A hydroxyethylpiperazine ethane sulfonic acid purification exchange column

Abstract

The application discloses a hydroxyethylpiperazine ethane sulfonic acid purification exchange column, and particularly relates to the technical field of ion exchange columns, which comprises a shell, the inner cavity bottom of the shell is coaxially embedded with an overhead plate which does not contact the inner cavity bottom wall of the shell, the overhead plate extends upwards to a plurality of first cylinders and second cylinders which are coaxial with the overhead plate, the top of the shell is provided with a top cover, the bottom of each first cylinder is provided with a plurality of transverse through holes, the edge of the overhead plate is provided with annular vertical through holes which are uniformly distributed, an annular sand core is embedded between the shell and the outermost second cylinder, the top cover is provided with a double-head feeding assembly which is provided with a dispersion outlet, and the top cover is provided with a breather valve which is in communication with the inner cavity of the first cylinder which is closest to the axis of the overhead plate, the application prolongs the flow distance of the components to be treated in the ion exchange resin, the impurities are adsorbed by the ion exchange resin or delayed to flow out, and the purification effect of the hydroxyethylpiperazine ethane sulfonic acid is improved.

Description

Technical Field

[0001] This invention belongs to the field of ion exchange column technology, specifically relating to a hydroxyethylpiperazine ethane sulfonic acid purification exchange column. Background Technology

[0002] Hydroxyethylpiperazine ethanesulfonic acid is a highly efficient, low-toxicity, and chemically stable hydrogen ion buffer with a pKa value (7.55) perfectly matching the physiological pH environment. It is one of the preferred reagents for maintaining pH stability in cell culture, protein research, and various biochemical experiments. Ion exchange columns are commonly used for reaction purification during the production of hydroxyethylpiperazine ethanesulfonic acid.

[0003] In traditional ion exchange columns, the inner cavity is filled only with ion exchange resin, resulting in a rapid liquid flow and a short exchange reaction time. Consequently, for some slower-reacting components, the exchange is incomplete, leading to lower solution purity. Chinese Patent CN215783417U discloses a high-yield ion exchange column for refining copper oxide from waste copper-containing etching solution. It features a deceleration ring inside the main column to significantly reduce the liquid's descent speed, allowing the liquid requiring ion exchange to react fully with the ion exchange resin, avoiding incomplete exchange due to slow reaction speed, and ensuring the reliability of ion exchange. It also incorporates flow-dispersing blades to effectively agitate the ion exchange resin within the main column, ensuring uniform reaction. However, this method requires real-time stirring, resulting in significant energy consumption throughout the reaction process. Therefore, a novel hydroxyethylpiperazine ethanesulfonic acid purification exchange column is needed. Utility Model Content

[0004] To address the aforementioned problems, this invention discloses a hydroxyethylpiperazine ethanesulfonic acid purification exchange column.

[0005] To achieve the above objectives, the technical solution of this utility model is as follows:

[0006] A hydroxyethylpiperazine ethane sulfonic acid purification exchange column includes a shell. An overhead plate, not in contact with the bottom wall of the shell's inner cavity, is coaxially embedded in the bottom of the shell's inner cavity. Several first and second cylinders, coaxial with the overhead plate, extend upwards from the overhead plate's axis and are staggered in sequence from the first and second cylinders. A top cover is provided at the top opening of the shell, and the tops of both the shell and the first cylinders are sealed and inserted into the top cover. Several transverse through holes are provided at the bottom of each first cylinder. Annularly distributed vertical through holes are provided along the edge of the overhead plate. An annular sand core is embedded between the shell and the outermost second cylinder, covering the vertical through holes of the overhead plate from above. A dual-head feed assembly with a dispersed outlet is installed on the top cover, with its bottom extending into the first cylinder closest to the axis of the overhead plate. A vent valve communicating with the inner cavity of the first cylinder closest to the axis of the overhead plate is installed on the top cover.

[0007] As a preferred technical solution of this utility model, a plurality of locking components extend from the side wall of the housing; each locking component includes a fixing seat fixedly connected to the outer wall of the housing, the fixing seat is rotatably connected to a rotating screw, and the rotating screw is vertically engaged in the edge notch of the top cover, and the rotating screw is threadedly connected to a nut for pressing down the top cover.

[0008] As a preferred embodiment of this utility model, the dual-head feeding assembly includes a dual-head feeder embedded in the top cover. A transverse valve core is slidably installed inside the top transverse tube of the dual-head feeder. The annular wall length of the transverse valve core is greater than the diameter of the vertical channel it controls. The bottom disc of the dual-head feeder is provided with several transverse outlets, and a baffle is provided around the bottom disc. The baffle is provided with several notches that are adapted to the transverse outlets and penetrate vertically.

[0009] As a preferred technical solution of this utility model, both ends of the transverse valve core are tapered heads, and the transverse tube of the double-headed feeder is provided with a tapered surface adapted to the tapered heads.

[0010] As a preferred embodiment of this utility model, the vent valve includes a valve body embedded in the top cover, an adjusting valve core is axially slidably installed in the inner cavity of the valve body, the adjusting valve core is rotatably connected to an adjusting bolt, and the adjusting bolt is threadedly connected to the valve body.

[0011] As a preferred embodiment of this utility model, the radially extending round rod of the regulating valve core is linearly slidably inserted into the through groove of the valve body.

[0012] As a preferred embodiment of this utility model, the control end of the regulating valve core is a conical head, and the valve body is provided with a conical surface adapted to the conical head.

[0013] As a preferred technical solution of this utility model, the first cylinder and the second cylinder form an integral flow channel in the inner cavity of the shell, which extends radially from the axis of the shell and reciprocates. The cross-sectional area of ​​the inner cavity of the first cylinder at the axis is the same as the cross-sectional area of ​​the annular cavity between the first cylinder and the second cylinder.

[0014] The beneficial effects of this utility model are as follows:

[0015] 1. This application uses a first cylinder and a second cylinder to form an integral flow channel within the shell cavity, extending radially from the shell axis and reciprocating. The cross-sectional area of ​​the first cylinder cavity at the axis is the same as the cross-sectional area of ​​the annular cavity between the first and second cylinders. The flow channel is filled with ion exchange resin, ensuring that the amount of ion exchange resin at the same horizontal height in the flow channel is as consistent as possible, and the treatment effect at different heights is as similar as possible. At the same time, it lengthens the flow distance of the components to be treated in the ion exchange resin, so that each component in the liquid has time to fully react with the ion exchange resin. Impurities are adsorbed by the ion exchange resin or their outflow is delayed, improving the purification effect of hydroxyethylpiperazine ethane sulfonic acid, and eliminating the need for stirring and energy consumption.

[0016] Second, this application is equipped with a dual-head feeder, which can flexibly switch between liquid feeding and liquid feeding. The liquid feeding enters the shell through dispersion, which increases the contact surface with the ion exchange resin and makes fuller use of the ion exchange resin at the same level. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure of an embodiment of the present utility model;

[0018] Figure 2 This is an embodiment of the present utility model. Figure 1 Enlarged view of point A in the middle;

[0019] Figure 3 This is an overall sectional view of an embodiment of the present utility model;

[0020] Figure 4 This is a cross-sectional view of the dual-head feeding assembly according to an embodiment of the present invention;

[0021] Figure 5 This is a cross-sectional view of the vent valve according to an embodiment of the present invention;

[0022] Figure 6 This is an exploded view of the overhead plate and annular sand core according to an embodiment of the present invention;

[0023] Figure 7 This is a top view of the overhead panel, the first cylinder, and the second cylinder in an embodiment of this utility model.

[0024] List of identifiers in attached diagrams:

[0025] 1. Shell; 2. Overhead plate; 3. Annular sand core; 4. First cylinder; 5. Second cylinder; 6. Top cover;

[0026] 7. Dual-head feeding assembly; 701. Dual-head feeder; 702. Lateral valve core; 703. Enclosure;

[0027] 8. Vent valve; 801. Valve body; 802. Adjusting valve core; 803. Adjusting bolt;

[0028] 9. Locking assembly; 901. Fixing base; 902. Rotating screw; 903. Nut;

[0029] 10. Orifice plate. Detailed Implementation

[0030] The present invention will be further explained below with reference to the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0031] Please see Figure 1-7 A hydroxyethylpiperazine ethane sulfonic acid purification exchange column includes a shell 1. A suspended plate 2, which does not contact the bottom wall of the shell 1, is coaxially embedded in the bottom of the inner cavity of the shell 1. A cavity separated at the bottom of the shell 1 by the suspended plate 2 communicates with the discharge pipe of the shell 1, and a stopcock is installed on the discharge pipe. Several first cylinders 4 and second cylinders 5 extend upward from the suspended plate 2, coaxial with it, and are arranged alternately in the order of the first cylinders 4 and second cylinders 5 starting from the axis of the suspended plate 2. A top cover 6 covers the top opening of the shell 1, and the tops of the shell 1 and the first cylinders 4 are sealed and inserted into the top cover 6. The top cover 6 has an annular groove adapted to the sealed insertion of the shell 1 and the first cylinders 4. Several transverse through holes are provided at the bottom of each first cylinder 4. The first cylinders 4 and second cylinders 5 form a whole flow channel extending radially from the axis of the shell 1 and reciprocating in a tortuous manner within the inner cavity of the shell 1. Figure 7 As shown, the cross-sectional area of ​​the inner cavity of the first cylinder 4 at the axis is the same as the cross-sectional area of ​​the annular cavity between the first cylinder 4 and the second cylinder 5. The edge of the overhead plate 2 is provided with uniformly distributed vertical through holes in an annular pattern. An annular sand core 3 is embedded between the shell 1 and the outermost second cylinder 5, and the annular sand core 3 covers the vertical through holes of the overhead plate 2 from above. The solution can only pass through the vertical through holes of the overhead plate 2 after being filtered by the annular sand core 3. After the inner cavity of the first cylinder 4 at the axis is filled with ion exchange resin, two perforated plates 10 are placed on top of the ion exchange resin, and degreased cotton is placed between the two perforated plates 10. The top cover 6 is equipped with a dual-head feed assembly 7 with a dispersion outlet, and the bottom of the dual-head feed assembly 7 extends into the first cylinder 4 closest to the axis of the overhead plate 2. The top cover 6 is equipped with a vent valve 8 that communicates with the inner cavity of the first cylinder 4 closest to the axis of the overhead plate 2.

[0032] The dual-head feed assembly 7 includes a dual-head feeder 701 embedded in the top cover 6, with a transverse valve core 702 slidably mounted inside the top transverse tube of the dual-head feeder 701. Threaded interfaces for connecting the components to be processed pipeline and the eluent pipeline are respectively provided at both ends of the top transverse tube of the dual-head feeder 701. The annular wall length of the transverse valve core 702 is greater than the diameter of the vertical channel it controls, ensuring that at most one side of the feed pipeline connects to the bottom disc when the transverse valve core 702 moves to any position. The bottom disc of the dual-head feeder 701 has several transverse outlets, and a retainer 703 is fitted over the bottom disc. The retainer 703 has several through-holes that adapt to the transverse outlets. After flowing out of the transverse outlets of the bottom disc, the liquid flows downwards under the obstruction of the retainer 703, preventing impact on the components to be separated.

[0033] Both ends of the transverse valve core 702 are tapered heads, and the transverse tube of the dual-head feeder 701 is provided with a tapered surface adapted to the tapered head, which can enhance the sealing performance and avoid mutual interference between the feed pipes on both sides.

[0034] The vent valve 8 includes a valve body 801 embedded in the top cover 6. An adjusting valve core 802 is axially slidably mounted inside the valve body 801. An adjusting bolt 803 is rotatably connected to the adjusting valve core 802, and the adjusting bolt 803 is threadedly connected to the valve body 801. The bottom annular protrusion of the adjusting bolt 803 is rotatably mounted inside the adjusting valve core 802, and a hexagonal nut is provided on the part of the adjusting bolt 803 that extends out of the valve body 801.

[0035] The radially extending round rod of the regulating valve core 802 is linearly slidably inserted into the through groove of the valve body 801, wherein the through groove of the valve body 801 also has the function of connecting the vertical channel of the valve body 801 with the outside atmosphere.

[0036] The control end of the regulating valve core 802 is a conical head, and the valve body 801 is provided with a conical surface adapted to the conical head, which can enhance the sealing performance of the vent valve 8 when it is closed.

[0037] Several locking components 9 extend from the side wall of the housing 1; each locking component 9 includes a fixing seat 901 fixedly connected to the outer wall of the housing 1, a rotating screw 902 rotatably connected to the fixing seat 901, and the rotating screw 902 vertically engaging in the edge notch of the top cover 6, and the rotating screw 902 is threadedly connected to a nut 903 that presses down the top cover 6. By unscrewing the nut 903, the rotating screw 902 can be rotated out of the edge notch of the top cover 6, and then the top cover 6 can be lifted upwards.

[0038] Working principle:

[0039] Before use, open the top cover 6 and fill the ion exchange resin of the mixed buffer solution into the top opening of the shell 1. Except for the inner cavity of the first cylinder 4 at the axis, fill the remaining annular space with ion exchange resin to the top opening of the shell 1 as much as possible. At the same time, place two perforated plates 10 with degreased cotton sandwiched in the middle on top of the ion exchange resin in the inner cavity of the first cylinder 4 at the axis. The top of the perforated plates 10 also has space reserved for placing the dual-head feed assembly 7. Then close the top cover 6 and lock the two sides of the top cover 6 with the locking assembly 9. At this time, the inner cavity of the shell 1 is filled with buffer solution in addition to the ion exchange resin.

[0040] In use, the top horizontal tube of the dual-head feeder 701 is connected to the solution to be treated (a solution containing hydroxyethylpiperazine ethanesulfonic acid) and the eluent solution at both ends. Then, the bottom stopcock of the housing 1 is opened, and the solution to be treated is continuously fed into the axis of the housing 1 through the dual-head feeder 7. Then, the feeding of the solution to be treated stops, and the eluent solution is pressurized and slowly fed into the axis of the housing 1 through the dual-head feeder 7. This eluent is used to elute the solution to be treated. Hydroxyethylpiperazine ethanesulfonic acid and other impurities are eluted in order of their strength of adhesion to the ion exchange resin (selected ion exchange resin). Ion exchange resins have a strong adsorption capacity for impurities. The type of ion exchange resin is selected according to the nature of the impurities. The impurities are eventually eluted or adsorbed in the ion exchange resin. Each component flows out from the bottom of the shell 1 through the annular sand core 3 in sequence (using conventional segmented collection, the components collected in segments are detected by thin plate chromatography, and finally the same components are combined). The shell 1 is provided with a flow channel that extends radially from the axis of the shell 1 and reciprocates, which lengthens the flow distance of the components to be treated in the ion exchange resin. Each component has time to fully react with the ion exchange resin, which improves the purification effect of hydroxyethylpiperazine ethane sulfonic acid.

[0041] After use, stop the eluent supply line, open the vent valve 8 to release the pressure and allow air to pass through the housing 1, and at the same time open the bottom stopcock of the housing 1 to release some of the liquid inside the housing 1, so as to prevent the top cover 6 from flying off due to excessive pressure inside the housing 1 when it is opened.

[0042] It should be noted that the above content merely illustrates the technical concept of this utility model and cannot be used to limit the scope of protection of this utility model. For those skilled in the art, several improvements and modifications can be made without departing from the principle of this utility model, and all such improvements and modifications fall within the scope of protection of the claims of this utility model.

Claims

1. A hydroxyethylpiperazine ethanesulfonic acid purification exchange column, comprising a shell (1), characterized in that, The bottom of the inner cavity of the housing (1) is coaxially fitted with a suspended plate (2) that does not contact the bottom wall of the inner cavity of the housing (1). Several first cylinders (4) and second cylinders (5) extend upward from the suspended plate (2) and are coaxial with it. The first cylinders (4) and second cylinders (5) are arranged alternately in the order of the first cylinders (4) and second cylinders (5) starting from the axis of the suspended plate (2). The top opening of the housing (1) is covered with a top cover (6), and the tops of the housing (1) and the first cylinders (4) are sealed and inserted into the top cover (6). Several transverse through holes are provided at the bottom of each first cylinder (4). The edge of the overhead plate (2) is provided with vertical through holes evenly distributed in a ring. An annular sand core (3) is embedded between the shell (1) and the outermost second cylinder (5), and the annular sand core (3) covers the vertical through holes of the overhead plate (2) from above. The top cover (6) is equipped with a double-headed feeding assembly (7) with a dispersed outlet, and the bottom of the double-headed feeding assembly (7) extends into the first cylinder (4) closest to the axis of the overhead plate (2). The top cover (6) is equipped with a vent valve (8) that communicates with the inner cavity of the first cylinder (4) closest to the axis of the overhead plate (2).

2. The hydroxyethylpiperazine ethanesulfonic acid purification exchange column according to claim 1, characterized in that, Several locking components (9) extend from the side wall of the housing (1); each locking component (9) includes a fixing seat (901) fixedly connected to the outer wall of the housing (1), the fixing seat (901) is rotatably connected to a rotating screw (902), and the rotating screw (902) is vertically inserted into the edge notch of the top cover (6), and the rotating screw (902) is threadedly connected to a nut (903) that presses down the top cover (6).

3. The hydroxyethylpiperazine ethanesulfonic acid purification exchange column according to claim 1, characterized in that, The dual-head feeding assembly (7) includes a dual-head feeder (701) embedded in the top cover (6). A transverse valve core (702) is slidably installed in the top transverse tube of the dual-head feeder (701). The length of the annular wall of the transverse valve core (702) is greater than the diameter of the vertical channel it controls. The bottom disc of the dual-head feeder (701) is provided with several transverse outlets, and the bottom disc is covered with a baffle (703). The baffle (703) is provided with several notches that are adapted to the transverse outlets and pass through vertically.

4. The hydroxyethylpiperazine ethanesulfonic acid purification exchange column according to claim 3, characterized in that, Both ends of the transverse valve core (702) are tapered heads, and the transverse tube of the double-headed feeder (701) is provided with a tapered surface adapted to the tapered head.

5. The hydroxyethylpiperazine ethanesulfonic acid purification exchange column according to claim 1, characterized in that, The vent valve (8) includes a valve body (801) embedded in the top cover (6), an adjusting valve core (802) is axially slidably installed in the inner cavity of the valve body (801), the adjusting valve core (802) is rotatably connected to an adjusting bolt (803), and the adjusting bolt (803) is threadedly connected to the valve body (801).

6. The hydroxyethylpiperazine ethanesulfonic acid purification exchange column according to claim 5, characterized in that, The radially extending round rod of the regulating valve core (802) slides linearly into the through groove of the valve body (801).

7. The hydroxyethylpiperazine ethanesulfonic acid purification exchange column according to claim 5, characterized in that, The control end of the regulating valve core (802) is a conical head, and the valve body (801) is provided with a conical surface adapted to the conical head.

8. The hydroxyethylpiperazine ethanesulfonic acid purification exchange column according to claim 1, characterized in that, The first cylinder (4) and the second cylinder (5) form an integral flow channel in the inner cavity of the shell (1) that extends radially from the axis of the shell (1) and reciprocates. The cross-sectional area of ​​the inner cavity of the first cylinder (4) at the axis is the same as the cross-sectional area of ​​the annular cavity between the first cylinder (4) and the second cylinder (5).

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