A condensation device for producing phenylethyl malonic acid diethyl ester

Abstract

The utility model discloses a condensation device for phenylethyl malonic acid diethyl ester production is provided with the kettle cover on the upper surface of cauldron body, the middle position of kettle cover upper surface is provided with motor through motor base, the output shaft of motor is connected with the main shaft top through the shaft coupling, and the lower part of main shaft is provided with first forward stirring paddle, second forward stirring paddle, first reverse stirring paddle and second reverse stirring paddle from below to above in proper order, and first forward stirring paddle, second forward stirring paddle, first reverse stirring paddle and second reverse stirring paddle all form the angle with main shaft, and the setting direction of first forward stirring paddle and second reverse stirring paddle is reverse and symmetrical, and the setting direction of first forward stirring paddle and second forward stirring paddle is reverse and symmetrical, and second forward stirring paddle and first reverse stirring paddle all are densely covered with through -hole, and the utility model discloses reasonable structure makes material mixing more fully, and the material of cauldron body bottom can also flow fully, avoids the reaction effect reduction caused by sinking bottom.

Description

Technical Field

[0001] This utility model relates to the field of condensation equipment technology, specifically a condensation device for the production of diethyl phenyl ethyl malonate. Background Technology

[0002] Diethyl phenylethyl malonate is an organic intermediate used in the production of central nervous system drugs. It can be used to produce neurotoxic drugs such as phenobarbital, benzoylphenobarbital, sodium phenobarbital, and primidone. It is widely used in scientific research and as an analytical reagent, possessing high added value and a promising market prospect. Currently, diethyl phenylmalonate is produced by the condensation reaction of ethyl phenylacetate and diethyl carbonate in the presence of sodium ethoxide. The intermediate is then alkylated by the addition of bromoethane, followed by acid adjustment and neutralization to obtain the crude product. The crude product is then obtained through distillation and mixing to yield the final product.

[0003] Condensation equipment for the production of diethyl phenylmalonate generally uses condensation reactors. Currently, the stirring paddles of most condensation equipment for the production of diethyl phenylmalonate adopt a flat plate structure. During stirring, on the one hand, there is still room for improvement in the stirring effect, and on the other hand, the bottom of the reactor is prone to accumulation, which affects the condensation effect. Therefore, an improved technology is urgently needed to solve this problem in the existing technology. Utility Model Content

[0004] The purpose of this invention is to provide a condensation apparatus for the production of diethyl phenyl ethyl malonate, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a condensation apparatus for the production of diethyl phenyl ethyl malonate, comprising a vessel body, a vessel lid, and a stirrer;

[0006] The upper surface of the vessel body is provided with a vessel lid, and a motor is installed in the middle of the upper surface of the vessel lid via a motor base. The vessel body is surrounded by a jacket, and a discharge port is provided at the bottom of the vessel body.

[0007] The stirring ball includes a main shaft, a first forward stirring paddle, a second forward stirring paddle, a first reverse stirring paddle, and a second reverse stirring paddle. The top of the main shaft is connected to the output shaft of a motor via a coupling. The first forward stirring paddle, the second forward stirring paddle, the first reverse stirring paddle, and the second reverse stirring paddle are arranged sequentially from bottom to top on the lower part of the main shaft. The first forward stirring paddle, the second forward stirring paddle, the first reverse stirring paddle, and the second reverse stirring paddle are all rotatably disposed inside the vessel body. The centerlines of the first forward stirring paddle and the second reverse stirring paddle are parallel to each other. The centerlines of the second forward stirring paddle and the first reverse stirring paddle are parallel to each other. The angle between the centerlines of the first forward stirring paddle and the second forward stirring paddle is 90°. The first forward stirring paddle, the second forward stirring paddle, the first reverse stirring paddle, and the second reverse stirring paddle all form an angle with the main shaft. The first forward stirring paddle and the second reverse stirring paddle are arranged in opposite directions and symmetrically. The second forward stirring paddle and the first reverse stirring paddle are densely covered with through holes.

[0008] Preferably, the present invention provides a condensation apparatus for the production of diethyl phenyl ethyl malonate, wherein the upper surface of the reactor lid is provided with at least three feed inlets and one drip inlet, and the upper surface of the reactor lid is also provided with a thermometer port and a pressure gauge port.

[0009] Preferably, the present invention provides a condensation device for the production of diethyl phenyl ethyl malonate, wherein the outer end of the jacket is provided with a plurality of support seats.

[0010] Preferably, the present invention provides a condensation device for the production of diethyl phenyl ethyl malonate, wherein a heat exchange medium inlet is provided at the bottom of the jacket, and a heat exchange medium outlet is provided on one side of the upper part of the jacket.

[0011] Preferably, in the condensation apparatus for the production of diethyl phenyl ethyl malonate provided by this utility model, the outer edge of the first forward stirring paddle matches the side wall of the bottom of the vessel.

[0012] Compared with the prior art, the beneficial effects of this utility model are:

[0013] The first and second forward-moving agitators guide the material upwards, while the first and second reverse-moving agitators guide the material downwards, thus ensuring more thorough mixing and allowing the material at the bottom of the vessel to flow freely, preventing it from settling and reducing the reaction efficiency. Furthermore, both the second forward-moving agitator and the first reverse-moving agitator are densely covered with through holes, thereby reducing the resistance between them and simultaneously dispersing the material, greatly improving the reaction efficiency. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model;

[0015] Figure 2 This is a schematic diagram of the stirrer structure.

[0016] In the diagram: 1. Vessel body; 2. Vessel cover; 3. Motor; 4. Discharge port; 5. Main shaft; 6. First forward stirring paddle; 7. Second forward stirring paddle; 8. First reverse stirring paddle; 9. Second reverse stirring paddle; 10. Through hole; 11. Jacket; 12. Feed inlet; 13. Dropping port; 14. Thermometer port; 15. Pressure gauge port; 16. Support base; 17. Heat exchange medium inlet; 18. Heat exchange medium outlet. Detailed Implementation

[0017] The technical solution of this utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0018] It should be noted that in the description of this utility model, the terms "inner", "outer", "upper", "lower", "both sides", "one end", "the other end", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0019] Please see Figure 1-2 This utility model provides a technical solution: a condensation device for the production of diethyl phenyl ethyl malonate, comprising a vessel body 1, a vessel cover 2, and a stirrer;

[0020] The upper surface of the vessel body 1 is provided with a vessel cover 2. A motor 3 is provided in the middle of the upper surface of the vessel cover 2 via a motor base. The vessel body 1 is surrounded by a jacket 11. The bottom of the vessel body 1 is provided with a discharge port 4. The upper surface of the vessel cover 2 is provided with at least three feed ports 12 and one drip port 13. The three feed ports 12 are used to add ethyl phenylacetate, diethyl carbonate, and sodium ethoxide, respectively. The upper surface of the vessel cover 2 is also provided with a thermometer port 14 and a pressure gauge port 15 to monitor the temperature and pressure, respectively. Several support seats 16 are provided at the outer end of the jacket 11 to support and fix the vessel body 1. The bottom of the jacket 11 is provided with a heat exchange medium inlet 17, and the upper side of the jacket 11 is provided with a heat exchange medium outlet 18 to allow the heat exchange medium to enter and leave the jacket 11.

[0021] The stirring ball includes a main shaft 5, a first forward stirring blade 6, a second forward stirring blade 7, a first reverse stirring blade 8, and a second reverse stirring blade 9. The top of the main shaft 5 is connected to the output shaft of the motor 3 via a coupling. The first forward stirring blade 6, the second forward stirring blade 7, the first reverse stirring blade 8, and the second reverse stirring blade 9 are sequentially arranged from bottom to top on the lower part of the main shaft 5. All three blades are rotatably mounted inside the vessel body 1. The axes of the first forward stirring blade 6 and the second reverse stirring blade 9 are parallel to each other, and the axes of the second forward stirring blade 7 and the first reverse stirring blade 8 are parallel to each other. The axes of the first forward stirring blade 6 and the second forward stirring blade 7 are parallel to each other, and the angle between them is 90°. The first forward stirring blade 6, the second forward stirring blade 7, the first reverse stirring blade 8 and the second reverse stirring blade 9 all form an angle with the main shaft 5. The first forward stirring blade 6 and the second reverse stirring blade 9 are arranged in opposite directions and are symmetrical. The first forward stirring blade 6 and the second forward stirring blade 7 are arranged in opposite directions and are symmetrical. The second forward stirring blade 7 and the first reverse stirring blade 8 are densely covered with through holes 10. The outer edge of the first forward stirring blade 6 matches the side wall of the bottom of the vessel body 1 to ensure that the first forward stirring blade 6 will not hit the inner wall of the vessel body 1.

[0022] Installation Method and Operating Principle: During processing, the first forward agitator 6, the second forward agitator 7, the first reverse agitator 8, and the second reverse agitator 9 are welded to the bottom of the main shaft 5. The first forward agitator 6 and the second forward agitator 7 are welded to the main shaft 5 at a positive angle, while the first reverse agitator 8 and the second reverse agitator 9 are welded to the main shaft 5 at a negative angle. The positive angle between the first forward agitator 6 and the second forward agitator 7 and the main shaft 5 is the same as the negative angle between the first reverse agitator 8 and the second reverse agitator 9 and the main shaft 5. In other words, the first forward agitator 6 and the second forward agitator 7 are symmetrically arranged at the bottom of the main shaft 5 as the first reverse agitator 8 and the second reverse agitator 9. Next, the top of the main shaft 5 is connected to the output shaft of the motor 3. After lifting the vessel cover 2, the bottom of the main shaft 5, the first forward agitator 6, the second forward agitator 7, the first reverse agitator 8, and the second reverse agitator 9 are placed inside the vessel body 1. The vessel cover 2 is then welded to the vessel body 1 or connected by a flange to complete the installation. In operation, one inlet 12 is connected to the ethyl phenylacetate storage tank via a pipeline, another inlet 12 is connected to the diethyl carbonate storage tank via a pipeline, and another inlet 12 is connected to the sodium ethoxide storage tank via a pipeline. The drip inlet 13 is connected to the bromoethane storage tank via a control valve. During operation, hot oil or hot gas is introduced into the jacket 11 at a temperature of 30–80°C. Ethyl phenylacetate and diethyl carbonate are added, and sodium ethoxide is added slowly. The motor 3 is started, which drives the main shaft 5 to rotate, thereby driving the first forward stirring paddle 6, the second forward stirring paddle 7, the first reverse stirring paddle 8, and the second reverse stirring paddle 9 to rotate and stir the materials. After the reaction is complete, an intermediate is obtained. Then, bromoethane is added dropwise, and the temperature is raised from 25°C to 50–60°C. After acid adjustment and neutralization, crude diethyl phenylethyl malonate is obtained. During the stirring process, the first forward stirring paddle 6 and the second forward stirring paddle 7 guide the material upward, while the first reverse stirring paddle 8 and the second reverse stirring paddle 9 guide the material downward, thereby making the material more thoroughly mixed. The material at the bottom of the vessel 1 can also flow fully, preventing it from settling to the bottom and reducing the reaction effect. Furthermore, both the second forward stirring paddle 7 and the first reverse stirring paddle 8 are densely covered with through holes 10, thereby reducing the resistance between the second forward stirring paddle 7 and the first reverse stirring paddle 8, and at the same time, the material can be dispersed, greatly improving the reaction effect.

[0023] Any aspects of this utility model not described in detail are well-known technologies to those skilled in the art.

[0024] Finally, it should be noted that the above specific embodiments are only used to illustrate the technical solution of this utility model and not to limit it. Although this utility model has been described in detail with reference to the embodiments, those skilled in the art should understand that modifications and equivalent substitutions can be made to the technical solution of this utility model without departing from the spirit and scope of the technical solution of this utility model, and all such modifications and substitutions should be covered within the scope of the claims of this utility model.

Claims

1. A condensation apparatus for the production of diethyl phenyl ethyl malonate, characterized in that: Includes a vessel body (1), a vessel lid (2), and a stirrer; The upper surface of the vessel body (1) is provided with a vessel lid (2), and a motor (3) is provided in the middle of the upper surface of the vessel lid (2) through a motor seat. The vessel body (1) is surrounded by a jacket (11), and the bottom of the vessel body (1) is provided with a discharge port (4). The stirring ball includes a main shaft (5), a first forward stirring paddle (6), a second forward stirring paddle (7), a first reverse stirring paddle (8), and a second reverse stirring paddle (9). The top of the main shaft (5) is connected to the output shaft of the motor (3) via a coupling. The lower part of the main shaft (5) is provided with the first forward stirring paddle (6), the second forward stirring paddle (7), the first reverse stirring paddle (8), and the second reverse stirring paddle (9) arranged sequentially from bottom to top. The first forward stirring paddle (6), the second forward stirring paddle (7), the first reverse stirring paddle (8), and the second reverse stirring paddle (9) are all rotatably disposed inside the vessel body (1). The axis of the first forward stirring paddle (6) and the second reverse stirring paddle (9) are intersecting. The axes of the second forward stirring blade (7) and the first reverse stirring blade (8) are parallel to each other. The angle between the axis of the first forward stirring blade (6) and the axis of the second forward stirring blade (7) is 90°. The first forward stirring blade (6), the second forward stirring blade (7), the first reverse stirring blade (8) and the second reverse stirring blade (9) all form an angle with the main shaft (5). The first forward stirring blade (6) and the second reverse stirring blade (9) are arranged in opposite directions and are symmetrical. The first forward stirring blade (6) and the second forward stirring blade (7) are arranged in opposite directions and are symmetrical. The second forward stirring blade (7) and the first reverse stirring blade (8) are densely covered with through holes (10).

2. The condensation apparatus for producing diethyl phenyl ethyl malonate according to claim 1, characterized in that: The upper surface of the lid (2) is provided with at least three feed inlets (12) and one drip inlet (13), and the upper surface of the lid (2) is also provided with a thermometer inlet (14) and a pressure gauge inlet (15).

3. The condensation apparatus for producing diethyl phenyl ethyl malonate according to claim 1, characterized in that: The outer end of the jacket (11) is provided with several support seats (16).

4. The condensation apparatus for producing diethyl phenyl ethyl malonate according to claim 1, characterized in that: The jacket (11) is provided with a heat exchange medium inlet (17) at the bottom and a heat exchange medium outlet (18) on one side of the upper part of the jacket (11).

5. A condensation apparatus for the production of diethyl phenyl ethyl malonate according to claim 1, characterized in that: The outer edge of the first forward stirring paddle (6) matches the side wall of the bottom of the vessel body (1).

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