A bilirubin extraction and purification all-in-one machine

Abstract

The utility model discloses a kind of bilirubin extraction and purification integrated machine, belong to bilirubin extraction equipment technical field.The utility model aims at solving the problem of the existing extraction device due to the poor mixing effect and affecting extraction speed and efficiency.The integrated machine includes base, support rod is equipped on base, support rod is rotatably equipped with support seat, tank body is equipped on support seat, tank body top is equipped with the feeding pipe with feeding cover, heating and heat preservation assembly is equipped outside tank body, stirring assembly is equipped inside, extraction assembly is communicated at bottom, rotating assembly for driving tank body rotation is equipped on support rod.The utility model drives tank body whole rotation by rotating assembly, cooperate inside stirring assembly, can substantially improve the mixing uniformity and reaction efficiency of raw liquid in tank body, to effectively improve the extraction speed and extraction rate of bilirubin, and overall structure is compact, convenient to operate.

Description

Technical Field

[0001] This utility model relates to the technical field of bilirubin extraction equipment, and in particular to an integrated machine for bilirubin extraction and purification. Background Technology

[0002] Bilirubin is found in bile and blood, and is the main pigment in bile, a reduction product of hemoglobin metabolism. Bilirubin and its calcium salts have clinical medical applications, including lowering blood pressure and promoting erythrocyte regeneration. Furthermore, bilirubin has strong inhibitory effects on Japanese encephalitis virus and W256 cancer cells, and is a key indicator component of the Class I new traditional Chinese medicine, cultured bezoar, with wide applications in medicine. There are various methods for extracting bilirubin, among which chloroform extraction and bilirubin calcium salt extraction are two commonly used methods. Based on the fact that bilirubin and its calcium salts are insoluble in water, distillation can be used to extract the calcium salts.

[0003] Existing bilirubin extraction devices require mixing multiple different materials during operation. However, existing mixing devices, by stirring the materials in one direction, result in poor mixing efficiency, affecting the extraction speed and efficiency of bilirubin. Utility Model Content

[0004] In order to overcome the shortcomings of the existing technology, this application provides an integrated machine for bilirubin extraction and purification.

[0005] This application provides an integrated machine for bilirubin extraction and purification, which adopts the following technical solution: A bilirubin extraction and purification integrated machine includes a base, a support rod on the base, a support seat rotatably mounted on the support rod, a tank on the support seat, a feeding pipe connected to the top of the tank, a feeding cover on the feeding pipe, a heating and heat preservation component on the outside of the tank, a stirring component for stirring the extract inside the tank, an extraction component connected to the bottom of the tank, and a rotating component on the support rod for driving the tank to rotate.

[0006] By adopting the above technical solution, fresh bile is added into the tank through a feeding pipe, and then saturated lime water supernatant and other raw materials are added into the tank through the feeding pipe. The raw liquid is then thoroughly mixed by a stirring component and a rotating component. The raw liquid in the tank is heated by a heating and heat preservation component, which causes the raw liquid to react. Then the tank is restored to a vertical position, and the reacted liquid is discharged into the extraction component by gravity, so that the precipitated bile pigment calcium salt particles are separated from the waste liquid.

[0007] Optionally, the stirring assembly includes a stirring shaft and a stirring motor. The stirring shaft is coaxially rotatable inside the tank in a vertical direction. The stirring motor is fixedly mounted on the top of the tank. The output shaft of the stirring motor is coaxially connected to the stirring shaft. Multiple stirring rods are evenly arranged on the stirring shaft along its length direction. Multiple auxiliary rods are evenly arranged on the stirring rods along their length direction.

[0008] By adopting the above technical solution, the stirring motor is started, and the stirring shaft will rotate coaxially during the rotation of the stirring motor. Multiple stirring rods and multiple auxiliary rods can increase the contact area between the stirring shaft and the original liquid, thereby enhancing the stirring effect on the original liquid.

[0009] Optionally, multiple stirring blades are coaxially and evenly arranged at the bottom of the stirring shaft, and fishbone blades are inclinedly arranged on the stirring blades.

[0010] By adopting the above technical solution, when the fishbone blades rotate, they cause the raw liquid to form a vortex, thereby fully agitating the raw liquid located at the bottom of the tank.

[0011] Optionally, the heating and insulation assembly includes a heating wire, a thermometer, and an insulation shell. The insulation shell is fitted onto the tank body, the heating wire is located between the insulation shell and the tank body and is wound around the outer wall of the tank body, the thermometer is located at the top of the tank body, and the probe of the thermometer extends into the interior of the tank body.

[0012] By adopting the above technical solution, the heating wire will generate heat after being powered on, and the heat will be conducted through the tank to heat the raw liquid.

[0013] Optionally, the rotating assembly includes an active dial, a grooved wheel, and a rotary motor. A mounting base is provided on the support rod, and the support base is rotatably mounted on the support rod via a rotating shaft that extends to the mounting base. The grooved wheel is rotatably mounted on the mounting base and is coaxially connected to the rotating shaft. The active dial is rotatably mounted on the mounting base, and the lever on the active dial is slidably mounted in the groove of the grooved wheel. The rotary motor is fixedly mounted on the mounting base, and the output shaft of the rotary motor is coaxially connected to the active dial.

[0014] By adopting the above technical solution, the rotating component drives the tank to rotate back and forth, thereby making the original liquid inside the tank more evenly mixed, and thus improving the bilirubin extraction rate to a certain extent.

[0015] Optionally, the extraction assembly includes an extraction hopper, a first filter screen, a second filter screen, and a third filter screen. A discharge switch is connected to the bottom of the tank, and the top of the extraction hopper is connected to the discharge switch. The second filter screen is fitted over the first filter screen, the third filter screen is fitted over the second filter screen, and the extraction hopper is fitted over the third filter screen. Each of the first, second, and third filter screens has a handle. The mesh size of the first, second, and third filter screens decreases sequentially, and the diameter of the first filter screen is the same as the diameter of the outlet end of the discharge switch.

[0016] By adopting the above technical solution, the particles are filtered three times in sequence through the first filter screen, the second filter screen, and the third filter screen, thereby improving the filtration and separation effect of precipitated bile pigment calcium salt particles.

[0017] Optionally, a connecting cylinder is coaxially fixed to the top of the extraction hopper, and the connecting cylinder is threadedly connected to the discharge switch.

[0018] By adopting the above technical solution, it is easy for staff to remove the extraction bucket, thereby collecting the precipitated bile pigment calcium salt particles.

[0019] Optionally, the extraction hopper is connected to the discharge switch via a pipe clamp.

[0020] By adopting the above technical solution, it is easier for staff to disassemble and assemble the extraction bucket.

[0021] This utility model has the following advantages: 1. By incorporating a stirring component and a rotating component, the stirring component mixes the raw liquid in the tank, while the rotating component drives the entire tank to rotate, thereby improving mixing efficiency and thus increasing the extraction speed and efficiency of bilirubin. 2. By installing a discharge switch and an extraction component at the bottom of the tank, after the raw liquid has reacted, opening the discharge switch allows the reacted liquid and bilirubin calcium salt to fall into the extraction hopper under gravity, thus achieving extraction and separation. The operation is simple and convenient.

[0022] 3. By setting up a first filter, a second filter, and a third filter, the separation effect of bilirubin calcium salts can be improved, and the collection rate of bilirubin calcium salts can be increased. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a schematic diagram of the installation structure of the rotating component of this utility model; Figure 3This is a schematic diagram of the installation structure of the stirring assembly of this utility model; Figure 4 This is a schematic diagram of the installation structure of the extraction component of this utility model; Figure 5 This is a schematic diagram of the installation structure of the pipe clamp of this utility model; In the diagram: 1. Base; 11. Support rod; 12. Support seat; 13. Mounting seat; 2. Tank body; 21. Feeding pipe; 211. Feeding cover; 3. Heating and insulation component; 31. Heating wire; 32. Thermometer; 33. Insulation shell; 4. Stirring component; 41. Stirring shaft; 42. Stirring motor; 43. Stirring rod; 44. Auxiliary rod; 45. Stirring blade; 46. Fishbone blade; 5. Extraction component; 51. Extraction hopper; 52. First filter screen; 53. Second filter screen; 54. Third filter screen; 55. Discharge switch; 56. Handle; 6. Rotating component; 61. Active dial; 62. Grooved wheel; 63. Rotating motor; 64. Rotating shaft; 7. Connecting cylinder; 71. Pipe clamp. Detailed Implementation

[0024] The present invention will be further described below with reference to the accompanying drawings, but the scope of protection of the present invention is not limited to the following description.

[0025] like Figures 1 to 4 As shown, a bilirubin extraction and purification integrated machine includes a base 1, a support rod 11 mounted vertically on the base 1, a support seat 12 rotatably mounted on the support rod 11, a tank 2 fixedly mounted vertically on the support seat 12, a feeding pipe 21 connected to the top of the tank 2, a feeding cover 211 for sealing itself mounted on the feeding pipe 21, the feeding cover 211 being threadedly connected to the feeding pipe 21, a heating and heat preservation component 3 for heating the raw materials inside the tank 2 mounted on the outside of the tank 2, a stirring component 4 for stirring the extract liquid mounted inside the tank 2, and an extraction component 5 for extracting the purified bilirubin connected to the bottom of the tank 2. The support rod 11... A rotating component 6 is installed to drive the tank 2 to rotate. When preparing bilirubin calcium salt, fresh bile is added into the tank 2 through the feeding pipe 21, and then saturated lime water supernatant and other raw materials are added into the tank 2 through the feeding pipe 21. When the stirring component 4 stirs and mixes the original liquid in the tank 2, the rotating component 6 can drive the tank 2 to rotate as a whole, thereby improving the mixing efficiency and thus improving the extraction speed and efficiency of bilirubin. Then, the heating and heat preservation component 3 heats the original liquid in the tank 2, thereby causing the original liquid to react. Then, the tank 2 is restored to the vertical direction, and the reacted liquid is discharged into the extraction component 5 by gravity, so that the precipitated bile pigment calcium salt particles are separated from the waste liquid.

[0026] like Figures 1 to 4As shown, the stirring assembly 4 includes a stirring shaft 41 and a stirring motor 42. The stirring shaft 41 is coaxially mounted inside the tank 2 in a vertical direction. The stirring motor 42 is fixedly mounted on the top of the tank 2. The output shaft of the stirring motor 42 is coaxially connected to the stirring shaft 41. Multiple stirring rods 43 are evenly mounted on the stirring shaft 41 along its length, and multiple auxiliary rods 44 are evenly mounted on the stirring rods 43 along their length. In use, when the stirring motor 42 is started, the stirring motor 42 will drive the stirring shaft 41 to rotate coaxially. During the rotation of the stirring shaft 41, the multiple stirring rods 43 will rotate synchronously. During the rotation of the stirring rods 43, the multiple auxiliary rods 44 will rotate synchronously. The multiple stirring rods 43 and the multiple auxiliary rods 44 can increase the contact area between the stirring shaft 41 and the original liquid, thereby enhancing the stirring effect on the original liquid.

[0027] like Figures 1 to 4 As shown, multiple stirring blades 45 are coaxially and evenly installed at the bottom of the stirring shaft 41. A fishbone blade 46 is inclinedly installed on one end of the stirring blade 45 away from the stirring shaft 41. During the rotation of the stirring shaft 41, the multiple stirring blades 45 will be driven to rotate synchronously, thereby driving the fishbone blade 46 to rotate synchronously. The fishbone blade 46 has comb-like teeth in the shape of fish bones, and the fishbone blade 46 is inclined. When the fishbone blade 46 rotates, it causes the original liquid to form a vortex, thereby fully agitating the original liquid located at the bottom of the tank 2 and improving the mixing effect of the original liquid.

[0028] like Figures 1 to 4 As shown, the heating and insulation component 3 includes a heating wire 31, a thermometer 32, and an insulation shell 33. The insulation shell 33 is fitted onto the tank body 2. The heating wire 31 is located between the insulation shell 33 and the tank body 2 and is wound around the outer wall of the tank body 2. The thermometer 32 is fixedly installed on the top of the tank body 2, and the probe of the thermometer 32 extends into the interior of the tank body 2. In use, when the heating wire 31 is energized, the energized heating wire 31 will generate heat, which will be conducted through the tank body 2 to heat the raw liquid. The operator can more intuitively observe the temperature of the raw material inside the tank body 2 through the thermometer 32, making it convenient for the operator to energize or de-energize the heating wire 31. The insulation shell 33 can keep the tank body 2 warm, thereby saving energy and reducing production costs.

[0029] like Figures 1 to 4As shown, the rotating assembly 6 includes an active dial 61, a grooved wheel 62, and a rotary motor 63. A mounting base 13 is fixedly mounted on the support rod 11. The support base 12 is rotatably mounted on the support rod 11 via a rotating shaft 64, which extends to the mounting base 13. The grooved wheel 62 is rotatably mounted on the mounting base 13 and coaxially connected to the rotating shaft 64. The active dial 61 is rotatably mounted on the mounting base 13, and the lever on the active dial 61 is slidably mounted in the groove of the grooved wheel 62. The rotary motor 63 is fixedly mounted on the mounting base 13, and its output shaft is coaxially connected to the active dial 61. In use, the rotary motor 63 is started, and its rotation drives the active dial 61. When the active dial 61 rotates, it drives its lever to rotate synchronously. When the lever moves into the groove on the grooved wheel 62, it pushes the grooved wheel 62 to rotate. During the rotation of the grooved wheel 62, it drives the rotating shaft 64 to rotate synchronously. During the rotation of the rotating shaft 64, it drives the tank 2 to rotate synchronously. In this embodiment, the grooved wheel 62 has four grooves, so that the tank 2 rotates 90 degrees each time. This allows the tank 2 to be quickly restored to a vertical state when it is flipped, which is convenient for subsequent bilirubin extraction. In use, the rotating component 6 drives the tank 2 to flip back and forth, so that the original liquid inside the tank 2 is mixed more evenly, thereby improving the bilirubin extraction rate to a certain extent.

[0030] like Figures 1 to 4 As shown, the extraction assembly 5 includes an extraction hopper 51, a first filter screen 52, a second filter screen 53, and a third filter screen 54. A discharge switch 55 is connected to the bottom of the tank body 2. The top of the extraction hopper 51 is connected to the discharge switch 55. The second filter screen 53 is fitted over the first filter screen 52, and the third filter screen 54 is fitted over the second filter screen 53. The extraction hopper 51 is fitted over the third filter screen 54. Handles 56 are installed on the first filter screen 52, the second filter screen 53, and the third filter screen 54. The mesh size of the first filter screen 52, the second filter screen 53, and the third filter screen 54 decreases sequentially. The diameter of the discharge switch 55 is the same as the outlet diameter of the discharge switch 55. After the original liquid in the tank 2 has reacted, the discharge switch 55 is opened, and the reacted liquid will be discharged into the extraction hopper 51 under the action of gravity. It will pass through the first filter screen 52, the second filter screen 53 and the third filter screen 54 in sequence. After three filtrations, the filtration and separation effect of the precipitated bile pigment calcium salt particles can be improved. After the liquid in the tank 2 has been discharged, the extraction hopper 51 is separated from the discharge switch 55. Then the first filter screen 52, the second filter screen 53 and the third filter screen 54 are separated, and the precipitated bile pigment calcium salt particles are collected separately.

[0031] Example 1 like Figures 1 to 4As shown, a connecting cylinder 7 is coaxially fixedly installed on the top of the extraction hopper 51, and the connecting cylinder 7 is threadedly connected to the discharge switch 55.

[0032] In use, fresh bile is added to tank 2 through feeding pipe 21, followed by the addition of saturated lime water supernatant and other raw materials. The mixing components 4 and 6 drive the original solution to mix thoroughly. The heating and heat preservation components 3 heat the original solution in tank 2, causing it to react. Then, tank 2 is restored to a vertical position, and gravity discharges the reacted liquid into extraction component 5, separating the precipitated bile pigment calcium salt particles from the waste liquid. Then, the connecting cylinder 7 is rotated to separate it from the discharge switch 55. The first filter screen 52, the second filter screen 53, and the third filter screen 54 are then used to separate the precipitated bile pigment calcium salt particles.

[0033] Example 2 like Figure 5 As shown, the extraction hopper 51 is connected to the discharge switch 55 via a pipe clamp 71.

[0034] In use, fresh bile is added to tank 2 through feeding pipe 21, followed by the addition of saturated lime water supernatant and other raw materials through feeding pipe 21. The mixing components 4 and 6 drive the original solution to mix thoroughly. The heating and heat preservation components 3 heat the original solution in tank 2, causing it to react. Then, tank 2 is restored to a vertical position, and gravity discharges the reacted liquid into extraction component 5, separating the precipitated bile pigment calcium salt particles from the waste liquid. Then, the pipe clamp 71 is loosened, separating extraction hopper 51 from discharge switch 55. The first filter screen 52, second filter screen 53, and third filter screen 54 are then used to separate the precipitated bile pigment calcium salt particles, which are then collected.

[0035] The above description is merely a preferred embodiment of this utility model and does not constitute any limitation on this utility model. Any person skilled in the art can make many possible variations and modifications to the technical solution of this utility model, or modify it into equivalent embodiments, without departing from the scope of the technical solution of this utility model. Therefore, any modifications, equivalent changes, and alterations made to the above embodiments based on the technology of this utility model without departing from the scope of the technical solution of this utility model shall fall within the protection scope of this technical solution.

Claims

1. A bilirubin extraction and purification integrated machine, characterized in that: The device includes a base (1), a support rod (11) on the base (1), a support seat (12) rotatably mounted on the support rod (11), a tank (2) on the support seat (12), a feeding pipe (21) connected to the top of the tank (2), a feeding cover (211) on the feeding pipe (21), a heating and heat preservation component (3) on the outside of the tank (2), a stirring component (4) for stirring the extract liquid inside the tank (2), an extraction component (5) connected to the bottom of the tank (2), and a rotating component (6) for driving the tank (2) to rotate on the support rod (11).

2. The bilirubin extraction and purification integrated machine according to claim 1, characterized in that: The stirring assembly (4) includes a stirring shaft (41) and a stirring motor (42). The stirring shaft (41) is coaxially rotated in the vertical direction inside the tank (2). The stirring motor (42) is fixedly installed on the top of the tank (2). The output shaft of the stirring motor (42) is coaxially connected to the stirring shaft (41). Multiple stirring rods (43) are evenly arranged on the stirring shaft (41) along its own length direction. Multiple auxiliary rods (44) are evenly arranged on the stirring rods (43) along their own length direction.

3. The bilirubin extraction and purification integrated machine according to claim 2, characterized in that: The bottom of the stirring shaft (41) is coaxially and evenly provided with multiple stirring blades (45), and fishbone blades (46) are inclinedly provided on the stirring blades (45).

4. The bilirubin extraction and purification integrated machine according to claim 1, characterized in that: The heating and heat preservation assembly (3) includes a heating wire (31), a thermometer (32) and a heat preservation shell (33). The heat preservation shell (33) is fitted onto the tank body (2). The heating wire (31) is located between the heat preservation shell (33) and the tank body (2) and the heating wire (31) is wound around the outer wall of the tank body (2). The thermometer (32) is located on the top of the tank body (2) and the probe of the thermometer (32) extends into the interior of the tank body (2).

5. The bilirubin extraction and purification integrated machine according to claim 1, characterized in that: The rotating assembly (6) includes an active dial (61), a grooved wheel (62), and a rotary motor (63). A mounting base (13) is provided on the support rod (11). The support base (12) is rotatably mounted on the support rod (11) via a rotating shaft (64), and the rotating shaft (64) extends to the mounting base (13). The grooved wheel (62) is rotatably mounted on the mounting base (13), and the grooved wheel (62) is coaxially connected to the rotating shaft (64). The active dial (61) is rotatably mounted on the mounting base (13). The lever on the active dial (61) is slidably mounted in the groove of the grooved wheel (62). The rotary motor (63) is fixedly mounted on the mounting base (13), and the output shaft of the rotary motor (63) is coaxially connected to the active dial (61).

6. The bilirubin extraction and purification integrated machine according to claim 5, characterized in that: The extraction assembly (5) includes an extraction bucket (51), a first filter screen (52), a second filter screen (53), and a third filter screen (54). A discharge switch (55) is connected to the bottom of the tank (2). The top of the extraction bucket (51) is connected to the discharge switch (55). The second filter screen (53) is fitted outside the first filter screen (52). The third filter screen (54) is fitted outside the second filter screen (53). The extraction bucket (51) is fitted outside the third filter screen (54). A handle (56) is provided on the first filter screen (52), the second filter screen (53), and the third filter screen (54). The mesh size of the first filter screen (52), the second filter screen (53), and the third filter screen (54) decreases sequentially. The diameter of the first filter screen (52) is the same as the diameter of the outlet end of the discharge switch (55).

7. The bilirubin extraction and purification integrated machine according to claim 6, characterized in that: A connecting cylinder (7) is coaxially fixed to the top of the extraction hopper (51), and the connecting cylinder (7) is threadedly connected to the discharge switch (55).

8. The bilirubin extraction and purification integrated machine according to claim 6, characterized in that: The extraction hopper (51) is connected to the discharge switch (55) via a pipe clamp (71).

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