Device for preparing a plant tube module and positive control

Abstract

The application relates to the technical field of positive sample preparation, in particular to a planting module and a preparation device for positive control samples. The preparation device comprises a clamping assembly and a processing assembly. The clamping assembly is used for clamping a target sample. The processing assembly comprises a plurality of processing modules. Each processing module can move relative to the clamping assembly. When the processing module and the clamping assembly correspond to a processing station of the target sample, the processing module processes the target sample. The plurality of processing modules comprise a punching module and a planting module. The punching module can punch the target sample to form a hole on the target sample. The planting module can plant a microtube in the hole. The preparation device punches and plants the target sample through the punching module and the planting module, replaces part of manual operation, completes microtube planting, and effectively improves the preparation efficiency of the positive control sample.

Description

Technical Field

[0001] This utility model relates to the field of positive sample preparation technology, and in particular to an implantation tube module and a device for preparing positive control. Background Technology

[0002] To ensure that pharmaceuticals meet safety and quality requirements, leak detectors are used to inspect the sealing integrity of pharmaceutical packaging systems during the actual production process. Commonly used leak detector methods include vacuum decay and high-voltage discharge. However, regardless of the method used, a positive control is required during the inspection process. A positive control is a pharmaceutical packaging system with known leaks.

[0003] Currently, positive controls are typically prepared by manually inserting microtubes into drug packaging to obtain positive controls with known leak defects. Proficiency testing of leak detectors, development of testing methods, and single-product validation all require positive controls. However, manual preparation is slow, making it difficult to meet the testing and validation requirements of leak detectors and impacting drug production cycles. Furthermore, manual preparation can easily lead to microtube tip breakage, resulting in substandard positive controls. Utility Model Content

[0004] The present invention aims to solve at least one of the technical problems existing in the related art.

[0005] Firstly, this application provides an apparatus for preparing a positive control, including a clamping assembly and a processing assembly. The clamping assembly is used to clamp a target sample. The processing assembly includes multiple processing modules, each of which is movable relative to the clamping assembly. When a processing module is positioned at a processing station corresponding to the clamping assembly and processing the target sample, the processing module processes the target sample. The multiple processing modules include a punching module and a tube implantation module. The punching module punches holes in the target sample to form pores. The tube implantation module implants microtubes into the pores of the target sample.

[0006] In one optional embodiment, the drilling module includes a first housing, a first driving unit, and a drill head, with the first driving unit connected to the first housing. The drill head is disposed on the driving end of the first driving unit, which can drive the drill head to rotate relative to the first housing to form a hole in the target sample.

[0007] In one optional embodiment, the implantation module includes a mounting base, a delivery channel, and a delivery assembly. The delivery channel is disposed on the mounting base and is used to deliver microtubes. When the implantation module is in the processing position of the target sample, the delivery port of the delivery channel is opposite to the orifice. The delivery assembly is disposed on the mounting base and is used to move the microtube located in the delivery channel to the delivery port.

[0008] In one alternative embodiment, the delivery channel includes a delivery groove with a top opening. The delivery assembly includes a delivery wheel whose surface is capable of contacting the microtube, and the delivery wheel rotates relative to the mounting base to move the microtube within the delivery groove.

[0009] In one alternative embodiment, the tube implantation module includes a fixing plate movably disposed on a mounting base. The fixing plate has a pressing position and a releasing position. When in the pressing position, it presses against the microtube located in the tube delivery groove. When in the releasing position, it moves away from the tube delivery groove.

[0010] In one alternative embodiment, the implantation module includes a positioning tube, which is mounted on a mounting base and communicates with the delivery port. The microtube moves into the hole through the delivery channel and the positioning tube.

[0011] In one alternative implementation, the inner diameter of the positioning tube gradually decreases in the direction away from the pipeline channel.

[0012] In one alternative embodiment, the positioning tube includes a tube body and a flexible body. The tube body is mounted on a mounting base, and one end of the tube body is connected to the inlet. The flexible body is located at the other end of the tube body and is capable of contacting the wall of the hole.

[0013] In one alternative embodiment, the flexible body includes a plurality of positioning ribs and connecting ribs. The positioning ribs are spaced apart and connected to the other end of the tube, with the free ends of the positioning ribs capable of extending into the holes. The connecting ribs are connected to the plurality of positioning ribs and are disposed close to the tube.

[0014] In one alternative embodiment, the processing module further includes a dust removal module capable of removing dust from the target sample to remove residual dust from the pores.

[0015] In one alternative embodiment, the processing module further includes a curing module capable of curing the target sample to solidify the microtubes within the pores.

[0016] In one alternative implementation, the processing module further includes a tube-cutting module capable of cutting the target sample to adjust the length of the cured microtubes.

[0017] In one optional embodiment, the dust removal module includes a second housing, a plasma generator, and an exhaust duct, with the plasma generator connected to the second housing. The exhaust duct is connected to the plasma generator and is capable of delivering the plasma air generated by the plasma generator to the pores of the target sample.

[0018] In one alternative implementation, the curing module includes an ultraviolet generator, with the pores of the target sample located within the ultraviolet light range of the generator.

[0019] In one alternative embodiment, the tube-cutting module includes a third housing, a second drive unit, and a cutting unit, with the second drive unit connected to the third housing. The cutting unit is disposed on the drive end of the second drive unit, and the second drive unit can drive the cutting unit to rotate to cut the cured microtubes.

[0020] In one alternative implementation, the tube cutting module further includes a collection groove with its opening located below the cutting section.

[0021] In one alternative embodiment, the clamping assembly includes a first clamping arm and a second clamping arm, the second clamping arm being movable relative to the first clamping arm to clamp the target sample between the first clamping arm and the second clamping arm.

[0022] In one alternative embodiment, the clamping assembly further includes a clamping seat, a clearance hole, a connecting rod, and a fastener. A first clamping arm and a second clamping arm are disposed on the clamping seat. The clearance hole is formed in the second clamping arm. The connecting rod passes through the clearance hole and is connected to the first clamping arm. The fastener is connected to the connecting rod and is located on the side of the second clamping arm opposite to the first clamping arm.

[0023] In one optional embodiment, the preparation device further includes multiple adjustment modules, which are respectively connected to multiple processing modules. When the processing module is in the processing position of the corresponding clamping component, the adjustment module is used to align the processing module with the target sample to be processed by the clamping component.

[0024] In one alternative embodiment, the adjustment module includes a connecting column and a connecting seat. The connecting seat is rotatably mounted on the connecting column via a connecting shaft. The processing module is disposed on the connecting seat. The processing module can adjust the position of the target sample relative to the clamping assembly by rotating the connecting seat.

[0025] In one optional embodiment, the adjustment module further includes a rotating groove, a first shaft hole, and a second shaft hole. The rotating groove is located at one end of the connecting column, and a portion of the connecting seat is located within the rotating groove. The first shaft hole is located on opposite side walls of the connecting column and communicates with the rotating groove. The second shaft hole is located on the connecting seat, and the connecting shaft passes through the second shaft hole and the first shaft hole respectively, so that the connecting seat and the connecting column are rotatably connected.

[0026] In one alternative embodiment, the preparation apparatus further includes a locking component, which is used to restrict the relative movement between the processing module and the clamping component when the processing module is in the processing position of the target sample.

[0027] In one alternative embodiment, the locking assembly includes a first locking seat, a plurality of second locking seats, and a locking part. The first locking seat is fixedly assembled with one of the processing modules or clamping assemblies. The plurality of second locking seats are respectively fixedly assembled with another of the processing modules or clamping assemblies. The locking part is disposed on the first locking seat and is selectively connected to one of the plurality of second locking seats.

[0028] In one alternative embodiment, the second locking seat includes a mating hole. The locking part includes a locking pin, which is movable relative to the first locking seat and, when in the locked position, extends into the mating hole to lock.

[0029] In one alternative implementation, the processing module and the clamping assembly can rotate or move relative to each other.

[0030] In one alternative embodiment, the fabrication apparatus further includes a first base and a second base, with one of the first base clamping assembly and the processing assembly disposed on the first base. The other of the second base clamping assembly and the processing assembly is disposed on the second base; the first base and the second base are capable of relative movement.

[0031] In one alternative implementation, the number of first base stations is one or more, and the number of second base stations is one or more.

[0032] In one alternative implementation, the second base is movable relative to the first base. The number of clamping assemblies is one or more, disposed on the same or different first bases, and multiple processing modules are disposed on the same or different second bases.

[0033] In one alternative implementation, the second base is movable relative to the first base. The number of clamping assemblies is one or more, disposed on the same or different second bases, and multiple processing modules are disposed on the same or different first bases.

[0034] In one alternative embodiment, the fabrication apparatus further includes a support platform, with a first base and a second base disposed on the support platform, forming an assembly space between the first base and the support platform. The second base is disposed around the first base and located within the assembly space.

[0035] In one alternative implementation, the first base is a circular platform and the second base is an annular platform. The second base can be fitted over the first base and rotate relative to the first base.

[0036] Secondly, this application provides a tube implantation module for implanting microtubes into pores of a target sample during the preparation of a positive control. The module includes a mounting base, a delivery channel, and a delivery assembly. The delivery channel is disposed on the mounting base and is used to deliver the microtubes. The delivery port of the delivery channel is positioned opposite a pore on the target sample. The delivery assembly is disposed on the mounting base and is used to move the microtube located within the delivery channel to the delivery port and implant it into the pore of the target sample.

[0037] In one alternative embodiment, the delivery channel includes a delivery groove with a top opening. The delivery assembly includes a delivery wheel whose surface is capable of contacting the microtube, and the delivery wheel rotates relative to the mounting base to move the microtube within the delivery groove.

[0038] In one alternative embodiment, the tube implantation module includes a fixing plate movably disposed on a mounting base. The fixing plate has a pressing position and a releasing position. When in the pressing position, it presses against the microtube located in the tube delivery groove. When in the releasing position, it moves away from the tube delivery groove.

[0039] In one alternative embodiment, the implantation module includes a positioning tube, which is mounted on a mounting base and communicates with the delivery port. The microtube moves into the hole through the delivery channel and the positioning tube.

[0040] In one alternative implementation, the inner diameter of the positioning tube gradually decreases in the direction away from the pipeline channel.

[0041] In one alternative embodiment, the positioning tube includes a tube body and a flexible body. The tube body is mounted on a mounting base, and one end of the tube body is connected to the inlet. The flexible body is located at the other end of the tube body and is capable of contacting the wall of the hole.

[0042] In one alternative embodiment, the flexible body includes a plurality of positioning ribs and connecting ribs. The positioning ribs are spaced apart and connected to the other end of the tube, with the free ends of the positioning ribs capable of extending into the holes. The connecting ribs are connected to the plurality of positioning ribs and are disposed close to the tube.

[0043] Compared with the prior art, the beneficial effects of this application are: The positive control preparation apparatus provided in this application allows for relative movement between the clamping assembly and the processing module, enabling positional adjustment between the processing module and the target sample. When the processing module is positioned at the target sample processing station, the target sample is perforated and implanted via a punching module and a tube insertion module, replacing some manual operations and completing the microtube implantation. This effectively increases the preparation speed of the positive control, ensuring a sufficient supply to meet the leak detection requirements of the leak detector and avoiding disruption to the drug production cycle. Furthermore, implanting microtubes into the target sample via the tube insertion module significantly reduces the number of microtube tip breakages, improving the success rate of positive control preparation. Additionally, when multiple processing modules operate simultaneously, multiple target samples can be prepared concurrently, further enhancing the efficiency of positive control preparation. Attached Figure Description

[0044] Figure 1 An exploded view of an apparatus for preparing a positive control according to an embodiment of the present invention is shown; Figure 2 A schematic diagram of the structure of a positive control preparation apparatus according to an embodiment of the present invention is shown; Figure 3 An exploded view of the punching module in one embodiment of the present invention is shown; Figure 4 A schematic diagram of the punching module in one embodiment of the present invention is shown; Figure 5 An exploded view of the drill head in the drilling module of one embodiment of the present invention is shown; Figure 6 This invention provides a schematic diagram of the structure of an implantation tube module according to an embodiment of the present invention. Figure 7 This image shows one of the enlarged views of a positioning tube in an implantation module according to an embodiment of the present invention. Figure 8 This is a second enlarged view of a portion of the positioning tube in the implantation module according to one embodiment of the present invention; Figure 9 This diagram illustrates the tube implantation module performing tube implantation on a target sample in one embodiment of the present invention. Figure 10 This illustration shows a schematic diagram of the positioning tube in the implantation module extending into the hole of the target sample in one embodiment of the present invention. Figure 11 A schematic diagram of the structure of a dust removal module according to an embodiment of the present invention is shown; Figure 12 A schematic diagram of the curing module according to an embodiment of the present invention is shown; Figure 13 A schematic diagram of the pipe cutting module according to an embodiment of the present invention is shown; Figure 14 A schematic diagram of the clamping assembly in one embodiment of the present invention is shown; Figure 15 A schematic diagram of the adjustment module in one embodiment of the present invention is shown; Figure 16 A schematic diagram of the locking assembly in one embodiment of the present invention is shown.

[0045] Figure Labels 1 Clamping assembly, 11 First clamping arm, 12 Second clamping arm, 13 Clamping seat, 14 Linkage, 15 Fastener; 2. Drilling module, 21. First housing, 22. First drive unit, 23. Drill head, 231. Drill spindle, 232. Drill bit, 233. Concave hole, 24. First switch, 25. Speed ​​adjustment knob, 26. First heat dissipation port; 3. Insertion module, 31. Mounting base, 32. Inlet channel, 321. Inlet port, 322. Inlet groove, 33. Conveying wheel, 333. Positioning groove, 34. Fixing plate, 35. Positioning tube, 351. Tube body, 352. Flexible body, 3521. Positioning rib, 3522. Connecting rib, 36. Microtube; 4 Dust removal module, 41 Second housing, 42 Plasma generator, 43 Air outlet duct, 44 Second switch, 45 Temperature adjustment knob, 46 Wind speed adjustment knob, 47 Generator output control knob, 48 Display screen, 49 Second heat dissipation vent; 5. Curing module; 51. UV generator; 52. UV light source; 6. Pipe cutting module, 61. Third housing, 62. Second drive unit, 63. Cutting unit, 64. Collection tank; 7 Adjustment module, 71 Connecting post, 711 First shaft hole, 712 Rotating groove, 72 Connecting seat, 721 Second shaft hole, 73 Connecting shaft; 8 Locking assembly, 81 First locking seat, 82 Second locking seat, 821 Mating hole, 83 Locking part; 91 First base, 92 Second base, 93 Assembly space, 94 Support platform, 941 Annular groove, 95 Guide component; 10 target samples, 101 holes. Detailed Implementation

[0046] To better understand the above technical solutions, the technical solutions of the embodiments of this application will be described in detail below with reference to the accompanying drawings and specific embodiments. It should be understood that the embodiments of this application and the specific features in the embodiments are detailed descriptions of the technical solutions of the embodiments of this application, rather than limitations on the technical solutions of this application. In the absence of conflict, the embodiments of this application and the technical features in the embodiments can be combined with each other.

[0047] Firstly, this application provides an apparatus for preparing a positive control, such as... Figure 1 and Figure 2 As shown, the preparation apparatus includes a clamping assembly 1 and a processing assembly. The clamping assembly 1 is used to clamp the target sample 10. The processing assembly includes multiple processing modules, each of which is movable relative to the clamping assembly 1. When a processing module is positioned at the processing station of the target sample 10 corresponding to the clamping assembly 1, the processing module processes the target sample 10. The multiple processing modules include at least a drilling module 2 and a tube implantation module 3. The drilling module 2 can drill holes in the target sample 10 to form holes 101. The tube implantation module 3 can implant tubes into the target sample 10 to insert microtubes 36 into the holes 101.

[0048] The processing module and the clamping assembly 1 are capable of relative movement, allowing for adjustment of the relative position between the processing module and the target sample 10. Specifically, when the processing module is positioned at the processing station of the target sample 10, corresponding to the clamping assembly 1, the processing module then processes the target sample 10. The relative movement between the processing module and the clamping assembly 1 can be achieved in several ways. For example, the clamping assembly 1 can be fixed in position, while the processing module can move relative to it to adjust their positions. Alternatively, the processing module can be fixed in position, while the clamping assembly 1 can move relative to it. Or, both the processing module and the clamping assembly 1 can move.

[0049] It should be noted that the relative movement between the processing module and the clamping assembly 1 may include relative movement between the processing module and the clamping assembly 1, and / or relative rotation between the processing module and the clamping assembly 1.

[0050] The positive control preparation apparatus provided in this application allows for relative movement between the clamping component 1 and the processing module, enabling positional adjustment between the processing module and the target sample 10. When the processing module is positioned at the processing station of the target sample 10, the target sample 10 is then perforated and implanted via the punching module 2 and the tube insertion module 3, replacing some manual operations and completing the implantation of the microtube 36. This effectively increases the preparation speed of the positive control, ensuring that the supply of positive controls meets the detection requirements of the leak detector and avoids impacting the drug production cycle. Implanting the microtube 36 into the target sample 10 via the tube insertion module 3 significantly reduces the number of times the microtube 36 tip breaks, thereby increasing the success rate of positive control preparation.

[0051] It should be noted that the multiple processing modules in this application can be processed simultaneously, that is, multiple target samples 10 can be prepared at the same time, which can further improve the preparation efficiency of positive control standards.

[0052] It should be noted that target sample 10 includes blister packs, soft bags, eye drop bottles, etc. Blister packs include BFS (Blow Fill Seal) blister packs.

[0053] In one alternative implementation, such as Figure 3 and Figure 4 As shown, the drilling module 2 includes a first housing 21, a first driving part 22, and a drill head 23. The first driving part 22 is connected to the first housing 21. The drill head 23 is disposed on the driving end of the first driving part 22. The first driving part 22 can drive the drill head 23 to rotate relative to the first housing 21 to form a hole 101 in the target sample 10.

[0054] In this embodiment, after the first drive unit 22 is started, the drill head 23 can be rotated relative to the first housing 21 by the drive end, thereby forming a hole 101 on the target sample 10.

[0055] The first drive unit 22 includes a first drive motor, and the drill head 23 is connected to the first drive shaft of the first drive motor.

[0056] The punching module 2 also includes a first switch 24, which is disposed on the first housing 21 and electrically connected to the first drive unit 22. The operator can control the start and stop of the first drive unit 22 through the first switch 24.

[0057] The drilling module 2 also includes a speed adjustment knob 25, which is located on the first housing 21 and is electrically connected to the first drive unit 22. The operator can adjust the speed of the first drive unit 22 through the speed adjustment knob 25, thereby controlling the speed of the drill bit 23.

[0058] The drilling module 2 also includes a first heat dissipation vent 26, which is disposed on the first housing 21 and / or the first driving part 22. The first heat dissipation vent 26 is used to dissipate heat inside the first housing 21 and / or the first driving part 22 to the outside in a timely manner, so as to avoid electronic component failure caused by overheating inside the first housing 21 and / or the first driving part 22. The first heat dissipation vent 26 is located on the side of the first housing 21 and / or the first driving part 22 opposite to the drill bit 23.

[0059] Among them, such as Figure 5 As shown, the drill head 23 includes a drill shaft 231 and a drill bit 232. The first end of the drill shaft 231 is connected to the drive end of the first drive unit 22, and the drill bit 232 is detachably mounted on the second end of the drill shaft 231. The second end of the drill shaft 231 has a recessed hole 233, and the drill bit 232 is inserted into the recessed hole 233 and connected to the drill shaft 231. Since the target sample 10 belongs to different types of packaging materials, during the drilling process, a corresponding drill bit 232 is required for each type of packaging material. By detachably mounting the drill bit 232 on the drill shaft 231, the drill bit 232 can be replaced to adapt to the drilling needs of different types of packaging materials, thus expanding the applicability of the drilling module 2.

[0060] In one alternative implementation, such as Figures 6 to 10 As shown, the implantation module 3 includes a mounting base 31, a delivery channel 32, and a delivery assembly. The delivery channel 32 is mounted on the mounting base 31 and is used to deliver the microtube 36. When the implantation module 3 is in the processing position of the target sample 10, the delivery port 321 of the delivery channel 32 is opposite to the hole 101. The delivery assembly is mounted on the mounting base 31 and is used to move the microtube 36 located in the delivery channel 32 to the delivery port 321 and implant it into the hole 101 of the target sample 10. The microtube 36 can move within the delivery channel 32.

[0061] In order to enable the microtube 36 to move within the delivery channel 32, a delivery component is provided on the mounting base 31, which can provide kinetic energy for the movement of the microtube 36.

[0062] Specifically, such as Figure 10 As shown, under the action of the delivery component, the microtube 36 can be delivered through the delivery port 321. When the implantation module 3 is in the processing position of the target sample 10, the delivery port 321 is aligned with the hole 101 of the target sample 10, that is, the delivery channel 32, the delivery port 321 and the hole 101 are coaxially arranged, and the microtube 36 will enter the hole 101 of the target sample 10 through the delivery port 321 to complete the implantation of the microtube 36.

[0063] It should be noted that the delivery channel 32 is a straight channel, which allows the microtube 36 to move smoothly within the straight channel, reducing the resistance during the delivery process of the microtube 36 and preventing damage to the microtube 36 during delivery.

[0064] In one alternative implementation, such as Figure 9 As shown, the delivery channel 32 includes a delivery groove 322 with a top opening. The delivery assembly includes a delivery wheel 33, the wheel surface of which can contact the microtube 36, and the delivery wheel 33 rotates relative to the mounting base 31 to drive the microtube 36 to move within the delivery groove 322.

[0065] In this embodiment, the delivery channel 32 includes a delivery groove 322, the top of which is open. When the microtube 36 is in the delivery groove 322, the operator can observe the movement state of the microtube 36 through the top opening of the delivery groove 322, thus realizing the visualization of the movement process of the microtube 36.

[0066] The conveying assembly includes a conveying wheel 33, which is rotatably mounted on a mounting base 31. The wheel surface of the conveying wheel 33 contacts the microtube 36 located in the delivery groove 322. When the conveying wheel 33 rotates, it can drive the microtube 36 to move along the delivery groove 322 toward the target sample 10.

[0067] When the microtube 36 is placed in the delivery groove 322, a part of the microtube 36 protrudes out of the delivery groove 322, thereby facilitating contact between the delivery wheel 33 and the microtube 36.

[0068] The conveyor wheel 33 has a positioning groove 333 on its surface. The positioning groove 333 is arranged around the circumference of the conveyor wheel 33, that is, the positioning groove 333 is an annular groove. The part of the microtube 36 that protrudes from the conduit groove 322 will cooperate with the positioning groove 333, thereby realizing the movement of the microtube 36 driven by the conveyor wheel 33.

[0069] In one alternative implementation, such as Figure 6 and Figure 9 As shown, the tube implantation module 3 includes a fixing plate 34, which is movably mounted on the mounting base 31. The fixing plate 34 has a pressing position and a releasing position. When it is in the pressing position, it presses against the microtube 36 located in the tube delivery groove 322. When it is in the releasing position, it moves away from the tube delivery groove 322.

[0070] In this embodiment, the fixing plate 34 is movably disposed on the mounting base 31. The fixing plate 34 has a pressing position and a releasing position, and can switch between the pressing position and the releasing position. When the microtube 36 moves along the delivery channel groove 322, the fixing plate 34 presses against the microtube 36, which can ensure the positional stability of the microtube 36 and prevent the microtube 36 from falling out of the delivery channel 32.

[0071] It should be noted that the clamping force applied by the fixed pressure plate 34 to the microtube 36 is small. The clamping force is only used to restrict the microtube 36 from coming out of the delivery channel 32, and will not affect the driving effect of the delivery wheel 33 on the microtube 36, nor will it affect the movement of the microtube 36 along the delivery channel 32 toward the target sample 10.

[0072] In one alternative implementation, such as Figure 7 , Figure 8 and Figure 10 As shown, the implantation tube module 3 includes a positioning tube 35, which is mounted on the mounting base 31. The positioning tube 35 is connected to the delivery port 321. The microtube 36 moves into the hole 101 through the delivery channel 32 and the positioning tube 35.

[0073] In this embodiment, a positioning tube 35 is provided on the side of the mounting base 31 near the target sample 10. The positioning tube 35 is connected to the delivery channel 32, thereby forming a complete movement channel for the microtube 36. The microtube 36 enters the positioning tube 35 through the delivery channel 32 and the delivery port 321. The positioning tube 35 can be aligned with the hole 101 of the target sample 10. The positioning tube 35 can extend into the hole 101, allowing the microtube 36 to be accurately delivered into the hole 101, protecting the tip of the microtube 36, and avoiding collisions that may occur due to misalignment between the tip of the microtube 36 and the target sample 10. This effectively reduces the occurrence of damage to the tip of the microtube 36.

[0074] In one alternative implementation, such as Figure 7 and Figure 8 As shown, the inner diameter of the positioning tube 35 gradually decreases along the direction away from the pipeline channel 32.

[0075] In this embodiment, the inner diameter of the positioning tube 35 gradually decreases along the direction away from the delivery channel 32, that is, the direction of movement of the microtube 36 within the delivery channel 32.

[0076] The smaller tip of the positioning tube 35 facilitates its connection with the hole 101 to form a channel, protecting the microtube 36 from collisions during implantation and preventing its tip from breaking. While the inner diameter of the positioning tube 35 gradually decreases, its tip remains larger than the microtube 36, ensuring smooth movement of the microtube 36 into the hole 101 and minimizing resistance during implantation.

[0077] In one alternative implementation, such as Figure 7 , Figure 8 and Figure 10 As shown, the positioning tube 35 includes a tube body 351 and a flexible body 352. The tube body 351 is mounted on the mounting base 31, and one end of the tube body 351 is connected to the inlet 321. The flexible body 352 is mounted on the other end of the tube body 351 and can contact the wall of the hole 101.

[0078] In this embodiment, the positioning tube 35 includes a tube body 351 and a flexible body 352. The tube body 351 is connected to the mounting base 31. One end of the tube body 351 is connected to the inlet 321, and the other end of the tube body 351 is provided with a flexible body 352. The flexible body 352 is used to contact the hole 101 of the target sample 10. The flexible body 352 can provide a certain buffer space. When the microtube 36 is transported into the hole 101 through the positioning tube 35, the flexible body 352 can protect the tip of the microtube 36 and prevent the tip of the microtube 36 from being broken by rigid impact.

[0079] In one alternative implementation, such as Figure 7 and Figure 8 As shown, the flexible body 352 includes multiple positioning ribs 3521 and connecting ribs 3522. The multiple positioning ribs 3521 are spaced apart and connected to the other end of the tube body 351. The free ends of the positioning ribs 3521 can extend into the holes 101. The connecting ribs 3522 are connected to the multiple positioning ribs 3521 and are arranged close to the tube body 351.

[0080] In this embodiment, the flexible body 352 includes a plurality of positioning ribs 3521 and connecting ribs 3522. The positioning ribs 3521 are spaced apart and connected to the other end of the tube body 351, with the tips of the positioning ribs 3521 approaching each other, causing the inner diameter of the flexible body 352 to gradually decrease. The connecting ribs 3522 are connected to the plurality of positioning ribs 3521 respectively, which can improve the connection stability of the connecting ribs 3522. Specifically, the connecting ribs 3522 are annular ribs.

[0081] The number of positioning ribs 3521 is 3, 4, 5, 6, 7, or 8. Multiple positioning ribs 3521 are evenly spaced and connected to the pipe body 351. Each positioning rib 3521 includes a first end connected to the pipe body 351 and a second end away from the pipe body 351, such as... Figure 8 As shown, the thickness of the second end of the positioning rib 3521 is less than the thickness of the first end of the positioning rib 3521. That is, along the direction away from the delivery channel 32, the thickness of the positioning rib 3521 gradually decreases, which makes it convenient for the second end of the positioning rib 3521 to extend into the hole 101 of the target sample 10.

[0082] It should be noted that, secondly, the implantation module 3 provided in this application can be used independently as a separate embodiment. It is used to implant microtubes 36 into the pores 101 of the target sample 10 during the preparation of a positive control. The implantation module 3 includes a mounting base 31, a delivery channel 32, and a delivery assembly. The delivery channel 32 is disposed on the mounting base 31 and is used to deliver the microtubes 36. The delivery port 321 of the delivery channel 32 is positioned opposite the pores 101 on the target sample 10. The delivery assembly is disposed on the mounting base 31 and is used to transfer the microtubes 36 located within the delivery channel 32 to the delivery port 321 and implant them into the pores 101 of the target sample 10.

[0083] The implantation module 3, which is an independent embodiment, also includes other structures included in the implantation module 3 in any of the above embodiments, which will not be described in detail here.

[0084] In one alternative implementation, such as Figure 1 , Figure 2 and Figure 11 As shown, the processing module also includes a dust removal module 4, which can perform dust removal on the target sample 10 to remove residual dust in the holes 101.

[0085] During the processing of target sample 10, the target sample 10 is first punched to form holes 101. During the punching process, debris and other residual dust will be generated. When the target sample 10 is an eye drop bottle, in addition to residual dust, the medicine may also overflow during the punching process. The overflowing medicine can be dried by the dust removal module 4.

[0086] In this embodiment, the dust removal module 4 removes residual dust and spilled medicine, and cleans the holes 101 of the target sample 10 to avoid interfering with the subsequent processing.

[0087] In one alternative implementation, such as Figure 11 As shown, the dust removal module 4 includes a second housing 41, a plasma generator 42, and an air outlet duct 43. The plasma generator 42 is connected to the second housing 41. The air outlet duct 43 is connected to the plasma generator 42 and can deliver the plasma air generated by the plasma generator 42 to the hole 101 of the target sample 10.

[0088] In this embodiment, the dust removal module 4 includes a second housing 41, a plasma generator 42, and an air outlet duct 43. The second housing 41 is used to install the plasma generator 42. After the plasma generator 42 is started, it can generate plasma air. The plasma air will be transported to the hole 101 of the target sample 10 through the air outlet duct 43, so that the residual dust, overflowing medicine and other substances at the hole 101 are removed.

[0089] The dust removal module 4 also includes a second switch 44, which is disposed on the second housing 41 and electrically connected to the plasma generator 42. The second switch 44 is used to control the opening or closing of the plasma generator 42.

[0090] The dust removal module 4 also includes a temperature control knob 45, which is used to control the temperature of the plasma gas generated by the plasma generator 42.

[0091] The dust removal module 4 also includes a wind speed adjustment knob 46, which is used to control the speed of the plasma gas generated by the plasma generator 42.

[0092] The dust removal module 4 also includes a plasma generation control knob 47, which is used to control the plasma generation amount corresponding to the plasma generator 42.

[0093] The dust removal module 4 also includes a display screen 48, which is used to display the operating parameters of the plasma generator 42.

[0094] The dust removal module 4 also includes a second heat dissipation port 49, which is disposed on the plasma generator 42 and / or the second housing 41, for timely dissipation of heat to the outside to prevent the dust removal module 4 from overheating and causing potential malfunctions. The second heat dissipation port 49 is located on the side of the second housing 41 and / or the plasma generator 42 opposite to the drill bit 23.

[0095] In one alternative implementation, such as Figure 1 , Figure 2 and Figure 12 As shown, the processing module also includes a curing module 5, which can cure the target sample 10 so that the microtube 36 is cured in the hole 101.

[0096] In this embodiment, the processing module also includes a curing module 5. After the microtube 36 is implanted into the hole 101 of the target sample 10, in order to prevent the microtube 36 from coming out of the hole 101, the curing module 5 performs curing treatment on the hole 101 of the target sample 10.

[0097] It is worth noting that during the curing process, the curing medium needs to be applied to the pores 101 of the target sample 10. During the curing process, the curing medium will change from one state to another, undergoing chemical or physical changes, ultimately forming a hard and stable structure. For example, if the curing medium is a photocurable medium, it will change its state under the influence of light.

[0098] In one alternative implementation, such as Figure 12 As shown, the curing module 5 includes an ultraviolet generator 51, and the pores 101 of the target sample 10 are located within the ultraviolet light range of the ultraviolet generator 51.

[0099] In this embodiment, the curing module 5 includes an ultraviolet generator 51, and the curing medium includes photosensitive resin. After the microtube 36 is implanted into the hole 101, the photosensitive resin is applied at the position between the hole wall of the hole 101 and the microtube 36. Since the photosensitive resin is within the ultraviolet light range generated by the ultraviolet generator 51, the photosensitive resin is cured under the action of ultraviolet light, thereby encapsulating the hole 101 of the target sample 10.

[0100] The curing medium includes epoxy resin.

[0101] The ultraviolet generator 51 includes multiple ultraviolet light sources 52, which are spaced apart and have their light-emitting ends close to each other. The multiple ultraviolet light sources 52 simultaneously cure the target sample 10, thus shortening the curing time. The number of ultraviolet light sources 52 may include 2, 3, 4, etc.

[0102] In one alternative implementation, such as Figure 1 , Figure 2 and Figure 13 As shown, the processing module also includes a tube cutting module 6, which can cut the target sample 10 to adjust the length of the microtube 36 after curing.

[0103] In this embodiment, the processing module also includes a tube cutting module 6, which is used to adjust the length of the cured microtubes 36 so that the outer contour surface of the target sample 10 is flat and there are no protruding microtubes 36, which facilitates subsequent transportation and other processing.

[0104] In one alternative implementation, such as Figure 13 As shown, the tube cutting module 6 includes a third housing 61, a second drive unit 62, and a cutting unit 63. The second drive unit 62 is connected to the third housing 61. The cutting unit 63 is disposed on the drive end of the second drive unit 62, and the second drive unit 62 can drive the cutting unit 63 to rotate to cut the solidified microtubes 36.

[0105] In this embodiment, the third housing 61 is used to mount the second drive unit 62. The cutting unit 63 is connected to the drive end of the second drive unit 62. After the second drive unit 62 is started, the drive end can drive the cutting unit 63 to rotate relative to the third housing 61, thereby realizing the cutting operation of the cutting unit 63 on the microtube 36.

[0106] The second drive unit 62 includes a second drive motor, and the cutting unit 63 is connected to the second drive shaft of the second drive motor. The cutting unit 63 includes a cutting blade, which is connected to the second drive shaft and moves synchronously with the second drive shaft.

[0107] The pipe cutting module 6 also includes a pipe cutting switch, which is mounted on the third housing 61 and is electrically connected to the second drive unit 62. The pipe cutting switch is used to control the start and stop of the second drive unit 62.

[0108] It should be noted that, considering that the microtube 36 is made of glass and glass has a high rigidity, when the cured microtube 36 is cut by the cutting part 63, the cutting part 63 can be controlled to cut the microtube 36 once or twice to form a cut on the microtube 36. The operator can then break the microtube 36, minimizing the number of cuts and reducing the generation of debris during the cutting process, thus avoiding the impact of debris on the quality of the positive control.

[0109] In one alternative implementation, such as Figure 13 As shown, the pipe cutting module 6 also includes a collection groove 64, the opening of which is located below the cutting section 63.

[0110] In this embodiment, a collection groove 64 is provided below the cutting section 63. The debris generated during the cutting process falls into the collection groove 64 through the groove opening under the action of gravity, ensuring that the debris generated during the preparation process is effectively collected, and avoiding debris from splashing everywhere and causing contamination and affecting the normal operation of other processing modules.

[0111] The inner surface of the collection tank 64 is coated with an antistatic coating. This coating reduces the accumulation of static electricity during the collection process of the microtubes 36, prevents electrostatic discharge, and safely dissipates the charge, avoiding dangers such as electric shock and sparks during the preparation of the positive control. Specifically, the antistatic coating is made of a conductive material.

[0112] In one alternative implementation, such as Figure 14 As shown, the clamping assembly 1 includes a first clamping arm 11 and a second clamping arm 12. The second clamping arm 12 is movable relative to the first clamping arm 11 to clamp the target sample 10 between the first clamping arm 11 and the second clamping arm 12.

[0113] In this embodiment, the clamping assembly 1 is used to clamp the target sample 10. The clamping assembly 1 includes two clamping arms, namely a first clamping arm 11 and a second clamping arm 12. The first clamping arm 11 is a fixed clamping arm, and the second clamping arm 12 is a movable clamping arm. The second clamping arm 12 can move relative to the first clamping arm 11, thereby realizing that the clamping space between the first clamping arm 11 and the second clamping arm 12 is adjustable.

[0114] On the one hand, different types of target samples 10 require different clamping spaces. On the other hand, a certain amount of installation space is needed during the installation of the target sample 10 onto the clamping assembly 1. In this embodiment, the second clamping arm 12 is movably set relative to the first clamping arm 11, which facilitates the installation of the target sample 10 and is also applicable to the clamping requirements of different types of target samples 10, thereby improving the versatility of the preparation device.

[0115] In one alternative implementation, such as Figure 14 As shown, the clamping assembly 1 also includes a clamping base 13, a clearance hole, a connecting rod 14, and a fastener 15. A first clamping arm 11 and a second clamping arm 12 are disposed on the clamping base 13. The clearance hole is formed in the second clamping arm 12. The connecting rod 14 passes through the clearance hole and connects to the first clamping arm 11. The fastener 15 is connected to the connecting rod 14 and is located on the side of the second clamping arm 12 opposite to the first clamping arm 11.

[0116] In this embodiment, the clamping assembly 1 further includes a clamping base 13, which is used to mount the first clamping arm 11 and the second clamping arm 12, thereby realizing the modular assembly of the clamping assembly 1. The first clamping arm 11 is fixedly mounted on the clamping base 13, and the second clamping arm 12 is movably mounted on the clamping base 13. The second clamping arm 12 is provided with a clearance hole, and the connecting rod 14 passes through the clearance hole and connects to the first clamping arm 11.

[0117] The target sample 10 is placed between the first clamping arm 11 and the second clamping arm 12. The second clamping arm 12 is moved to clamp the target sample 10 with the first clamping arm 11. Then, the position of the second clamping arm 12 and the target sample 10 is stabilized by tightening the fastener 15 located on the connecting rod 14.

[0118] The number of clearance holes, connecting rods 14, and fasteners 15 corresponds one-to-one. Optionally, the number of clearance holes, connecting rods 14, and fasteners 15 is two.

[0119] In one alternative implementation, such as Figure 1 , Figure 2 and Figure 15 As shown, the preparation device also includes multiple adjustment modules 7, which are respectively connected to multiple processing modules. When the processing module is in the processing position of the corresponding clamping component 1, the processing module is adjusted to align the processing module with the target sample 10 to be processed by the clamping component 1.

[0120] In this embodiment, the preparation apparatus further includes multiple adjustment modules 7, which are configured one-to-one with multiple processing modules. Each processing module is installed at the installation position via an adjustment module 7. When the processing module is at the processing station of the target sample 10, the adjustment module 7 can be used to adjust the alignment of the processing module with the processing position of the target sample 10.

[0121] It should be noted that for each target sample 10, the processing station refers to the station directly opposite the target sample 10. Through the relative movement between the processing module and the clamping assembly 1, the processing module is positioned at the processing station, so that the processing module can process the target sample 10.

[0122] Meanwhile, for each target sample 10, the processing position refers to the specific position where the target sample 10 needs to be processed. The processing module 7 can finely control the processing posture of the processing module, so that the processing module can be aligned with the processing position of the target sample 10 to achieve precise processing.

[0123] Specifically, the drilling module 2 is installed on the adjustment module 7. Under the action of the adjustment module 7, the drilling module 2 can move in the direction of approaching or moving away from the target sample 10, adjust the position of the drill bit 232, and align the drilling position and drilling depth of the target sample 10.

[0124] Specifically, the implantation module 3 is mounted on the adjustment module 7. Under the action of the adjustment module 7, the implantation module 3 can move in directions approaching and moving away from the target sample 10. Before implanting the microtube 36, the adjustment module 7 controls the implantation module 3 to move in the direction approaching the target sample 10, so that the positioning tube 35 of the implantation module 3 extends into the hole 101 of the target sample 10. Next, the delivery wheel 33 is controlled to rotate, so that the delivery wheel 33 drives the microtube 36 to move along the delivery channel 32, and is delivered to the hole 101 through the delivery port 321 and the positioning tube 35. Finally, the adjustment module 7 controls the implantation module 3 to move in the direction away from the target sample 10, so that the microtube 36 detaches from the implantation module 3, completing the implantation process.

[0125] Specifically, the dust removal module 4 is mounted on the adjustment module 7. Under the action of the adjustment module 7, the dust removal module 4 can move in directions towards and away from the target sample 10. During the dust removal process, the dust removal module 4 can move closer to the target sample 10, so that the air outlet duct 43 in the dust removal module 4 is close to the hole 101, thereby removing the residual dust in the hole 101. After the dust removal is completed, the dust removal module 4 can be moved away from the target sample 10.

[0126] Specifically, the curing module 5 is mounted on the adjustment module 7. Under the action of the adjustment module 7, the curing module 5 can move in directions towards and away from the target sample 10. During the curing process, the curing module 5 can move closer to the target sample 10, allowing the ultraviolet generator 51 in the curing module 5 to approach and align with the hole 101, thereby concentrating ultraviolet light to irradiate the curing medium between the hole wall of the hole 101 and the microtube 36, achieving rapid curing and quick fixation of the microtube 36. After curing, the curing module 5 can be moved away from the target sample 10 and slowly returned to its original position.

[0127] Specifically, the tube cutting module 6 is mounted on the adjustment module 7. Under the action of the adjustment module 7, the tube cutting module 6 can move in the direction of approaching or moving away from the target sample 10.

[0128] In one alternative implementation, such as Figure 15 As shown, the adjustment module 7 includes a connecting column 71 and a connecting seat 72. The connecting seat 72 is rotatably mounted on the connecting column 71 via a connecting shaft 73. The processing module is set on the connecting seat 72. The processing module can adjust the position of the target sample 10 held by the clamping assembly 1 by rotating the connecting seat 72.

[0129] In this embodiment, the adjustment module 7 includes a connecting post 71 and a connecting seat 72. The connecting seat 72 is rotatably connected to the connecting post 71, and the connecting post 71 is used to install at the desired position. The processing module is located on the connecting seat 72. When the connecting seat 72 rotates relative to the connecting post 71, the processing module can move closer to or further away from the target sample 10.

[0130] It is worth noting that the connector 72 has a structure adapted to the processing module. For example, the connector 72 has a connecting groove, in which a portion of any one of the drilling module 2, dust removal module 4, curing module 5, and pipe cutting module 6 is embedded. Alternatively, the connector 72 has a connecting surface, on which the mounting base 31 of the pipe insertion module 3 is located. It is conceivable that, in order to achieve the mating connection between the connector 72 and the processing module, the adapting structure provided on the connector 72 can also be of other forms, which are not limited in this application.

[0131] In one alternative implementation, such as Figure 15 As shown, the adjustment module 7 also includes a rotating groove 712, a first shaft hole 711, and a second shaft hole 721. The rotating groove 712 is located at one end of the connecting post 71, and a portion of the connecting seat 72 is located within the rotating groove 712. The first shaft hole 711 is located on opposite side walls of the connecting post 71 and communicates with the rotating groove 712. The second shaft hole 721 is located on the connecting seat 72, and the connecting shaft 73 passes through the second shaft hole 721 and the first shaft hole 711 respectively, so that the connecting seat 72 and the connecting post 71 are rotatably connected.

[0132] In this embodiment, the adjustment module 7 further includes a rotating groove 712, which is disposed at one end of the connecting post 71, and the other end of the connecting post 71 is used to install at the position to be installed. Specifically, the connecting post 71 includes a top end and a bottom end, the bottom end of the connecting post 71 is used to connect to the position to be installed, and the top end of the connecting post 71 is provided with the rotating groove 712.

[0133] A portion of the connecting seat 72 is located within the rotating groove 712. The connecting shaft 73 passes through the first shaft hole 711 on the connecting post 71 and the second shaft hole 721 on the connecting seat 72, respectively, achieving a rotatable connection between the connecting seat 72 and the connecting post 71. When the connecting seat 72 rotates around the connecting shaft 73, the processing module located on the connecting seat 72 also moves with the connecting seat 72. Specifically, when the connecting seat 72 rotates counterclockwise around the connecting shaft 73, the processing module located on the connecting seat 72 moves towards the target sample 10. When the connecting seat 72 rotates clockwise, the processing module moves away from the target sample 10.

[0134] In one alternative implementation, such as Figure 1 , Figure 2 and Figure 16 As shown, the preparation device also includes a locking component 8, which is used to restrict the relative movement between the processing module and the clamping component 1 when the processing module is in the processing position of the target sample 10.

[0135] In this embodiment, the preparation device also includes a locking component 8. When the processing module is in the processing station, the locking component 8 restricts the relative movement between the processing module and the clamping component 1, providing a stable processing environment for the processing module during the processing process and avoiding processing failure caused by the relative movement between the processing module and the target sample 10 during the processing process.

[0136] The locking component 8 includes a magnetic locking structure, a snap-locking structure, etc.

[0137] In one alternative implementation, such as Figure 16 As shown, the locking assembly 8 includes a first locking seat 81, a plurality of second locking seats 82, and a locking part 83. The first locking seat 81 is fixedly assembled with one of the processing modules or clamping assemblies 1. The plurality of second locking seats 82 are respectively fixedly assembled with the other of the processing modules or clamping assemblies 1. The locking part 83 is disposed on the first locking seat 81, and the locking part 83 is selectively connected to one of the plurality of second locking seats 82.

[0138] In this embodiment, the locking assembly 8 includes a first locking seat 81 having a locking portion 83 and a plurality of second locking seats 82. The first locking seat 81 is disposed on one of the processing module or the clamping assembly 1, and the plurality of second locking seats 82 are disposed on the other of the processing module or the clamping assembly 1.

[0139] When the processing module is at the processing station of the target sample 10, the locking part 83 selects one of the multiple second locking seats 82 for locking connection.

[0140] In one alternative implementation, such as Figure 16As shown, the second locking seat 82 includes a mating hole 821. The locking part 83 includes a locking pin, which is movable relative to the first locking seat 81. When in the locked position, the locking pin extends into the mating hole 821 to lock.

[0141] In this embodiment, each second locking seat 82 is provided with a mating hole 821, and the locking part 83 includes a locking pin, which can move relative to the first locking seat 81 to switch between the locking position and the unlocking position.

[0142] When the processing module is in the processing position, the locking pin is in the locked position and is inserted into the mating hole 821 of the second locking seat 82, thus stabilizing the position between the processing module and the clamping assembly 1. After the processing is completed, the locking pin returns to the unlocked position, that is, the locking pin exits from the mating hole 821 and returns to the first locking seat 81, at which point the position lock between the processing module and the clamping assembly 1 is released.

[0143] In one possible implementation, such as Figure 1 and Figure 2 As shown, the processing module and the clamping assembly 1 can rotate or move relative to each other.

[0144] In this embodiment, the processing module and the clamping assembly 1 can rotate relative to each other. For example, the clamping assembly 1 remains stationary while the processing module rotates around the clamping assembly 1. Alternatively, the clamping assembly 1 can rotate around the processing module.

[0145] In this embodiment, the processing module and the clamping component 1 can move relative to each other, that is, they can move linearly, for example, the processing module and the clamping component 1 can move in a straight line or a curve.

[0146] In one alternative implementation, such as Figure 1 and Figure 2 As shown, the preparation apparatus further includes a first base 91 and a second base 92, with one of the clamping assembly 1 and the processing assembly disposed on the first base 91. The other of the clamping assembly 1 and the processing assembly is disposed on the second base 92; the first base 91 and the second base 92 are capable of relative movement.

[0147] In this embodiment, mounting structures are provided for the clamping component 1 and the processing component respectively, which enables motion control of the clamping component 1 and the processing component. The structure is simple and easy to control. Specifically, when the first base 91 and the second base 92 can move relative to each other, the first base 91 and the second base 92 drive the clamping component 1 and the processing component to move relative to each other.

[0148] In one alternative implementation, the number of first base stations 91 is one or more, and the number of second base stations 92 is one or more.

[0149] In this embodiment, the number of clamping components 1 can be one or more. The processing component includes multiple processing modules. The number of first bases 91 and second bases 92 can be one or more, providing multiple options for the installation of clamping components 1 and multiple processing modules, so that the clamping components 1 and multiple processing modules can be arranged on an appropriate number of first bases 91 and second bases 92 according to actual production needs.

[0150] For example, multiple clamping components 1 are disposed on a first base 91, and multiple processing modules are disposed on multiple second bases 92. The multiple second bases 92 are capable of relative movement with respect to the first base 91.

[0151] In one alternative implementation, the second base 92 moves relative to the first base 91. That is, the first base 91 remains stationary, while the second base 92 moves relative to the first base 91.

[0152] For example, there may be one or more clamping components 1, which are set on the same or different first bases 91, and multiple processing modules are set on the same or different second bases 92. That is, the clamping components 1 are different, and multiple processing modules move.

[0153] For example, there may be one or more clamping components 1, which are set on the same or different second bases 92, and multiple processing modules are set on the same or different first bases 91. That is, multiple processing modules are stationary while clamping components 1 move.

[0154] In one alternative embodiment, the preparation apparatus further includes a support platform 94, on which a first base 91 and a second base 92 are disposed, forming an assembly space 93 between the first base 91 and the support platform 94. The second base 92 is disposed around the first base 91 and located within the assembly space 93.

[0155] In this embodiment, the support platform 94 is used to support the first base 91 and the second base 92. The first base 91 is disposed on the support platform 94, and an assembly space 93 is formed between the first base 91 and the support platform 94. The second base 92 is disposed around the first base 91 and can rotate relative to the first base 91 and the support platform 94, thereby realizing the relative movement between the clamping component 1 and the processing module.

[0156] In one alternative implementation, such as Figure 1 and Figure 2 As shown, the first base 91 is a circular platform and the second base 92 is an annular platform. The second base 92 can be fitted outside the first base 91 and rotate relative to the first base 91.

[0157] In this embodiment, the first base 91 is a circular platform, and the support platform 94 is disposed at the bottom of the circular platform to support it. The support platform 94 is provided with an annular groove 941, the diameter of which is larger than the diameter of the circular platform. A guide member 95 is provided inside the annular groove 941.

[0158] When the annular platform is fitted over the circular platform, the guide 95 is clamped between the annular platform and the support platform 94. The guide 95 can assist the annular platform to rotate relative to the circular platform, so that the annular platform can move stably and smoothly along the annular groove 941.

[0159] In one specific embodiment, multiple adjustment modules 7 are arranged on a ring-shaped platform, and multiple processing modules are connected to the top of the multiple adjustment modules 7. A first locking seat 81 is arranged on the ring-shaped platform. The multiple processing modules include a drilling module 2, a dust removal module 4, a tube insertion module 3, a curing module 5, and a tube cutting module 6, which are arranged at intervals around the ring-shaped platform.

[0160] Multiple clamping assemblies 1 are arranged on a circular platform. Multiple second locking seats 82 are arranged on the circular platform. It is worth noting that the clamping assemblies 1 and the second locking seats 82 are alternately arranged on the circular platform.

[0161] This application provides a method for preparing a positive control, implemented using the apparatus for preparing a positive control in any of the above embodiments. The preparation method includes: The target sample is held by the clamping components; Control the relative movement of the clamping assembly and the drilling module to position the drilling module at the processing station of the target sample; The target sample is perforated using a perforation module to create holes in the sample. Control the relative movement of the clamping assembly and the tube insertion module to position the tube insertion module at the processing station of the target sample; The target sample is treated with a tube implantation module to implant microtubes into the pores.

[0162] In the method for preparing the positive control provided in this application, the target sample is first fixed by a clamping assembly, and then the relative movement of the clamping assembly holding the target sample and the punching module is controlled so that the punching module is positioned at the processing station of the target sample. Simultaneously, locking between the first locking seat and the second locking seat can be achieved through the locking part on the first locking seat.

[0163] Next, the attitude of the drilling module is adjusted by the adjustment module, so that the drill head of the drilling module is aligned with the position to be processed on the target sample. The drilling module is then activated to form a hole at the position to be processed on the target sample. After the drilling process is completed, the locking part is released.

[0164] Then, the relative movement of the clamping assembly and the implantation module is controlled so that the implantation module is positioned at the processing station of the target sample. At this point, a hole has been formed at the processing location of the target sample. Simultaneously, locking between the first locking seat and the second locking seat can be achieved through the locking part on the first locking seat.

[0165] Next, the orientation of the implantation module is adjusted using the adjustment module to align the positioning tube of the implantation module with the hole in the target sample, and the position of the implantation module is adjusted so that the positioning tube extends into the hole. The delivery component in the implantation module is activated to transport the microtube within the delivery channel to the outlet of the positioning tube, i.e., the microtube is inserted into the hole. Then, the implantation module is adjusted again to move the implantation module away from the target sample, causing the microtube to detach from the implantation module, completing the implantation process. After the implantation process is complete, the locking mechanism is released.

[0166] The method for preparing positive controls provided in this application adjusts the position between the processing module and the target sample by controlling the relative movement of the clamping assembly and the processing module. When the processing module is at the processing station of the target sample, the target sample is then perforated and implanted using the punching module and the tube implantation module. This replaces some manual operations and completes the microtube implantation, effectively improving the preparation speed of positive controls and ensuring that the supply of positive controls can meet the detection requirements of leak detectors, thus avoiding impact on the drug production cycle. Implanting microtubes into the target sample using the tube implantation module significantly reduces the number of times the microtube tip breaks, thereby improving the success rate of positive control preparation.

[0167] In one optional embodiment, the preparation method further includes: Control the relative movement of the clamping assembly and the dust removal module so that the dust removal module is positioned at the processing station of the target sample; The dust removal module is used to remove dust from the target sample to remove residual dust from the pores.

[0168] In this embodiment, after the target sample is punched by the punching module, holes are formed on the target sample. Then, the dust removal module removes residual dust and spilled medicine from the holes, cleaning the holes of the target sample to avoid interfering with subsequent processing.

[0169] Specifically, the relative movement of the dust removal module and the clamping assembly is first controlled, positioning the dust removal module at the processing station of the target sample. Simultaneously, locking can be achieved between the first locking seat and the second locking seat via the locking part on the first locking seat.

[0170] Next, the adjustment module brings the dust removal module closer to the target sample, allowing the exhaust pipe within the dust removal module to approach the hole, thus removing residual dust from the hole. After dust removal is complete, the adjustment module moves the dust removal module away from the target sample. Finally, the locking mechanism is released after the dust removal process is finished.

[0171] In one optional embodiment, the preparation method further includes: Control the relative movement of the clamping components and the curing module so that the curing module is positioned at the processing station of the target sample; The target sample is cured using a curing module to solidify the microtubes within the pores.

[0172] In this embodiment, after the tube implantation process is completed, the target sample with microtubes is solidified. The solidification module and the clamping assembly move relative to each other, positioning the solidification module at the processing station of the target sample. Simultaneously, locking between the first locking seat and the second locking seat can be achieved through the locking part on the first locking seat.

[0173] Under the control of the adjustment module, the curing module can move towards the target sample. During the curing process, the curing module can move closer to the target sample, allowing the UV generator in the curing module to approach and align with the pores, thereby concentrating UV light to irradiate the curing medium between the pore walls and the microtubes, achieving rapid curing and quick fixation of the microtubes. After curing, the adjustment module moves the curing module away from the target sample, eventually slowly returning it to its original position, and then the locking mechanism is released.

[0174] In one preferred embodiment, the preparation method further includes: Control the relative movement of the clamping assembly and the tube cutting module so that the tube cutting module is positioned at the processing station of the target sample; The target sample is cut using a tube-cutting module to adjust the length of the microtubes after curing.

[0175] In this embodiment, after the curing process is completed, the cured microtubes are cut. The cutting module and the clamping assembly are moved relative to each other, positioning the cutting module at the processing station of the target sample. Simultaneously, locking between the first locking seat and the second locking seat can be achieved through the locking part on the first locking seat.

[0176] Under the action of the adjustment module, the cutting module is brought closer to the target sample. The cutting part in the cutting module is activated and contacts the remaining microtubes, thereby adjusting the cutting length. After the cutting process is completed, the adjustment module moves the cutting module away from the target sample, and then the locking part is released.

[0177] For the preparation of positive control samples, the process involves drilling, dust removal, tube insertion, curing, and tube cutting. After the tube cutting is completed, the target sample with microtubes can be removed from the clamping assembly and placed into the transport box.

[0178] In the description of this utility model, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0179] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. For those skilled in the art, the specific meaning of the above terms in this utility model can be understood according to the specific circumstances.

[0180] In this utility model, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "beneath" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0181] In the description of this specification, the terms "one embodiment," "some embodiments," "embodiment," "exemplary embodiment," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0182] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make modifications, alterations, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. An apparatus for preparing a positive control, characterized in that, include: Clamping assembly (1) for clamping target sample (10); The processing assembly includes multiple processing modules, each of which is movable relative to the clamping assembly (1). When a processing module is positioned at a processing station corresponding to the clamping assembly (1) on the target sample (10), the processing module processes the target sample (10); wherein, The plurality of processing modules include: The punching module (2) is capable of punching the target sample (10) to form holes (101) in the target sample (10). The tube implantation module (3) is capable of performing tube implantation on the target sample (10) to implant microtubes (36) into the hole (101).

2. The apparatus for preparing a positive control according to claim 1, characterized in that, The punching module (2) includes: First shell (21); The first drive unit (22) is connected to the first housing (21); The drill bit (23) is disposed on the drive end of the first drive unit (22), which can drive the drill bit (23) to rotate relative to the first housing (21) to form the hole (101) on the target sample (10).

3. The apparatus for preparing a positive control according to claim 1, characterized in that, The implantation module (3) includes: Mounting bracket (31); The delivery channel (32) is provided on the mounting base (31). The delivery channel (32) is used to deliver microtubes (36). When the implantation module (3) is in the processing position of the target sample (10), the delivery port (321) of the delivery channel (32) is opposite to the hole (101). A delivery assembly is provided on the mounting base (31) for transferring a microtube (36) located in the delivery channel (32) to the delivery port (321).

4. The apparatus for preparing a positive control according to claim 3, characterized in that, The pipeline channel (32) includes a pipeline groove (322) with a top opening; The conveying assembly includes a conveying wheel (33) whose wheel surface can contact the microtube (36). The conveying wheel (33) rotates relative to the mounting base (31) to drive the microtube (36) to move within the conveying groove (322).

5. The apparatus for preparing a positive control according to claim 4, characterized in that, The implantation module (3) includes: The fixed pressure plate (34) is movably disposed on the mounting base (31) and has a pressing position and a depressurized position. When it is in the pressing position, it is pressed onto the microtube (36) located in the delivery groove (322). When it is in the depressurized position, it is away from the delivery groove (322).

6. The apparatus for preparing a positive control according to claim 3, characterized in that, The implantation module (3) includes: A positioning tube (35) is provided on the mounting base (31). The positioning tube (35) is connected to the inlet (321). The microtube (36) moves through the inlet channel (32) and the positioning tube (35) into the hole (101).

7. The apparatus for preparing a positive control according to claim 6, characterized in that, Along the direction away from the pipeline channel (32), the inner diameter of the positioning tube (35) gradually decreases.

8. The apparatus for preparing a positive control according to claim 6, characterized in that, The positioning tube (35) includes: A pipe body (351) is disposed on the mounting base (31), and one end of the pipe body (351) is connected to the inlet (321); A flexible body (352) is disposed at the other end of the tube (351), and the flexible body (352) is able to contact the hole wall of the hole (101).

9. The apparatus for preparing a positive control according to claim 8, characterized in that, The flexible body (352) includes: Multiple positioning ribs (3521) are connected at intervals to the other end of the tube body (351), and the free ends of the positioning ribs (3521) can extend into the hole (101); The connecting ribs (3522) are connected to the plurality of positioning ribs (3521) and are located close to the tube body (351).

10. The apparatus for preparing a positive control according to claim 1, characterized in that, The processing module also includes: The dust removal module (4) is capable of performing dust removal treatment on the target sample (10) to remove residual dust inside the pores (101); and / or The curing module (5) is capable of curing the target sample (10) to solidify the microtube (36) within the pore (101); and / or The tube cutting module (6) can cut the target sample (10) to adjust the length of the microtube (36) after curing.

11. The apparatus for preparing a positive control according to claim 10, characterized in that, The dust removal module (4) includes: Second shell (41); The plasma generator (42) is connected to the second housing (41); An air outlet pipe (43) is connected to the plasma generator (42), and the air outlet pipe (43) can deliver the plasma wind generated by the plasma generator (42) to the hole (101) of the target sample (10).

12. The apparatus for preparing a positive control according to claim 10, characterized in that, The curing module (5) includes: The ultraviolet generator (51) has holes (101) in the target sample (10) located within the ultraviolet light range of the ultraviolet generator (51).

13. The apparatus for preparing a positive control according to claim 10, characterized in that, The tube cutting module (6) includes: Third shell (61); The second drive unit (62) is connected to the third housing (61); The cutting part (63) is disposed on the driving end of the second driving part (62). The second driving part (62) can drive the cutting part (63) to rotate to cut the microtube (36) after curing treatment.

14. The apparatus for preparing a positive control according to claim 13, characterized in that, The tube cutting module (6) also includes: Collection groove (64), the opening of which is located below the cutting part (63).

15. The apparatus for preparing a positive control according to claim 1, characterized in that, The clamping assembly (1) includes: First clamping arm (11); The second clamping arm (12) is movable relative to the first clamping arm (11) to clamp the target sample (10) between the first clamping arm (11) and the second clamping arm (12).

16. The apparatus for preparing a positive control according to claim 15, characterized in that, The clamping assembly (1) further includes: A clamping base (13) is provided with the first clamping arm (11) and the second clamping arm (12). A clearance hole is provided on the second clamping arm (12); The connecting rod (14) passes through the clearance hole and is connected to the first clamping arm (11); Fastener (15) is attached to the link (14) and located on the side of the second clamping arm (12) away from the first clamping arm (11).

17. The apparatus for preparing a positive control according to any one of claims 1 to 16, characterized in that, The preparation apparatus further includes: Multiple adjustment modules (7) are respectively connected to multiple processing modules, and are used to adjust the processing module to align the processing module with the target sample (10) held by the clamping component (1) when the processing module is in the processing position of the corresponding clamping component (1).

18. The apparatus for preparing a positive control according to claim 17, characterized in that, The adjustment module (7) includes: Connecting column (71); The connecting seat (72) is rotatably mounted on the connecting column (71) via the connecting shaft (73). The processing module is set on the connecting seat (72). The processing module can adjust the position of the target sample (10) held by the clamping assembly (1) by rotating the connecting seat (72).

19. The apparatus for preparing a positive control according to claim 18, characterized in that, The adjustment module (7) further includes: A rotating groove (712) is provided at one end of the connecting post (71), and a portion of the connecting seat (72) is located within the rotating groove (712); The first shaft hole (711) is provided on the opposite two side walls of the connecting column (71), and the first shaft hole (711) communicates with the rotating groove (712); The second shaft hole (721) is provided on the connecting seat (72), and the connecting shaft (73) passes through the second shaft hole (721) and the first shaft hole (711) respectively, so that the connecting seat (72) and the connecting post (71) can be rotatably connected.

20. The apparatus for preparing a positive control according to any one of claims 1 to 16, characterized in that, The preparation apparatus further includes: The locking component (8) is used to restrict the relative movement between the processing module and the clamping component (1) when the processing module is in the processing position of the target sample (10).

21. The apparatus for preparing a positive control according to claim 20, characterized in that, The locking assembly (8) includes: The first locking seat (81) is fixedly assembled with one of the processing module or the clamping assembly (1); Multiple second locking seats (82) are respectively assembled and fixed together with another of the processing module or the clamping assembly (1); A locking part (83) is disposed on the first locking seat (81), and the locking part (83) is selectively connected to one of the plurality of second locking seats (82).

22. The apparatus for preparing a positive control according to claim 21, characterized in that, The second locking seat (82) includes a mating hole (821); The locking part (83) includes a locking pin that is movable relative to the first locking seat (81). When in the locked position, the locking pin extends into the mating hole (821) for locking.

23. The apparatus for preparing a positive control according to any one of claims 1 to 16, characterized in that, The processing module and the clamping assembly (1) can rotate or move relative to each other.

24. The apparatus for preparing a positive control according to any one of claims 1 to 16, characterized in that, The preparation apparatus further includes: A first base (91) is provided on the first base (91), and one of the clamping assembly (1) and the processing assembly is disposed on the first base (91); The second base (92) is provided on the clamping assembly (1) and the other of the processing assembly; the first base (91) and the second base (92) are capable of relative movement.

25. The apparatus for preparing a positive control according to claim 24, characterized in that, The number of the first base station (91) is one or more, and the number of the second base station (92) is one or more.

26. The apparatus for preparing a positive control according to claim 25, characterized in that, The second base (92) moves relative to the first base (91); The number of clamping components (1) is one or more, and they are disposed on the same or different first bases (91), and the plurality of processing modules are disposed on the same or different second bases (92); or The number of clamping components (1) is one or more, and they are disposed on the same or different second bases (92). The multiple processing modules are disposed on the same or different first bases (91).

27. The apparatus for preparing a positive control according to claim 24, characterized in that, The preparation apparatus further includes: A support platform (94) is provided, with a first base (91) and a second base (92) disposed on the support platform (94), and an assembly space (93) is formed between the first base (91) and the support platform (94). The second base (92) is disposed around the first base (91) and located in the assembly space (93).

28. The apparatus for preparing a positive control according to claim 24, characterized in that, The first base (91) is a circular platform, and the second base (92) is an annular platform. The second base (92) can be fitted outside the first base (91) and rotate relative to the first base (91).

29. A planting tube module, characterized in that, It is used in the preparation of a positive control to implant a microtube into a hole (101) in the target sample (10), the implantation module (3) comprising: Mounting bracket (31); A delivery channel (32) is provided on the mounting base (31). The delivery channel (32) is used to deliver microtubes (36). The delivery port (321) of the delivery channel (32) is used to be opposite to the hole (101) on the target sample (10). A delivery assembly is provided on the mounting base (31) for transferring a microtube (36) located in the delivery channel (32) to the delivery port (321) and implanting it into a hole (101) on the target sample (10).

30. The implantation tube module according to claim 29, characterized in that, The pipeline channel (32) includes a pipeline groove (322) with a top opening; The conveying assembly includes a conveying wheel (33) whose wheel surface can contact the microtube (36). The conveying wheel (33) rotates relative to the mounting base (31) to drive the microtube (36) to move within the conveying groove (322).

31. The implantation tube module according to claim 30, characterized in that, The implantation module (3) includes: The fixed pressure plate (34) is movably disposed on the mounting base (31) and has a pressing position and a depressurized position. When it is in the pressing position, it is pressed onto the microtube (36) located in the delivery groove (322). When it is in the depressurized position, it is away from the delivery groove (322).

32. The implantation tube module according to claim 29, characterized in that, The implantation module (3) includes: A positioning tube (35) is provided on the mounting base (31). The positioning tube (35) is connected to the inlet (321). The microtube (36) moves through the inlet channel (32) and the positioning tube (35) into the hole (101).

33. The implantation module according to claim 32, characterized in that, Along the direction away from the pipeline channel (32), the inner diameter of the positioning tube (35) gradually decreases.

34. The implantation tube module according to claim 32, characterized in that, The positioning tube (35) includes: A pipe body (351) is disposed on the mounting base (31), and one end of the pipe body (351) is connected to the inlet (321); A flexible body (352) is disposed at the other end of the tube (351), and the flexible body (352) is able to contact the hole wall of the hole (101).

35. The implantation tube module according to claim 34, characterized in that, The flexible body (352) includes: Multiple positioning ribs (3521) are connected at intervals to the other end of the tube body (351), and the free ends of the positioning ribs (3521) can extend into the hole (101); The connecting ribs (3522) are connected to the plurality of positioning ribs (3521) and are located close to the tube body (351).

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