Crystallization collection device for chenodeoxycholic acid

Abstract

The utility model relates to the technical field of production and processing of chenodeoxycholic acid, and particularly discloses a chenodeoxycholic acid crystallization collecting device, which comprises a mounting seat, a tank body arranged on the mounting seat, a filter screen coaxially arranged in the tank body, a power shaft coaxially arranged on the bottom wall of the tank body along the vertical direction, a driving assembly arranged on the mounting seat, a tank cover arranged on the top of the tank body, a mounting cylinder coaxially arranged on the tank cover, a scraping assembly arranged on the mounting cylinder, and a flushing assembly arranged on the tank cover. The utility model has the advantages that the driving assembly drives the filter screen to rotate synchronously, centrifugal force generated when the filter screen rotates is utilized to filter chenodeoxycholic acid crystals, the filtering effect is good, the filtering speed is fast, the flushing assembly pumps clean water into the liquid inlet pipe and sprays the water through multiple nozzles, thereby cleaning the filtered chenodeoxycholic acid crystals, and the quality of the extracted chenodeoxycholic acid crystals is improved.

Description

Technical Field

[0001] This utility model relates to the field of chenodeoxycholic acid production and processing technology, and in particular to a chenodeoxycholic acid crystal collection device. Background Technology

[0002] Chenodeoxycholic acid (CEA) is an important bile acid, belonging to the class of bile acids. It is formed by the partial carboxylation of chenodeoxycholic acid and the hydroxyl groups of bile acids. CEA is a major component of bile, participating in bile production and excretion along with bile salts, and playing a crucial role in fat digestion and absorption. CEA and its derivatives have wide applications in medicine, chemical engineering, and biopharmaceuticals. They are used as drug components, bile acid derivatives, and cosmetic raw materials, and play an important role in drug development, biocatalysis, and chemical synthesis. In the extraction of CEA, separation and purification equipment may be used to extract and purify CEA from porcine bile.

[0003] In traditional porcine bile, chenodeoxycholic acid can be further purified through crystallization. However, traditional chenodeoxycholic acid separation and purification devices are slow in crystallization extraction and cannot wash the chenodeoxycholic acid, resulting in low filtration efficiency and low extraction quality. Utility Model Content

[0004] In order to overcome the shortcomings of the prior art, this application provides a chenodeoxycholic acid crystal collection device.

[0005] This application provides a chenodeoxycholic acid crystal collection device, which adopts the following technical solution: A chenodeoxycholic acid crystal collection device includes a mounting base, a tank body mounted on the mounting base, a filter screen coaxially mounted inside the tank body, a power shaft rotatably mounted coaxially along the vertical direction on the bottom wall of the tank body, a mounting plate mounted on the top of the power shaft, a plurality of mounting pins evenly arranged on the mounting plate, a plurality of mounting holes opened on the bottom of the filter screen, the bottom of the power shaft extending outside the tank body, a drive assembly for driving the power shaft to rotate mounted on the mounting base, a tank cover mounted on the top of the tank body, a feed inlet mounted on the tank cover, a mounting cylinder coaxially mounted on the tank cover, the mounting cylinder slidably sleeved on the power shaft, a scraping assembly for scraping the inner wall of the filter screen mounted on the mounting cylinder, a rinsing assembly for rinsing the raw material mounted on the tank cover, a drain pipe connected to the bottom of the tank body, a collection box mounted on one side of the mounting base, and the end of the drain pipe away from the tank body connected to the collection box.

[0006] By adopting the above technical solution, chenodeoxycholic acid crystals and the mixture are added to the top of the filter screen through the feed inlet. The drive component drives the power shaft to rotate, and the rotation of the power shaft drives the filter screen to rotate synchronously. The centrifugal force generated when the filter screen rotates filters the chenodeoxycholic acid crystals, resulting in good filtration effect and fast speed.

[0007] Optionally, the scraping assembly includes a mounting rod, one end of which is connected to a mounting cylinder. The end of the mounting rod away from the mounting cylinder is hollow. A sliding rod is slidably disposed inside the mounting rod. A scraper seat is disposed at the end of the sliding rod away from the mounting rod. A return spring is disposed on the sliding rod. The other end of the return spring is connected to the mounting rod. The length direction of the scraper seat is consistent with the length direction of the mounting cylinder. Flexible scraper strips are disposed on both sides of the scraper seat. The flexible scraper strips are in contact with the inner wall of the filter screen.

[0008] By adopting the above technical solution, the scraper block scrapes the chenodeoxycholic acid crystals on the side wall of the filter screen, and scrapes the chenodeoxycholic acid crystals located on the side wall of the filter screen to the bottom of the filter screen, thereby avoiding the clogging of the filter screen to a certain extent.

[0009] Optionally, the drive assembly includes a first drive motor, a drive pulley, and a driven pulley. The drive motor is fixedly mounted on the mounting base. The drive pulley is coaxially mounted on the output shaft of the drive motor. The driven pulley is coaxially mounted at the bottom of the power shaft. The drive pulley is connected to the driven pulley via a belt. The diameter of the drive pulley is larger than that of the driven pulley.

[0010] By adopting the above technical solution, the diameter of the driving pulley is larger than that of the driven pulley, which enables the filter screen to rotate faster and improves the separation effect of the filter screen.

[0011] Optionally, the rinsing assembly includes a circular tube, which is coaxially fixed on the tank cover. Multiple nozzles are evenly connected along the circumference of the circular tube. An inlet pipe is connected to the tank cover. A water pump is provided on one side of the mounting base, and the outlet of the water pump is connected to the inlet pipe.

[0012] By adopting the above technical solution, the water pump is started, and the water pump pumps the cleaning water into the upper liquid pipe. Then the cleaning water flows into the circular pipe and is finally sprayed out through multiple nozzles, thereby cleaning the chenodeoxycholic acid crystals.

[0013] Optionally, multiple springs are evenly arranged at the bottom of the mounting base, a base is provided at the bottom of the mounting base, the end of the spring away from the mounting base is connected to the base, and a vibration motor is provided on the mounting base.

[0014] By adopting the above technical solution, the vibration motor will cause the filter screen to vibrate synchronously, which will, to a certain extent, prevent the filter screen from being blocked by chenodeoxycholic acid crystals.

[0015] Optionally, the filter screen is provided with a filter mesh inside.

[0016] By adopting the above technical solution, the filter screen has a smaller pore size, which can filter the reaction solution, thereby better filtering and collecting chenodeoxycholic acid crystals.

[0017] Optionally, the top of the filter screen is provided with a handle.

[0018] By adopting the above technical solution, it is easier for staff to remove the filter screen from the tank.

[0019] Optionally, the drive assembly includes a second drive motor and a rotating shaft. The rotating shaft is rotatably mounted on a mounting base. Multiple drive sprockets with different diameters are coaxially arranged on the rotating shaft. A driven sprocket is coaxially arranged at the bottom of the drive shaft. The drive sprocket is connected to the driven sprocket via a chain.

[0020] By adopting the above technical solution, the chain is connected to driven sprockets with different diameters, which makes it easy to adjust the transmission ratio according to the situation, and thus adjust the rotation speed of the filter screen to a certain extent.

[0021] This utility model has the following advantages: 1. By setting up a tank, a filter screen and a drive assembly, the filter screen is driven to rotate synchronously by the drive assembly. The centrifugal force generated when the filter screen rotates is used to filter chenodeoxycholic acid crystals, resulting in good filtration effect and fast speed. 2. By setting up a rinsing component, the water pump pumps the cleaning water into the upper liquid pipe, and then the cleaning water flows into the circular pipe and is finally sprayed out through multiple nozzles, thereby cleaning the filtered chenodeoxycholic acid crystals and improving the quality of the extracted chenodeoxycholic acid crystals. 3. By setting up a scraping component, the scraping component scrapes the chenodeoxycholic acid crystals located on the side wall of the filter screen to the bottom of the filter screen, which to a certain extent avoids the screen from being blocked. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a schematic diagram of the installation structure of the water pump of this utility model; Figure 3 This is a schematic diagram of the installation structure of the scraping component of this utility model; Figure 4This is a schematic diagram of the installation structure of the filter screen of this utility model; Figure 5 This is a schematic diagram of the installation structure of the drive sprocket of this utility model; In the diagram: 1. Mounting base; 11. Collection box; 12. Spring; 13. Base; 14. Vibration motor; 2. Tank body; 21. Filter screen; 22. Drive shaft; 23. Mounting plate; 24. Mounting pin; 25. Mounting hole; 26. Tank cover; 27. Inlet; 28. Mounting cylinder; 29. ​​Drain pipe; 3. Drive assembly; 31. First drive motor; 32. Drive pulley; 33. Driven pulley; 34. Belt; 35. Second drive motor; 36. Rotating shaft; 37. Drive sprocket; 38. Driven sprocket; 39. Chain; 4. Scraper assembly; 41. Mounting rod; 42. Slide rod; 43. Scraper seat; 44. Return spring; 45. Flexible scraper; 5. Flushing assembly; 51. Circular tube; 52. Nozzle; 53. Liquid inlet pipe; 54. Water pump; 6. Filter screen; 61. Handle. Detailed Implementation

[0023] The present invention will be further described below with reference to the accompanying drawings, but the scope of protection of the present invention is not limited to the following description.

[0024] like Figures 1 to 4As shown, a chenodeoxycholic acid crystal collection device includes a mounting base 1, a tank 2 fixedly mounted on the mounting base 1, a filter screen 21 coaxially rotatably mounted inside the tank 2, a power shaft 22 coaxially rotatably mounted on the bottom wall of the tank 2 along a vertical direction, a mounting plate 23 coaxially mounted on the top of the power shaft 22, a plurality of mounting pins 24 evenly fixedly mounted on the mounting plate 23, a plurality of mounting holes 25 opened at the bottom of the filter screen 21, and the plurality of mounting pins 24 corresponding one-to-one with the plurality of mounting holes 25. Inside the mounting hole 25, the bottom of the power shaft 22 extends to the outside of the tank body 2. A drive assembly 3 for rotating the power shaft 22 is mounted on the mounting base 1. A tank cover 26 is detachably installed on the top shell of the tank body 2. A mounting cylinder 28 is coaxially mounted on the tank cover 26 and slidably sleeved on the power shaft 22. A scraping assembly 4 for scraping the inner wall of the filter screen 21 is mounted on the mounting cylinder 28. A rinsing assembly 5 for rinsing the raw materials is mounted on the tank cover 26. A drain pipe 29 is connected to the bottom of the tank body 2. A collection box 11 is installed on one side of the mounting base 1, and the end of the drain pipe 29 away from the tank body 2 is connected to the collection box 11. In use, chenodeoxycholic acid crystals and the mixed solution are added to the top of the filter screen 21 through the inlet 27. The drive assembly 3 drives the power shaft 22 to rotate, which in turn drives the filter screen 21 to rotate synchronously. The centrifugal force generated by the rotation of the filter screen 21 filters the chenodeoxycholic acid crystals, resulting in good filtration effect and fast speed. The scraping assembly 4 is installed on the tank cover 26, and in relative motion... Under the effect, the scraping component 4 will scrape the side wall of the filter screen 21, thereby avoiding clogging of the filter screen 21 to a certain extent, and scraping the chenodeoxycholic acid crystals thrown onto the side wall of the filter screen 21 onto the bottom wall of the filter screen 21. Then, the rinsing component 5 will pump cleaning water into the tank 2 to rinse the chenodeoxycholic acid crystals to a certain extent, thereby improving the quality of the separated chenodeoxycholic acid crystals. The separated liquid will flow into the collection tank 11 under the action of gravity for storage, so as to facilitate subsequent processing.

[0025] like Figures 1 to 4As shown, the scraping assembly 4 includes a mounting rod 41, one end of which is connected to the mounting cylinder 28. The end of the mounting rod 41 away from the mounting cylinder 28 is hollow. A sliding rod 42 is slidably mounted inside the mounting rod 41. A scraper seat 43 is mounted on the end of the sliding rod 42 away from the mounting rod 41. A return spring 44 is mounted on the sliding rod 42, and the other end of the return spring 44 is connected to the mounting rod 41. The length direction of the scraper seat 43 is consistent with the length direction of the mounting cylinder 28. Flexible scraper strips 45 are mounted on both sides of the scraper seat 43. The flexible scraper strips 45 are connected to the scraper... The inner wall of the filter screen 21 is fitted; during use, the drive assembly 3 drives the filter screen 21 to rotate. Under the action of centrifugal force, some chenodeoxycholic acid crystals will be thrown onto the side wall of the filter screen 21. The filter screen 21 and the scraper seat 43 move relative to each other, thereby causing the scraper seat 43 to scrape the chenodeoxycholic acid crystals on the side wall of the filter screen 21. Under the action of the return spring 44, the scraper seat 43 will abut against the side wall of the filter screen 21. The flexible scraper strip 45 can play a certain protective role on the surface of the filter screen 21 to avoid damage to the filter screen 21.

[0026] like Figures 1 to 4 As shown, the rinsing assembly 5 includes a circular tube 51, which is coaxially fixedly installed at the bottom of the tank cover 26. Multiple nozzles 52 are evenly connected and installed along the circumference of the circular tube 51. An upper liquid pipe 53 is connected and installed on the tank cover 26. A water pump 54 is installed on one side of the mounting base 1, and the outlet of the water pump 54 is connected to the upper liquid pipe 53. In use, the water pump 54 is started, and the water pump 54 pumps the cleaning water into the upper liquid pipe 53. Then the cleaning water flows into the circular tube 51 and is finally sprayed out through the multiple nozzles 52. The multiple nozzles 52 can increase the uniformity of the cleaning water spray, thereby better cleaning the chenodeoxycholic acid crystals.

[0027] like Figures 1 to 4 As shown, multiple springs 12 are evenly installed at the bottom of the mounting base 1, and a base 13 is installed at the bottom of the mounting base 1. The end of the spring 12 away from the mounting base 1 is connected to the base 13. A vibration motor 14 is installed on the mounting base 1. When in use, the vibration motor 14 is started, and the vibration of the vibration motor 14 will drive the mounting base 1 and the tank 2 to vibrate as a whole, thereby driving the filter screen 21 to vibrate synchronously, which to a certain extent avoids the situation where chenodeoxycholic acid crystals clog the filter screen 21.

[0028] like Figures 1 to 4 As shown, a filter screen 6 is installed inside the filter sieve 21; the filter screen 6 has a small pore size, which can filter the reaction solution, thereby better filtering and collecting chenodeoxycholic acid crystals.

[0029] like Figures 1 to 4 As shown, a handle 61 is fixedly installed on the top of the filter screen 21, which makes it easy for workers to remove the filter screen 21 from the tank 2.

[0030] Example 1 like Figures 1 to 4 As shown, the drive assembly 3 includes a first drive motor 31, a drive pulley 32, and a driven pulley 33. The drive motor is fixedly mounted on the mounting base 1. The drive pulley 32 is coaxially fixedly mounted on the output shaft of the drive motor. The driven pulley 33 is coaxially fixedly mounted on the bottom of the power shaft 22. The drive pulley 32 is connected to the driven pulley 33 via a belt 34. The diameter of the drive pulley 32 is larger than that of the driven pulley 33. In use, when the first drive motor 31 is started, the rotation of the first drive motor 31 will drive the drive pulley 32 to rotate. The rotation of the drive pulley 32 will synchronously drive the driven pulley 33 to rotate via the belt 34, thereby driving the power shaft 22 and the filter screen 21 to rotate synchronously. Since the diameter of the drive pulley 32 is larger than that of the driven pulley 33, the filter screen 21 can rotate faster, improving the separation effect of the filter screen 21.

[0031] Example 2 like Figure 5 As shown, the drive assembly 3 includes a second drive motor 35 and a rotating shaft 36. The rotating shaft 36 is rotatably mounted on the mounting base 1. Multiple drive sprockets 37 with different diameters are coaxially mounted on the rotating shaft 36. A driven sprocket 38 is coaxially mounted on the bottom of the power shaft 22. The drive sprockets 37 are connected to the driven sprockets 38 via a chain 39. In use, the second drive motor 35 is started. During the rotation of the second drive motor 35, the rotating shaft 36 will rotate, thereby driving the drive sprockets 37 to rotate. During the rotation of the drive sprockets 37, the driven sprockets 38 will be driven to rotate synchronously via the chain 39, thereby driving the filter screen 21 to rotate. By connecting the chain 39 to the drive sprockets 37 with different diameters, the transmission ratio can be easily adjusted according to the situation, thereby adjusting the rotation speed of the filter screen 21 to a certain extent.

[0032] The above description is merely a preferred embodiment of this utility model and does not constitute any limitation on this utility model. Any person skilled in the art can make many possible variations and modifications to the technical solution of this utility model, or modify it into equivalent embodiments, without departing from the scope of the technical solution of this utility model. Therefore, any modifications, equivalent changes, and alterations made to the above embodiments based on the technology of this utility model without departing from the scope of the technical solution of this utility model shall fall within the protection scope of this technical solution.

Claims

1. A device for collecting chenodeoxycholic acid crystals, characterized in that: The system includes a mounting base (1), on which a tank (2) is mounted. A filter screen (21) is coaxially mounted inside the tank (2). A power shaft (22) is coaxially mounted on the bottom wall of the tank (2) in the vertical direction. A mounting plate (23) is mounted on the top of the power shaft (22). Multiple mounting pins (24) are evenly distributed on the mounting plate (23). Multiple mounting holes (25) are opened at the bottom of the filter screen (21). The bottom of the power shaft (22) extends outside the tank (2). A drive assembly (3) for driving the power shaft (22) to rotate is mounted on the mounting base (1). The tank (2)... A can lid (26) is provided on the top, and a feed inlet (27) is provided on the can lid (26). An installation cylinder (28) is coaxially provided on the can lid (26). The installation cylinder (28) is slidably sleeved on the power shaft (22). A scraping component (4) for scraping the inner wall of the filter screen (21) is provided on the installation cylinder (28). A rinsing component (5) for rinsing the raw materials is provided on the can lid (26). A drain pipe (29) is connected to the bottom of the tank body (2). A collection box (11) is provided on one side of the mounting base (1). The end of the drain pipe (29) away from the tank body (2) is connected to the collection box (11).

2. The chenodeoxycholic acid crystal collection device according to claim 1, characterized in that: The scraping assembly (4) includes a mounting rod (41), one end of which is connected to the mounting cylinder (28). The end of the mounting rod (41) away from the mounting cylinder (28) is hollow. A slide rod (42) is slidably arranged inside the mounting rod (41). A scraper seat (43) is provided at the end of the slide rod (42) away from the mounting rod (41). A return spring (44) is provided on the slide rod (42). The other end of the return spring (44) is connected to the mounting rod (41). The length direction of the scraper seat (43) is consistent with the length direction of the mounting cylinder (28). Flexible scraper strips (45) are provided on both sides of the scraper seat (43). The flexible scraper strips (45) are in contact with the inner wall of the filter screen (21).

3. The chenodeoxycholic acid crystal collection device according to claim 1, characterized in that: The drive assembly (3) includes a first drive motor (31), a drive pulley (32) and a driven pulley (33). The drive motor is fixedly mounted on the mounting base (1). The drive pulley (32) is coaxially mounted on the output shaft of the drive motor. The driven pulley (33) is coaxially mounted on the bottom of the power shaft (22). The drive pulley (32) is connected to the driven pulley (33) via a belt (34). The diameter of the drive pulley (32) is larger than that of the driven pulley (33).

4. The chenodeoxycholic acid crystal collection device according to claim 2, characterized in that: The rinsing assembly (5) includes a circular tube (51), which is coaxially fixed on the tank cover (26). Multiple nozzles (52) are evenly connected along the circumference of the circular tube (51). An upper liquid pipe (53) is connected to the tank cover (26). A water pump (54) is provided on one side of the mounting base (1), and the outlet of the water pump (54) is connected to the upper liquid pipe (53).

5. The chenodeoxycholic acid crystal collection device according to claim 1, characterized in that: The bottom of the mounting base (1) is evenly provided with multiple springs (12), and the bottom of the mounting base (1) is provided with a base (13). The end of the spring (12) away from the mounting base (1) is connected to the base (13). The mounting base (1) is provided with a vibration motor (14).

6. The chenodeoxycholic acid crystal collection device according to claim 1, characterized in that: The filter screen (21) is equipped with a filter mesh (6) inside.

7. The chenodeoxycholic acid crystal collection device according to claim 1, characterized in that: The filter screen (21) is provided with a handle (61) on top.

8. The chenodeoxycholic acid crystal collection device according to claim 1, characterized in that: The drive assembly (3) includes a second drive motor (35) and a rotating shaft (36). The rotating shaft (36) is rotatably mounted on the mounting base (1). Multiple drive sprockets (37) with different diameters are coaxially arranged on the rotating shaft (36). A driven sprocket (38) is coaxially arranged at the bottom of the power shaft (22). The drive sprocket (37) is connected to the driven sprocket (38) through a chain (39).

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