A reaction kettle for preparation of medical intermediates

Abstract

The utility model discloses a reaction kettle for medical intermediate preparation belongs to the field of pharmaceutical preparation reaction kettle, and the main liquid inlet pipe is connected through the interface on the sealing cover, and the main pump body for liquid inlet is installed on the main liquid inlet pipe, and the medical intermediate is injected into the reaction kettle body through the main pump body, and one interface of reaction kettle body passes through the vice packing liquid inlet pipe, and the vice pump body for the input of auxiliary material is connected on the vice packing liquid inlet pipe, and the other end of vice pump body is connected with vice packing liquid inlet pipe, thereby realizing the main liquid, and the packing input reaction kettle, another interface of reaction kettle body is connected with the connecting pipeline through the butt joint pipeline. The common effect of vice packing system and backwashing system realizes the accurate control of auxiliary material in the reaction process and the thorough cleaning of the system after reaction. On the one hand, vice packing system ensures the accuracy of reaction ratio, improves product quality, on the other hand, backwashing system carries out the comprehensive cleaning to the system after reaction, provides good conditions for the next reaction.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical preparation reaction vessels, and in particular to a reaction vessel for preparing pharmaceutical intermediates. Background Technology

[0002] As a core piece of equipment in the pharmaceutical industry, reaction vessels used for the preparation of pharmaceutical intermediates bear the brunt of key processes such as drug synthesis, purification, and crystallization. Their design, performance, and application directly impact drug quality, safety, and production efficiency. Pharmaceutical intermediate reaction vessels generally consist of a vessel body, a stirring system, a heating / cooling device, sealing components, a transmission system, and safety accessories. The vessel body is typically made of 316L stainless steel or Hastelloy, with the inner surface mirror-polished to Ra≤0.4μm to eliminate dead zones and meet GMP aseptic requirements. The stirring system is equipped with multi-layer impellers or special stirrers, such as double-layer turbine stirrers, which can achieve dissolved oxygen uniformity ≥95% and shorten dehydration time by 30%. The heat transfer system combines jacketed and coiled designs. The jacket utilizes heat medium circulation to achieve wide temperature range control from -40℃ to 400℃, while the coils are in direct contact with the material, achieving temperature control accuracy of ±0.5℃. The sealing device employs double mechanical seals combined with a nitrogen protection system, with a leakage rate <0.01ml / h, meeting FDA standards. Safety accessories include explosion-proof discs, safety valves, pressure gauges, and over-temperature protection devices to ensure rapid release in case of overpressure / over-temperature.

[0003] Currently, reactors used for preparing pharmaceutical intermediates typically require the input of multiple excipients during actual operation. When a single-input mechanism is used to input these different excipients, a series of problems arise. During each delivery of a different excipient, some of the excipient adheres to the contact area between the input mechanism and the reactor's inner wall. Due to the differences in the properties of the various excipients, it is difficult to completely remove the residual excipients adhering to the inner wall and the input mechanism.

[0004] Such inadequate cleanliness can have numerous negative impacts on subsequent production processes. Firstly, residual excipients may chemically react with newly introduced excipients, altering their chemical properties and affecting the quality and purity of pharmaceutical intermediates, ultimately leading to products that do not meet quality standards. Secondly, the continuous accumulation of residual excipients can clog the input channels, hindering normal excipient transport and reducing production efficiency. Furthermore, prolonged incomplete cleaning can cause corrosion of the reactor's inner wall and input mechanisms, shortening equipment lifespan and increasing production costs for the company. Utility Model Content

[0005] The main objective of this invention is to provide a reaction vessel for the preparation of pharmaceutical intermediates, which can effectively solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the technical solution adopted by this utility model is as follows: A reaction vessel for preparing pharmaceutical intermediates includes a reaction vessel body, a sealing cover, and interfaces. The sealing cover is fixed to the reaction vessel body by bolts, and multiple interfaces are located on the side wall, bottom, and top of the sealing cover of the reaction vessel body, respectively. The sealing cap is connected to a main liquid inlet pipe via an interface. A main pump body for liquid inlet is installed on the main liquid inlet pipe. The main pump body injects the pharmaceutical intermediate into the reactor body. One interface of the reactor body is connected to a secondary packing inlet pipe, and a secondary pump body for excipient input is connected to the secondary packing inlet pipe. The other end of the secondary pump body is connected to a secondary packing delivery pipe, thereby realizing the input of the main liquid and packing into the reactor. Another interface of the reactor body is connected to a connecting pipe via a docking pipe. One end of the connecting pipe is connected to a backwash infusion pipe. The backwash infusion pipe is connected to the auxiliary packing infusion pipe via the connecting pipe and the connecting pipe. The other end of the backwash infusion pipe is connected to a backwash pump. The other end of the backwash pump is connected to a backwash inlet pipe. The backwash system performs backwashing operations on the auxiliary packing system and the reactor.

[0007] In a further preferred embodiment, the bottom of the reactor body is connected to a drain pipe via an interface, and a butterfly valve is connected to the drain pipe to discharge the mixture from the reactor body. In a further preferred embodiment, the interface is a connecting flange, and a sealing ring is attached to the connecting flange by adhesive. The reactor body, the sealing cover and the interface in contact with it are welded and fixed. The sealing cover and the reactor body are fixed by bolts, and a sealing ring is provided at the connection between the sealing cover and the reactor body. In a further preferred embodiment, butterfly valves are connected to both the main liquid inlet pipe and the main pump body pipe. The flow rate of the pharmaceutical intermediate preparation mixture input into the main liquid inlet pipe is controlled by the butterfly valves. Another butterfly valve is installed on the auxiliary packing inlet pipe to control the input of the auxiliary packing. In a further preferred embodiment, the cross-section of the auxiliary packing infusion pipe, the connecting pipe, and the connecting pipe is designed in an "I" shape, and a butterfly valve is provided on the connecting pipe to achieve communication between the auxiliary packing infusion pipe and the connecting pipe. In a further preferred embodiment, the backwash inlet pipe is connected to the backwash storage tank, and butterfly valves are installed on the backwash inlet pipe and the backwash delivery pipe, while a flow meter is installed on the backwash delivery pipe.

[0008] Compared with the prior art, the present invention has the following beneficial effects: By incorporating the auxiliary packing inlet pipe, auxiliary pump body, and auxiliary packing delivery pipe, the main liquid and packing are simultaneously introduced into the reactor. This ensures the timely and accurate supply of excipients during the reaction process, facilitating the smooth progress of the reaction according to the predetermined ratio and conditions, and improving the efficiency and product quality of pharmaceutical intermediate preparation reactions.

[0009] The backwashing system, through its components such as backwash inlet pipes, connecting pipes, link pipes, and backwash pumps, effectively backwashes the auxiliary packing system and reactor. This helps remove residual reactants and impurities from the system, keeping it clean, preventing pipe blockage and equipment corrosion, thereby extending equipment lifespan and ensuring the efficient execution of subsequent reactions.

[0010] The combined effect of the auxiliary packing system and the backwashing system enables precise control of excipients during the reaction and thorough cleaning of the system after the reaction. On the one hand, the auxiliary packing system ensures the accuracy of the reaction ratios and improves product quality; on the other hand, the backwashing system thoroughly cleans the system after the reaction, providing favorable conditions for the next reaction. This combined effect improves the stability and reliability of the entire pharmaceutical intermediate preparation process, reduces production costs, and contributes to environmental protection and sustainable development. Attached Figure Description

[0011] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a diagram showing the overall structure of the present invention; Figure 3 This is a top view of the overall structure of this utility model; Figure 4 This is a diagram illustrating the auxiliary packing system and backwashing system of this utility model; Figure 5 This is a schematic diagram of the auxiliary packing system and backwashing system of this utility model.

[0012] In the diagram: 1. Reactor body; 2. Sealing cover; 3. Interface; 4. Main liquid inlet pipe; 5. Main pump body; 6. Auxiliary packing inlet pipe; 7. Auxiliary pump body; 8. Auxiliary packing delivery pipe; 9. Connecting pipe; 10. Backwash pump; 11. Backwash inlet pipe; 12. Backwash delivery pipe; 13. Connecting pipe; 14. Docking pipe; 15. Drainage pipe. Detailed Implementation

[0013] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.

[0014] like Figure 1 - Figure 5As shown, a reaction vessel for preparing pharmaceutical intermediates mainly includes a reaction vessel body 1, a sealing cover 2, and multiple interfaces 3. The sealing cover 2 is tightly fixed to the top of the reaction vessel body 1 by bolts, while the multiple interfaces 3 are respectively located on the side wall, bottom, and top of the sealing cover 2 to facilitate the connection and operation of various pipelines.

[0015] On the sealing cap 2, a main liquid inlet pipe 4 is connected to one of the interfaces 3, and a main pump body 5 for liquid inlet is installed on the main liquid inlet pipe 4. Driven by the main pump body 5, the pharmaceutical intermediate can be efficiently injected into the reactor body 1. In addition, the other interface 3 of the reactor body 1 is connected through a secondary packing inlet pipe 6, and a secondary pump body 7 for excipient input is connected to the secondary packing inlet pipe 6. The other end of the secondary pump body 7 is connected to a secondary packing delivery pipe 8, thereby realizing the simultaneous input of the main liquid and packing into the reactor, ensuring the smooth progress of the reaction process.

[0016] To achieve the backwashing function, another interface 3 of the reactor body 1 is connected to a connecting pipe 13 via a docking pipe 14. One end of the connecting pipe 13 is connected to a backwash inlet pipe 12. The backwash inlet pipe 12 is connected to the auxiliary packing inlet pipe 8 via the connecting pipe 13 and the connecting pipe 9. The other end of the backwash inlet pipe 12 is connected to a backwash pump 10, and the other end of the backwash pump 10 is connected to a backwash inlet pipe 11. Through this backwashing system, the auxiliary packing system and the reactor can be effectively backwashed, maintaining the cleanliness and efficient operation of the system.

[0017] The bottom of the reactor body 1 is also connected to a drain pipe 15 via interface 3. A butterfly valve is installed on the drain pipe 15, which allows the mixture inside the reactor body 1 to be discharged easily, ensuring that the reacted materials can be processed in a timely manner.

[0018] Interface 3 adopts a connecting flange design, and a sealing ring is attached to the connecting flange with adhesive to ensure the sealing performance of the connection. The reactor body 1, the sealing cover 2 and the interface 3 in contact with it are fixed by welding, and the sealing cover 2 and the reactor body 1 are fixed by bolts. A sealing ring is provided at the connection between the sealing cover 2 and the reactor body 1 to further enhance the overall sealing performance.

[0019] Butterfly valves are connected to both the main liquid inlet pipe 4 and the main pump body 5. These butterfly valves allow for precise control of the flow rate of the pharmaceutical intermediate preparation mixture entering the main liquid inlet pipe 4. Another butterfly valve is installed on the auxiliary packing inlet pipe 6 to control the input flow rate of the auxiliary packing, ensuring the accuracy of the reaction ratio.

[0020] The cross-sections of the auxiliary packing infusion pipe 8, the connecting pipe 9, and the connecting pipe 13 are designed in an "I" shape. This design not only enhances the strength of the pipes but also optimizes fluid flow. A butterfly valve is installed on the connecting pipe 9, which can control the connection status between the auxiliary packing infusion pipe 8 and the connecting pipe 13.

[0021] The backwash inlet pipe 11 is connected to the backwash storage tank. Both the backwash inlet pipe 11 and the backwash delivery pipe 12 are equipped with butterfly valves to control the flow rate of the backwash fluid. In addition, a flow meter is installed on the backwash delivery pipe 12 to monitor the flow rate of the backwash fluid in real time, ensuring the accuracy and effectiveness of the backwash operation.

[0022] Place the reactor body 1 in a suitable position. Next, secure the sealing cover 2 tightly to the top of the reactor body 1 with bolts, and install a sealing ring at the connection between the sealing cover 2 and the reactor body 1. Then, connect each interface 3 to the reactor body 1 and the sealing cover 2 via connecting flanges, and attach the sealing rings to the connecting flanges with adhesive.

[0023] At one interface 3 on the sealing cap 2, the main liquid inlet pipe 4 is connected, and the main pump body 5 is installed on the main liquid inlet pipe 4. A butterfly valve is also installed on the pipes connecting the main liquid inlet pipe 4 and the main pump body 5. At the other interface 3 on the reactor body 1, the auxiliary packing inlet pipe 6 is connected, and the auxiliary pump body 7 is installed on the auxiliary packing inlet pipe 6. The other end of the auxiliary pump body 7 is connected to the auxiliary packing delivery pipe 8, and a butterfly valve is installed on the auxiliary packing inlet pipe 6.

[0024] At another interface 3 of the reactor body 1, a connecting pipe 13 is connected via a docking pipe 14. One end of the connecting pipe 13 is connected to a backwash delivery pipe 12. The backwash delivery pipe 12 is connected to the auxiliary packing delivery pipe 8 via the connecting pipe 13 and the connecting pipe 9. The other end of the backwash delivery pipe 12 is connected to a backwash pump 10. The other end of the backwash pump 10 is connected to a backwash inlet pipe 11, which is connected to a backwash storage tank. Butterfly valves are installed on the backwash inlet pipe 11 and the backwash delivery pipe 12, and a flow meter is installed on the backwash delivery pipe 12. A butterfly valve is also installed on the connecting pipe 9. The auxiliary packing delivery pipe 8, the connecting pipe 9, and the connecting pipe 13 adopt an "I"-shaped cross-section design. Finally, a drain pipe 15 is connected at interface 3 at the bottom of the reactor body 1, and a butterfly valve is installed on the drain pipe 15.

[0025] Start the main pump body 5 and open the butterfly valve on the main liquid inlet pipe 4 to inject the pharmaceutical intermediate into the reactor body 1 through the main liquid inlet pipe 4. Simultaneously, start the auxiliary pump body 7 and open the butterfly valve on the auxiliary packing inlet pipe 6 to input the excipients into the reactor body 1 through the auxiliary packing inlet pipe 6 and the auxiliary packing delivery pipe 8 for the preparation reaction of the pharmaceutical intermediate. After the reaction is complete, open the butterfly valve on the drain pipe 15 to drain the mixture from the reactor body 1.

[0026] Close the butterfly valve on the auxiliary packing inlet pipe 6 to cut off the input of auxiliary packing. Open the butterfly valves on the backwash inlet pipe 11 and the backwash delivery pipe 12, and start the backwash pump 10. The backwash fluid enters the backwash pump 10 from the backwash storage tank through the backwash inlet pipe 11, then through the backwash delivery pipe 12, and via the connecting pipe 13 and the connecting pipe 9 into the auxiliary packing delivery pipe 8 to backwash the auxiliary packing system. At the same time, some backwash fluid will also enter the reactor body 1 to backwash the reactor. The flow rate of the backwash fluid is monitored in real time by the flow meter on the backwash delivery pipe 12, and the opening of the butterfly valve is adjusted as needed to control the flow rate of the backwash fluid. After backwashing is completed, close the backwash pump 10 and the butterfly valves on the backwash inlet pipe 11 and the backwash delivery pipe 12.

[0027] It should be noted that, in this document, relational terms such as first and second (number one, number two), etc., are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes the element.

[0028] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A reaction vessel for preparing pharmaceutical intermediates, comprising a reaction vessel body (1), a sealing cover (2), and interfaces (3), wherein the sealing cover (2) is fixed to the reaction vessel body (1) by bolts, and multiple interfaces (3) are respectively located on the side wall, bottom, and top of the sealing cover (2) of the reaction vessel body (1), characterized in that: The sealing cap (2) is connected to the main liquid inlet pipe (4) via the interface (3). The main liquid inlet pipe (4) is equipped with a main pump body (5) for liquid inlet. The pharmaceutical intermediate is injected into the reactor body (1) through the main pump body (5). One interface (3) of the reactor body (1) is connected to the auxiliary packing inlet pipe (6), and the auxiliary packing inlet pipe (6) is connected to the auxiliary pump body (7) for excipient input. The other end of the auxiliary pump body (7) is connected to the auxiliary packing delivery pipe (8), thereby realizing the input of the main liquid and packing into the reactor. Another interface (3) of the reactor body (1) is connected to a connecting pipe (13) via a docking pipe (14). One end of the connecting pipe (13) is connected to a backwash infusion pipe (12). The backwash infusion pipe (12) is connected to the auxiliary packing infusion pipe (8) via the connecting pipe (13) and the connecting pipe (9). The other end of the backwash infusion pipe (12) is connected to a backwash pump (10). The other end of the backwash pump (10) is connected to a backwash inlet pipe (11). The backwash system performs backwashing operations on the auxiliary packing system and the reactor.

2. The reaction vessel for preparing pharmaceutical intermediates according to claim 1, characterized in that: The bottom of the reactor body (1) is connected to a drain pipe (15) via an interface (3). A butterfly valve is connected to the drain pipe (15), and the mixture inside the reactor body (1) is discharged through the drain pipe (15).

3. A reaction vessel for preparing pharmaceutical intermediates according to claim 2, characterized in that: The interface (3) is a connecting flange, and a sealing ring is connected to the connecting flange by adhesive. The reactor body (1), the sealing cover (2) and the interface (3) in contact with it are welded and fixed. The sealing cover (2) and the reactor body (1) are fixed by bolts, and a sealing ring is provided at the connection between the sealing cover (2) and the reactor body (1).

4. A reaction vessel for preparing pharmaceutical intermediates according to claim 3, characterized in that: Both the main liquid inlet pipe (4) and the main pump body (5) are connected to butterfly valves. The flow rate of the pharmaceutical intermediate preparation mixture input into the main liquid inlet pipe (4) is controlled by the butterfly valves. Another butterfly valve is installed on the auxiliary packing inlet pipe (6). The input of the auxiliary packing is controlled by the butterfly valves.

5. A reaction vessel for preparing pharmaceutical intermediates according to claim 4, characterized in that: The cross-sections of the auxiliary packing infusion pipe (8), the connecting pipe (9) and the connecting pipe (13) are designed in the shape of an "I". A butterfly valve is provided on the connecting pipe (9) to connect the auxiliary packing infusion pipe (8) and the connecting pipe (13).

6. A reaction vessel for preparing pharmaceutical intermediates according to claim 5, characterized in that: The backwash inlet pipe (11) is connected to the backwash storage tank. Butterfly valves are installed on the backwash inlet pipe (11) and the backwash delivery pipe (12). A flow meter is installed on the backwash delivery pipe (12).

Images