An automatic lifting and quick harvesting supernatant tank
Patent Information
- Application Number
- CN202522066531.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-25
- Publication Date
- 2026-09-15
- Estimated Expiration
- 2035-09-25
AI Technical Summary
[0003]现行行业收获上清液的沉淀罐出液管路都是采用一根固定的不锈钢出液管安装在沉淀罐顶部的出液口上，通过沉淀罐内加微正压将含有疫苗有效成分的上清液压出罐内输送到下一工艺段处理，因为是固定的不锈钢出液管路，长度都已经定好，如果沉淀罐内的出液管路尽量贴近于罐底部虽然能够确保将上清液收获完全，但是尽量贴近于罐底部的出液管路和沉淀的杂质间距很小，想要快速进行上清液的收获只有加大出液流速，出液流速加大而出液口和沉淀页面间距又小会导致沉淀的杂质也容易随上清液一起顺带排出，导致提取纯化失败，这样的情况下只能通过降低出液流速、延长操作时间来确保沉淀提取纯化完成，如果增加出液口和沉降液面的间距，虽然可以确保在加大出液流速同时不带出沉淀，快速完成沉淀提取纯化工作，但是因为加大了出液口和沉淀液面的间距，又不能将上清液完全收获，导致疫苗有效成分收获量减少，降低疫苗年总产量，为了解决现有技术的不足，我们提出一种可自动升降快速收获上清液的沉淀罐
该可自动升降快速收获上清液的沉淀罐，通过设置的纯蒸汽进气管路、蒸汽冷凝水疏水管路与组件基座、外圆精加工套管间的密封结构，构建闭环灭菌回路，灭菌过程中，高温纯蒸汽可充分填充出液管与套管的间隙，冷凝水通过蒸汽冷凝水疏水阀快速排出，确保出液管升降全程罐内及组件全域无菌，有效规避杂菌污染引发的批次报废风险，保障疫苗产品质量的稳定性与安全性。
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Figure CN224748601U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the technical field of precipitation equipment in the extraction and purification process of vaccine preparation, and in particular to a precipitation tank that can automatically lift and quickly harvest the supernatant. Background Technology
[0002] The sedimentation tank is a crucial piece of equipment in the vaccine preparation process. Its operating principle is based on the fact that the active ingredients in a vaccine are readily soluble in a specific solvent, while impurities are insoluble in this solvent. By adding the solvent, the active ingredients and impurities are separated. After the solution has settled for a period of time, the supernatant is discharged to harvest the active ingredients, while the settled impurities are discharged from the bottom of the tank. This process achieves the extraction and purification of the active ingredients. To achieve this function, after the active ingredients dissolve in the supernatant and the impurities settle to the bottom of the tank, an outlet pipe is needed to discharge the supernatant outside the tank for further processing. It is essential to harvest as much supernatant as possible, and the flow rate of the outlet pipe should be as high as possible to improve the operational efficiency of the sedimentation process, shorten vaccine preparation time, and increase vaccine yield.
[0003] Currently, the industry standard for harvesting supernatant from sedimentation tanks uses a fixed stainless steel outlet pipe installed at the top of the tank. A slight positive pressure is applied within the tank to force the supernatant, containing the vaccine's active ingredients, out to the next processing stage. Because this is a fixed stainless steel outlet pipe with a predetermined length, while placing the pipe as close to the bottom of the tank as possible ensures complete supernatant harvesting, this results in a very small gap between the outlet pipe and the sediment. To quickly harvest the supernatant, the flow rate must be increased. However, increasing the flow rate further complicates the process, as the gap between the outlet and the sediment particles is very small. Small flow rates can cause impurities to be easily discharged along with the supernatant, leading to extraction and purification failure. In such cases, the only way to ensure the completion of precipitation extraction and purification is to reduce the outflow rate and extend the operation time. Increasing the distance between the outlet and the sedimentation surface can ensure that the precipitation is not carried out while increasing the outflow rate and quickly completing the precipitation extraction and purification work, but because the distance between the outlet and the sedimentation surface is increased, the supernatant cannot be completely harvested, resulting in a reduction in the amount of effective vaccine components harvested and a decrease in the total annual vaccine production. To address the shortcomings of existing technologies, we propose a sedimentation tank that can automatically lift and quickly harvest the supernatant. Utility Model Content
[0004] The main objective of this invention is to provide a sedimentation tank that can automatically lift and quickly harvest the supernatant, which can effectively solve the problems in the background art.
[0005] To achieve the above objectives, the technical solution adopted by this utility model is as follows: A sedimentation tank capable of automatically lifting and rapidly harvesting supernatant includes a stainless steel sedimentation tank. A sedimentation tank cover is detachably connected to the top of the stainless steel sedimentation tank. Several support legs are fixedly connected to the bottom of the stainless steel sedimentation tank. An assembly interface is fixedly connected to the top of the stainless steel sedimentation tank, and a component base is detachably installed at the upper end of the assembly interface. A locking sleeve is fitted to the upper end of the component base. An outer circular precision-machined sleeve passes through the component base, and a supernatant harvesting outlet pipe is located inside the outer circular precision-machined sleeve. A connecting hose is connected to the top of the supernatant harvesting outlet pipe. A connector is fixedly connected to the outer surface of the outer circular precision-machined sleeve. Two fixing blocks are symmetrically fixed to one side of the component base, and telescopic positioning cylinders are fixedly connected to one side of the two fixing blocks. A pure steam inlet pipe is fixedly connected to the upper part of one side of the component base, and a steam condensate drain pipe is fixedly connected to the lower part of the other side of the component base. A steam condensate drain valve is detachably connected to the middle of the steam condensate drain pipe.
[0006] Preferably, the connection surface between the sedimentation tank cover and the stainless steel sedimentation tank is provided with an annular sealing ring, and the sedimentation tank cover is provided with a quick-opening buckle. The quick-opening buckle cooperates with the locking platform on the top of the stainless steel sedimentation tank to achieve quick fixation of the tank cover.
[0007] Preferably, there are four support legs, which are evenly distributed along the circumference of the bottom of the stainless steel sedimentation tank. Each support leg is threaded with a horizontal adjustment foot at its bottom. The horizontal adjustment foot includes an adjustment screw and a support pad. The upper end of the adjustment screw is engaged with the threaded hole at the bottom of the support leg, and the lower end is welded and fixed to the support pad.
[0008] Preferably, the component base has a through hole for the outer diameter precision-machined sleeve to pass through, and the supernatant harvesting outlet pipe is sleeved on the upper part of the outer diameter precision-machined sleeve.
[0009] Preferably, the bottom end of the supernatant harvesting outlet pipe is provided with an inclined bend, and the curvature of the inclined bend is adapted to the curvature of the bottom end cap of the stainless steel settling tank. The top of the supernatant harvesting outlet pipe is connected to the downstream process equipment pipeline via a flexible hose.
[0010] Preferably, the piston rod end of the telescopic positioning cylinder is detachably connected to the connecting piece, and the telescopic positioning cylinder's telescopic direction is consistent with the axial direction of the outer diameter precision-machined sleeve. The connecting piece is welded and fixed to the outer surface of the outer diameter precision-machined sleeve.
[0011] Compared with the prior art, the present invention has the following beneficial effects: This sedimentation tank, which can automatically lift and quickly harvest supernatant, constructs a closed-loop sterilization circuit through a sealed structure between the pure steam inlet pipeline, the steam condensate drain pipeline, the component base, and the precision-machined outer sleeve. During sterilization, high-temperature pure steam can fully fill the gap between the outlet pipe and the sleeve, and the condensate is quickly discharged through the steam condensate drain valve, ensuring that the entire tank and the entire component are sterile throughout the lifting and lowering process of the outlet pipe. This effectively avoids the risk of batch spoilage caused by bacterial contamination and ensures the stability and safety of vaccine product quality.
[0012] This sedimentation tank, capable of automatically lifting and rapidly harvesting supernatant, achieves coordinated adjustment of the outlet pipe height and tank pressure through the linkage control of a telescopic positioning cylinder and the main control program. In the early stage of the process, the outlet pipe moves upward to a large distance of about 100mm from the sediment surface, and with the help of slight positive pressure, the supernatant can be harvested quickly. In the later stage, the outlet pipe slowly moves downward as the liquid level drops, and the tank pressure is reduced simultaneously to slow down the flow rate. This not only completely avoids the carry-over of impurities, but also further improves the supernatant harvest rate, significantly increases the yield of effective vaccine components, and reduces the production cost per unit of vaccine for enterprises. Attached Figure Description
[0013] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a schematic diagram of the overall structure of this utility model from another angle; Figure 3 This is a partial structural schematic diagram of the present invention; Figure 4 This is an overall sectional view of the present invention.
[0014] In the diagram: 1. Stainless steel settling tank; 2. Settling tank cover; 3. Support leg; 4. Assembly interface; 5. Component base; 6. Locking sleeve; 7. Outer diameter precision-machined sleeve; 8. Supernatant harvesting outlet pipe; 9. Connecting hose; 10. Connector; 11. Fixing block; 12. Telescopic positioning cylinder; 13. Pure steam inlet pipe; 14. Steam condensate drain pipe; 15. Steam condensate drain valve. Detailed Implementation
[0015] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.
[0016] Example 1, as Figure 1 , Figure 2 , Figure 3 and Figure 4As shown, a sedimentation tank capable of automatically lifting and rapidly harvesting supernatant includes a stainless steel sedimentation tank 1. Four support legs 3 are uniformly fixedly connected to the bottom of the stainless steel sedimentation tank 1 along its circumference. Each support leg 3 has a threaded connection to a horizontal adjustment foot at its bottom. The upper end of the adjustment screw is screwed into the threaded hole at the bottom of the support leg 3, and the lower end is welded to a support pad, achieving horizontal calibration and stable support of the tank. A sedimentation tank cover 2 is detachably connected to the top of the stainless steel sedimentation tank 1, with an annular sealing ring on the connection surface. A quick-opening buckle on the outer periphery of the sedimentation tank cover 2 cooperates with a locking platform on the top of the tank to achieve quick fixing and sealing. An assembly interface 4 is fixedly connected to the top of the stainless steel sedimentation tank 1. The lower end of a component base 5 is detachably installed on the upper end of the assembly interface 4 via bolts. A locking sleeve 6 is fitted onto the upper end of the component base 5 to enhance sealing. An outer diameter precision-machined sleeve 7 passes through the central through hole of the component base 5. The supernatant harvesting outlet pipe 8 is inserted inside the outer circular precision-machined sleeve 7. Its bottom end is integrally formed into an inclined bend, and the curvature of the bend matches the curvature of the tank bottom end cap. The top of the supernatant harvesting outlet pipe 8 is connected to the connecting hose 9 via a clamp and connected to the downstream process pipeline. Two fixing blocks 11 are symmetrically welded to one side of the outer wall of the component base 5. The cylinder body of the telescopic positioning cylinder 12 is fixed to the outside of the fixing block 11 by bolts. The piston rod end is connected to the connecting piece 10 via a flange. The connecting piece 10 is welded to the outer surface of the outer circular precision-machined sleeve 7, and the extension and retraction direction of the piston rod is consistent with the axis of the outer circular precision-machined sleeve 7 to ensure stable lifting and lowering of the outlet pipe. A pure steam inlet pipe 13 is welded to the upper part of one side of the component base 5 for connecting to an external pure steam source. A steam condensate drain pipe 14 is welded to the lower part of the other side. A steam condensate drain valve 15 is connected to the middle of the pipe via a thread to form a sterilization circuit.
[0017] It should be noted that this utility model is a sedimentation tank that can automatically lift and quickly harvest supernatant. In use, first complete the connection of all components, close the bottom slag discharge valve and sedimentation tank cover 2 and fasten the quick-opening buckle, open the pure steam inlet pipe 13 valve, and introduce high-temperature pure steam to sterilize the gaps between components and inside the tank. Condensate is discharged through the steam condensate drain pipe 14 and drain valve 15. After sterilization, close the valve and wait for the system to cool to room temperature for use. Next, open the sedimentation tank cover 2, add the vaccine material to be extracted and purified and a specific suitable solvent into the tank, close the tank cover tightly and fasten the quick-opening buckle, start the stirring component to stir the material, stop stirring after stirring, and let it stand for a sufficient time to allow insoluble impurities to settle to the bottom of the tank, forming a layered structure of supernatant containing the effective components of the vaccine in the upper part and sedimented impurities in the lower part. Then, the supernatant harvesting stage begins. In the first stage, the piston rod of the telescopic positioning cylinder 12 is extended by the sedimentation tank main control program, driving the supernatant to be harvested. The supernatant is harvested by moving the outlet pipe 8 upwards to maintain a larger distance between the outlet and the sediment surface. A slight positive pressure is then introduced into the tank, using the pressure difference to push the supernatant into the outlet pipe quickly. The supernatant is then transported to downstream process equipment via the connecting hose 9, quickly harvesting most of the supernatant. In the second stage, when the liquid level in the tank approaches the outlet or the flow rate decreases significantly, the main control program automatically controls the piston rod of the telescopic positioning cylinder 12 to slowly retract, causing the supernatant harvesting outlet pipe 8 to gradually move downwards, slowly reducing the distance between the outlet and the sediment surface. At the same time, the slight positive pressure in the tank is reduced to slow down the flow rate and prevent impurities from being carried out with the supernatant due to the reduced distance. This adjustment continues until the flow rate is extremely low, indicating that the supernatant has been completely harvested. The positive pressure system in the tank is then shut off, and the telescopic positioning cylinder 12 stops operating. Finally, the bottom slag discharge valve is opened to discharge the bottom sediment impurities. Afterward, the pure steam inlet pipe 13 is turned on again to perform secondary sterilization of the system. After completion, all valves are closed, awaiting the next batch of process use.
[0018] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.
Claims
1. A sedimentation tank capable of automatic lifting and rapid harvesting of supernatant, comprising a stainless steel sedimentation tank (1), characterized in that: The stainless steel sedimentation tank (1) is detachably connected to a sedimentation tank cover (2) at the top. Several support legs (3) are fixedly connected to the bottom of the stainless steel sedimentation tank (1). An assembly interface (4) is fixedly connected to the top of the stainless steel sedimentation tank (1), and a component base (5) is detachably installed on the upper end of the assembly interface (4). A locking sleeve (6) is installed on the upper end of the component base (5). An outer circular precision-machined sleeve (7) is inserted inside the component base (5). A supernatant harvesting outlet pipe (8) is installed inside the outer circular precision-machined sleeve (7), and the top of the supernatant harvesting outlet pipe (8) is... A connecting hose (9) is connected, and a connector (10) is fixedly connected to the outer surface of the outer round precision-machined sleeve (7). Two fixing blocks (11) are symmetrically fixed on one side of the component base (5), and a telescopic positioning cylinder (12) is fixedly connected to one side of the two fixing blocks (11). A pure steam inlet pipe (13) is fixedly connected to the upper part of one side of the component base (5), and a steam condensate drain pipe (14) is fixedly connected to the lower part of the other side of the component base (5). A steam condensate drain valve (15) is detachably connected to the middle of the steam condensate drain pipe (14).
2. The sedimentation tank for automatically lifting and rapidly harvesting supernatant according to claim 1, characterized in that: The connection surface between the sedimentation tank cover (2) and the stainless steel sedimentation tank (1) is provided with an annular sealing ring, and the sedimentation tank cover (2) is provided with a quick-opening buckle. The quick-opening buckle cooperates with the locking platform on the top of the stainless steel sedimentation tank (1) to achieve quick fixing of the tank cover.
3. A sedimentation tank for automatically lifting and rapidly harvesting supernatant according to claim 1, characterized in that: The number of the support legs (3) is four, and they are evenly distributed along the bottom circumference of the stainless steel sedimentation tank (1). Each support leg (3) has a threaded connection to a horizontal adjustment foot at its bottom. The horizontal adjustment foot includes an adjustment screw and a support pad. The upper end of the adjustment screw is engaged with the threaded hole at the bottom of the support leg (3), and the lower end is welded and fixed to the support pad.
4. A sedimentation tank for automatically lifting and rapidly harvesting supernatant according to claim 1, characterized in that: The component base (5) has a through hole for the outer diameter precision-machined sleeve (7) to pass through, and the supernatant harvesting outlet pipe (8) is sleeved on the upper part of the outer diameter precision-machined sleeve (7).
5. A sedimentation tank for automatically lifting and rapidly harvesting supernatant according to claim 1, characterized in that: The bottom end of the supernatant harvesting outlet pipe (8) is provided with an inclined bend, and the curvature of the inclined bend is adapted to the curvature of the bottom end cap of the stainless steel sedimentation tank (1). The top of the supernatant harvesting outlet pipe (8) is connected to the downstream process equipment pipeline through a hose (9).
6. A sedimentation tank for automatically lifting and rapidly harvesting supernatant according to claim 1, characterized in that: The piston rod end of the telescopic positioning cylinder (12) is detachably connected to the connector (10), and the telescopic positioning cylinder (12) extends in the same direction as the axis of the outer round precision-machined sleeve (7). The connector (10) is welded and fixed to the outer surface of the outer round precision-machined sleeve (7).