A novel mobile phase distributor structure

Abstract

The utility model discloses a novel mobile phase distributor structure, including distributor, the distribution front is equipped with H shape groove, each H shape groove is through branch one groove, branch two grooves, branch three grooves, branch four grooves, branch five grooves, branch six grooves gradually converges to main road groove, gathers to the distributor center again through the tree shape intercommunication, every H shape groove all is through the round hole vertical and penetrates the distributor to the distribution reverse, relate mobile phase distributor structure technical field, through the main road, branch etc. long design, the resistance compensation of distributor center to each H shape groove flow path total length is consistent, the main road width depth is greater than the branch width depth, eliminates the partial flow thoroughly, and the chromatographic column filler utilization rate is effectively improved, and the separation peak shape is more symmetrical, sharp.

Description

Technical Field

[0001] This utility model relates to the technical field of mobile phase distributor structure, specifically a novel mobile phase distributor structure. Background Technology

[0002] In the field of preparative chromatography, the mobile phase distributor is a core component that determines separation efficiency. However, the existing technology lacks a unified standard for the length, width, and depth of the main and branch paths, resulting in significant differences in the flow rate and pressure of the mobile phase in each branch path. The packing material in the chromatographic column often experiences "local overflow and local idleness," directly causing peak broadening and decreased resolution. The front of the distributor only serves to distribute the mobile phase, while the back does not have a matching flow guiding structure. After the mobile phase penetrates from the front, it diffuses unevenly in the radial direction on the back, further amplifying the distribution deviation. In addition, the existing flow path layout is poorly compatible with the annular flow channel of large-section preparative chromatographic columns, and the flow deviation problem is aggravated under high flow rate conditions, making it difficult to meet the demand for high-efficiency separation in industrial preparative processes. These defects together make it difficult to improve the purity and separation efficiency of preparative chromatography products, thus restricting the process of large-scale production. Utility Model Content

[0003] The purpose of this invention is to provide a novel flow phase distributor structure to solve the problem mentioned in the background art that the lack of a unified standard for the design of the length, width, and depth of the main flow path and branch flow paths leads to significant differences in the flow velocity and pressure of the flow phase in each branch flow path.

[0004] To achieve the above objectives, this utility model provides the following technical solution: A novel mobile phase distributor structure includes a distributor with H-shaped grooves on the front side. Each H-shaped groove merges into a main channel groove through branch groove 1, branch groove 2, branch groove 3, branch groove 4, branch groove 5, and branch groove 6, and then converges to the center of the distributor through a tree-like connection. Each H-shaped groove penetrates the distributor vertically through a circular hole to the back side of the distributor.

[0005] In a preferred embodiment of this utility model, the width of the main road trench is greater than the width of the branch road trench 1, branch road trench 2, branch road trench 3, branch road trench 4, branch road trench 5, and branch road trench 6; the center of the distributor is the flow phase inlet.

[0006] In a preferred embodiment of this utility model, the center of the distributor is connected to the main road trench and the branch road trenches 1, 2, 3, 4, 5 and 6.

[0007] In a preferred embodiment of this utility model, the total length of the flow path from the center of the distributor through the main road trench, branch road one trench, branch road two trench, branch road three trench, branch road four trench, branch road five trench, and branch road six trench to each H-shaped trench is the same.

[0008] In a preferred embodiment of this utility model, the depth of the main road trench is greater than the depth of the branch road trenches one, two, three, four, five, and six.

[0009] In a preferred embodiment of this utility model, one end of the circular hole is connected to the bottom of the H-shaped groove, and the other end extends to the reverse side of the dispenser, with the axis of the circular hole perpendicular to the surface of the dispenser.

[0010] In a preferred embodiment of this utility model, the distributor is provided with a cross-shaped groove on the reverse side, and a central hole coaxially connected to the circular hole is provided in the center of the cross-shaped groove. The branch groove 1, branch groove 2, branch groove 3, branch groove 4, branch groove 5, and branch groove 6 are evenly distributed along the circumference of the distributor.

[0011] In a preferred embodiment of this utility model, the end of each branch trench is connected to an H-shaped trench, and each branch of the cross-shaped trench is connected to the opening of the corresponding circular hole on the reverse side of the distributor.

[0012] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.

[0013] 1. By designing the main path and branch paths to be of equal length, the total length of the flow path from the center of the distributor to each H-shaped groove is consistent, and the resistance compensation of the main path being wider and deeper than that of the branch paths completely eliminates flow deviation, effectively improves the utilization rate of the chromatographic column packing, and makes the separation peaks more symmetrical and sharp. 2. The circular holes are vertically connected to the front and back to achieve flow path connection. The distributor has a star-shaped groove on the back, and the central hole is coaxially connected to the circular holes and the branch grooves are connected accordingly. This guides the mobile phase to diffuse radially and uniformly. Combined with the tree-shaped layout of "main path → branch path → H-shaped groove", it perfectly matches the annular flow channel of the large cross-section preparative chromatography column. Even at high flow rates, it can still ensure the uniformity of distribution and improve the separation efficiency. Attached Figure Description

[0014] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which: Figure 1 This is a front view of a novel mobile phase distributor structure. Figure 2 This is a schematic diagram of the groove in a novel mobile phase distributor structure; Figure 3 This is a reverse view of a novel mobile phase distributor structure. Figure 4 This is a schematic diagram of a cross-shaped groove in a novel mobile phase distributor structure.

[0015] In the diagram: 1. Center of the distributor; 2. H-shaped groove; 3. Second branch groove; 4. Fourth branch groove; 5. Fifth branch groove; 6. Sixth branch groove; 7. Third branch groove; 8. First branch groove; 9. Main road groove; 10. Circular hole. Detailed Implementation

[0016] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0017] Example 1: As Figure 1 and 2 The system includes a distributor with H-shaped grooves 2 on the front. Each H-shaped groove 2 merges into the main road groove 9 through branch road groove 8, branch road groove 3, branch road groove 7, branch road groove 4, branch road groove 5, and branch road groove 6, and then converges into the center 1 of the distributor through a tree-like connection. Each H-shaped groove 2 passes vertically through the distributor to the back of the distributor through a round hole 10.

[0018] The specific application scenario of this embodiment is as follows: The H-shaped grooves 2 on the front of the distributor serve as the final distribution units of the mobile phase. Each H-shaped groove 2 forms branch flow paths through branch channel 1 groove 8, branch channel 2 groove 3, branch channel 3 groove 7, branch channel 4, branch channel 5, and branch channel 6. These branch channel grooves converge step by step to form the main channel groove 9. Finally, all flow paths converge to the center 1 of the distributor. When the mobile phase enters, it can flow from the center 1 of the distributor to each H-shaped groove 2 along the above flow paths. At the same time, each H-shaped groove 2 is vertically penetrated through the circular hole 10 to the back of the distributor, realizing the through transmission of the mobile phase from the front to the back of the distributor. This is suitable for chromatographic separation in which the mobile phase needs to be initially distributed on both the front and back of the distributor.

[0019] Example 2: Figure 1 and Figure 2 The width of the main road trench 9 is greater than the width of the branch road trench 8, branch road trench 3, branch road trench 7, branch road trench 4, branch road trench 5, and branch road trench 6. The distributor center 1 is the inlet of the flowing phase, and the distributor center 1 is connected to the branch road trench 8, branch road trench 3, branch road trench 7, branch road trench 4, branch road trench 5, and branch road trench 6 through the main road trench 9.

[0020] The specific application scenario of this embodiment is as follows: The distributor center 1 serves as the inlet for the mobile phase. After entering through the center 1, the mobile phase first flows into the main channel trench 9 and then flows through the main channel trench 9 to the branch channel trench 8, branch channel trench 3, branch channel trench 7, branch channel trench 4, branch channel trench 5, and branch channel trench 6, respectively. Since the width of the main channel trench 9 is greater than the width of each branch channel trench, the resistance of the mobile phase in the main channel transmission can be reduced, ensuring sufficient flow to be distributed to each branch channel. This allows the mobile phase to be more evenly distributed from the main channel to each branch channel trench and finally delivered to the H-shaped trench 2. This is suitable for high-flow-rate chromatographic separation that requires balancing the flow rate through the difference in flow path width.

[0021] Example 3: Figures 1-2 The total length of the flow path from the center 1 of the distributor to each H-shaped groove 2 is the same, through the main channel groove 9, branch channel 1 groove 8, branch channel 2 groove 3, branch channel 3 groove 7, branch channel 4, branch channel 5, and branch channel 6 groove 6. The depth of the main channel groove 9 is greater than that of the branch channel 1 groove 8, branch channel 2 groove 3, branch channel 3 groove 7, branch channel 4, branch channel 5, and branch channel 6 groove ...

[0022] The specific application scenario of this embodiment is as follows: The mobile phase starts from the center 1 of the distributor, flows through the main channel trench 9, each branch channel trench, branch channel 1 trench 8, branch channel 2 trench 3, branch channel 3 trench 7, branch channel 4 trench 4, branch channel 5 trench 5, and branch channel 6 trench 6, and flows to the H-shaped trench 2. Since the total length of the flow path from the center 1 of the distributor to each H-shaped trench 2 is the same, it can be ensured that the flow reaches each H-shaped trench 2 at the same time. At the same time, the depth of the main channel trench 9 is greater than that of each branch channel trench, which can further optimize the transmission efficiency of the mobile phase and reduce the difference in flow resistance. The circular hole 10 connects to the bottom of the H-shaped trench 2 at one end and extends vertically to the opposite side of the distributor at the other end, which can ensure the smooth vertical transmission of the mobile phase from the front to the back. It is suitable for precision chromatographic separation with high requirements for mobile phase distribution synchronization and transmission efficiency.

[0023] Example 4: Figures 3-4 The distributor has a star-shaped groove on its reverse side. The center of each star-shaped groove has a small central hole coaxially connected to the circular hole 10. Branch grooves 8 (branch one), 3 (branch two), 7 (branch three), 4 (branch four), 5 (branch five), and 6 (branch six) are evenly distributed along the circumference of the distributor. The end of each branch groove connects to an H-shaped groove 2. Each branch groove of the star-shaped groove connects to the corresponding opening of the circular hole 10 on the reverse side of the distributor.

[0024] The specific application scenario of this embodiment is as follows: After the mobile phase flows from the front to the back of the distributor through the circular hole 10, the cross-shaped groove on the back of the distributor begins to function. The small hole in the center of the cross-shaped groove is coaxially connected with the circular hole 10 and can receive the mobile phase transmitted from the front. At the same time, the branch groove 8, branch groove 3, branch groove 7, branch groove 4, branch groove 5, and branch groove 6 are evenly distributed along the circumference of the distributor, so that the openings of each H-shaped groove 2 and the corresponding circular hole 10 on the back are also evenly distributed. Each branch groove of the cross-shaped groove is connected to the opening of these circular holes 10 respectively.

[0025] The working principle of this utility model is as follows: When used by those skilled in the art, after the mobile phase is injected from the center 1 of the distributor, it is first diverted through the main channel trench 9 to the branch channel 1 trench 8, branch channel 2 trench 3, branch channel 3 trench 7, branch channel 4 trench 4, branch channel 5 trench 5, and branch channel 6 trench 6. The wider and deeper structure of the main channel trench 9 reduces the main channel flow resistance. Combined with the equal-length flow path design from the center 1 of the distributor to each H-shaped trench 2, it ensures that the mobile phase arrives at each H-shaped trench 2 synchronously. At the same time, the circular hole 10 at each H-shaped trench 2 vertically penetrates the distribution channel. The distributor guides the mobile phase to the reverse side. On the reverse side of the distributor, the star-shaped groove is coaxially connected to the central hole and the round hole 10 to receive the fluid. Each branch groove is connected to the opening of the corresponding round hole 10 on the reverse side. Through the hierarchical structure of the distributor center 1 → main channel groove 9 and each branch channel groove → H-shaped groove 2 → round hole 10 → star-shaped groove, the precise distribution and uniform supply of the mobile phase from the center to the distribution plate are achieved by means of the difference in width and depth of the flow path, the equal length layout and the forward and reverse synergistic flow guidance, which is suitable for the separation of high flow rate and wide cross section of the preparative chromatographic column.

[0026] Although embodiments of the present invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A novel mobile phase distributor structure, characterized in that, The device includes a distributor. The front of the distributor is provided with H-shaped grooves (2). Each H-shaped groove (2) is connected to the main road groove (9) through branch road groove (8), branch road groove (3), branch road groove (7), branch road groove (4), branch road groove (5), and branch road groove (6) in a tree-like manner. Then, it is connected to the center (1) of the distributor. Each H-shaped groove (2) is vertically penetrated through the distributor to the back of the distributor through a round hole (10).

2. The novel mobile phase distributor structure according to claim 1, characterized in that, The width of the main road trench (9) is greater than the width of the branch road trench (8), branch road trench (3), branch road trench (7), branch road trench (4), branch road trench (5), and branch road trench (6); the center (1) of the distributor is the inlet of the mobile phase.

3. The novel mobile phase distributor structure according to claim 2, characterized in that, The distributor center (1) is connected to the branch road first ditch (8), branch road second ditch (3), branch road third ditch (7), branch road fourth ditch (4), branch road fifth ditch (5), and branch road sixth ditch (6) through the main road ditch (9).

4. The novel mobile phase distributor structure according to claim 1, characterized in that, The total length of the flow path from the center of the distributor (1) through the main road trench (9), branch road one trench (8), branch road two trench (3), branch road three trench (7), branch road four trench (4), branch road five trench (5), and branch road six trench (6) to each H-shaped trench (2) is the same.

5. The novel mobile phase distributor structure according to claim 1, characterized in that, The depth of the main road trench (9) is greater than the depth of the branch road trench (8), branch road trench (3), branch road trench (7), branch road trench (4), branch road trench (5), and branch road trench (6).

6. The novel mobile phase distributor structure according to claim 1, characterized in that, One end of the circular hole (10) is connected to the bottom of the H-shaped groove (2), and the other end extends to the back of the dispenser. The axis of the circular hole (10) is perpendicular to the surface of the dispenser.

7. The novel mobile phase distributor structure according to claim 1, characterized in that, The distributor has a cross-shaped groove on the reverse side, and a central hole coaxially connected to the round hole (10) is provided in the center of the cross-shaped groove. The branch groove (8), branch groove (3), branch groove (7), branch groove (4), branch groove (5), and branch groove (6) are evenly distributed along the circumference of the distributor.

8. The novel mobile phase distributor structure according to claim 7, characterized in that, The ends of each branch trench are connected to the H-shaped trench (2), and each branch trench of the cross-shaped trench is connected to the opening of the corresponding circular hole (10) on the opposite side of the distributor.

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