A sample filtration device for liquid chromatography detection

Abstract

The utility model discloses a kind of sample filtering devices of liquid chromatography detection, including filter body and filter membrane, the quantity of the filter membrane is greater than or equal to 1;The inside of the filter body is equipped with containing cavity, the filter membrane is located inside the containing cavity;The connecting portion of the filter membrane and the containing cavity is equipped with sealing ring, for ensuring the sealing between the filter membrane and the filter body;Improve the efficiency and security of sample filtration, ensure the sealing between filter membrane and filter body by using sealing ring, prevent sample leakage, ensure the security of filtration process.Adapt to the filtration needs of different samples, the pore size range of filter membrane is 0.22 microns to 5 microns, can meet the filtration requirements of different particle size samples.Reduce the turbulence and dead volume of sample in filtration process, flow channel inner wall is smooth inner wall, help to reduce the turbulence and dead volume of sample in filtration process.

Description

Technical Field

[0001] This utility model relates to the field of analytical instrument technology, specifically to a sample filtration device for liquid chromatography detection. Background Technology

[0002] In related technical fields, liquid chromatography (LC) is widely used as an analytical technique for the separation, identification, and quantitative analysis of components in mixtures. Before the sample is introduced into the chromatographic column, it is usually filtered to remove suspended particles and avoid contamination of the column and detector.

[0003] In the process of implementing the embodiments of this disclosure, we have discovered that the related technology has at least the following problems: Current sample filtration devices typically consist of a filter membrane and a filter body. However, these devices have certain shortcomings in terms of filtration efficiency, ease of operation, and compatibility with liquid chromatography systems. Utility Model Content

[0004] The purpose of this invention is to provide a sample filtration device for liquid chromatography detection to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a sample filtration device for liquid chromatography detection, comprising a filter body and a filter membrane, wherein the number of filter membranes is greater than or equal to 1; the filter body has an internal cavity, and the filter membrane is disposed inside the cavity; a sealing ring is provided at the connection between the filter membrane and the cavity to ensure the sealing between the filter membrane and the filter body; the upper end of the filter body has a sample inlet, and the lower end has a sample outlet; the sample inlet and the sample outlet are respectively connected to the injection system and the chromatographic column of the liquid chromatography system.

[0006] Preferably, the filter body is a corrosion-resistant material cylinder, such as a polyetheretherketone cylinder or a stainless steel cylinder.

[0007] Preferably, the filter membrane is an organic or inorganic membrane, and the pore size of the filter membrane ranges from 0.22 micrometers to 5 micrometers to meet the filtration requirements of different samples.

[0008] Preferably, a flow channel is provided between the sample inlet and the sample outlet, and the inner wall of the flow channel is a smooth inner wall to reduce turbulence and dead volume of the sample during the filtration process.

[0009] Preferably, both the sample inlet and the sample outlet are equipped with quick connectors, which are compatible with the injection system and the connection port of the chromatographic column of the liquid chromatography system.

[0010] Compared with the prior art, the beneficial effects of this utility model are: improving the efficiency and safety of sample filtration, ensuring the sealing between the filter membrane and the filter body by using a sealing ring, preventing sample leakage, and ensuring the safety of the filtration process.

[0011] To meet the filtration needs of different samples, the pore size of the filter membrane ranges from 0.22 micrometers to 5 micrometers, which can satisfy the filtration requirements of samples with different particle sizes.

[0012] The smooth inner wall of the flow channel helps reduce turbulence and dead volume of the sample during the filtration process, thereby improving filtration efficiency and sample integrity.

[0013] The system features convenient and quick connection methods, with quick connectors at both the sample inlet and outlet, allowing for rapid and easy connection to the injection system and column of a liquid chromatography system, thus improving the convenience of experimental operations.

[0014] Corrosion resistance: The filter body is made of corrosion-resistant materials, such as polyetheretherketone (PEEK) cartridges or stainless steel cartridges, ensuring the durability and compatibility of the device. It can adapt to various chemical environments and extend the service life of the equipment.

[0015] To ensure sample purity, filtration membranes can effectively remove particulate impurities from the sample, ensuring the purity of the sample entering the liquid chromatography system and thus improving the accuracy of analytical results. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the main structure of this utility model; Figure 2 This is a top view of the filter membrane.

[0017] In the diagram: 1. Filter body; 2. Filter membrane; 3. Receiving cavity; 4. Sealing ring; 5. Sample inlet; 6. Sample outlet; 7. Flow channel; 8. Quick connector. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0019] Please see Figure 1-2This utility model provides a technical solution: a sample filtration device for liquid chromatography detection. This device is ingeniously designed and can effectively improve the accuracy and efficiency of detection. It mainly consists of a filter body 1 and at least one filter membrane 2. The filter body 1 has a carefully designed receiving cavity 3. The size and shape of this receiving cavity 3 are precisely calculated to ensure that it can perfectly accommodate at least one filter membrane 2. The filter membrane 2 is precisely placed in the internal space of the receiving cavity 3, ensuring full contact between the filter membrane and the sample, thereby achieving the best filtration effect. To ensure a good seal between the filter membrane 2 and the filter body 1, thereby guaranteeing the high efficiency and safety of the filtration process, a sealing ring 4 was specially designed at the connection between the filter membrane 2 and the receiving cavity 3. This sealing ring 4 was carefully selected and designed to ensure that it can adapt to various working environments and maintain its sealing performance during long-term use, preventing any possible leakage.

[0020] The upper part of the filter body 1 is carefully designed and equipped with a sample inlet 5, which is located in the top area of ​​the device; at the same time, the lower part is also carefully planned and equipped with a sample outlet 6, which is located in the bottom area of ​​the device. Both the sample inlet 5 and the sample outlet 6 are designed to seamlessly interface with the injection system and column of the liquid chromatography system, thereby ensuring smooth sample transfer and analysis, greatly improving the efficiency and accuracy of the experiment.

[0021] In a more detailed and specific design, the core component of the filter, namely the filter body 1, is a cylindrical structure meticulously crafted from materials with highly corrosion-resistant properties. These materials include, but are not limited to, polyetheretherketone (PEEK) cylinders, or cylinders made of stainless steel. This design choice ensures that the entire device can maintain stable operation in various chemical environments, whether acidic, alkaline, or other corrosive media, thereby providing durable and reliable filtration performance.

[0022] The filter membrane 2 can be designed using either organic or inorganic membranes, with its pore size carefully designed to range from 0.22 micrometers to 5 micrometers. This design allows researchers or technicians to select the most suitable filter membrane based on the characteristics and requirements of their respective samples. In this way, the filtration process can be optimized to effectively separate impurities from the sample, ensuring sample purity and the quality of subsequent experiments or applications.

[0023] Furthermore, to further optimize the sample processing, we meticulously designed and installed a dedicated flow channel 7 between the sample inlet 5 and the sample outlet 6. The inner wall of this flow channel 7 has undergone special treatment, designed with a smooth inner wall structure. This design aims to effectively reduce turbulence during the filtration process and minimize dead volume. Through this improvement, we are able to significantly increase filtration efficiency and ensure enhanced sample purity.

[0024] To facilitate easier and faster connection and disconnection for users, quick connectors 8 are specially designed for the sample inlet 5 and sample outlet 6. These quick connectors 8 are precisely designed to perfectly match the injection system and column connection ports of the liquid chromatography system. This design not only simplifies the entire operation process but also significantly improves work efficiency, making the entire experimental process more efficient and smooth.

[0025] Working principle: When this utility model is in operation, the sample to be analyzed is injected into the filter body 1 through the sample inlet 5.

[0026] The sample is filtered through the filter membrane 2 within the receiving cavity 3 of the filter body 1. The pore size of the filter membrane 2 ranges from 0.22 micrometers to 5 micrometers. An appropriate pore size is selected according to the characteristics of the sample to remove particulate impurities, microparticles, microorganisms, etc., ensuring the cleanliness of the sample.

[0027] A sealing ring 4 is provided at the connection between the filter membrane 2 and the receiving cavity 3 to ensure good sealing between the filter membrane 2 and the filter body 1, and to prevent sample leakage and external contamination.

[0028] The filtered sample flows out of the filter body 1 through the sample outlet 6. A flow channel 7 is provided between the sample inlet 5 and the sample outlet 6. The smooth inner wall design of the flow channel 7 helps to reduce turbulence and dead volume of the sample during the filtration process, thereby improving filtration efficiency and sample integrity.

[0029] Sample outlet 6 is connected to the chromatographic column of the liquid chromatography system, and sample inlet 5 is connected to the injection system of the liquid chromatography system. Both sample inlet 5 and sample outlet 6 are equipped with quick connectors 8, which are compatible with the injection system and column connection ports of the liquid chromatography system, facilitating the rapid and accurate introduction of filtered samples into the chromatographic system for analysis.

[0030] The filtered sample is separated, detected, and analyzed in a liquid chromatography system to obtain qualitative and quantitative information on each component in the sample.

[0031] The entire filtration device is designed to ensure that samples are effectively filtered before entering the chromatographic system, thereby improving the accuracy and reproducibility of the analysis.

[0032] In the description of this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0033] All standard parts used in this invention can be purchased from the market, and irregular parts can be customized according to the description and drawings. The specific connection methods of each part adopt conventional methods such as bolts, rivets, and welding that are mature in the prior art. The machinery, parts and equipment adopt conventional models in the prior art, and the circuit connection adopts conventional connection methods in the prior art, which will not be described in detail here.

[0034] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A sample filtration device for liquid chromatography detection, characterized in that: It includes a filter body (1) and a filter membrane (2), wherein the number of filter membranes (2) is greater than or equal to 1; The filter body (1) has a receiving cavity (3) inside, and the filter membrane (2) is disposed inside the receiving cavity (3); A sealing ring (4) is provided at the connection between the filter membrane (2) and the receiving cavity (3) to ensure the sealing between the filter membrane (2) and the filter body (1); The filter body (1) has a sample inlet (5) at the upper end and a sample outlet (6) at the lower end. The sample inlet (5) and the sample outlet (6) are respectively connected to the injection system and the column of the liquid chromatography system.

2. The sample filtration device for liquid chromatography detection according to claim 1, characterized in that: The filter body (1) is a corrosion-resistant material cylinder, such as a polyether ether ketone cylinder or a stainless steel cylinder.

3. The sample filtration device for liquid chromatography detection according to claim 1, characterized in that: The filter membrane (2) is an organic or inorganic membrane, and the pore size of the filter membrane (2) ranges from 0.22 micrometers to 5 micrometers to meet the filtration requirements of different samples.

4. The sample filtration device for liquid chromatography detection according to claim 1, characterized in that: A flow channel (7) is provided between the sample inlet (5) and the sample outlet (6), and the inner wall of the flow channel (7) is a smooth inner wall to reduce turbulence and dead volume of the sample during the filtration process.

5. The sample filtration device for liquid chromatography detection according to claim 1, characterized in that: Both the sample inlet (5) and the sample outlet (6) are equipped with quick connectors (8), which are matched with the injection system and the connection port of the chromatographic column of the liquid chromatography system.

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