Pharmaceutical tablet granulation apparatus

Abstract

The utility model relates to the technical field of medicine granulation, concretely to medicine tablet granule granulation equipment, including granulation kettle, the granulation kettle side wall fixed communication has the feeding opening, the granulation kettle bottom fixed communication has the discharge gate, the granulation kettle is installed with the granulation assembly of making powder raw material into medicine granule, the drying assembly that the granulation kettle is installed to the drying treatment of the medicine granule made is carried out. The medicine granule made by granulation assembly falls into the clearance between the rotation cover and the granulation kettle, and the medicine granule is heated and dried through the electric heating tube, and the moving block and fixed block of staggered arrangement can reduce the falling speed of medicine granule, makes the medicine granule fully dry, and under the drive of motor, the moving block reciprocating rotation makes the medicine granule falling constantly collide with moving block, fixed block, prevents the medicine granule from caking, thereby realizes the drying treatment to the medicine granule immediately after granulation, and can prevent the medicine granule from caking in the process of drying treatment, makes production efficiency and product quality get the guarantee.

Description

Technical Field

[0001] This utility model relates to the field of drug granulation technology, specifically to a drug tablet granulation equipment. Background Technology

[0002] In the pharmaceutical manufacturing industry, granulation is a crucial step in preparing drug tablet granules. Granulation improves drug formability, enhances drug stability, and facilitates subsequent processing. Traditional wet granulation technology is widely used in the pharmaceutical industry. It mixes drug powder with a binder solution to form granules with a specific shape and size. These granules have good formability, high density, and excellent compressibility, making them suitable for the production of most pharmaceutical formulations.

[0003] However, traditional wet granulation has significant technical drawbacks. Current processes involve drying the granules immediately after granulation, resulting in high granule moisture content before drying. Due to the close contact between the granules and their high moisture content, clumping is highly likely to occur while waiting for drying. Clumping not only affects granule uniformity, making it difficult to guarantee the quality of subsequent tablets, but may also render some granules unusable for tablet production, leading to raw material waste and increased production costs. Furthermore, drying clumped granules requires more energy and time, reducing production efficiency and hindering large-scale industrial production. To enable immediate drying of granules after granulation, prevent clumping, improve production efficiency, and ensure the quality of subsequent tablets, we propose a pharmaceutical tablet granulation equipment. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides a pharmaceutical tablet granulation equipment that can dry the granules immediately after granulation, preventing granule clumping, improving production efficiency, and ensuring the quality of subsequent tablets.

[0005] To achieve the above objectives, this utility model provides the following technical solution: A pharmaceutical tablet granulation equipment includes a granulation kettle, a feeding port fixedly connected to the side wall of the granulation kettle, a discharge port fixedly connected to the bottom of the granulation kettle, a granulation component for making powder raw materials into drug granules installed on the granulation kettle, and a drying component for drying the produced drug granules installed on the granulation kettle. The drying assembly includes a heat insulation cover, which is fixedly sleeved outside the granulation vessel. An electric heating tube is fixedly installed on the inner wall of the heat insulation cover. Several sets of connecting blocks are fixedly connected to the inner wall of the granulation vessel. An installation cover is fixedly connected to the side of the connecting blocks away from the granulation vessel. A rotating cover is rotatably connected to the top of the installation cover. Several sets of moving blocks are fixedly connected to the outer wall of the rotating cover. Several sets of fixed blocks are fixedly connected to the inner wall of the granulation vessel. The moving blocks and fixed blocks are staggered. A rotating mechanism that drives the rotating cover to reciprocate is installed on the installation cover.

[0006] Preferably, the rotating mechanism includes a connecting cylinder, which is fixedly connected to the top of the inner cavity of the rotating cover. An upper bevel gear and a lower bevel gear are fixedly sleeved on the outside of the connecting cylinder. An mounting plate is fixedly installed on the mounting cover. A rotating rod is rotatably connected to the side of the mounting plate near the connecting cylinder. A half bevel gear is fixedly connected to the left end of the rotating rod. The half bevel gear meshes with the upper bevel gear and with the lower bevel gear. A power mechanism for driving the rotating mechanism is installed on the mounting cover.

[0007] Preferably, the power mechanism includes a motor, which is fixedly mounted on the top of the mounting cover. A drive rod is fixedly connected to the output end of the motor. A drive wheel is fixedly sleeved on the drive rod. A transmission rod is rotatably mounted on the top of the mounting cover. A driven wheel is fixedly sleeved on the transmission rod. A belt is tensioned and sleeved between the drive wheel and the driven wheel. A transmission bevel gear is fixedly connected to the top of the driven wheel. A rotating bevel gear is fixedly sleeved on the rotating rod. The rotating bevel gear meshes with the transmission bevel gear.

[0008] Preferably, the granulation assembly includes a cylinder, which is fixedly installed at the top of the inner cavity of the granulation vessel. A pressure plate is fixedly connected to the output end of the cylinder. The outer side of the pressure plate is slidably connected to the inner wall of the granulation vessel. A granulation plate is fixedly connected to the inner wall of the granulation vessel. Several sets of granulation holes are opened on the granulation plate. The drive rod rotates through a rotating cover and a connecting cylinder. A cutting disc is fixedly connected to the top of the drive rod. Several sets of cutting blades are fixedly connected to the outer side of the cutting disc. The top of the cutting blades abuts against the bottom of the granulation plate.

[0009] Preferably, the drive rod is rotatably fitted with a conical cover, the bottom of the conical cover is fixedly connected to the top of the rotating cover, and the connecting block is set as a triangular block.

[0010] Preferably, a baffle is fixedly connected to the top of the pressure plate, and the outer side of the baffle is slidably connected to the inner wall of the granulation vessel.

[0011] Preferably, the outer wall of the granulation vessel is fixedly connected to an exhaust port, and a protective net is provided on the exhaust port.

[0012] Beneficial effects This invention provides a granulation device for pharmaceutical tablets. Compared with the prior art, it has the following advantages: This pharmaceutical tablet granulation equipment produces granules that, under the action of a conical shroud, enter the gap between a rotating shroud and a granulation vessel. The granules are then heated and dried by electric heating tubes. The staggered arrangement of moving and fixed blocks reduces the falling speed of the granules, extending the drying time and ensuring thorough drying. Simultaneously, driven by a motor, the moving blocks reciprocate, causing the falling granules to continuously collide with the moving and fixed blocks, preventing clumping during the drying process. This allows for immediate drying of the granules after granulation and prevents clumping during the drying process, ensuring both production efficiency and product quality. Attached Figure Description

[0013] Figure 1 This is a front view structural diagram of the main body of this utility model; Figure 2 This is a schematic diagram of the main cross-sectional structure of the present invention; Figure 3 For the present utility model Figure 2 Enlarged schematic diagram of the structure at point A in the middle; Figure 4 This is an exploded view of the internal structure of the granulation reactor of this utility model.

[0014] In the diagram: 1. Granulation kettle; 2. Feeding port; 3. Exhaust port; 4. Insulation cover; 5. Discharge port; 6. Cylinder; 7. Pressure plate; 8. Granulation plate; 9. Conical cover; 10. Heating tube; 11. Moving block; 12. Mounting plate; 13. Rotating cover; 14. Motor; 15. Mounting cover; 16. Fixing block; 17. Material baffle; 18. Cutting disc; 19. Connecting block; 20. Connecting cylinder; 21. Upper bevel gear; 22. Lower bevel gear; 23. Driving wheel; 24. Drive rod; 25. Transmission rod; 26. Driven wheel; 27. Rotating rod; 28. Transmission bevel gear; 29. ​​Rotating bevel gear; 30. Half bevel gear. Detailed Implementation

[0015] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0016] Please see Figures 1-4This utility model provides a technical solution: a pharmaceutical tablet granulation equipment, including a granulation kettle 1, a feeding port 2 fixedly connected to the side wall of the granulation kettle 1, a discharge port 5 fixedly connected to the bottom of the granulation kettle 1, a granulation component for making powder raw materials into pharmaceutical granules installed on the granulation kettle 1, and a drying component for drying the produced pharmaceutical granules installed on the granulation kettle 1. The drying assembly includes a heat insulation cover 4, which is fixedly sleeved outside the granulation vessel 1. An electric heating tube 10 is fixedly installed on the inner wall of the heat insulation cover 4. Several sets of connecting blocks 19 are fixedly connected to the inner wall of the granulation vessel 1. An installation cover 15 is fixedly connected to the side of the connecting block 19 away from the granulation vessel 1. A rotating cover 13 is rotatably connected to the top of the installation cover 15. Several sets of moving blocks 11 are fixedly connected to the outer wall of the rotating cover 13. Several sets of fixed blocks 16 are fixedly connected to the inner wall of the granulation vessel 1. The moving blocks 11 and the fixed blocks 16 are staggered. A rotating mechanism that drives the rotating cover 13 to reciprocate is installed on the installation cover 15.

[0017] In use, the mixed raw materials are fed into the granulation vessel 1 through the feeding port 2. Under the action of the granulation component, the raw materials are made into granules. The granules fall under the action of gravity and enter the gap between the rotating cover 13 and the granulation vessel 1. The granules are heated and dried by the electric heating tube 10 in the heat insulation cover 4. The staggered moving blocks 11 and fixed blocks 16 can reduce the falling speed of the granules and extend the drying time of the granules, so that the granules are fully dried. At the same time, under the action of the rotating mechanism, the rotating cover 13 rotates back and forth, driving the moving blocks 11 to rotate back and forth, so that the falling granules continuously collide with the moving blocks 11 and fixed blocks 16, which can prevent the granules from clumping during the drying process and prevent the granules from accumulating on the top of the moving blocks 11 or fixed blocks 16. The dried granules flow out from the discharge port 5, thus realizing the drying treatment of granules immediately after granulation and preventing the granules from clumping during the drying process, so as to ensure production efficiency and product quality.

[0018] The rotating mechanism includes a connecting cylinder 20, which is fixedly connected to the top of the inner cavity of the rotating cover 13. An upper bevel gear 21 and a lower bevel gear 22 are fixedly sleeved on the outside of the connecting cylinder 20. A mounting plate 12 is fixedly installed on the mounting cover 15. A rotating rod 27 is rotatably connected to the side of the mounting plate 12 near the connecting cylinder 20. A half bevel gear 30 is fixedly connected to the left end of the rotating rod 27. The half bevel gear 30 meshes with the upper bevel gear 21 and the lower bevel gear 22. A power mechanism for driving the rotating mechanism is installed on the mounting cover 15.

[0019] Under the action of the power mechanism, the rotating rod 27 rotates, driving the half bevel gear 30 to rotate. During the rotation of the half bevel gear 30, when the half bevel gear 30 meshes with the lower bevel gear 22, it drives the connecting cylinder 20 to rotate in the forward direction. When the half bevel gear 30 meshes with the upper bevel gear 21, it drives the connecting cylinder 20 to rotate in the reverse direction, thereby causing the connecting cylinder 20 to rotate back and forth, driving the rotating cover 13 to rotate back and forth.

[0020] The power mechanism includes a motor 14, which is fixedly mounted on the top of the mounting cover 15. A drive rod 24 is fixedly connected to the output end of the motor 14. A drive wheel 23 is fixedly sleeved on the drive rod 24. A transmission rod 25 is rotatably mounted on the top of the mounting cover 15. A driven wheel 26 is fixedly sleeved on the transmission rod 25. A belt is tensioned between the drive wheel 23 and the driven wheel 26. A transmission bevel gear 28 is fixedly connected to the top of the driven wheel 26. A rotating bevel gear 29 is fixedly sleeved on the rotating rod 27. The rotating bevel gear 29 meshes with the transmission bevel gear 28.

[0021] When the motor 14 is started, it drives the drive rod 24 to rotate. This, in turn, causes the transmission rod 25 to rotate via the drive wheel 23 and the driven wheel 26. This causes the transmission bevel gear 28 to rotate, which in turn drives the rotating bevel gear 29 to rotate, which in turn drives the rotating rod 27 to rotate.

[0022] The granulation assembly includes a cylinder 6, which is fixedly installed on the top of the inner cavity of the granulation vessel 1. A pressure plate 7 is fixedly connected to the output end of the cylinder 6. The outer side of the pressure plate 7 is slidably connected to the inner wall of the granulation vessel 1. A granulation plate 8 is fixedly connected to the inner wall of the granulation vessel 1. Several sets of granulation holes are opened on the granulation plate 8. The drive rod 24 rotates through the rotating cover 13 and the connecting cylinder 20. A cutting disc 18 is fixedly connected to the top of the drive rod 24. Several sets of cutting blades are fixedly connected to the outer side of the cutting disc 18. The top of the cutting blades abuts against the bottom of the granulation plate 8.

[0023] Raw materials are fed into the granulation vessel 1 through the feeding port 2. The raw materials fall on the top of the granulation plate 8. The cylinder 6 is started to drive the pressure plate 7 to descend and squeeze the raw materials. Under pressure, the raw materials are squeezed out of the granulation hole into strips. At the same time, the drive rod 24 rotates to drive the cutting disc 18 and the cutting blade to rotate, cutting the strip raw materials into granules, thus completing the granulation.

[0024] The drive rod 24 is fitted with a conical cover 9, the bottom of the conical cover 9 is fixedly connected to the top of the rotating cover 13, and the connecting block 19 is set as a triangular block.

[0025] Under the action of the conical shroud 9, all the manufactured drug particles fall into the space between the rotating shroud 13 and the granulation vessel 1 for drying. The triangular design of the connecting block 19 can prevent the drug particles from accumulating on the top of the connecting block 19.

[0026] A baffle 17 is fixedly connected to the top of the pressure plate 7, and the outer side of the baffle 17 is slidably connected to the inner wall of the granulation kettle 1. This prevents raw materials from falling onto the top of the pressure plate 7 and becoming difficult to clean due to human error during the granulation process.

[0027] The outer wall of the granulation vessel 1 is fixedly connected to an exhaust port 3, and a protective net is installed on the exhaust port 3. The water vapor generated during the drying of the granules can be quickly discharged through the exhaust port 3, improving the drying efficiency, and the protective net can prevent the granules from leaking out of the exhaust port 3.

[0028] Working principle: When in use, the mixed raw materials are fed into the granulation kettle 1 through the feeding port 2. The raw materials fall on the top of the granulation plate 8. The cylinder 6 is started to drive the pressure plate 7 to descend and squeeze the raw materials. Under the pressure, the raw materials are squeezed out of the granulation hole into strips. At the same time, the motor 14 is started to drive the drive rod 24 to rotate. The rotation of the drive rod 24 drives the cutting disc 18 and the cutting blade to rotate, cutting the strip raw materials into granules, thus completing the granulation. The granules fall under gravity and enter the gap between the rotating cover 13 and the granulation vessel 1 under the action of the conical cover 9. The granules are heated and dried by the electric heating tubes 10 in the heat preservation cover 4. The staggered moving blocks 11 and fixed blocks 16 can reduce the falling speed of the granules and extend the drying time, so that the granules are fully dried. At the same time, the drive rod 24 rotates, which drives the transmission rod 25 to rotate through the drive wheel 23 and the driven wheel 26. Then the transmission bevel gear 28 rotates, which drives the rotating bevel gear 29 to rotate, which drives the rotating rod 27 to rotate, which drives the half bevel gear 30 to rotate. During the rotation of the half bevel gear 30, when the half bevel gear 30 meshes with the lower bevel gear 22... The connecting cylinder 20 rotates forward. When the half bevel gear 30 meshes with the upper bevel gear 21, it drives the connecting cylinder 20 to rotate in the opposite direction, thus causing the connecting cylinder 20 to rotate back and forth, driving the rotating cover 13 to rotate back and forth, and driving the moving block 11 to rotate back and forth. This causes the falling granules to continuously collide with the moving block 11 and the fixed block 16, which can prevent the granules from clumping during the drying process. At the same time, it can prevent the granules from accumulating on the top of the moving block 11 or the fixed block 16. The dried granules flow out from the discharge port 5, thus achieving immediate drying of the granules after granulation and preventing clumping during the drying process, ensuring production efficiency and product quality.

[0029] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0030] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A pharmaceutical tablet granulation equipment, comprising a granulation kettle (1), characterized in that: The granulation vessel (1) has a feeding port (2) fixedly connected to its side wall, and a discharge port (5) fixedly connected to its bottom. The granulation vessel (1) is equipped with a granulation component for making powder raw materials into granules, and a drying component for drying the granules. The drying assembly includes a heat insulation cover (4), which is fixedly sleeved on the outside of the granulation vessel (1). An electric heating tube (10) is fixedly installed on the inner wall of the heat insulation cover (4). Several sets of connecting blocks (19) are fixedly connected to the inner wall of the granulation vessel (1). An installation cover (15) is fixedly connected to the side of the connecting block (19) away from the granulation vessel (1). A rotating cover (13) is rotatably connected to the top of the installation cover (15). Several sets of moving blocks (11) are fixedly connected to the outer wall of the rotating cover (13). Several sets of fixed blocks (16) are fixedly connected to the inner wall of the granulation vessel (1). The moving blocks (11) and the fixed blocks (16) are staggered. A rotating mechanism that drives the rotating cover (13) to rotate back and forth is installed on the installation cover (15).

2. The pharmaceutical tablet granulation equipment according to claim 1, characterized in that: The rotating mechanism includes a connecting cylinder (20), which is fixedly connected to the top of the inner cavity of the rotating cover (13). An upper bevel gear (21) and a lower bevel gear (22) are fixedly sleeved on the outside of the connecting cylinder (20). An mounting plate (12) is fixedly installed on the mounting cover (15). A rotating rod (27) is rotatably connected to the side of the mounting plate (12) near the connecting cylinder (20). A half bevel gear (30) is fixedly connected to the left end of the rotating rod (27). The half bevel gear (30) meshes with the upper bevel gear (21) and meshes with the lower bevel gear (22). A power mechanism for driving the rotating mechanism is installed on the mounting cover (15).

3. The pharmaceutical tablet granulation equipment according to claim 2, characterized in that: The power mechanism includes a motor (14), which is fixedly mounted on the top of the mounting cover (15). The output end of the motor (14) is fixedly connected to a drive rod (24). A drive wheel (23) is fixedly sleeved on the drive rod (24). A transmission rod (25) is rotatably mounted on the top of the mounting cover (15). A driven wheel (26) is fixedly sleeved on the transmission rod (25). A belt is tensioned between the drive wheel (23) and the driven wheel (26). A transmission bevel gear (28) is fixedly connected to the top of the driven wheel (26). A rotating bevel gear (29) is fixedly sleeved on the rotating rod (27). The rotating bevel gear (29) meshes with the transmission bevel gear (28).

4. The pharmaceutical tablet granulation equipment according to claim 3, characterized in that: The granulation assembly includes a cylinder (6), which is fixedly installed on the top of the inner cavity of the granulation vessel (1). A pressure plate (7) is fixedly connected to the output end of the cylinder (6). The outer side of the pressure plate (7) is slidably connected to the inner wall of the granulation vessel (1). A granulation plate (8) is fixedly connected to the inner wall of the granulation vessel (1). Several sets of granulation holes are opened on the granulation plate (8). The drive rod (24) rotates through the rotating cover (13) and the connecting cylinder (20). A cutting disc (18) is fixedly connected to the top of the drive rod (24). Several sets of cutting blades are fixedly connected to the outer side of the cutting disc (18). The top of the cutting blades abuts against the bottom of the granulation plate (8).

5. The pharmaceutical tablet granulation equipment according to claim 3, characterized in that: The drive rod (24) is rotatably fitted with a conical cover (9), the bottom of the conical cover (9) is fixedly connected to the top of the rotating cover (13), and the connecting block (19) is set as a triangular block.

6. The pharmaceutical tablet granulation equipment according to claim 4, characterized in that: The top of the pressure plate (7) is fixedly connected to a baffle (17), and the outer side of the baffle (17) is slidably connected to the inner wall of the granulation kettle (1).

7. The pharmaceutical tablet granulation equipment according to claim 1, characterized in that: The outer wall of the granulation vessel (1) is fixedly connected to an exhaust port (3), and a protective net is provided on the exhaust port (3).

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