Chemiluminescent immunoassay instrument's magnetic particle support structure

Abstract

The utility model discloses a magnetic particle support structure of chemiluminescence immunoassay appearance, including reagent support, the reagent support places reagent bottle on, one side of reagent support is equipped with the support part fixedly, the support part below is equipped with the support part fixedly, the upper surface of support part is equipped with the locating column fixedly, the support part in places magnetic particle reagent bottle, through the conical bottom with the magnetic particle gathering in the bottom center, the residual quantity reduces, and the reagent utilization rate promotes, and the magnetic particle dispersion homogeneity improves, and the batch precision CV value is lower, and the accurate detection of low concentration marker is guaranteed, and the magnetic particle agglomeration block is reduced, and the failure rate of sample adding needle is reduced.

Description

Technical Field

[0001] This utility model relates to the field of magnetic microparticle chemiluminescence immunoassay technology, specifically to the magnetic microparticle support structure of a chemiluminescence immunoassay analyzer. Background Technology

[0002] Magnetic microparticle chemiluminescence immunoassay is widely used in the detection of tumor markers (such as AFP and CA19-9) and neurodegenerative disease markers (such as Aβ1-42) due to its high sensitivity and high degree of automation. In existing technologies, magnetic microparticle reagents are typically stored in cylindrical flat-bottomed or round-bottomed reagent bottles, mixed by instrument shaking, and then aspirated by a sampling needle. However, this design has significant drawbacks: magnetic microparticle sedimentation and aggregation: due to their high density and surface energy, magnetic microparticles tend to aggregate at the center of the bottle bottom, forming difficult-to-disperse clumps, leading to uneven sampling; residue and waste: the flat / round-bottom structure results in a large dispersion area for the magnetic microparticles, making it difficult for the sampling needle to completely aspirate the magnetic microparticles at the bottom edge and corners of the bottle, resulting in a residue of 15%–20%, causing reagent waste; low mixing efficiency: the liquid eddy shear force inside traditional cylindrical bottles is insufficient, requiring extended shaking time or increased frequency, increasing instrument noise and energy consumption; insufficient sealing: the porous rubber cap easily leads to reagent evaporation and spillage, affecting detection accuracy. Utility Model Content

[0003] The purpose of this invention is to provide a magnetic microparticle scaffold structure for a chemiluminescence immunoassay analyzer to solve the problems mentioned in the background art.

[0004] To achieve the above objectives, this utility model provides the following technical solution: a magnetic microparticle support structure for a chemiluminescence immunoassay analyzer, including a reagent support, on which a reagent bottle is placed, a support portion is fixedly provided on one side of the reagent support, a supporting portion is fixedly provided below the support portion, a positioning post is fixedly provided on the upper surface of the supporting portion, and a magnetic microparticle reagent bottle is placed inside the support portion.

[0005] Preferably, the magnetic particle reagent bottle includes a bottle body, a transmission part is provided at the bottom of the bottle body, a conical bottom is provided inside the bottle body, and a spiral protrusion is provided on the inner wall of the bottle body.

[0006] Preferably, magnetic microparticles are added to the magnetic microparticle reagent bottle, and the magnetic microparticle reagent bottle is made of hydrophobic transparent organic plastic.

[0007] Preferably, a fixing groove is provided on the bottom surface of the bottle body, and a positioning post is inserted into the fixing groove.

[0008] Compared with the prior art, the beneficial effects of this utility model are: by gathering magnetic particles at the bottom center through the conical bottom, the residual amount is reduced, the reagent utilization rate is improved, the uniformity of magnetic particle dispersion is improved, the intra-batch precision CV value is lower, the accurate detection of low concentration markers is guaranteed, the aggregation and blockage of magnetic particles is reduced, and the failure rate of the sample dispensing needle is reduced. Attached Figure Description

[0009] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a schematic diagram of the reagent holder structure of this utility model; Figure 3 This is a schematic diagram of the magnetic particle reagent bottle structure of this utility model; Figure 4 This is a schematic diagram of the interior of the magnetic particle reagent bottle of this utility model.

[0010] In the diagram: 1. Reagent holder; 2. Reagent bottle; 3. Support; 4. Supporting part; 5. Magnetic particle reagent bottle; 51. Bottle body; 52. Transmission part; 53. Conical bottom; 6. Positioning post. Detailed Implementation

[0011] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the scope of protection of the present utility model.

[0012] Please refer to 1-4. One embodiment of this utility model is a magnetic microparticle support structure for a chemiluminescence immunoassay analyzer, including a reagent support 1, a reagent bottle 2 placed on the reagent support 1, a support part 3 fixedly provided on one side of the reagent support 1, a support part 4 fixedly provided below the support part 3, a positioning post 6 fixedly provided on the upper surface of the support part 4, a magnetic microparticle reagent bottle 5 placed inside the support part 3, and magnetic microparticles are placed into the magnetic microparticle reagent bottle 5. The internal structure of the magnetic microparticle reagent bottle 5 guides the liquid to form a vortex, ensuring that the magnetic microparticles do not clump together.

[0013] The magnetic particle reagent bottle 5 includes a bottle body 51, a transmission part 52 at the bottom of the bottle body 51, a conical bottom 53 inside the bottle body 51, and spiral protrusions on the inner wall of the bottle body 51. The magnetic particles enter the conical bottom 53 inside the bottle body 51, reducing the area on which the magnetic particles scatter inside the bottle body 51, thus preventing the sampling needle from drawing up the magnetic particles. When the liquid enters the bottle body 51, the transmission part 52 can drive the bottle body 51 to rotate. During the rotation, the spiral protrusions will drive the internal liquid and magnetic particles to rotate, forming a vortex. The transmission part 52 can be connected to an external drive source to achieve drive.

[0014] Magnetic microparticles are added to the magnetic microparticle reagent bottle 5. The magnetic microparticle reagent bottle 5 is made of hydrophobic transparent organic plastic, which can reduce adsorption and allow the internal liquid to be observed.

[0015] A fixing groove is provided on the bottom surface of the bottle body 51, and a positioning post 6 is inserted into the fixing groove. The transmission part 52 drives the bottle body 51 to rotate on the support part 3, so that the internal liquid rotates and forms a vortex.

[0016] Working principle: When in use, place reagent bottle 2 and magnetic particle reagent bottle 5 in their respective positions, place magnetic particle reagent bottle 5 on support part 3, and use transmission part 52 to drive magnetic particle reagent bottle 5 to rotate. During the rotation, the liquid and magnetic particles are affected by the spiral protrusion and conical bottom 53 to form eddies, which effectively prevents magnetic particles from clumping. After the liquid stops, the magnetic particles gather at the conical bottom 53, thus reducing the probability of the sampling needle picking up magnetic particles.

Claims

1. A magnetic particle support structure for a chemiluminescent immunoassay instrument comprising a reagent support (1), characterized in that: A reagent bottle (2) is placed on the reagent holder (1). A support part (3) is fixedly provided on one side of the reagent holder (1). A support part (4) is fixedly provided below the support part (3). A positioning post (6) is fixedly provided on the upper surface of the support part (4). A magnetic particle reagent bottle (5) is placed inside the support part (3).

2. The magnetic microparticle holder structure of a chemiluminescent immunoassay analyzer according to claim 1, characterized by: The magnetic particle reagent bottle (5) includes a bottle body (51), a transmission part (52) is provided at the bottom of the bottle body (51), a conical bottom (53) is provided inside the bottle body (51), and a spiral protrusion is provided on the inner wall of the bottle body (51).

3. The magnetic microparticle holder structure of a chemiluminescent immunoassay analyzer according to claim 1, wherein: Magnetic microparticles are added to the magnetic microparticle reagent bottle (5), which is made of hydrophobic transparent organic plastic.

4. The magnetic microparticle holder structure of a chemiluminescent immunoassay analyzer according to claim 2, wherein: The bottom surface of the bottle body (51) is provided with a fixing groove, and the fixing groove is connected to a positioning post (6).

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