Detection consumables and detection apparatus

Abstract

The utility model belongs to medical instrument technical field and provide a kind of detection consumables and detection equipment, and detection consumables include sample tube, reaction tube, isolating component and piston assembly.Sample tube includes outlet pipe section, the inner wall of outlet pipe section is equipped with thread, reaction tube is screwed in outlet pipe section, isolating component is used to isolate outlet pipe section and reaction tube, piston assembly is arranged in sample tube and includes piston rod and puncture head, puncture head is arranged in the end of piston rod and is used to puncture isolating component, wherein, reaction tube is equipped with deformation structure between outlet pipe section, deformation structure is used to be extruded and occur elastic deformation when reaction tube is screwed in and reaches set depth.When reaction tube is installed on the outlet pipe section of sample tube and the depth of screw reaches set depth, deformation structure will be extruded and occur elastic deformation, and the elastic deformation of deformation structure constructs a elastic sealing interface for the connecting fit between reaction tube and outlet pipe section.

Description

Technical Field

[0001] This utility model belongs to the field of medical device technology, specifically relating to a testing consumable and testing equipment. Background Technology

[0002] In medical testing, before nucleic acid extraction or PCR amplification of samples such as sputum and blood, pretreatment with a processing solution is often required in test tubes, followed by transfer of the mixture using a pipette. This process is cumbersome, and opening the tube can easily lead to aerosol contamination. To simplify the process and reduce risks, integrated consumables have emerged. These devices typically integrate the sample tube and reaction tube into one unit, separated by a sealed diaphragm. The diaphragm is punctured through specific steps to achieve liquid contact and transfer, effectively reducing the need for opening the tubes.

[0003] Currently, sample tubes and reaction tubes are generally connected by a detachable connection, but due to the lack of a reliable sealing design, this connection method is prone to reagent leakage. Utility Model Content

[0004] In view of the above-mentioned defects or deficiencies, this utility model provides a testing consumable and testing equipment, which aims to solve the technical problem that reagent leakage is prone to occur between the sample tube and the reaction tube in existing testing consumable tubes.

[0005] To achieve the above objectives, this utility model provides a testing consumable, which includes a sample tube, a reaction tube, an isolation component, and a piston assembly. The sample tube includes an outlet section with threads on its inner wall. The reaction tube is threaded into the outlet section. The isolation component isolates the outlet section from the reaction tube. The piston assembly is disposed within the sample tube and includes a piston rod and a piercing head. The piercing head is located at the end of the piston rod and is used to pierce the isolation component. A deformation structure is provided between the reaction tube and the outlet section. This deformation structure is designed to be compressed and elastically deformed when the reaction tube is screwed into a predetermined depth.

[0006] In this embodiment, a limiting step is formed on the inner wall of the outlet pipe section. The limiting step is used to limit the maximum spiral depth of the reaction tube, and the deformation structure is set on the limiting step.

[0007] In this embodiment, the deformable structure is an annular thin wall fixedly connected to the limiting step. The annular thin wall and the inner peripheral wall of the outlet pipe section are radially spaced to form an annular embedding groove. The annular embedding groove is used for the pipe wall at the inlet of the reaction tube to be nested and inserted when the reaction tube is screwed into the set depth. When the reaction tube is inserted into the annular embedding groove, the annular thin wall is interference-fitted with the pipe wall at the inlet of the reaction tube and undergoes elastic deformation.

[0008] In this embodiment, the outer wall of the annular thin wall is an interference fit surface, which is set facing the inner peripheral wall of the outlet pipe section. From the end near the outlet end of the sample tube to the end away from the outlet end of the sample tube, the interference fit surface is inclined towards the inner peripheral wall of the outlet pipe section.

[0009] In this embodiment, the inner wall of the nested tube segment is a conical inner wall. The conical inner wall is used to embed into the annular embedding groove and contact the annular thin wall when the reaction tube is screwed into a set depth. The diameter of the end of the conical inner wall near the inlet of the reaction tube is larger than the diameter of the end of the conical inner wall away from the inlet of the reaction tube.

[0010] In this embodiment, the deformable structure is an elastic sealing ring installed on the limiting step. The elastic sealing ring is used to elastically hold the reaction tube between the reaction tube and the limiting step when the reaction tube is screwed to a set depth.

[0011] In this embodiment, the outlet pipe section includes an annular thin wall disposed on a limiting step. The annular thin wall and the inner peripheral wall of the outlet pipe section are radially spaced to form an annular embedding groove. The annular embedding groove is used for the pipe wall at the inlet of the reaction pipe to be nested and inserted when the reaction pipe is screwed to a set depth. An elastic sealing ring is installed in the annular embedding groove.

[0012] In this embodiment, the reaction tube includes a threaded connection tube section and a solution reaction tube section connected in sequence. The threaded connection tube section is used to screw into the outlet tube section, and the outer wall of the solution reaction tube section is provided with a tightening force-assisting structure.

[0013] In this embodiment, the sample tube also includes a base connecting part, which is spaced apart on the periphery of the outlet tube section; the testing consumables also include a tube base, which is detachably connected to the base connecting part, and the reaction tube is disposed inside the tube base and threadedly connected to the outlet tube section.

[0014] To achieve the above objectives, this utility model also provides a testing device, wherein the testing device includes the testing consumables described above.

[0015] Through the above technical solution, the testing consumables provided in this utility model embodiment have the following beneficial effects: When the reaction tube is installed on the outlet section of the sample tube and screwed in to the set depth, the deformable structure is squeezed and undergoes elastic deformation. The elastically deformed structure can increase the contact stress with the reaction tube or outlet section and can adaptively fill the assembly gap between the sample tube and the outlet section to a certain extent, thereby creating an elastic sealing interface at the connection between the reaction tube and the outlet section. Through the elastic sealing interface, the leakage of reagents from the connection between the reaction tube and the outlet section can be fundamentally prevented.

[0016] Other features and advantages of this invention will be described in detail in the following detailed description section. Attached Figure Description

[0017] The accompanying drawings are provided to illustrate the present invention and form part of the specification. They are used together with the following detailed description to explain the present invention, but do not constitute a limitation thereof. In the drawings: Figure 1 This is a schematic diagram of the overall structure of the testing consumables in this embodiment; Figure 2 This is a schematic cross-sectional view of the detection consumables according to the first embodiment of this example; Figure 3 This is in this embodiment. Figure 2 Enlarged structural diagram at point A; Figure 4 This is a partial cross-sectional view of the testing consumables according to the first embodiment of this example; Figure 5 This is in this embodiment. Figure 4 Enlarged structural diagram at point B; Figure 6 This is a schematic cross-sectional view of the detection consumables according to the second embodiment of this example; Figure 7 This is in this embodiment. Figure 6 Enlarged structural diagram at point C; Figure 8 This is a schematic diagram of the overall structure of the reaction tube in this embodiment.

[0018] Explanation of reference numerals in the attached figures 1. Sample tube; 1a. Inlet end; 1b. Outlet end; 11. Outlet tube section; 111. Limiting step; 112. Annular thin wall; 113. Annular embedded groove; 114. Interference fit surface; 12. Base connection part; 2. Reaction tube; 2a. Conical inner wall; 21. Threaded connection tube section; 22. Solution reaction tube section; 23. Tightening force structure; 24. Nested tube section; 3. Isolation component; 4. Piston assembly; 41. Piston rod; 411. Adsorption hole; 412. Baffle; 42. Puncture head; 5. Elastic sealing ring; 6. Sealing component; 7. Tube base; 8. Cap. Detailed Implementation

[0019] The specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are for illustration and explanation only and are not intended to limit the scope of this utility model.

[0020] The testing consumables of this utility model are described below with reference to the accompanying drawings.

[0021] This utility model discloses a testing consumable, such as Figure 1 , Figure 2 and Figure 6 As shown, the testing consumables include a sample tube 1, a reaction tube 2, an isolation component 3, and a piston assembly 4.

[0022] The sample tube 1 has an inlet end 1a at one end and an outlet end 1b at the other end. The sample tube 1 is used to contain a first reagent, which can be a sample solution or a mixed reagent of the sample and a pretreatment solution. The sample tube 1 includes an outlet tube section 11 located near the outlet end 1b, and the inner wall of the outlet tube section 11 is threaded.

[0023] The reaction tube 2 is threaded onto the outlet tube section 11, and the reaction tube 2 is used to contain the second reagent.

[0024] The isolation component 3 is used to isolate the outlet pipe section 11 from the reaction pipe 2.

[0025] Piston assembly 4, disposed within sample tube 1, includes piston rod 41 and piercing head 42. Piercing head 42 is disposed at the end of piston rod 41 and is used to pierce isolation component 3. When piston rod 41 drives piercing head 42 toward isolation component 3, piercing head 42 pierces isolation component 3. After isolation component 3 is pierced, the first reagent flows from outlet tube section 11 into reaction tube 2.

[0026] Among them, a deformation structure is provided between the reaction tube 2 and the outlet tube section 11. The deformation structure is used to be squeezed and elastically deformed when the reaction tube 2 is rotated to a set depth.

[0027] When the reaction tube 2 is installed on the outlet section 11 of the sample tube 1 and the screw-in depth reaches the set depth, the deformable structure will be squeezed and undergo elastic deformation. The elastically deformed structure can increase the contact stress with the reaction tube 2 or the outlet section 11, and can adaptively fill the assembly gap between the sample tube 1 and the outlet section 11 to a certain extent, thereby creating an elastic sealing interface at the connection between the reaction tube 2 and the outlet section 11. Through the elastic sealing interface, the leakage of reagents from the connection between the reaction tube 2 and the outlet section 11 can be fundamentally prevented.

[0028] like Figure 2 and Figure 6As shown, in this embodiment, to facilitate smooth contact and compression of the deformation structure when the sample tube 1 reaches the set depth, a limiting step 111 can be provided on the inner wall of the outlet tube section 11, and the deformation structure can be disposed on the limiting step 111. The limiting step 111 can limit the maximum spiral depth of the reaction tube 2. When the spiral depth of the reaction tube 2 reaches the set depth, the port of the reaction tube 2 will contact and compress the deformation structure on the limiting step 111, thereby forming an elastic sealing interface between the deformation structure and the reaction tube 2 at the limiting step 111.

[0029] In this embodiment, the deformation structure can be an elastic structure fixedly installed on the inner peripheral wall of the outlet pipe section 11, or it can be a detachable elastic element detachably installed on the inner wall of the outlet pipe section 11.

[0030] Taking the deformation structure fixedly installed on the inner circumferential wall of the outlet pipe section 11 as an example, such as Figures 2-3 ,as well as Figures 4-5 As shown, the deformable structure can be an annular thin wall 112 fixedly connected to the limiting step 111. The annular thin wall 112 is disposed on the side of the limiting step 111 facing the outlet end 1b of the sample tube 1, and the annular thin wall 112 and the inner peripheral wall of the outlet tube section 11 are radially spaced to form an annular embedding groove 113. The reaction tube 2 includes a nested tube section 24 located at the inlet. The nested tube section 24 is used to insert into the annular embedding groove 113 and to have an interference fit with the annular thin wall 112 when the reaction tube 2 is screwed into a set depth.

[0031] When the reaction tube 2 is screwed into the set depth, the nested tube section 24 will extend into the annular embedding groove 113. Since the nested tube section 24 is press-fitted with the annular thin wall 112, the inner wall of the nested tube section 24 will be in close contact with the annular thin wall 112 and form an annular, close-contact elastic sealing interface. The elastic sealing interface can effectively prevent reagent leakage.

[0032] Furthermore, such as Figure 2 , Figure 3 and Figure 5 As shown, the outer wall of the annular thin wall 112 is an interference fit surface 114. The interference fit surface 114 is set facing the inner peripheral wall of the outlet pipe section 11. From the end near the outlet end 1b of the sample tube 1 to the end away from the outlet end 1b of the sample tube 1, the interference fit surface 114 is inclined towards the inner peripheral wall of the outlet pipe section 11. That is, the cross-section of the annular embedded groove 113 is a trapezoidal structure groove with a wide opening and a narrow bottom. By setting the annular thin wall 112 at an inclination, it can be ensured that the reaction tube 2 contacts and squeezes the annular thin wall 112 when it is screwed in. The deeper the reaction tube 2 is screwed in, the greater the squeezing force of the reaction tube 2 on the annular thin wall 112 will be, and the better the sealing effect will be.

[0033] like Figure 4, Figure 5 and Figure 8 As shown, in this embodiment, the inner wall of the nested tube segment 24 can also be configured as a conical inner wall 2a. The conical inner wall 2a is used to embed into the annular embedding groove 113 and contact the annular thin wall 112 when the reaction tube 2 is screwed to a set depth. The diameter of the end of the conical inner wall 2a near the inlet of the reaction tube 2 is larger than the diameter of the end of the conical inner wall 2a away from the inlet of the reaction tube 2. That is, the inlet end of the nested tube segment 24 has a larger diameter than the other end. By configuring the inner wall of the nested tube segment 24 as a conical inner wall 2a, the effect of a higher degree of tightening of the reaction tube 2 and a better sealing performance can also be achieved.

[0034] Another example is a detachable elastic component with a deformable structure that can be detachably installed on the inner wall of the outlet pipe section 11. Figure 6 and Figure 7 As shown, in this embodiment, the deformation structure can be an elastic sealing ring 5 installed on the limiting step 111. The elastic sealing ring 5 is used to elastically resist the reaction tube 2 and the limiting step 111 when the reaction tube 2 is screwed to a set depth.

[0035] When the reaction tube 2 is screwed into the set depth, the end face at the inlet of the reaction tube 2 will contact and compress the elastic sealing ring 5. When the elastic sealing ring 5 is compressed, under the action of its own elastic restoring force, the elastic sealing ring 5 will contact the reaction tube 2 with a large force, thereby ensuring that the elastic sealing ring 5 and the reaction tube 2 fit tightly. At the same time, the deformation of the elastic sealing ring 5 can also fill the assembly gap between the sample tube 1 and the outlet tube section 11. In addition, if there is a machining flatness error at the end face of the inlet of the reaction tube 2, the compressed elastic sealing ring 5 can automatically adapt to the undulation of the end face. In summary, through the deformation of the elastic sealing ring 5, an elastic sealing interface can be constructed at the connection between the reaction tube 2 and the outlet tube section 11, preventing reagent leakage from the connection.

[0036] In this embodiment, the elastic sealing ring 5 can be an O-ring.

[0037] like Figure 6 and Figure 7 As shown, in this embodiment, an annular thin wall 112 can be provided on the limiting step 111. The annular thin wall 112 and the inner peripheral wall of the outlet pipe section 11 are radially spaced to form an annular embedding groove 113. The annular embedding groove 113 is used for the pipe wall at the inlet of the reaction pipe 2 to be nested and inserted when the reaction pipe 2 is screwed to a set depth. The elastic sealing ring 5 is installed in the annular embedding groove 113.

[0038] By setting the annular embedding groove 113, it is not only convenient to install the elastic sealing ring 5, but also to limit the elastic sealing ring 5. When the reaction tube 2 is screwed into the set depth, it is ensured that the reaction tube 2 can accurately contact and squeeze the elastic sealing ring 5.

[0039] It is understood that, in this embodiment, the deformation structure can be set not only on the limiting step 111, but also in other locations, such as on the internal thread of a specific location on the outlet pipe section 11.

[0040] like Figure 8 As shown, in this embodiment, the reaction tube 2 includes a threaded connection tube section 21 and a solution reaction tube section 22 connected in sequence. The threaded connection tube section 21 is used to screw into the outlet tube section 11. Since the surface of the solution reaction tube section 22 is generally smooth, in order to facilitate the screwing of the threaded connection tube section 21 into the outlet tube section 11, a tightening force-assisting structure 23 can be provided on the outer wall of the solution reaction tube section 22.

[0041] In addition, the reaction tube 2 may also include a nested tube section 24, which is located at the end of the threaded connection tube section 21 away from the solution reaction tube section 22.

[0042] In this embodiment, the tightening force-assisting structure 23 can be a protrusion on the outer wall of the solution reaction tube section 22. The protrusion facilitates the use of force when tightening the reaction tube 2. The protrusion can be a plate, a wrench, or something else fixedly connected to the outer surface of the solution reaction tube section 22, or it can be knurled on the surface of the solution reaction tube section 22.

[0043] like Figure 2 and Figure 6 As shown, in this embodiment, the sample tube 1 also includes a base connecting part 12, which is spaced apart on the periphery of the outlet tube section 11; the detection consumable also includes a tube base, which is detachably connected to the base connecting part 12, and the reaction tube 2 is disposed in the tube base and threadedly connected to the outlet tube section 11.

[0044] The tube base and the base connecting part 12 can be connected by threads, snaps, or other means. After the reaction tube 2 and the tube base are installed on the sample tube 1, the tube base wraps around the outside of the reaction tube 2. The tube base facilitates the vertical placement of testing consumables and also protects the reaction tube 2.

[0045] like Figure 1 and Figure 2 As shown, in this embodiment, the inlet end 1a of the sample tube 1 may also be provided with a cap 8.

[0046] like Figure 2As shown, in this embodiment, the piston rod 41 is also provided with a baffle 412, which can guide the path when the piston rod 41 moves along the length direction of the sample tube 1.

[0047] In this embodiment, a clearance notch may be provided on the baffle 412 to facilitate the entry of the sample into the sample tube 1.

[0048] like Figure 2 As shown, in this embodiment, the piston rod 41 is provided with a sealing member 6 at the end away from the puncture head 42. The sealing member 6 is used to block the inlet of the sample tube 1 to prevent the first reagent from spilling out from the inlet end 1a of the sample tube 1.

[0049] In this embodiment, the isolation device may be an isolation membrane.

[0050] like Figure 2 As shown, in this embodiment, the piston rod 41 can be configured as a hollow rod, and an adsorption element can be disposed inside the hollow rod. The peripheral wall of the hollow rod can be provided with a plurality of adsorption holes 411 communicating with the inner cavity of the hollow rod. By providing the adsorption holes 411 and the adsorption element, impurities in the first reagent can be adsorbed, thereby improving the purity of the first reagent.

[0051] To achieve the above objectives, this utility model also provides a testing device, wherein the testing device includes the testing consumables described above. Since the testing device adopts all the technical solutions of the above embodiments, it at least possesses the beneficial effects brought by the above embodiments, and will not be repeated here.

[0052] In the description of this utility model, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this utility model, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0053] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between them; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0054] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0055] Although embodiments of the present invention have been described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A detection consumable, characterized in that, The testing consumables include: The sample tube (1) includes an outlet pipe section (11), the inner wall of which is threaded; The reaction tube (2) is threaded into the outlet pipe section (11); Isolation component (3) is used to isolate the outlet pipe section (11) from the reaction pipe (2); A piston assembly (4) is disposed inside the sample tube (1) and includes a piston rod (41) and a piercing head (42), wherein the piercing head (42) is disposed at the end of the piston rod (41) and is used to pierce the isolation component (3). The reaction tube (2) and the outlet tube section (11) are provided with a deformation structure, which is used to be squeezed and elastically deformed when the reaction tube (2) is rotated to a set depth.

2. The test consumable of claim 1, wherein, The inner wall of the outlet pipe section (11) forms a limiting step (111), which is used to limit the maximum spiral depth of the reaction tube (2), and the deformation structure is disposed on the limiting step (111).

3. The test consumable of claim 2, wherein, The deformable structure is an annular thin wall (112) fixedly connected to the limiting step (111). The annular thin wall (112) and the inner peripheral wall of the outlet pipe section (11) are radially spaced to form an annular embedding groove (113). The reaction pipe (2) includes a nested pipe section (24) located at the inlet. The nested pipe section (24) is used to insert into the annular embedding groove (113) and press against the annular thin wall (112) when the reaction pipe (2) is screwed to a set depth.

4. The test consumable of claim 3, wherein, The outer wall of the annular thin wall (112) is an interference fit surface (114), which is set facing the inner peripheral wall of the outlet pipe section (11). From one end close to the outlet end (1b) of the sample tube (1) to the end far from the outlet end (1b) of the sample tube (1), the interference fit surface (114) is inclined towards the inner peripheral wall of the outlet pipe section (11).

5. The test consumable of claim 3, wherein, The inner wall of the nested tube segment (24) is a conical inner wall (2a). The conical inner wall (2a) is used to embed into the annular embedding groove (113) and contact the annular thin wall (112) when the reaction tube (2) is screwed to a set depth. The diameter of the end of the conical inner wall (2a) near the inlet of the reaction tube (2) is larger than the diameter of the end of the conical inner wall (2a) away from the inlet of the reaction tube (2).

6. The test consumable of claim 2, wherein, The deformation structure is an elastic sealing ring (5) installed on the limiting step (111). The elastic sealing ring (5) is used to elastically resist the reaction tube (2) and the limiting step (111) when the reaction tube (2) is screwed to a set depth.

7. The test consumable of claim 6, wherein, The outlet pipe section (11) includes an annular thin wall (112) disposed on the limiting step (111). The annular thin wall (112) and the inner peripheral wall of the outlet pipe section (11) are radially spaced to form an annular embedding groove (113). The annular embedding groove (113) is used for the pipe wall at the inlet of the reaction tube (2) to be nested and inserted when the reaction tube (2) is screwed to a set depth. The elastic sealing ring (5) is installed in the annular embedding groove (113).

8. The test consumable of any one of claims 1 to 7, wherein, The reaction tube (2) includes a threaded connection tube section (21) and a solution reaction tube section (22) connected in sequence. The threaded connection tube section (21) is used to be screwed into the outlet tube section (11). The outer wall of the solution reaction tube section (22) is provided with a tightening force-assisted structure (23).

9. The test consumable of any one of claims 1 to 7, wherein, The sample tube (1) also includes a base connection part (12), which is spaced around the outlet tube section (11). The testing consumable also includes a tube base, which is detachably connected to the base connection part (12). The reaction tube (2) is located inside the tube base and is threadedly connected to the outlet tube section (11).

10. A detection device, characterized by Includes the testing consumables according to any one of claims 1 to 9.

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