A vascular support platform for constructing a mouse aortic valve calcification model

Abstract

The application discloses a blood vessel supporting platform for constructing a mouse aortic valve calcification model, which comprises a first supporting plate, the side end of the first supporting plate is connected with a second supporting plate, and the second supporting plate has an included angle with the first supporting plate; one end of the first supporting plate and the second supporting plate forms an operation end; the other end of the first supporting plate and the second supporting plate forms an insertion end, which is used for inserting under the blood vessel; and the top surfaces of the first supporting plate and the second supporting plate jointly form a supporting surface which is used for contacting the blood vessel. The application has the advantages of providing appropriate tension for the blood vessel, effectively assisting in accurately completing the front and rear injuries, and reducing the operation difficulty.

Description

Technical Field

[0001] This application relates to the field of basic medical research technology, and in particular to a vascular support platform for constructing a mouse aortic valve calcification model. Background Technology

[0002] Calcific aortic valve disease is one of the most common valvular heart diseases, characterized by thickening, fibrosis, and mineralization of the aortic valve, ultimately leading to aortic stenosis. Its incidence increases with age, and currently there are no effective drugs to slow or halt its progression; the primary treatment is valve replacement surgery. To study its pathogenesis and intervention strategies, there is an urgent need to establish stable and reliable animal models. Traditional models often use LDLR- / - or ApoE- / - mice fed a high-fat diet, but these models are time-consuming, expensive, have low success rates, and are difficult to simulate the clinical ineffectiveness of statins.

[0003] In recent years, a model has emerged that induces valvular fibrosis and calcification by inducing mechanical injury through a guidewire inserted into the aortic valve region via the common carotid artery. This model has advantages such as low cost, short cycle time, and high success rate, and is gradually being widely used. However, during implementation, due to the small diameter and high blood flow velocity of the mouse common carotid artery, problems such as difficulty in accurate guidewire insertion, complex operation, and large amount of bleeding occur, leading to a high mortality rate. Utility Model Content

[0004] The main purpose of this application is to provide a vascular support platform for constructing a mouse aortic valve calcification model, aiming to solve the technical problem of the high operational difficulty in the current mouse aortic valve calcification model construction process.

[0005] To achieve the above objectives, this application provides a vascular support platform for constructing a mouse aortic valve calcification model, comprising a first support plate, a second support plate connected to the side end of the first support plate, an angle between the second support plate and the first support plate, one end of the first support plate and the second support plate forming an operating end, and the other end of the first support plate and the second support plate forming an insertion end for insertion under a blood vessel, and the top surfaces of the first support plate and the second support plate together forming a support surface in contact with the blood vessel.

[0006] Optionally, the second support plate is provided with multiple stepped grooves on one side near the insertion end, so that the width of the section of the second support plate near the insertion end gradually increases in the direction away from the insertion end.

[0007] Optionally, a transition slope connects adjacent step grooves.

[0008] Optionally, the insertion end is V-shaped, and the tip of the insertion end is rounded.

[0009] Optionally, the included angle ranges from 120° to 170°.

[0010] Optionally, the first support plate and the second support plate are integrally fixedly connected.

[0011] Optionally, the first support plate and the second support plate are hinged together, and the included angle between the first support plate and the second support plate is adjustable.

[0012] Optionally, a compression spring is provided between the bottom surfaces of the first support plate and the second support plate.

[0013] Optionally, the bottom surfaces of both the first support plate and the second support plate are provided with connecting parts, and a compression spring is connected between the two connecting parts.

[0014] Optionally, both the first support plate and the second support plate are made of biocompatible materials.

[0015] The beneficial effects that this application can achieve are as follows:

[0016] This application includes a first support plate, a second support plate connected to the side end of the first support plate, an angle between the second support plate and the first support plate, one end of the first support plate and the second support plate forming an operating end, and the other end of the first support plate and the second support plate forming an insertion end for insertion below a blood vessel. The top surfaces of the first support plate and the second support plate together form a support surface that contacts the blood vessel.

[0017] Based on the structure of this application, during operation, after exposing the common carotid artery in the mouse's neck, the operator can hold the operating end and place the entire support plate in an inverted V shape. Then, the insertion end is slowly inserted under the mouse's blood vessel. Because there is an angle between the second support plate and the first support plate, the entire support plate has a certain support height and supports the blood vessel through the support surface, thereby assisting in the expansion, fixation and temporary occlusion of blood flow. This provides a stable platform for the precise entry of the guidewire and valve injury, and can provide appropriate tension to the blood vessel, effectively assisting in the precise completion of anterior and posterior injuries, reducing the difficulty of operation. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the specific embodiments of this application or the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.

[0019] Figure 1 This is a schematic diagram of the structure of a vascular support platform for constructing a mouse aortic valve calcification model, as described in an embodiment of this application.

[0020] Figure 2This is a schematic diagram of the bottom view of a vascular support platform used for constructing a mouse aortic valve calcification model, as described in an embodiment of this application.

[0021] Figure 3 This is a schematic diagram (top view) of the structure of a vascular support platform used to construct a mouse aortic valve calcification model in an embodiment of this application when it supports the blood vessel;

[0022] Figure 4 This is a schematic diagram (side view) of the insertion end in an embodiment of this application;

[0023] Figure 5 This is a schematic diagram of another structure of a vascular support platform for constructing a mouse aortic valve calcification model, as described in an embodiment of this application.

[0024] Figure label:

[0025] 110-First support plate, 120-Second support plate, 121-Step groove, 130-Operating end, 140-Insertion end, 150-Supporting surface, 160-Transition slope, 170-Compression spring, 180-Connecting part, 190-Blood vessel.

[0026] The realization of the purpose, functional features and advantages of this application will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0027] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0028] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of this application are only used to explain the relative positional relationship and movement of each component in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0029] In this application, unless otherwise expressly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral part; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0030] Furthermore, if the embodiments of this application involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the meaning of "and / or" throughout the text includes three parallel solutions; for example, "A and / or B" includes solution A, solution B, or a solution where both A and B are satisfied simultaneously. Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed in this application.

[0031] Example

[0032] Reference Figures 1-5 This embodiment provides a vascular support platform for constructing a mouse aortic valve calcification model, including a first support plate 110, a second support plate 120 connected to the side end of the first support plate 110, the second support plate 120 and the first support plate 110 having an included angle, one end of the first support plate 110 and the second support plate 120 forming an operating end 130, the other end of the first support plate 110 and the second support plate 120 forming an insertion end 140, the insertion end 140 being used to insert below a blood vessel 190, and the top surfaces of the first support plate 110 and the second support plate 120 together forming a support surface 150 in contact with the blood vessel 190.

[0033] In this embodiment, during operation, after exposing the common carotid artery in the mouse's neck, the operator can hold the operating end 130 and place the entire support platform in an inverted V shape. Then, the insertion end 140 is slowly inserted under the mouse's blood vessel 190. Since there is an angle between the second support plate 120 and the first support plate 110, the entire support plate has a certain support height and supports the blood vessel 190 through the support surface 150, thereby assisting in the expansion, fixation and temporary occlusion of blood flow in the blood vessel 190. This provides a stable platform for the precise entry of the guidewire and valve injury, and can provide appropriate tension to the blood vessel 190, which can effectively assist in the precise completion of anterior and posterior injuries, reducing the difficulty of operation.

[0034] As an optional implementation, the second support plate 120 is provided with a plurality of stepped grooves 121 on the side near the insertion end 140, so that the width of the section of the second support plate 120 near the insertion end 140 gradually increases in the direction away from the insertion end 140.

[0035] In this embodiment, due to the varying vascular tension in different mice, multiple stepped grooves 121 are designed to improve versatility. This allows the section of the second support plate 120 near the insertion end 140 to gradually form different widths, resulting in varying support widths across the entire support surface 150. When the tension of the blood vessel 190 is high, it is positioned within the area of ​​the support surface 150 with a smaller support width; conversely, when the tension of the blood vessel 190 is low, it is positioned within the area of ​​the support surface 150 with a larger support width. By adjusting the insertion depth of the insertion end 140, the blood vessel 190 can be laid flat on the support surface 150 to achieve appropriate tension. When the tension of the common carotid artery is appropriate, the pulsation stops, facilitating the cutting of the blood vessel 190 and the introduction of the guidewire. After the guidewire is inserted, the support plate provides stable support for the blood vessel 190, assisting in the precise completion of anterior and posterior injury procedures and minimizing bleeding. Experiments show that the use of this support platform can significantly reduce mouse mortality during guidewire-based modeling, improving operational stability and model construction success rate.

[0036] It should be noted that the support platform is a long and narrow strip structure with a total length of about 18mm, a width of about 3.2mm, a thickness of about 2mm, and a height range of 0.7 to 2.2mm for the stepped groove 121.

[0037] As an optional implementation, a transition slope 160 is connected between adjacent stepped grooves 121. When the insertion end 140 moves forward, the blood vessel 190 can be smoothly transferred from one stepped groove 121 to another stepped groove 121 area through the transition slope 160, reducing the risk of prematurely rupturing the blood vessel 190 by using a right-angle structure and improving the success rate of platform construction.

[0038] As an alternative implementation, the insertion end 140 is V-shaped. The V-shaped insertion end 140 can help to gradually support the mouse blood vessel 190 and quickly locate the insertion position of the blood vessel 190. In addition, the tip of the insertion end 140 is rounded, which can greatly reduce the risk of puncturing the blood vessel 190.

[0039] As an optional implementation method, the included angle ranges from 120° to 170°, so that support platforms of different specifications can be prefabricated according to this included angle range to meet various experimental needs and experimental scenarios.

[0040] As an optional implementation, the first support plate 110 and the second support plate 120 are integrally fixedly connected structures, and the overall structure is robust and stable, and can be precisely manufactured by 3D printing.

[0041] As an optional implementation, the first support plate 110 and the second support plate 120 are hinged together, and the included angle between the first support plate 110 and the second support plate 120 is adjustable. In use, the first support plate 110 and the second support plate 120 can be rotated relative to each other to adjust the included angle between the two plates, so as to form different support heights as a whole, thereby adapting to different support requirements and further improving versatility and flexibility of use.

[0042] As an optional implementation, a compression spring 170 is provided between the bottom surfaces of the first support plate 110 and the second support plate 120.

[0043] In this embodiment, in the initial state, the first support plate 110 and the second support plate 120 are at their maximum angle and the support height is at its minimum. When it is necessary to increase the support height, the first support plate 110 and the second support plate 120 can be manually pressed to make them rotate closer to each other, thereby reducing the angle between the two plates and increasing the support height. When released, they can automatically reset, making the operation convenient and quick.

[0044] As an optional implementation, the bottom surfaces of the first support plate 110 and the second support plate 120 are both provided with connecting portions 180, and the compression spring 170 is connected between the two connecting portions 180.

[0045] In this embodiment, since the overall structure of the support platform is relatively thin and light, there is a risk of breakage due to compression by the compression spring 170 when the first support plate 110 and the second support plate 120 are pressed. Therefore, a connecting part 180 is provided on the bottom surface of the two plates to connect the compression spring 170. The connecting part 180 can form a reinforcing structure at the force-bearing position of the first support plate 110 and the second support plate 120, thereby reducing the risk of breakage and ensuring their service life.

[0046] As an optional implementation, both the first support plate 110 and the second support plate 120 are made of biocompatible materials, supporting single use or sterilization and reuse.

[0047] The above are merely preferred embodiments of this application and do not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A vascular support platform for constructing a mouse aortic valve calcification model, characterized in that, It includes a first support plate, a second support plate connected to the side end of the first support plate, the second support plate and the first support plate having an included angle, one end of the first support plate and the second support plate forming an operating end, the other end of the first support plate and the second support plate forming an insertion end, the insertion end being used to insert below a blood vessel, and the top surfaces of the first support plate and the second support plate together forming a support surface in contact with the blood vessel.

2. The vascular support platform for constructing a mouse aortic valve calcification model as described in claim 1, characterized in that, The second support plate has multiple stepped grooves on one side near the insertion end, so that the width of the section of the second support plate near the insertion end gradually increases in the direction away from the insertion end.

3. The vascular support platform for constructing a mouse aortic valve calcification model as described in claim 2, characterized in that, Each adjacent stepped groove is connected by a transition slope.

4. The vascular support platform for constructing a mouse aortic valve calcification model as described in claim 1, characterized in that, The insertion end is V-shaped, and the tip of the insertion end is rounded.

5. The vascular support platform for constructing a mouse aortic valve calcification model as described in claim 1, characterized in that, The included angle ranges from 120° to 170°.

6. A vascular support platform for constructing a mouse aortic valve calcification model as described in any one of claims 1-5, characterized in that, The first support plate and the second support plate are integrally fixedly connected structures.

7. A vascular support platform for constructing a mouse aortic valve calcification model as described in any one of claims 1-5, characterized in that, The first support plate and the second support plate are hinged together, and the included angle between the first support plate and the second support plate is adjustable.

8. The vascular support platform for constructing a mouse aortic valve calcification model as described in claim 7, characterized in that, A compression spring is provided between the bottom surfaces of the first support plate and the second support plate.

9. The vascular support platform for constructing a mouse aortic valve calcification model as described in claim 8, characterized in that, Both the bottom surfaces of the first support plate and the second support plate are provided with connecting parts, and the compression spring is connected between the two connecting parts.

10. The vascular support platform for constructing a mouse aortic valve calcification model as described in claim 1, characterized in that, Both the first support plate and the second support plate are made of biocompatible materials.

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