High-efficiency crystallization kettle for famotidine production

Abstract

The utility model belongs to the crystallization kettle field, concretely relates to a kind of high-efficiency crystallization kettle for famotidine production, including kettle body, the upper end of kettle body is hinged with kettle cover, opening and closing mechanism is arranged on the kettle body, the inner wall upper portion of kettle body is equipped with locating ring by bearing, the inside of locating ring is slidably connected with filter hopper, drive shaft is fixedly installed in the inside of filter hopper, the lower end inside of kettle body passes through hexagonal shaft, the lower end of kettle body is fixedly installed with motor.The utility model is equipped with filter hopper, shaft and opening and closing mechanism etc. structure in the inside of kettle body, in the process of use, the raw materials in the inside of kettle body can also be disturbed by the rotation of filter hopper, and the material after crystallization can be filtered by filter hopper, so as to improve crystallization efficiency, and when needing to clean, only need to take out filter hopper, after taking out, the inside structure of kettle body is simple, so that kettle body is more convenient to clean.

Description

Technical Field

[0001] This utility model relates to the field of crystallization reactor technology, specifically a high-efficiency crystallization reactor for famotidine production. Background Technology

[0002] As an important pharmaceutical ingredient, the crystallization process in the production of famotidine has a crucial impact on product quality and production efficiency. The crystallization vessel, as the core equipment for realizing the crystallization process, directly affects the particle size distribution, purity, and crystallization rate of the crystals through its structural design and performance optimization. Currently, traditional famotidine crystallization vessels still have some shortcomings in practical applications. For example, the separation efficiency between crystals and mother liquor during crystallization is low, often requiring additional filtration steps, increasing the production cycle and operational complexity. Furthermore, conventional crystallization vessels often use external jackets or internal coils for heat exchange, which have limited heat exchange efficiency and may lead to uneven temperature distribution within the vessel, affecting crystal consistency. In addition, the discharge of the solid-liquid mixture and cleaning of the vessel after crystallization are often cumbersome, resulting in low crystallization efficiency of the raw materials. In particular, the disassembly and cleaning of the stirring components and filter elements are inconvenient, increasing equipment maintenance time and the risk of cross-contamination. Furthermore, in terms of the sealing and opening / closing mechanisms of the equipment, traditional kettle lids mostly use bolts for fastening, which is time-consuming and labor-intensive to open and close, affecting production efficiency, and the sealing performance is prone to degradation under frequent operation. Therefore, it is necessary to improve the existing technology. Utility Model Content

[0003] The purpose of this invention is to provide a high-efficiency crystallization reactor for famotidine production, which solves the problems of low crystallization efficiency and inconvenience in opening and closing the reactor lid.

[0004] To achieve the above objectives, this utility model provides the following technical solution: a high-efficiency crystallization reactor for famotidine production, comprising a reactor body, a reactor cover hinged to the upper end of the reactor body, an opening and closing mechanism provided on the reactor body, a positioning ring mounted on the upper part of the inner wall of the reactor body via a bearing, a filter bucket slidably connected inside the positioning ring, a drive shaft fixedly installed inside the filter bucket, a motor fixedly installed at the lower end of the reactor body via a hexagonal shaft, a central frame fixedly connected to the upper part of the inner wall of the filter bucket, a rotating frame mounted on the outer side of the upper end of the central frame via a bearing, a lower pressure frame slidably connected inside the rotating frame, and a spring provided on the outer side of the lower pressure frame.

[0005] Preferably, a heat exchange hood is fixedly installed on the outer side of the vessel body, and multiple evenly distributed heat exchange rings are fixedly installed inside the heat exchange hood. A discharge pipe is fixedly connected to the upper left end of the heat exchange hood, and a liquid inlet pipe is fixedly connected to the lower right end of the heat exchange hood. The heat exchange rings can increase the heat exchange efficiency of the heat exchange hood.

[0006] Preferably, the output shaft of the motor is fixedly connected to the hexagonal shaft, and the hexagonal shaft is slidably connected to the hexagonal groove of the drive shaft. The hexagonal shaft can drive the filter bucket to rotate through the drive shaft.

[0007] Preferably, a support bar is fixedly installed on the lower inner side of the vessel body, the support bar is connected to the hexagonal shaft through a bearing, and a sealing ring is fixedly installed on the bottom inner side of the vessel body, the sealing ring is rotatably connected to the hexagonal shaft, and the support bar can support the hexagonal shaft.

[0008] Preferably, a sealing ring is fixedly installed at the upper end of the vessel body, and the sealing ring contacts the vessel lid, so that the sealing ring can seal the connection between the vessel lid and the vessel body.

[0009] Preferably, one end of the first spring is fixedly connected to the lower pressure frame, and the other end of the first spring is fixedly connected to the rotating frame. The lower pressure frame is in contact with the vessel lid, and the first spring can support the rotating frame through its elastic force.

[0010] Preferably, in the opening and closing mechanism, a fixing pin is fixedly installed on the outer side of the vessel body, a movable cover is slidably connected to the outer side of the vessel body, a positioning pin is fixedly connected to the upper end of the movable cover, a second spring is provided on the outer side of the fixing pin, the positioning pin is slidably connected to the vessel cover, one end of the second spring is fixedly connected to the fixing pin, and the other end of the second spring is connected to the movable cover. The second spring can support the movable cover with its elastic force.

[0011] Compared with the prior art, the beneficial effects of this utility model are as follows: 1. This utility model adds a filter bucket, a rotating shaft, and an opening and closing mechanism inside the kettle body. During use, the rotation of the filter bucket can agitate the raw materials inside the kettle body in multiple ways. At the same time, the crystallized material can be filtered through the filter bucket, thereby improving the crystallization efficiency. When cleaning is required, the filter bucket can be removed. After removal, the internal structure of the kettle body is simple, making the kettle body easier to clean.

[0012] 2. This utility model adds a heat exchange hood, heat exchange ring and water inlet pipe to the outside of the reactor body. When cooling the reactor body, cold water can be supplied to the inside of the heat exchange hood through the water inlet tank. The cold water can evenly cool the inside of the reactor body through the heat exchange ring, thereby making the crystallization more uniform and further improving the crystallization efficiency.

[0013] 3. This utility model adds a fixing nail, a movable cover and a positioning nail to the vessel body. When the vessel lid needs to be locked, the positioning nail can be driven by the elastic force of the second spring to slide into the groove of the vessel lid, thus locking the vessel lid. When it needs to be opened, the positioning nail can be removed from the vessel lid to release the limit, thus making the vessel lid easier to open and lock. Attached Figure Description

[0014] Figure 1 This is a perspective view of the overall structure of this utility model; Figure 2 For the present utility model Figure 1 A three-dimensional sectional view; Figure 3 For the present utility model Figure 2 A three-dimensional view of the filter bucket; Figure 4 For the present utility model Figure 2 Enlarged view of the structure of part A.

[0015] In the diagram: 1. Vessel body; 2. Vessel lid; 3. Opening and closing mechanism; 4. Positioning ring; 5. Filter hopper; 6. Drive shaft; 7. Hexagonal shaft; 8. Support bar; 9. Motor; 10. Sealing ring; 11. Heat exchange hood; 12. Heat exchange ring; 13. Discharge pipe; 14. Liquid inlet pipe; 15. Rotating frame; 16. Lower pressure frame; 17. Spring 1; 18. Sealing ring; 19. Central frame; 31. Fixing pin; 32. Moving cover; 33. Positioning pin; 34. Spring 2. Detailed Implementation

[0016] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0017] Please see Figure 1-4 A high-efficiency crystallization reactor for famotidine production includes a reactor body 1, a reactor cover 2 hinged to the upper end of the reactor body 1, an opening and closing mechanism 3 on the reactor body 1, a positioning ring 4 mounted on the upper part of the inner wall of the reactor body 1 via a bearing, a filter bucket 5 slidably connected inside the positioning ring 4, a drive shaft 6 fixedly mounted inside the filter bucket 5, a motor 9 fixedly mounted at the lower end of the reactor body 1 via a hexagonal shaft 7, a central frame 19 fixedly connected to the upper part of the inner wall of the filter bucket 5, a rotating frame 15 mounted on the outer side of the upper end of the central frame 19 via a bearing, a lower pressure frame 16 slidably connected inside the rotating frame 15, and a spring 17 provided on the outer side of the lower pressure frame 16.

[0018] Please see Figure 1-4 A heat exchange hood 11 is fixedly installed on the outside of the vessel body 1. Multiple evenly distributed heat exchange rings 12 are fixedly installed inside the heat exchange hood 11. A discharge pipe 13 is fixedly connected to the upper left end of the heat exchange hood 11, and a liquid inlet pipe 14 is fixedly connected to the lower right end of the heat exchange hood 11. The heat exchange rings 12 can increase the heat exchange efficiency of the heat exchange hood 11.

[0019] Please see Figure 1-4 The output shaft of motor 9 is fixedly connected to hexagonal shaft 7, and hexagonal shaft 7 is slidably connected to the hexagonal groove of drive shaft 6. Hexagonal shaft 7 can drive filter bucket 5 to rotate through drive shaft 6. Support bar 8 is fixedly installed on the lower inner side of the vessel body 1. Support bar 8 is connected to hexagonal shaft 7 through bearing. Sealing ring 10 is fixedly installed on the bottom inner side of the vessel body 1. Sealing ring 10 is rotatably connected to hexagonal shaft 7. Support bar 8 can support hexagonal shaft 7. Sealing ring 18 is fixedly installed on the upper end of vessel body 1. Sealing ring 18 contacts vessel cover 2. Sealing ring 18 can seal the connection between vessel cover 2 and vessel body 1. One end of spring 17 is fixedly connected to lower pressure frame 16. The other end of spring 17 is fixedly connected to rotating frame 15. Lower pressure frame 16 contacts vessel cover 2. Spring 17 can support rotating frame 15 through elasticity.

[0020] Please see Figure 1-4 The opening and closing mechanism 3 has a fixing nail 1 fixedly installed on the outside of the vessel body 1. A movable cover 32 is slidably connected to the outside of the vessel body 31. A positioning nail 33 is fixedly connected to the upper end of the movable cover 32. A spring 34 is provided on the outside of the fixing nail 31. The positioning nail 33 is slidably connected to the vessel cover 2. One end of the spring 34 is fixedly connected to the fixing nail 31, and the other end of the spring 34 is connected to the movable cover 32. The spring 34 can support the movable cover 32 with its elastic force.

[0021] The specific implementation process of this utility model is as follows: In use, the raw material is placed inside the vessel body 1, and then the vessel lid 2 is placed on top of the vessel body 1. Then, the motor 9 is started, and the motor 9 drives the hexagonal shaft 7 to rotate. The hexagonal shaft 7 drives the filter bucket 5 to rotate through the drive shaft 6. During the rotation of the filter bucket 5, the internal liquid can be disturbed. At the same time, the liquid inlet pipe 14 injects coolant into the heat exchange cover 11. The coolant cools the vessel body 1. During the cooling process, the raw material begins to crystallize. During the crystallization process, the crystals can be filtered through the filter bucket 5. After the crystallization is completed, the movable cover 32 is pulled. The movable cover 32 drives the positioning pin 33 to move and compresses the spring 34. When the positioning pin 33 is disengaged from the vessel lid 2, the limitation on the vessel lid 2 can be released. Then, the vessel lid 2 is flipped upward. After the flip is completed, the filter bucket 5 can be removed from the inside of the vessel body 1, thereby effectively improving the crystallization efficiency.

[0022] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A high-efficiency crystallization reactor for famotidine production, comprising a reactor body (1), characterized in that: The upper end of the vessel body (1) is hinged with a vessel lid (2). The vessel body (1) is provided with an opening and closing mechanism (3). The upper part of the inner wall of the vessel body (1) is equipped with a positioning ring (4) through a bearing. The inside of the positioning ring (4) is slidably connected to a filter bucket (5). The inside of the filter bucket (5) is fixedly installed with a drive shaft (6). The lower end of the vessel body (1) is connected to a hexagonal shaft (7). The lower end of the vessel body (1) is fixedly installed with a motor (9). The upper part of the inner wall of the filter bucket (5) is fixedly connected with a central frame (19). The outer side of the upper end of the central frame (19) is equipped with a rotating frame (15) through a bearing. The inside of the rotating frame (15) is slidably connected with a lower pressure frame (16). The outer side of the lower pressure frame (16) is provided with a spring (17).

2. The high-efficiency crystallization reactor for famotidine production according to claim 1, characterized in that: A heat exchange hood (11) is fixedly installed on the outside of the vessel body (1). Multiple heat exchange rings (12) are fixedly installed inside the heat exchange hood (11). A discharge pipe (13) is fixedly connected to the upper left end of the heat exchange hood (11). A liquid inlet pipe (14) is fixedly connected to the lower right end of the heat exchange hood (11).

3. The high-efficiency crystallization reactor for famotidine production according to claim 1, characterized in that: The output shaft of the motor (9) is fixedly connected to the hexagonal shaft (7), and the hexagonal shaft (7) is slidably connected to the hexagonal groove of the drive shaft (6).

4. The high-efficiency crystallization reactor for famotidine production according to claim 1, characterized in that: A support bar (8) is fixedly installed on the lower inner side of the vessel body (1). The support bar (8) is connected to the hexagonal shaft (7) through a bearing. A sealing ring (10) is fixedly installed on the bottom inner side of the vessel body (1). The sealing ring (10) is rotatably connected to the hexagonal shaft (7).

5. The high-efficiency crystallization reactor for famotidine production according to claim 1, characterized in that: A sealing ring (18) is fixedly installed at the upper end of the vessel body (1), and the sealing ring (18) is in contact with the vessel cover (2).

6. The high-efficiency crystallization reactor for famotidine production according to claim 1, characterized in that: One end of the spring (17) is fixedly connected to the lower pressure frame (16), and the other end of the spring (17) is fixedly connected to the rotating frame (15). The lower pressure frame (16) is in contact with the lid (2).

7. The high-efficiency crystallization reactor for famotidine production according to claim 1, characterized in that: The opening and closing mechanism (3) has a fixing nail (1) fixedly installed on the outside of the vessel body (1), a movable cover (32) slidably connected to the outside of the vessel body (1), a positioning nail (33) fixedly connected to the upper end of the movable cover (32), a spring (34) provided on the outside of the fixing nail (31), the positioning nail (33) slidably connected to the vessel cover (2), one end of the spring (34) fixedly connected to the fixing nail (31), and the other end of the spring (34) connected to the movable cover (32).

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