Liquid chromatography tandem mass spectrometer sample plate

Abstract

The utility model relates to chemical detection equipment technical field, concretely relates to a liquid chromatography tandem mass spectrometer sample plate, including bottom plate and cover plate, the bottom plate is compatible with cover plate, its characterized in that, the bottom plate all uniformly has a plurality of sample injection holes, the bottom of sample injection hole is provided with adjustable piston device, the both sides of bottom plate are provided with recess, the cover plate is same with bottom plate size, the cover plate all is provided with silica gel gasket on each sample injection hole, the both sides of cover plate are provided with convex, the convex corresponds with recess, and the surface of convex and recess is provided with magnetic strip. The utility model adopts magnetic attraction type sealing structure to combine independent silica gel gasket, effectively prevents sample volatilization and cross contamination, and magnetic sealing structure is not easy to wear, and through adjustable piston device can adapt to the sample injection demand of different properties or different volume sample.

Description

Technical Field

[0001] This utility model relates to the field of chemical detection equipment technology, specifically to a sample injection plate for a liquid chromatography-tandem mass spectrometer. Background Technology

[0002] In chemical detection, liquid chromatography-tandem mass spectrometry (LC-MS / MS) is a commonly used and important detection device, and the sample plate, as a key supporting component, plays a crucial role in the accuracy of the detection results. Existing sample plates have several technical shortcomings. For example, patent CN217278119U describes a sample plate for LC or LC-MS / MS, comprising a sample plate body and a top cap. The sample plate body has several injection holes for holding a certain volume of liquid reagent. A sealing ring is provided on the outer top of each injection hole. The sample plate body and the top cap are connected by a snap-fit ​​connection, and a matching sealing cap is provided on the lower surface of the top cap corresponding to the position of the sealing ring. This utility model, by setting up the sample plate body, top cap, and sealing ring, can achieve sealed preservation of the sample plate body containing liquid, preventing liquid evaporation and avoiding potential aerosol risks. By setting the sealing ring and sealing cap, it can seal the reagent contained in the injection holes, preventing liquid spillage due to shaking, and improving safety during use.

[0003] However, during use, it was found that although the sample plate has a sealing design, the sealing structure is prone to wear, which leads to a decrease in sealing performance and cannot effectively prevent liquid evaporation and cross-contamination, affecting the accuracy of the test results. Moreover, the sample inlet structure is simple and cannot meet the sample introduction requirements of samples with different properties and volumes. Utility Model Content

[0004] The technical problem to be solved by this utility model is to provide a sample injection plate for liquid chromatography-tandem mass spectrometry, so as to solve the problems of unstable sealing performance, poor adaptability of injection holes and inconvenience of operation of the sample injection plate under the existing technology.

[0005] To solve the above-mentioned technical problems, an embodiment of the present invention provides a liquid chromatography-tandem mass spectrometry sample injection plate, including a base plate and a cover plate. The base plate and the cover plate are adapted to each other. A plurality of sample injection holes are evenly opened on the base plate. An adjustable piston device is provided at the bottom of the sample injection hole. Grooves are provided on both the upper and lower sides of the base plate. The cover plate is the same size as the base plate. Each sample inlet hole on the cover plate is provided with a silicone sealing gasket. The upper and lower sides of the cover plate are provided with protrusions, which correspond to grooves. Magnetic strips are provided on the surfaces of the protrusions and grooves.

[0006] The adjustable piston device includes a piston, an adjusting screw, and an adjusting knob. The piston is movably disposed within the injection port. An adjusting screw is disposed at the bottom of the piston. The adjusting screw passes through the injection port and is threadedly connected to the adjusting knob. Rotating the adjusting knob drives the adjusting screw to rotate, thereby causing the piston to slide up and down within the injection port.

[0007] The piston is slightly smaller than the diameter of the injection port.

[0008] The top edge of the injection port is set as an elastic edge, which is a silicone sleeve and corresponds to the silicone sealing gasket.

[0009] Each of the four corners of the base plate is provided with a foot pad.

[0010] The top of the cover plate is provided with a sample information recording area.

[0011] Both the base plate and the cover plate are made of polypropylene (PP) material.

[0012] The beneficial effects of the above-mentioned technical solution of this utility model are as follows: This invention employs a magnetic sealing structure combined with an independent silicone sealing gasket, effectively preventing sample evaporation and cross-contamination. The magnetic sealing structure is not easily worn, ensuring stable and reliable sealing performance and guaranteeing the accuracy of test results. Furthermore, the adjustable piston device can adapt to the sample injection requirements of samples with different properties or volumes. Additionally, an elastic edge is provided at the edge of the injection port to reduce the risk of pipette operation errors leading to off-center dripping or overfilling and overflow, which could contaminate adjacent injection ports. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 This is a schematic diagram of the structure of the bottom plate in this utility model; Figure 3 This is a schematic diagram of the cover plate in this utility model; Figure 4 This is a schematic diagram of the cross-sectional structure of the bottom plate in this utility model.

[0014] Explanation of reference numerals in the attached figures: 1. Base plate; 2. Cover plate; 3. Sample inlet; 4. Adjustable piston device; 41. Piston; 42. Adjusting screw; 43. Adjusting knob; 5. Protrusion; 6. Groove; 7. Magnetic strip; 8. Sample information recording area; 9. Elastic edge; 10. Silicone sealing gasket; 11. Foot pad. Detailed Implementation

[0015] To make the technical problems, technical solutions and advantages of this utility model clearer, a detailed description will be given below in conjunction with the accompanying drawings and specific embodiments.

[0016] This utility model provides a sample injection plate for a liquid chromatography-tandem mass spectrometer, including a base plate 1 and a cover plate 2. The base plate 1 and the cover plate 2 are adapted to each other. A plurality of sample injection holes 3 are evenly opened on the base plate 1. An adjustable piston device 4 is provided at the bottom of the sample injection hole 3. Grooves 6 are provided on the upper and lower sides of the base plate 1. A foot pad 11 is provided at each of the four corners of the base plate 1. The height of the foot pad 11 is slightly greater than the height of the adjustable piston device 4, so that the sample injection plate can be placed horizontally inside the liquid chromatography-tandem mass spectrometer.

[0017] The adjustable piston device 4 includes a piston 41, an adjusting screw 42, and an adjusting knob 43. The piston 41 is movably disposed within the sample inlet 3, and the size of the piston 41 is slightly smaller than the diameter of the sample inlet 3. The adjusting screw 42 is disposed at the bottom of the piston 41, and the adjusting screw 42 passes through the sample inlet 3 and is threadedly connected to the adjusting knob 43. By rotating the adjusting knob 43, the adjusting screw 42 is rotated, thereby causing the piston 41 to slide up and down within the sample inlet 3, thus adapting to the sample injection requirements of samples with different properties or volumes.

[0018] The cover plate 2 is the same size as the base plate 1. A silicone sealing gasket 10 is provided on each sample inlet 3 of the cover plate 2. Protrusions 5 are provided on the upper and lower sides of the cover plate 2, corresponding to grooves 6. Magnetic strips 7 are provided on the surfaces of the protrusions 5 and grooves 6. Through the concave-convex structure and the magnetic strips 7, the cover plate 2 and the base plate 1 are sealed together, which is more convenient to operate and less prone to wear than a snap-on design. Both the base plate 1 and the cover plate 2 are made of polypropylene (PP) material. Handles can also be provided on both sides of the base plate 1 and the cover plate 2 for easy removal of the sample inlet plate.

[0019] The top of the cover plate 2 is provided with a sample information recording area 8, which can be used to record relevant sample information with a marker. When it is necessary to update or change the information, the original record can be erased with an eraser and rewritten, which is convenient and quick.

[0020] The top edge of the injection port 3 is set as an elastic edge 9. In this embodiment, the elastic edge 9 is a silicone sleeve. The elastic edge 9 corresponds to the silicone sealing gasket 10. When the pipette tip is inserted, the elastic edge 9 can adaptively expand or contract according to the diameter of the pipette tip, closely fitting the pipette tip, reducing the risk of sample residue and cross-contamination, and improving the accuracy of injection. When the injection is completed and sealed, the elastic edge 9 can also achieve a sealing effect with the silicone sealing gasket 10, effectively preventing sample volatilization and cross-contamination.

[0021] The working principle of this utility model is as follows: During sample injection, the experimenter rotates the adjustment knob 43 at the bottom of the base plate 1 according to the required sample volume. By adjusting the knob 43, the height of the piston 41 is adjusted, thereby adjusting the depth of the injection port 3. After the pipette draws an appropriate amount of the liquid to be tested, it is inserted into the injection port 3. At this time, the elastic edge 9 set at the edge of the injection port will fit tightly against the tip of the pipette, ensuring that the liquid to be tested enters the injection port accurately and reducing sample residue.

[0022] After sample injection, the experimenter places the cover plate 2 over the base plate 1. The magnetic strips 7 on the upper and lower sides of the cover plate 2, along with its convex-concave structure, seal the cover plate 2 and base plate 1 together. Simultaneously, the silicone sealing gasket 10 above each injection hole 3 and the elastic edge 9 along the edge of the injection hole 3 further enhance the sealing effect, effectively preventing sample evaporation and cross-contamination. If long-term sample preservation is required, this sealing structure ensures sample stability over a longer period, without affecting subsequent test results. During sample injection and sealing, the experimenter can record relevant sample information using a marker in the sample information recording area 8 on one side of the injection plate. When updating or changing information is needed, the original record can be erased and rewritten, making the process convenient and quick.

[0023] The above description is the preferred embodiment of this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of this utility model, and these improvements and modifications should also be considered within the protection scope of this utility model.

Claims

1. A sample injection plate for a liquid chromatography-tandem mass spectrometry (LC-MS / MS) instrument, comprising a base plate and a cover plate, wherein the base plate and the cover plate are adapted to each other, characterized in that, The base plate is provided with a plurality of sample inlet holes evenly distributed, and an adjustable piston device is provided at the bottom of the sample inlet holes. The upper and lower sides of the base plate are provided with grooves. The cover plate is the same size as the base plate. Each sample inlet of the cover plate is provided with a silicone sealing gasket. The upper and lower sides of the cover plate are provided with protrusions, which correspond to grooves. Magnetic strips are provided on the surfaces of the protrusions and grooves.

2. The liquid chromatography-tandem mass spectrometry sample introduction plate according to claim 1, characterized in that, The adjustable piston device includes a piston, an adjusting screw, and an adjusting knob. The piston is movably disposed within the injection port. An adjusting screw is disposed at the bottom of the piston. The adjusting screw passes through the injection port and is threadedly connected to the adjusting knob. By rotating the adjusting knob, the adjusting screw is driven to rotate, causing the piston to slide up and down within the injection port.

3. The liquid chromatography-tandem mass spectrometry sample introduction plate according to claim 2, characterized in that, The piston is slightly smaller than the diameter of the injection port.

4. The liquid chromatography-tandem mass spectrometry sample introduction plate according to claim 1, characterized in that, The top edge of the injection port is set as an elastic edge, which is a silicone sleeve, and the elastic edge corresponds to the silicone sealing gasket.

5. The liquid chromatography-tandem mass spectrometry sample introduction plate according to claim 1, characterized in that, Each of the four corners of the base plate is provided with a foot pad.

6. The liquid chromatography-tandem mass spectrometry sample introduction plate according to claim 1, characterized in that, The top of the cover plate is provided with a sample information recording area.

7. The liquid chromatography-tandem mass spectrometry sample introduction plate according to claim 1, characterized in that, Both the base plate and the cover plate are made of polypropylene (PP) material.

Images