel contains an anticoagulant. The monitoring device also includes an injection assembly, which includes a driving device and a pushing assembly. The pushing assembly has a pushing part, which is disposed opposite to the first end of the movable seal. The driving device is connected to the pushing assembly to drive the pushing assembly to move along a first direction. The monitoring assembly is disposed on the pushing part.

6. The monitoring device as described in claim 5, characterized in that, The injection assembly further includes a lead screw, and the pushing assembly includes a slider, a connecting rod, and the pushing part. The connecting rod connects the slider and the pushing part. The driving device is connected to the lead screw, and the slider is connected to the lead screw.

7. The monitoring device as described in claim 5, characterized in that, The injection assembly further includes a displacement sensor for monitoring the position of the pushing part; the displacement sensor includes an electrode plate and a potentiometer, the electrode plate is disposed on the pushing assembly, and the electrode plate and the potentiometer are in electrical contact.

8. The monitoring device as described in claim 5, characterized in that, It also includes a control component, which is connected to the monitoring component and the drive device respectively. The control component is used to receive electrical signals from the monitoring component and control the drive device to operate according to the electrical signals.

9. The monitoring device as described in claim 1, characterized in that, The fluid channel includes a connecting channel, which connects the fluid channel to the experimental perfusion system. The flow cross-sectional area of ​​the connecting channel is smaller than that of the fluid channel. The monitoring device also includes a replenishment assembly and an injection solenoid valve. The fluid channel contains an anticoagulant. The replenishment assembly includes a reservoir, a replenishment pump, a replenishment pipeline, and a replenishment solenoid valve. The reservoir stores the anticoagulant and is connected to the fluid channel via the replenishment pipeline. The replenishment pump and the replenishment solenoid valve are both located on the replenishment pipeline, and the injection solenoid valve is located on the connecting channel.

10. An experimental irrigation system, characterized in that, include: Irrigation circuit; An irrigation device, wherein the irrigation device is disposed on the irrigation circuit; The monitoring device according to any one of claims 1 to 9, wherein the monitoring device is connected to the irrigation circuit and is located at the inlet end and / or outlet end of the irrigation device.

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